1) Lamotrigine all True Except :
a) Adjunctivetherapy
b) Enzyme inducer ( no effect on liver enzyme)
c)Life threatening dermatitis d) Inhibits release of excitatory neurotransmitters .
3) regarding Pramipexole all true Except :
a) safelyusedinrenalinsufficiency
b) used as monotherapy in milled cases of PD
c) neuroprotective
d) may cause mental disturbance
4) levodopa in combination w/ carbidopa : (choose ! correct )
a)daily dose of levodopa
Levodopa can causes all the AE EXCEPT: MCQ
a) Arrhythmia
b) Glaucoma
c)Retroperitoneal fibrosis
d)Mood change
DOC of febrile seizures: MCQ
a)Diazepam
Carbamazepine is DOC in: MCQ
a)Partial complex seizures
Phenytoine: Woman is using phynitoin, if she get pregnant, what is the best thing to do??
a)abrupt stop of phynitoin
b)gradual stop
c)decrease dose .....
Anti-epileptic drugs:I think MCQ
a)Suppress but not cure seizures
b)Drugs combination commonly used initially
c)Abrupt withdrawal recommended in non responding patients
d)Their plasma level must be monitored weekly
5) selegiline T or F:
a) ↓ on & off phenomenon
b) ↓ nigral damage by toxins
c) Lack cheese reaction
d)Dependence upon chronic use
Lamotrigine:
a- Can work by inhibiting the transmission of excitatory amino acids
b- Can be used as monotherapy for treatment of Grand-mal seizures
c- Can cause weight gain
d- Is an enzyme inhibitor.
Regarding antiepileptic drugs
a- They relieve the symptoms but they don’t cure the disease (T)
b- Plasma levels should be monitored daily (F)
c- Sudden withdrawl is advised if the drug doesn’t relieve the symptoms (F)
d- We should start treatment with combination of drugs (F)
Pramipexole :
a- Has a neuroprotective effect (T)
b- Can be used as a monotherapy in severe Parkinson disease (F)
c- Causes mental disturbances (T)
d- Dose should be adjusted in renal failure (T)
yo has abscense seizure with some attacks of generalize tonic clonic the DOC is;
b. Ethosoximid
Doesn't treat status eplyptic is
a.Valproic acida
b. Clonazepam
c. Diazepam
d. Phenobarbitone
e. Phenytoin
1) Which one of the following antiepileptic drugs is effective in manicdepressive illness ?
a) Ethosuximide
b) Phenobarbital
c) Carbamazepine
d) Phenytoin
2) Adverse effects of phenytoin may includes ;
a) Ataxia
b) Hirsutism
c) Gum hyperplasia
d) Hyponatremia
3) Which one of the following is not an adverse effect of sodium valporate ?
a) Hepatitis
b) Loss of hair
c) Anorexia
d) Tremor
4) Regarding carbamazepine :
a) Its plasma half-life decreases after chronic use .
b) It is not effective in complex partial seizure
c) Can be used in the treatment of trigeminal neuralgia
d) Causes megaloblastic anaemia
5) Lamotrigine :
a)
b)
c)
d)
blocks sodium channels
is used as monotherapy for partial seizures
is not effective in absence seizures
may cause life-threating dermatitis
6) The drug of choice for febrile convulsions is :
a) Phenytoin
b) Diazepam
c) Primidone
d) Carbamazepine
7) Regarding the mechanism of action of vigabatrin : It
a) inactivates Na+ channels .
b) inhibits the activated Ca+ channels.
c) inhibits GABA aminotransferase .
d) potentiates GAD enzyme.
8) Topiramate :
a) potentiates the inhibitory effect of GABA .
b) is effective in the treatment of generalized tonic-clonic seizures
c) has no adverse effect on the CNS .
d) is safely used during pregnancy .
9) The following statements regarding the treatment of epilepsy are true,
except :
a) The choice of drug depends on the cause of epilepsy and not on
the seizure type .
b) Monotherapy is preferred initially .
c) Treatment must not be for life .
d) Avoid sudden withdrawal of drugs .
10) An epileptic woman controlled by phenytoin , she became pregnant .
which of the following measures is most appropriate?
a) Medical termination of pregnancy .
b) Withdraw phenytoin therapy .
c) Gradually reduce phenytoin dose to the lowest effective level .
d) Substitute phenytoin with a combination of carbamazepine and
sodium valporate .
11) Which of the following is the drug of choice for the treatment of absence
seizures associated with generalized tonic-clonic seizures ?
a) Ethosuximide.
b) Sodium valporate.
c) Carbamazepine.
d) Phenytoin.
1. The mechanism of action of antiepileptic drugs is :
a) Enhancement of GABA-ergic (inhibitory) transmission
b) inhibition of excitatory (usually glutamate-ergic) transmission
c) Modification of ionic conductance
d) All of the above .
2. which of the following has an impotent effect on the T-type calcium channels in
thalamic neurons?
a) Carbamazepine
b) Lamotrigine
c) Ethosuximide
d) Phenytoin .
3. The drug which does not produce a voltage-dependent inactivation of sodium
channels is :
a) Lamotrigine
b) Carbamazepine
c) Phenytoin
d) Vigabatrine .
4. The antiepileptic drug, which produce inhibition of the central effects of excitatory
amino acids is :
a) Ethosuximide
b) Lamotrigine
c) Diazepam
d) Tiagabine .
