Supplementary Figure 3
Smoking status (ever/never)
Standard analysis
Cross-sectional
at T0
Adjusted for cell type
SVA
-log10(observed p value)
8
6
4
λ = 0.973
λ = 1.009
λ = 0.980
2
0
8
-log10(observed p value)
Cross-sectional
at T1
6
4
λ = 1.155
λ = 0.977
λ = 1.066
2
0
0
1
2
3
4
-log10(expected p value)
5
6
0
1
2
3
4
-log10(expected p value)
5
6
0
1
2
3
4
-log10(expected p value)
5
6
Smoking (years since quitting, former smokers)
Standard analysis
Cross-sectional
at T0
Adjusted for cell type
SVA
-log10(observed p value)
8
6
4
λ = 0.986
λ = 1.043
λ = 1.082
2
0
8
-log10(observed p value)
Cross-sectional
at T1
6
4
λ = 1.027
λ = 1.012
λ = 0.993
2
0
0
1
2
3
4
-log10(expected p value)
5
6
0
1
2
3
4
-log10(expected p value)
5
6
0
1
2
3
4
-log10(expected p value)
5
6
Smoking (age at smoking initiation)
Standard analysis
Cross-sectional
at T0
Adjusted for cell type
SVA
-log10(observed p value)
8
6
4
λ = 0.987
λ = 0.987
λ = 0.967
2
0
0
1
2
3
4
-log10(expected p value)
5
6
0
1
2
3
4
-log10(expected p value)
5
6
0
1
2
3
4
-log10(expected p value)
5
6