Dr. Sharrie, Neurotherapist 4701 Wrightsville Ave., Bldg. 1 Wilmington, NC 28403 910 524 5277 PTSD & Neurofeedback Camp Pendleton’s Deployment Health Clinic: “Clinical practice and observations of infra-low neurofeedback as an adjunctive treatment.” April 26, 2011, presented to Combat & Operational Stress Control conference, on 350 active duty service members. Results: over 350 cases of PTSD with or without TBI were tracked through neurofeedback training over 10-20 sessions. Over 60 symptom categories were tracked. Forty-five symptom categories were analyzed quantitatively. Average effect size of 0.80 was found for the 45 symptom categories. (Typically an effect size in research of 0.2 is considered small, 0.5 medium, and 0.8 is large). Briefly, some of the results included 75% of active duty Pendleton Marines showing significant recovery from PTSD symptoms, and 80% have experienced significant relief specifically from depression. Statistically, these results exceed what can be achieved with anti-depressant medication. Moreover, 60-80% of the personnel showed a significant decrease in a variety of other symptoms (see the table below). The military has expanded the research to five other bases in the U.S. Symptom % of military personnel who had a decrease in symptoms (comparison of before & after 5 months of neurofeedback) Suicidal thoughts 75% Flashbacks 70% Panic attacks 80% Agitation 70% Anxiety & depression 70% Fears/phobias 60% Night sweats 80% Headaches 75% More specifically, about one fourth of trainees respond quite rapidly to training, within 10-20 sessions, and the improvement tends to cut across all symptom categories. about another half of trainees respond at a more typical rate, requiring 20-40 sessions for substantial symptom abatement. this leaves another quarter of trainees who either respond more slowly or not at all. the most common complaints related to sleep quality, involving 200 of the 350 subject. An effect size of 0.8 was obtained irritability was an issue with 164 subjects, and yielded an effect size of 0.96. PTSD and neurofeedback Dr. Sharrie 2 being unmotivated was a complaint of 114 subjects, and that yielded an effect size of 1.0 depression symptoms were a complaint of 104, and that yielded an effect size of 0.84. migraines were a complaint of 84, and that yielded an effect size of 0.5 This plot shows substantial relief from depressive symptoms was obtained by four out of five participants. The initial quick response time across the board is quite striking. This uniformity of behavior argues for a common underlying mechanism, one that is clearly accessible to us in EEG feedback. Antidepressant medication certainly does not work this fast. Results of this kind have been obtained for all the classic symptoms of PTSD. However, the target of neurofeedback is not PTSD per se, but rather physiological disregulation in general. “A Pilot Study of Neurofeedback for Chronic PTSD” Mark Gapen, et al, Applied Psychophysiolology Biofeedback, 40(4), 2016. Participants were between the ages of 32-64, recruited from the Boston metro area. The sample was primarily white (N=19) and female (N=15). They were included as having PTSD if they met criteria on the Davidson Trauma Scale, were medically stable and able to maintain meds through the course of the study. Measures used were the Stressful Life Events Screening Questionnaire (SLESQ), a 13 item self-report measure self-report designed to elicit information about traumas. PTSD and neurofeedback Dr. Sharrie 3 Davidson Trauma Scale (DTS), a 17 item self-report measure assessing the presence and severity of PTSD. Inventory of Altered Self-Capacities (IASC) consists of 63 items on a 5 point Likert scale assessing disturbed functioning of self to others, including one subscale ‘Affect Dysregulation’ (AD) as it assesses problems in affect regulation and control. ‘Changes Observed After Neurofeedback’ was developed for this study and asks participants to rate over- and under-arousal symptoms on a 5 point Likert scale. It contains 36 items, the sole purpose being to guide decisions on whether to make changes to the reward band. The study employed two groups designed to assess effectiveness of two alternative scalp placements for sensors (T4-P4 or T3-T4). Post-testing was done after session 40. Results of the study support the notion that neurofeedback may be a promising addition to existing treatments for PTSD. Overall, we found that individuals’ PTSD symptoms were significantly reduced (from a score of 69.14 to 49.26), and that such reductions in PTSD were related to decreases in affect dysregulation (which went from 23.63 to 17.20). We were unable to detect statistically significant differences in sensor placements and both appeared to provide benefit, although there was a trend toward the T4-P4 showing a larger decrease in symptoms. While 40 sessions of treatment provided significant decreases in PTSD symptoms, it by no means provided complete recovery. Our sample consisted of a chronic treatment resistant population, who had received a mean of more than ten years of therapy. All had significant trauma exposure that resulted in developing PTSD prior to age 18. The mean time since their primary trauma was more than 27 years. While we expected the most significant results with hyper arousal symptoms, all three clusters of PTSD symptoms (intrusion, avoidance, and hyper arousal) were reduced significantly. In addition, the reductions in PTSD symptoms preceded reductions in affect dysregulation symptoms. We conjecture that affect regulation appears to be related to executive functions of the frontal lobes, while our sensor placement was over the temporal-parietal regions and therefore not likely directly affecting the neural underpinnings of the executive functioning system. This was the first study to examine neurofeedback in a non-veteran PTSD population. “Neurotherapy of traumatic brain injury/PTSD stress symptoms of OEF/OIF veterans” J. Neuropsychiatry Clinical Neuroscience, Spring 