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The unique solution to
predictable bone regeneration
NovaBone Dental Putty increases productivity with its ease of use and superlative handling characteristics. It delivers predictable bone fast.
Feature
Benefit
Superlative Handling
No mixing is required. Putty can be placed directly into the defect.
Completely Resorbable
Putty resorbs completely and gets replaced by bone. Re-entry time is about
4-5 months and is dependent on the size and site of the defect
Retention & Adaptability
Putty stays together after placement and irrigation. It is moldable into different shapes and adapts
well to the defects and implant surfaces
Osteostimulation
Putty exhibits enhanced bone regeneration rates compared to other bone graft substitutes by a unique
phenomenon: Osteostimulation
Storage & Shelf Life
Putty does not require special storage conditions.
It can be stored at room temperature. 4-year shelf life.
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NovaBone Dental Putty is available in multiple delivery
mechanisms including syringes, clam shells and
“Centrix-like” cartridge delivery systems to suit various
clinical applications.
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Cartridge Applicator Gun
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Clam Shell
The “Cartridge” delivery system is unique and an industry
first! NovaBone Dental Putty is the only graft material in the
world that is available in disposable uni-dose ‘Cartridges’ that
will significantly simplify the delivery of graft to the defect
site following minimally invasive surgical techniques that will
reduce morbidity and enhance healing at the defect site.
NovaBone Dental Putty: Cartridge System
EU3620 0.5cc Cartridges (blue)
2/pkg
EU3640 0.5cc Cartridges (blue)
4/pkg
EU3621 1.0cc Cartridges (orange) 2/pkg
NA3600 Centrix Applicator Gun
each
Syringes
Cartridges
NovaBone Dental Putty: Syringe
EU1610 0.5cc Syringe
1/Pack
EU1620 0.5cc Syringe
2/Pack
NovaBone Dental Putty: Clam Shell
EU0610 0.5cc Shell
1/Pack
EU0620 0.5cc Shell
2/Pack
EU0611 1.0cc Shell
1/Pack
Manufactured by:
NovaBone Products, LLC
"MBDIVB'MPSJEBtXXw.nbputty.com
0D8334
DENTAL PUTTY
The Synthetic Solution to Bone Regeneration
Making Bone Regeneration
Putty In Your Hands
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Uncommon handling.
Uncompromised results.
NovaBone Dental Putty Case Study
(Case Courtesy: Dr. Frederic Joachim)
Patient presented with a decayed
mandibular premolar that required
extraction. Upon extraction, it was
noticed that the buccal wall was
missing and the area was grafted
with NovaBone Dental Putty. The
mucosa was sutured to obtain primarily closure without the use of a
membrane. A six month post-operative radiograph demonstrates good
trabecular pattern and Radiodensity
comparable to the adjacent native
bone. The mucosa was exposed
and upon visual confirmation of the
regenerated ridge an implant was
placed in the area.
Unique Formulation
NovaBone Dental putty is the only commercially available non-settable completely synthetic bone graft substitute. Quite simply, it is
designed to deliver unprecedented ease-of-handling without compromising on the quality of the outcome. It is not just a ‘bone void
filler’; rather, it is a calcium phosphosilicate composed of minerals found naturally in the body that allow for rapid bone regeneration.
NovaBone contains a binder that helps maintain space between the particles to allow for vascularization, tissue growth and new bone
formation. It is indicated for all periodontal, implant related and craniofacial defects.
Osteostimulation
NovaBone Dental Putty belongs to the class of bioactive regenerative materials that not only acts as an osteoconductive scaffold
but also imparts an osteostimulatory effect. Release of Si from the putty particles is the key in signaling & recruitment of
bone precursor cells to the defect site and stimulate osteoblast differentiation and proliferation; the basis for new bone growth.
Gaisser DM, Katta SA, Greenspan DC NovaBone Mechanisms of Osteostimulation, White Paper, NovaBone, Alachua, FL.
Uncompromised Regeneration
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The CPS particles in NovaBone Dental Putty has more than 20 years of international clinical use behind it with over 50 studies on
file. Data shows that NovaBone Dental Putty is clinically superior to the granular particulate alternatives with regard to the ultimate
end result—the successful regeneration of bone between the implant and the existing bone structure. Yet Putty is dramatically more
convenient to use.
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3. Regenerated Buccal Ridge
4. 6 month Post-Operative Radiograph
Dr. Frederic Joachim, Lille, France
Bioactive Healing
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After 12 weeks
% New Bone
Bio-Oss
After 6 weeks
2. Suturing – no membrane used
NovaBone Dental Putty Testimonial
“I have worked with several bone graft substitutes over the years for Socket Preservation surgeries and found NovaBone Dental Putty
to be a revelation. I currently am using NovaBone Putty exclusively and love the cartridge system. I find the handling, healing with
good clinical & histological results far superior to any bone grafts that I have used.”
NovaBone Dental Putty vs. Bio-Oss: Histomorphometry
NovaBone Dental Putty was significantly superior to Bio-Oss at both 6 and 12 weeks following implantation. Comparative histological
analysis and histomorphometry revealed excellent bone regeneration after use of NovaBone Dental Putty, occurring simultaneously
with graft resorption. Also, a reduction in size of putty particles in the histology sections indicated that putty is being absorbed. Sections
of Bio-Oss revealed very minimal graft absorption with particles occupying the majority of the graft area at both 6 and 12 weeks.
Nova Bone Dental Putty
After 6 weeks
1. Extraction and putty placement
% Residual Graft
Weeks
6
12
6
12
NB Dental Putty
33.78
52.90
30.66
24.42
Bio-Oss
18.06
23.01
66.72
57.98
A Timeline of Bioactive Healing
After 12 weeks
“Evaluation of Alloplast Putty and Xenograft Particulate as
Bone Graft Substitutes in a Sheep Lumbar Spine Model.”
Aron Gonshor, Jipin Zhong, David Gaisser
Poster presented at the Academy of Osseointegration, Phoenix, March 2012.
Making Bone Regeneration
Putty In Your Hands
Initial burst of NA+
CA+ & Po4- ions from
smaller CPS particles
Precipitation of calcium
phosphate nodules &
Clot stabilization
Interaction of larger
CPS particles
Differentiation
of the stem cells
Within Minutes
6 Hours
20 Hours
100 Hours
1 Hour
10 Hours
50 Hours
Initiation of Glycerin/PEG
absorption cascade
(continues for 3-5 days)
Crystallization of
Hydroxy carbonate
apatite layer
Recruitment and
fixation of stem cells