Table S1. Molecular Function GO terms over-represented in each transcript cluster
encoding highly disordered proteins.
Group
Odds
Pvalue
GO:0046965
GO term
retinoid X receptor binding
Description
567.35
3.78E-04
GO:0004862
cAMP-dependent protein kinase inhibitor
Inf
2.43E-02
GO:0051427
Hormone receptor binding
GO:0042974
retinoic acid receptor binding
GO:0008134
15.87
4.73E-02
567.35
3.78E-04
transcription factor binding
5.61
2.26E-02
GO:0030528
transcription regulator
7.08
3.59E-06
GO:0005198
structural molecule
3.76
3.24E-02
GO:0042975
peroxisome proliferator activated receptor binding
567.35
3.78E-04
GO:0003714
transcription corepressor
11.88
2.09E-02
GO:0043565
sequence-specific DNA binding
12.37
7.09E-07
GO:0030374
ligand-dependent nuclear receptor coactivator
51.90
8.12E-03
GO:0003677
DNA binding
5.33
3.52E-05
GO:0003700
transcription factor
8.70
2.25E-06
GO:0003680
AT DNA binding
GO:0005201
extracellular matrix structural constituent
31.62
3.59E-06
GO:0035257
nuclear hormone receptor binding
16.33
4.73E-02
GO:0003712
transcription cofactor
7.46
8.12E-03
GO:0008147
structural constituent of bone
567.35
3.78E-04
GO:0004869
Cysteine protease inhibitor
117.31
6.08E-09
GO:0004857
enzyme inhibitor
13.02
2.46E-05
GO:0030234
enzyme regulator
4.99
4.11E-03
GO:0030161
calpain inhibitor
GO:0004866
endopeptidase inhibitor
18.26
5.05E-05
GO:0030414
Protease inhibitor
18.08
5.05E-05
GO:0003891
Delta DNA polymerase
191.49
4.51E-02
GO:0043565
sequence-specific DNA binding
15.09
1.31E-06
GO:0003677
DNA binding
6.05
1.06E-04
GO:0003700
transcription factor
9.78
7.63E-06
GO:0016564
transcriptional repressor
8.48
4.51E-02
GO:0005201
extracellular matrix structural constituent
19.49
6.07E-03
GO:0030528
transcription regulator
8.61
7.63E-06
GO:0003735
structural constituent of ribosome
Inf
1.58E-02
GO:0005198
structural molecule
Inf
1.58E-02
GO:0003676
nucleic acid binding
Inf
8.03E-04
GO:0003723
RNA binding
Inf
1.01E-04
GO:0005488
Binding
Inf
GO:0003682
chromatin binding
GO:0030528
GO:0031490
Inf
2.31E-04
Inf
2.34E-13
1.58E-02
8.84
1.11E-03
transcription regulator
12.18
2.64E-33
chromatin DNA binding
172.06
4.77E-02
GO:0017049
GTP-Rho binding
Inf
1.61E-02
GO:0031267
Small GTPase binding
GO:0003677
DNA binding
GO:0003700
17.53
6.79E-05
8.98
1.71E-27
transcription factor
14.46
3.06E-34
GO:0017016
Ras GTPase binding
19.13
4.07E-05
GO:0017137
Rab GTPase binding
35.17
1.92E-03
GO:0043565
sequence-specific DNA binding
19.74
1.39E-35
GO:0051020
GTPase binding
15.78
1.25E-04
GO:0005201
extracellular matrix structural constituent
12.32
1.19E-04
Table S2. Biological Process GO terms enriched in transcript clusters encoding
highly disordered proteins.