5. The drug which is not used for partial and generalized tonic-clonic seizures is :
a) Carbamazepine
b) Valproate
c) Phenytoin
d) Vigabatrine .
6. The drug which is used for absence seizures is :
a) Sodium valproate
b) Phenobarbital
c) Carbamazepine
d) Phenytoin .
7. The drug which is used for myoclonic seizures is:
a) Primidone
b) Carbamazepine
c) Clonazepam
d) Phenytoin .
8. The most effective drug in status epilepticus in adults is :
a) Carbamazepine
b) Ethosuximide
c) Diazepam
d) Zonisamide .
9. Regarding phenytoin:
a)
b)
c)
d)
It effects on Ca2+ currents, reducing the low-threshold (T-type) current
It blocks Na+ channels
It inhibits GABA-transaminase, which catalyzes the breakdown of GABA
None of the above .
10. Phenytoin is used in the treatment of:
a) Petit mal epilepsy
b) Grand mal epilepsy
c) Myoclonic seizures
d) None of the above .
11. Dose-related adverse effect caused by phenytoin is:
a) Physical and psychological dependence
b) Gingival hyperplasia
c) Exacerbated grand mal epilepsy
d) Steven-Johnson syndrome .
12. Granulocytopenia , GI irritation and facial hirsutism are possible adverse effects of:
a) Phenobarbital
b) Ethosuximide
c) Phenytoin
d) Carbamazepine .
13. which of the following does not induce hepatic microsomal enzymes ?
a) Carbamazepine
b) Phenytoin
c) Phenobarbital
d) Sodium valproate .
14. The drug of choice for partial seizures is:
a) Carbamazepine
b) Diazepam
c) Ethosuximide
d) Phenytoin .
15. The mechanism of action of Carbamazepine appears to be similar to that of:
a) Benzodiazepines
b) Sodium valproate
c) Phenytoin
d) Ethosuximide .
16. Which of the following is also effective in treating trigeminal neuralgia?
a) Carbamazepine
b) Phenytoin
c) Vigabatrine
d) Lamotrigine .
17. The most common adverse effects of Carbamazepine are:
a) Diplopia, ataxia, and nausea
b) Gingival hyperplasia, hirsutism
c) Sedation, physical and psychological dependence
d) All of the above .
18. Phenobarbital causes :
a) Physical and phychological dependence
b) Exacerbated petit mal epilepsy
c) Sedation
d) All of the above .
19. Lamotrigine can be used alone in the treatment of all the following except :
a) Partial seizures
b) Absence
c) Myoclonic seizures
d) Generalized tonic - clonic seizures .
20. The mechanism of action of vigabatrine is :
a) Direct action on the GABA receptor-chloride channel complex
b) Inhibition of GABA aminotransferase
c) NMDA receptor blockade via the glycine binding site
d) Inhibition of GABA neuronal reuptake from synapses .
21. The mechanism of topiramate’s action is:
a) Reduction of excitatory glutamate-ergic neurotransmission
b) Inhibition of voltage sensitive Na+ channels
c) Potentiation of GABA-ergic neuronal transmission
d) All of the above .
22.The drug of choice in the treatment of petit mal (absence seizures) is:
a) Phenytoin
b) Ethosuximide
c) Phenobarbital
d) Carbamazepine .
23.adverse effects of ethosuximide are all the following except :
a) Gastric upset such as anorexia, pain, nausea and vomiting
b) Exacerbated grand mal epilepsy
c) Fatigue , Dizziness and headache
d) Aggressive behavior .
24.
a)
b)
c)
d)
Sodium valproate is very effective against all the following except :
Absence seizures
Myoclonic seizures
Generalized tonic-clonic seizures
Partial seizures .
25.The drug of choice in the treatment of myoclonic seizures is:
a) Sodium valproate
b) Phenobarbital
c) Phenytoin
d) Ethosuximide .
26. Which of the following antiepileptic drugs may produce teratogenicity?
a) Phenytoin
b) Valproate
c) Topiramate
d) All of the above .
27. The most dangerous effect of antiepileptic drugs after large overdoses is:
a) Respiratory depression
b) Gastrointestinal irritation
c) Alopecia
d) Sedation
Answers
:
1.d
2.c
3.d
4.b
5.d
6.a
7.c
8.c
9.b
10.b
11.b
12.c
13.d
1-
Topiramate t or f
Weight loss
Safe on pregnancy
Potentiantes GABA
2-
Carbidopa is compined to levadopa to :
Increase it’s T ½
Decrease it’s therapeutic use
Decrease central adverse effects
Increase oral bioavailability
14.a
15.c
16.a
17.a
18.d
19.d
20.b
21.d
22.b
23.d
24.d
25.a
26.d
27.a
- MATCHING
- 1) (The drug with its adverse effect)
-
a)
Gum hyperplasia. 2
b)
Hepatotoxicity. 5
c)
Physical dependence1
d)
Hyponatremia 4
1. Diazepam 2. Phenytoin 3. Gabapentine 4. Carbamazepine 5. Valporic acid
-
1 – Na valporate
2- Diazepam
3- Phenytoin
4- Carbamezapine
-
a- Absence seizures and others b- Febrile c- Osteomalacia d- Partial seizure