Supplemental Table 1 Patient Characteristics by HMRS Category
HMRS Category
Low
n = 2622
Age Group
B: 19-29
C: 30-39
D: 40-49
E: 50-59
F: 60-69
G: 70-79
H: 80+
Patient Profile at Time of Implant
1 Critical Cardiogenic Shock
2 Progressive Decline
3 Stable but Inotrope Dependent
4 Resting Symptoms
5 Exertion Intolerant
6 Exertion Limited
7 Advanced NYHA Class 3
Missing (.)
IMclass
Class 1
Class 2
Class 3
Class 4+
Missing
Mid
n = 4162
Total
High
n = 4063
n = 10847
p Value
< 0.001
314 ( 12.0% )
480 ( 18.3% )
602 ( 23.0% )
749 ( 28.6% )
403 ( 15.4% )
70 ( 2.7% )
4 ( 0.2% )
103 ( 2.5% )
208 ( 5.0% )
602 ( 14.5% )
1315 ( 31.6% )
1442 ( 34.6% )
477 ( 11.5% )
15 ( 0.4% )
45 ( 1.1% )
92 ( 2.3% )
324 ( 8.0% )
908 ( 22.3% )
1743 ( 42.9% )
897 ( 22.1% )
54 ( 1.3% )
462 ( 4.3% )
780 ( 7.2% )
1528 ( 14.1% )
2972 ( 27.4% )
3588 ( 33.1% )
1444 ( 13.3% )
73 ( 0.7% )
< 0.001
233 ( 8.9% )
891 ( 34.1% )
944 ( 36.1% )
410 ( 15.7% )
73 ( 2.8% )
46 ( 1.8% )
18 ( 0.7% )
7
494 ( 11.9% )
1539 ( 37.2% )
1285 ( 31.0% )
617 ( 14.9% )
133 ( 3.2% )
43 ( 1.0% )
28 ( 0.7% )
23
795 ( 19.7% )
1603 ( 39.6% )
1051 ( 26.0% )
460 ( 11.4% )
78 ( 1.9% )
32 ( 0.8% )
25 ( 0.6% )
19
1522 ( 14.1% )
4033 ( 37.3% )
3280 ( 30.4% )
1487 ( 13.8% )
284 ( 2.6% )
121 ( 1.1% )
71 ( 0.7% )
49
< 0.001
233 ( 8.9% )
891 ( 34.1% )
944 ( 36.1% )
547 ( 20.9% )
7
1
494 (
1539 (
1285 (
821 (
11.9% )
37.2% )
31.0% )
19.8% )
23
795 (
1603 (
1051 (
595 (
19.7% )
39.6% )
26.0% )
14.7% )
19
1522 (
4033 (
3280 (
1963 (
14.1% )
37.3% )
30.4% )
18.2% )
49
HMRS Category
Low
n = 2622
Mid
n = 4162
Total
High
n = 4063
n = 10847
Creatinine (mg/dL)
Mean ± SD
Median (IQR)
1.1 ± 0.3
1.0 (0.9, 1.2)
1.3 ± 0.4
1.2 (1.0, 1.5)
1.8 ± 1.0
1.6 (1.2, 2.0)
1.4 ± 0.7
1.3 (1.0, 1.6)
INR
Mean ± SD
Median (IQR)
1.2 ± 0.2
1.1 (1.0, 1.2)
1.2 ± 0.2
1.2 (1.1, 1.3)
1.5 ± 0.6
1.3 (1.2, 1.6)
1.3 ± 0.4
1.2 (1.1, 1.4)
Albumin (g/dL)
Mean ± SD
Median (IQR)
p Value
< 0.001
< 0.001
< 0.001
3.8 ± 0.6
3.8 (3.5, 4.1)
3.5 ± 0.5
3.5 (3.2, 3.8)
3.1 ± 0.7
3.1 (2.7, 3.5)
3.4 ± 0.7
3.4 (3.0, 3.8)
5 ( 0.2% )
27 ( 1.0% )
589 ( 22.5% )
1836 ( 70.0% )
164 ( 6.3% )
1
4 ( 0.1% )
38 ( 0.9% )
773 ( 18.6% )
3090 ( 74.3% )
256 ( 6.2% )
1
6 ( 0.1% )
29 ( 0.7% )
592 ( 14.6% )
3129 ( 77.0% )
305 ( 7.5% )
2
15 ( 0.1% )
94 ( 0.9% )
1954 ( 18.0% )
8055 ( 74.3% )
725 ( 6.7% )
4
90 Day Mortality
121 ( 4.6% )
340 ( 8.2% )
524 ( 12.9% )
985 ( 9.1% )
< 0.001
1 Year Mortality
273 ( 10.4% )
635 ( 15.3% )
933 ( 23.0% )
1841 ( 17.0% )
< 0.001
2 Year Mortality
374 ( 14.3% )
855 ( 20.5% )
1191 ( 29.3% )
2420 ( 22.3% )
< 0.001
NYHA Class
Class I: No Limitation or Symptoms
Class II: Slight Limitation
Class III: Marked Limitation
Class IV: Unable to Carry on Minimal Physical Act
ivity
Unknown
Missing (.)