Group
GO term
GO:0001547
Description
Odds
Inf
Pvalue
GO:0019219
antral ovarian follicle growth
regulation of nucleobase, side, tide and nucleic acid metabolic
process
3.09E-02
4.10
5.81E-04
GO:0051246
regulation of protein metabolic process
12.53
2.61E-05
GO:0032984
macromolecular complex disassembly
56.55
8.18E-03
GO:0051129
negative regulation of cell organization and biogenesis
GO:0031110
regulation of microtubule polymerization or depolymerisation
GO:0048523
negative regulation of cellular process
GO:0006337
nucleosome disassembly
GO:0006820
anion transport
GO:0045815
89.13
1.46E-09
142.10
2.86E-09
4.32
4.52E-03
251.04
1.14E-03
11.85
4.41E-04
positive regulation of gene expression, epigenetic
251.04
1.14E-03
GO:0030837
negative regulation of actin filament polymerization
Inf
3.09E-02
GO:0006817
phosphate transport
37.98
1.39E-06
GO:0032956
regulation of actin cytoskeleton organization and biogenesis
18.21
4.30E-02
GO:0043624
cellular protein complex disassembly
56.55
8.18E-03
GO:0045449
regulation of transcription
4.25
4.35E-04
GO:0051128
regulation of cellular component organization and biogenesis
48.49
2.86E-09
GO:0008064
regulation of actin polymerization and/or depolymerisation
18.21
4.30E-02
GO:0022411
cellular component disassembly
21.24
3.67E-02
GO:0032508
DNA duplex unwinding
33.99
1.81E-02
GO:0006338
chromatin remodelling
18.21
4.30E-02
GO:0032392
DNA geometric change
33.99
1.81E-02
GO:0006355
regulation of transcription, DNA-dependent
4.60
1.86E-04
GO:0015698
inorganic anion transport
15.32
1.33E-04
GO:0051248
negative regulation of protein metabolic process
41.73
7.17E-09
GO:0032535
regulation of cellular component size
18.21
4.30E-02
GO:0031111
negative regulation of microtubule de/polymerization
212.50
8.66E-10
GO:0048519
negative regulation of biological process
4.60
1.71E-03
GO:0001544
initiation of primordial ovarian follicle growth
Inf
3.09E-02
GO:0042989
sequestering of actin monomers
Inf
3.09E-02
GO:0030832
regulation of actin filament length
GO:0031498
chromatin disassembly
GO:0009892
negative regulation of metabolic process
GO:0031114
regulation of microtubule depolymerisation
GO:0006268
DNA unwinding during replication
GO:0006345
loss of chromatin silencing
GO:0043241
protein complex disassembly
GO:0007026
negative regulation of microtubule depolymerisation
GO:0006397
mRNA processing
GO:0033043
18.21
4.30E-02
251.04
1.14E-03
12.89
4.40E-07
212.50
8.66E-10
33.99
1.81E-02
502.25
6.84E-04
56.55
8.18E-03
212.50
8.66E-10
11.38
1.11E-02
regulation of organelle organization and biogenesis
24.58
2.51E-02
GO:0008064
regulation of actin polymerization and/or depolymerisation
28.09
2.22E-02
GO:0006333
chromatin assembly or disassembly
10.59
1.11E-02
GO:0051016
barbed-end actin filament capping
65.44
1.11E-02
GO:0030834
regulation of actin filament depolymerisation
56.14
1.11E-02
GO:0006325
establishment and/or maintenance of chromatin architecture
8.72
1.11E-02
GO:0031497
chromatin assembly
10.26
2.72E-02
GO:0006323
DNA packaging
8.58
1.11E-02
GO:0006334
nucleosome assembly
11.11
2.48E-02
GO:0051017
actin filament bundle formation
98.07
1.11E-02
GO:0016071
mRNA metabolic process
9.72
1.32E-02
GO:0051493
regulation of cytoskeleton organization and biogenesis
24.58
2.51E-02
GO:0065004
protein-DNA complex assembly
7.95
5.00E-02
GO:0007001
chromosome organization and biogenesis
7.80
1.11E-02
GO:0051129
negative regulation of cell organization and biogenesis
28.09
2.22E-02
GO:0032535
regulation of cellular component size
28.09
2.22E-02
GO:0051276
chromosome organization and biogenesis
GO:0008380
RNA splicing
GO:0006996
organelle organization and biogenesis
GO:0006396
RNA processing
GO:0030832
regulation of actin filament length
GO:0042255
ribosome assembly
GO:0032956
GO:0030835
7.31
1.32E-02
14.42
1.11E-02
5.65
1.11E-02
8.06
1.11E-02
28.09
2.22E-02
187.22
4.97E-02
regulation of actin cytoskeleton organization and biogenesis
