Purinergic Signaling in the Cardiovascular System
by Geoffrey Burnstock
Circulation Research
Volume 120(1):207-228
January 6, 2017
Copyright © American Heart Association, Inc. All rights reserved.
Cellular sources of nucleotides and nucleosides relevant to the control of blood vessel
contractility.
Geoffrey Burnstock Circ Res. 2017;120:207-228
Copyright © American Heart Association, Inc. All rights reserved.
Central vagal cardiocardiac reflex triggered by ATP.230 Illustration Credit: Ben Smith.
Geoffrey Burnstock Circ Res. 2017;120:207-228
Copyright © American Heart Association, Inc. All rights reserved.
Schematic diagram illustrating the main receptor subtypes for purines and pyrimidines present
in blood vessels involved in control of vascular tone.
Geoffrey Burnstock Circ Res. 2017;120:207-228
Copyright © American Heart Association, Inc. All rights reserved.
A–C, Intracellular recording of the electric responses of single smooth muscle cells of the rat tail
artery to field stimulation of the sympathetic motor nerves (the pulse width was 0.1 ms at 0.5 Hz,
indicated by •).
Geoffrey Burnstock Circ Res. 2017;120:207-228
Copyright © American Heart Association, Inc. All rights reserved.
Schematic diagram of long-term (trophic) actions of purines released from nerves, platelets, and
endothelial cells (which also release UTP) acting on P2 receptors to stimulate or inhibit cell
proliferation.
Geoffrey Burnstock Circ Res. 2017;120:207-228
Copyright © American Heart Association, Inc. All rights reserved.
Three P2 receptor subtypes, P2X1, P2Y1, and P2Y12, are involved in ADP-induced platelet
activation.
Geoffrey Burnstock Circ Res. 2017;120:207-228
Copyright © American Heart Association, Inc. All rights reserved.