< 0.001
Continuous variables compared using one-way analysis of variance.
Categorical variables compared using chi-square or Fisher's exact test.
2
Supplemental Table 2 Comparison With HMRS Original Derivation Cohort
INTERMACS
Original HMRS
Cohort Used in This
p Value
Derivation Cohort
Study
Age
58.9 ± 13.3
57.03 ± 12.86
<0.001
Male
77%
78%
0.14
Albumin, g/dl
3.44 ± 0.58
3.4 ± 0.7
0.09
Creatinine, mg/dl
1.47 ± 0.55
1.4 ± 0.7
0.009
INR
1.31 ± 0.33
1.3 ± 0.4
0.28
Supplemental Table 3 HMRS Hazard Ratio for Mortality by INTERMACS Class With 95% CI
INTERMACS Class
INTERMACS Class
INTERMACS Class
INTERMACS
1
2
3
Class 4+
90-day
1.291 (1.171, 1.423)
1.266 (1.181, 1.357)
1.304 (1.178,1.444)
1.342 (1.197,1.505)
0.85
1-year
1.281 (1.183, 1.386)
1.253 (1.190, 1.320)
1.234 (1.143, 1.333)
1.254 (1.143, 1.376)
0.94
2-year
1.276 (1.188, 1.370)
1.231 (1.174, 1.290)
1.224 (1.146, 1.307)
1.226 (1.129, 1.332)
0.86
3
p Value
Supplemental Figure 1 One-Year Survival by HMRS
Product-Limit Survival Estimates
1.0
+ Censored
Survival Probability
0.8
0.6
0.4
0.2
0.0
0.0
2.5
5.0
7.5
10.0
12.5
Interval for 1 year Mortality
HMRS Category
High
Low
Mid
Probability of 1 year survival by HMRS categories. 1 year survival probability for high-HMRS is 0.749, for mid-HMRS is 0.828, for lowHMRS is 0.875. Hazard Ratio for high-HMRS vs low-HMRS is 1/0.439=2.278, Hazard Ratio for high-HMRS vs mid-HMRS is 1/0.648= 1.543. X
-axis represents time in months. Log rank test for difference p<0.0001
4
Supplemental Figure 2 Two-Year Survival by HMRS
Product-Limit Survival Estimates
1.0
+ Censored
Survival Probability
0.8
0.6
0.4
0.2
0.0
0
5
10
15
20
25
Interval for 2 year Mortality
HMRS Category
High
Low
Mid
Probability of 2 years survival by HMRS categories. 2 year survival probability for high-HMRS is 0.634, for mid-HMRS is 0.718, for lowHMRS is 0.785. Hazard Ratio for high-HMRS vs low-HMRS is 1/0.481= 2.079, Hazard Ratio for high-HMRS vs mid-HMRS is 1/0.690 = 1. 449.
X-axis represents time in months. Log rank test for difference p<0.0001
5