28.09
2.22E-02
-ve regulation of actin filament depolymerisation
60.43
1.11E-02
GO:0051693
actin filament capping
65.44
1.11E-02
GO:0051128
regulation of cellular component organization and biogenesis
22.32
1.11E-02
GO:0007015
actin filament organization
39.32
1.55E-02
GO:0045941
positive regulation of transcription
8.45
2.11E-02
GO:0045935
+ve regulation of nucleobase side tide and nucleic acid metabolism
8.25
2.11E-02
GO:0040001
establishment of mitotic spindle localization
194.28
3.80E-02
GO:0055007
cardiac muscle cell differentiation
194.28
3.80E-02
GO:0007275
Multicellular organismal development
9.75
2.50E-04
GO:0009887
organ morphogenesis
7.70
4.24E-02
GO:0009893
positive regulation of metabolic process
6.13
3.80E-02
GO:0006355
regulation of transcription, DNA-dependent
6.44
3.24E-04
GO:0015698
inorganic anion transport
11.20
2.61E-02
GO:0048732
gland development
32.82
2.11E-02
GO:0035051
cardiac cell differentiation
98.11
4.99E-02
GO:0030878
thyroid gland development
98.11
4.99E-02
GO:0045893
+ve regulation of transcription, DNA-dependent
7.38
4.47E-02
GO:0051293
establishment of spindle localization
130.44
4.47E-02
GO:0006820
anion transport
8.72
3.80E-02
GO:0035050
embryonic heart tube development
162.52
2.50E-03
GO:0035295
tube development
116.60
3.80E-03
GO:0000731
DNA synthesis during DNA repair
194.28
3.80E-02
GO:0010468
regulation of gene expression
6.48
2.80E-04
GO:0031325
positive regulation of cellular metabolic process
6.60
3.46E-02
GO:0048738
cardiac muscle development
98.11
4.99E-02
GO:0001947
heart looping
194.28
3.80E-02
GO:0032502
developmental process
3.65
2.11E-02
GO:0051146
striated muscle cell differentiation
98.11
4.99E-02
GO:0006817
phosphate transport
26.77
4.45E-03
GO:0031323
regulation of cellular metabolic process
6.10
3.42E-04
GO:0033205
Cytokinesis during cell cycle
384.43
3.46E-02
GO:0045449
regulation of transcription
GO:0000281
Cytokinesis after mitosis
GO:0009888
6.99
2.50E-04
384.43
3.46E-02
tissue development
8.43
3.80E-02
GO:0048856
anatomical structure development
4.47
2.28E-02
GO:0006357
regulation of transcription from RNA pol II promoter
5.67
3.89E-02
GO:0044260
cellular macromolecule metabolic process
Inf
2.43E-02
GO:0019538
protein metabolic process
Inf
2.45E-02
GO:0006412
Translation
Inf
GO:0045941
positive regulation of transcription
4.14
6.27E-03
GO:0045935
+ve regulation of nucleobase side tide and nucleic acid metabolism
4.56
2.22E-03
GO:0017156
calcium ion-dependent exocytosis
19.85
4.73E-02
GO:0001654
Eye development
12.29
2.30E-02
2.19E-04
GO:0048513
organ development
GO:0007275
Multicellular organismal development
GO:0031274
positive regulation of pseudopodium formation
GO:0006351
transcription, DNA-dependent
GO:0007423
sensory organ development
GO:0045934
-ve regulation of nucleobase side tide and nucleic acid metabolism
GO:0031272
regulation of pseudopodium formation
GO:0032502
developmental process
6.32
3.90E-18
GO:0050793
regulation of developmental process
4.82
5.11E-03
GO:0048856
anatomical structure development
5.77
7.04E-12
GO:0006357
regulation of transcription from RNA pol II promoter
GO:0001708
Cell fate specification
GO:0003002
7.79
1.46E-11
13.45
6.09E-27
Inf
1.84E-03
7.81
1.89E-05
12.29
2.30E-02
4.56
2.22E-03
Inf
1.84E-03
4.60
1.96E-04
27.04
4.18E-03
regionalization
6.26
3.86E-02
GO:0016481
negative regulation of transcription
4.43
4.38E-03
GO:0045892
negative regulation of transcription, DNA-dependent
5.55
2.63E-03
GO:0030198
extracellular matrix organization and biogenesis
10.81
2.83E-02
GO:0015698
inorganic anion transport
7.90
1.30E-04
GO:0035107
Appendage morphogenesis
16.40
5.51E-04
GO:0048858
Cell projection morphogenesis
11.76
2.46E-02
GO:0030326
embryonic limb morphogenesis
14.56
3.47E-03
GO:0035108
Limb morphogenesis
16.40
5.51E-04
GO:0007409
axonogenesis
14.24
1.66E-02
GO:0030154
Cell differentiation
4.60
1.89E-05
GO:0007517
muscle development
6.18