24(2), 237-240. Abstract: The Flexyx Neurotherapy System, a novel variant of EEG biofeedback, was adapted for intervention with seven treatment refractory Afghanistan/Iraq veterans, and brought about significant decreases in bothersome neurobehavioral and PTSD. It may help ameliorate mixed trauma spectrum syndromes. “Alpha-Theta Brainwave Neurofeedback for Vietnam Veterans with Combatrelated PTSD”. Eugene Peniston, Paul Kulkosky. Medical Psychotherapy, 1991, vol. 4, pp 47-60 PTSD and neurofeedback Dr. Sharrie 4 The MMPI was used to assess personality changes in Vietnam combat veterans with PTSD, after either traditional medical treatment (TC), or alpha-theta brainwave neurofeedback (BWT). Brainwave training was for 30 half hour sessions resulted in decreases in MMPI T-scores on all the main clinical scales. The traditional medical group showed decreased T-score only on scale Sc. All 14 BWT patients initially receiving psychotropic meds reduced their dosages after treatment, but only 1 of 13 TC patients reduced dosage. A 30 month follow up study showed all 14 TC patients had relapsed, in contrast to only 3 of 15 BWT patients. These findings indicated that application of alpha-theta brainwave training is a more efficacious treatment modality for PTSD and prevention of relapse. Understanding the graphs: T-score of 50 is average. Standard deviation of 10. Scores at 70 or above are clinical. The little bar above each graph is the standard deviation. TC group was given only pre- and post-MMPI, and base rate EEG brain wave measures. They were also instructed not to use any biofeedback relaxation training during the study. PTSD and neurofeedback Dr. Sharrie Scale Number L F K Hs D Hy Pd Mf Pa Pt Sc Ma Si 5 What it measures ‘Lie’ scale. Attempting to portray oneself overly favorably. (‘Fake bad’) Detects atypical ways of responding ‘Fake good.’ Attempting to deny or exaggerate problems. Tendency to deny good health and admit to a variety of physical symptoms (hypochondriacal) Depression Somatic complaints, tendency to deny psych or social problems. Alienation, rebellion Gender stereotypes patterns (masculine/feminine) Feeling misunderstood, persecuted, treated unfairly Anxious, worry, obsess, ruminate Disturbed thinking, mood, behavior Activity/energy level, excitability Introversion, tendency to withdraw from social contact and responsibilities Results: F: only BWT showed a significant decrease and it was lower than TC on post-test. L, and K were not significant changes. Hs: Significant decrease in BWT, and significantly lower than TC on post-test. D: significant decrease in BWT, and a significant between groups post-test. PTSD and neurofeedback Dr. Sharrie 6 Hy had a significant decrease for BWT and was significantly lower than TC on the posttest (p<.05). Pd, a significant decrease for BWT and a significant difference between groups on posttest. Mf, a decrease in BWT and lower than TC on post-test. Pa, BWT scores decreased over time, and were lower than TC on post-test (p<.05). Pt, BWT decreased significantly and were lower than TC on post-test. Sc, both groups decreased significantly over time, and BWT had lower scores than TC post-test (p<.05). Ma, BWT showed a significant decline across time, and was lower than TC on post-test. Si, only BWT had a significant decrease. The PTSD scale showed a significant decline for BWT and it was significantly lower than TC on post-test. Medication (antidepressant and anti-anxiety) changes in the group, over time Group Increase Decrease No change BWT (N=15) 0 14 0 TC (N=14) 10 1 2 (The control group had 13 people on meds at the outset of the study.) 30 month follow-up study Group Relapse No relapse BWT 3 12 TC 14 0 PTSD and neurofeedback Dr. Sharrie 7 Follow up study was by phone contact, monthly for 30 months after completion of BWT. Subjects were asked to report instances of PTSD symptoms such as flashbacks, nightmares, anxiety attacks, depression, etc. “Neurofeedback Treatment & PTSD: effectiveness of neurofeedback on PTSD and the optimal choice of protocol.” Karen Andersen, Søren Bo, Jessica Carlsson. J. of Nervous and Mental Disease, Feb. 2016, 24(2), 69-77. Abstract included: neurofeedback had a statistically significant effect in three of five studies reviewed. Neurobiological changes were reported in three studies. The optimistic results presented here qualify neurofeedback as probably efficacious for PTSD treatment. “The Effectiveness of Neurofeedback Training on Reducing Symptoms of War Veterans with PTSD.” Zahra Yeganeh, Behrouz Dolatashalee, Ebrahi Dogaheh. Practice in Clinical Psychology, 4(1), 17-24. Abstract includes: Patients with PTSD were randomly selected by purposive sampling method and assigned in experimental (15 persons) and control groups (15 persons). Data were collected by the Post-Traumatic Checklist (PCL). After the pre-test, the experimental group received neurofeedback for 20 sessions, 3 days per week. Results showed differences between adjusted mean of PTSD symptoms in groups posttest by removing the impact of pretest scores. Conclusions were that our findings show that neurofeedback training has significantly decreased the score of total symptoms (p<.001). “EEG alpha-theta synchronization in Vietnam theater veterans with combat-related PTSD and alcohol abuse.” EG Peniston, et al. Advances in Medical Psychotherapy, 1993, 6, 37-50. Abstract: 20 Vietnam vets with chronic PSD, all with comorbid alcohol abuse, were randomly selected. All showed frequent (2-3 times/week) episodes of PTSD symptoms and had been hospitalized for PTSD an average of five times. They were treated with 30 thirty minute sessions of alpha-theta neurofeedback training. Follow-up interviews with the patients and their wives or family members were done monthly for 26 months. During that time only 4 of 20 patients reported a few (1-3) instances of reoccurrence of nightmares or flashbacks, and the other 16 patients had no reoccurrence of PTSD sx.
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