1. Logistic model estimates used to generate curves in Figure 5
Figure A is based on the model
Risk factor
Intercept
QRS
QRS (log transformed)
Overall p value for QRS is 0.059
c-statistics =0.69
Coefficient
SE
P-value
-174
-0.27
43
87
0.13
21
0.04
0.03
0.04
Coefficient
SE
P-value
90
0.13
22
219
0.32
0.38
0.42
0.39
0.18
0.13
53
0.17
Figure B is based on the model
Risk factor
Intercept
-78
QRS
-0.11
QRS (log transformed)
19
Female
-293
Interaction of QRS and Female
-0.49
Interaction of QRS (log transformed)
74
and Female
Overall p value for interactions of QRS and female is 0.05
c-statistics =0.77
----------------------Figure C is based on the model
Risk factor
Intercept
QRS†
QRS† (log transformed)
†
QRS normalized by BSA
Coefficient
SE
P-value
-53
-0.17
16
26
0.088
7.6
0.04
0.06
0.04
Coefficient
SE
P-value
57
0.22
17
83
0.28
0.92
0.84
0.91
0.41
0.34
24
0.38
Overall p value for QRS† is 0.097
c-statistics =0.65
Figure D is based on the model
Risk factor
Intercept
5.6
QRS†
0.045
QRS† (log transformed)
-1.9
Female
-69
Interaction of QRS† and Female
-0.27
Interaction of QRS† (log
transformed) and Female
21
†
QRS normalized by BSA
Overall p value for interactions of QRS† and gender is 0.59.
c-statistics =0.74
Figure E is based on the model
Risk factor
Intercept
QRS†
QRS† (log transformed)
†
QRS normalized by biplane LV MASS
Coefficient
SE
P-value
7.7
-5.3
7.1
3.6
3.5
3.0
0.03
0.12
0.02
Coefficient
SE
P-value
3.2
-1.0
3.8
3.3
-3.0
13
14
8.9
15
16
0.81
0.94
0.67
0.82
0.85
1.2
11
0.92
Coefficient
SE
P-value
-1.3
3.1
0.71
0.89
0.07
0.0004
Coefficient
SE
P-value
-1.6
3.2
2.2
-1.6
0.93
1.3
1.6
1.9
0.08
0.01
0.17
0.4
Overall p value for QRS† is 0.0004
c-statistics =0.75
Figure F is based on the model
Risk factor
Intercept
QRS†
QRS† (log transformed)
Female
Interaction of QRS† and Female
Interaction of QRS† (log
transformed) and Female
†
QRS normalized by biplane LV MASS
Overall p value for interactions of QRS† and gender is 0.94.
c-statistics =0.76
Figure G is based on the model
Risk factor
Intercept
QRS†
†
QRS normalized by LVEDV
c-statistics = 0.75
Figure H is based on the model
Risk factor
Intercept
QRS†
Female
Interaction of QRS† and Female
†
QRS normalized by LVEDV
c-statistics =0.78
2. CRT Response defined by decrease in ESV ≥15%
(n= 118; since 12/130 patients did not have follow-up ESV available).
Probability of CRT response according to QRS duration, and its transformations
(without adjusting for other patient characteristics). Parametric estimates are shown with
corresponding 68% confidence limits (comparable to ±1 SD). The points representing
mean percentage of responders according to the QRSd for equal number of patients
are given as a crude verification of model fit.
Red: female; Blue: male
Figure 2-A is based on the model
Risk factor
Coefficient
SE
P-value
Intercept
QRS
QRS (log transformed)
Overall p value for QRS is 0.005
c-statistics =0.72
-324
-0.50
80
105
0.16
26
0.002
0.002
0.002
Figure 2-B is based on the model
Risk factor
Coefficient
-157
Intercept
QRS
-0.21
QRS (log transformed)
38
Female
-404
Interaction of QRS and Female
-0.65
Interaction of QRS (log
101
transformed) and Female
Overall p value for interactions of QRS and female is 0.08
c-statistics =0.82
SE
P-value
138
0.20
34
242
0.36
0.26
0.29
0.26
0.10
0.07
59
0.09
Figure 2-C is based on the model
Risk factor
Intercept
QRS†
QRS† (log transformed)
† QRS normalized by biplane LV MASS
Overall p value for QRS† is 0.0003
c-statistics =0.75
Coefficient SE
6.4
-4.7
6.7
3.9
3.8
3.3
P-value
0.10
0.2
0.04
Figure 2-D is based on the model
Risk factor
Intercept
QRS†
QRS† (log transformed)
Female
Interaction of QRS† and Female
Interaction of QRS† (log
transformed) and Female
† QRS normalized by biplane LV MASS
Coefficient SE P-value
-4.6
6.6
15
16
0.8
0.7
-0.87
5.3
-5.5
10
17
17
0.9
0.8
0.8
0.34
13
0.98
Overall p value for interactions of QRS† and gender is 0.53.
c-statistics =0.77