1.71E-02
GO:0001501
skeletal development
12.06
7.18E-06
GO:0006350
transcription
3.73
3.54E-06
GO:0048731
system development
GO:0031344
regulation of cell projection organization and biogenesis
GO:0032774
RNA biosynthetic process
GO:0045944
positive regulation of transcription from RNA pol II promoter
GO:0031346
positive regulation of cell projection organization and biogenesis
GO:0001764
neuron migration
GO:0009893
positive regulation of metabolic process
GO:0022604
regulation of cell morphogenesis
GO:0006366
transcription from RNA polymerase II promoter
GO:0007420
brain development
GO:0009653
GO:0007389
3.89
3.50E-03
177.77
4.19E-03
7.69
2.06E-05
6.32
2.89E-03
Inf
1.84E-03
10.81
2.83E-02
3.75
4.38E-03
10.81
2.83E-02
7.78
5.19E-05
15.89
1.26E-04
anatomical structure morphogenesis
6.74
1.38E-09
pattern specification process
8.00
3.52E-04
GO:0006820
anion transport
6.08
7.62E-04
GO:0007417
central nervous system development
9.91
1.10E-03
GO:0006139
Nucleobase, side, tide and nucleic acid metabolic process
2.25
1.84E-03
GO:0006817
phosphate transport
20.44
1.39E-07
GO:0030182
neuron differentiation
15.82
2.80E-03
GO:0000122
negative regulation of transcription from RNA pol II promoter
6.78
2.18E-03
GO:0016070
RNA metabolic process
2.41
4.29E-02
GO:0045449
regulation of transcription
10.77
4.48E-29
GO:0022603
regulation of anatomical structure morphogenesis
10.81
2.83E-02
GO:0009887
organ morphogenesis
5.34
1.81E-03
GO:0006355
regulation of transcription, DNA-dependent
10.76
4.48E-29
GO:0035113
embryonic appendage morphogenesis
14.56
3.47E-03
GO:0031324
negative regulation of cellular metabolic process
3.87
5.77E-03
GO:0045893
positive regulation of transcription, DNA-dependent
4.47
7.44E-03
GO:0048812
neurite morphogenesis
11.76
2.46E-02
GO:0031325
positive regulation of cellular metabolic process
3.63
8.43E-03
GO:0008360
regulation of cell shape
GO:0009892
negative regulation of metabolic process
GO:0042472
inner ear morphogenesis
GO:0048598
embryonic morphogenesis
10.81
2.83E-02
3.35
1.46E-02
38.27
2.19E-05
8.18
6.00E-03
Table S3. Percentage of transcripts encoding disordered proteins likely to be targeted
by miRNA. For each dataset, the total number of transcripts encoding proteinsa and
the number of unique protein sequencesb encoded by transcripts are given. A matchc
occurs when a transcript of a protein sequence matches an mRNA targeted by a
miRNA. The percentaged calculations are described in the methods. (a) The types of
disorder (Figures 1d, 2d). (b) The percentages of disordered residues (Figure 3c).
(a)
Data Set
Removal of proteins that share 90% or higher sequence identity
using CD Hit - Li & Godzik (2006), Bioinformatics 22:1658-1659.
Type of disorder
Totala
Uniqueb
Highly disordered
Highly ordered
Disordered
Ordered
All proteins
Matchc
Percentaged
667
4363
667
4363
197
649
29.54
14.88
11477
14534
26011
11477
14534
26011
4118
2858
6976
35.88
19.66
26.82
Completely ordered
485
485
45
9.28
Completely
21
21
6
28.57
Disordered
(b)
Data Set
Removal of proteins that share 90% or higher sequence identity
using CD Hit (Li & Godzik, 2006)
Percentage disorder
Totala
Uniqueb
Matchc
Percentaged
Disordered
[0,20]
[20,40]
[40,60]
[60,80]
[80,100]
Total
3316
5276
2253
522
110
11477
3316
5276
2253
522
110
11477
1151
1883
890
181
13
4118
34.71
35.69
39.50
34.67
11.82
35.88
Ordered
[0,20]
[20,40]
[40,60]
[60,80]
[80,100]
Total
12664
1656
179
26
9
14534
12664
1656
179
26
9
14534
2534
291
30
3
0
2858
20.01
17.57
16.76
11.54
0
19.66
Proteome
[0,20]
[20,40]
[40,60]
[60,80]
[80,100]
Total
12664
6930
2440
547
120
26011
1266
6930
2440
547
120
26011
3682
2177
920
184
13
6976
23.05
31.41
37.70
33.64
10.83
26.82
Table S4. The extent of overlap of the proteins predicted to be ubiquinated and
the identified targets of the SCF ubiquitin ligase. The method and result for this
investigation is described in the “Protein Disorder and miRNA targets” section.
GENE_ID
26751
84445
9238
9238
9238
3853
3853
55526
55526
55526
55526
9946
7289
7289
7289
7289
7289
10948
60680
28231
28231
4793
4793
285172
285172
285172
5690
79873
79873
79873
79873
11083
11083
11083
11083
11083
11083
11083
11083
11083
57125
27229
4722
4722
4722
54981
54981
5098
GENE_SYMBOL
SH3YL1
LZTS2
TBRG4
TBRG4
TBRG4
KRT6A
KRT6A
DHTKD1
DHTKD1
DHTKD1
DHTKD1
CRYZL1
TULP3
TULP3
TULP3
TULP3
TULP3
STARD3
BRUNOL5
SLCO4A1
SLCO4A1
NFKBIB
NFKBIB
MGC39518
MGC39518
MGC39518
PSMB2
NUDT18
NUDT18
NUDT18
NUDT18
DATF1
DATF1
DATF1
DATF1
DATF1
DATF1
DATF1
DATF1
DATF1
PLXDC1
76P
NDUFS3
NDUFS3
NDUFS3
C9orf95
C9orf95
PCDHGC3
MAPPED_ACCESSION
ENSP00000384910
ENSP00000359243
ENSP00000379016
ENSP00000379016
ENSP00000379016
ENSP00000369317
ENSP00000369317
ENSP00000263035
ENSP00000263035
ENSP00000263035
ENSP00000263035
ENSP00000370966
ENSP00000380321
ENSP00000380321
ENSP00000380321
ENSP00000380321
ENSP00000380321
ENSP00000377794
ENSP00000335182
ENSP00000359538
ENSP00000359538
ENSP00000375929
ENSP00000375929
ENSP00000286181
ENSP00000286181
ENSP00000286181
ENSP00000362337
ENSP00000307852
ENSP00000307852
ENSP00000307852
ENSP00000307852
ENSP00000378749
ENSP00000378749
ENSP00000378749
ENSP00000378749
ENSP00000378749
ENSP00000378749
ENSP00000378749
ENSP00000378749
ENSP00000378749
ENSP00000377853
ENSP00000382387
ENSP00000263774
ENSP00000263774
ENSP00000263774
ENSP00000366004
ENSP00000366004
ENSP00000306918
UBQ_RESIDUE
34
526
230
399
498
338
436
37
72
244
881
344
35
59
92
287
436
242
40
56
640
135
258
132
504
515
158
5
28
307
466
4
141
247
339
372
446
515
540
1182
47
503
56
144
259
40
49
156
5098
5098
27132
27132
4129
4129
126961
22977
22977
993
993
993
5725
6500
6500
81614
5283
57628
57628
57628
9545
84735
84735
84735
80020
54784
23172
2870
9653
9653
54956
54956
2132
2132
51307
50613
54935
54518
54518
54518
54518
54518
54518
84869
54470
54470
1819
1819
1026
9411
9411
79083
79083
79083
PCDHGC3
PCDHGC3
CPNE7
CPNE7
MAOB
MAOB
HIST2H3C
AKR7A3
AKR7A3
CDC25A
CDC25A
CDC25A
PTBP1
SKP1A
SKP1A
NIPA2
PIGH
DPP10
DPP10
DPP10
RAB3D
CNDP1
CNDP1
CNDP1
FLJ23322
FLJ20013
KIAA0157
GRK6
HS2ST1
HS2ST1
PARP16
PARP16
EXT2
EXT2
FAM53C
UBQLN3
DUSP23
APBB1IP
APBB1IP
APBB1IP
APBB1IP
APBB1IP
APBB1IP
CBR4
ARMCX6
ARMCX6
DRG2
DRG2
CDKN1A
ARHGAP29
ARHGAP29
MLPH
MLPH
MLPH
ENSP00000306918
ENSP00000306918
ENSP00000317374
ENSP00000317374
ENSP00000380428
ENSP00000380428
ENSP00000358154
ENSP00000355377
ENSP00000355377
ENSP00000343166
ENSP00000343166
ENSP00000343166
ENSP00000349428
ENSP00000231487
ENSP00000231487
ENSP00000381096
ENSP00000216452
ENSP00000386565
ENSP00000386565
ENSP00000386565
ENSP00000222120
ENSP00000351682
ENSP00000351682
ENSP00000351682
ENSP00000380401
ENSP00000292566
ENSP00000357827
ENSP00000377204
ENSP00000359582
ENSP00000359582
ENSP00000261888
ENSP00000261888
ENSP00000379032
ENSP00000379032
ENSP00000239906
ENSP00000347997
ENSP00000357089
ENSP00000365411
ENSP00000365411
ENSP00000365411
ENSP00000365411
ENSP00000365411
ENSP00000365411
ENSP00000303525
ENSP00000378560
ENSP00000378560
ENSP00000379076
ENSP00000379076
ENSP00000384849
ENSP00000359237
ENSP00000359237
ENSP00000386338
ENSP00000386338
ENSP00000386338
648
920
133
521
21
230
123
136
250
28
66
141
46
5
28
210
161
137
697
715
121
167
455
483
681
117
10
14
126
135
80
233
6
285
304
32
140
87
254
289
373
421
493
196
101
257
46
172
161
366
371
3
44
300
79083
122011
122011
7517
115704
11135
8772
27250
27250
27250
27250
27250
27250
7287
7287
7287
7867
7867
7867
10487
30833
3728
3728
64093
64093
64093
56000
148022
148022
54762
27242
27242
27242
11267
54984
54984
9725
9725
9725
9725
27044
27044
27044
27044
27044
27044
10208
10208
1831
79912
79912
79912
10949
10949
MLPH
CSNK1A1L
CSNK1A1L
XRCC3
EVI5L
CDC42EP1
FADD
PDCD4
PDCD4
PDCD4
PDCD4
PDCD4
PDCD4
TULP1
TULP1
TULP1
MAPKAPK3
MAPKAPK3
MAPKAPK3
CAP1
NT5C
JUP
JUP
SMOC1
SMOC1
SMOC1
NXF3
TICAM1
TICAM1
DKFZp434C0328
TNFRSF21
TNFRSF21
TNFRSF21
SNF8
PINX1
PINX1
TMEM63A
TMEM63A
TMEM63A
TMEM63A
SND1
SND1
SND1
SND1
SND1
SND1
C13orf22
C13orf22
TSC22D3
PYROXD1
PYROXD1
PYROXD1
HNRPA0
HNRPA0
ENSP00000386338
ENSP00000369126
ENSP00000369126
ENSP00000343392
ENSP00000270530
ENSP00000249014
ENSP00000301838
ENSP00000376816
ENSP00000376816
ENSP00000376816
ENSP00000376816
ENSP00000376816
ENSP00000376816
ENSP00000362999
ENSP00000362999
ENSP00000362999
ENSP00000350639
ENSP00000350639
ENSP00000350639
ENSP00000383844
ENSP00000245552
ENSP00000377508
ENSP00000377508
ENSP00000370680
ENSP00000370680
ENSP00000370680
ENSP00000378504
ENSP00000344347
ENSP00000344347
ENSP00000350881
ENSP00000296861
ENSP00000296861
ENSP00000296861
ENSP00000290330
ENSP00000346908
ENSP00000346908
ENSP00000355800
ENSP00000355800
ENSP00000355800
ENSP00000355800
ENSP00000346762
ENSP00000346762
ENSP00000346762
ENSP00000346762
ENSP00000346762
ENSP00000346762
ENSP00000255304
ENSP00000255304
ENSP00000378386
ENSP00000240651
ENSP00000240651
ENSP00000240651
ENSP00000316042
ENSP00000316042
441
46
325
18
109
390
153
53
84
103
233
324
453
247
331
536
36
192
332
149
194
124
303
165
223
414
199
3
538
300
342
420
529
13
39
59
378
598
658
729
25
310
359
488
603
752
516
709
51
148
201
448
133
171
10949
51225
25804
80149
80149
80149
2257
84263
84263
84263
84263
84263
23212
23212
23212
23212
23212
23212
92715
440
56675
56675
56675
56675
57687
84948
84948
84948
84948
219654
808
808
808
284058
284058
5307
84958
1937
1937
222171
148932
23117
7171
7171
7171
7171
53340
53340
53340
53340
5157
25945
25945
25945
HNRPA0
ABI3
LSM4
ZC3H12A
ZC3H12A
ZC3H12A
FGF12
HSDL2
HSDL2
HSDL2
HSDL2
HSDL2
RRS1
RRS1
RRS1
RRS1
RRS1
RRS1
C9orf112
ASNS
NRIP3
NRIP3
NRIP3
NRIP3
KIAA1576
TIGD5
TIGD5
TIGD5
TIGD5
C10orf56
CALM3
CALM3
CALM3
LOC284058
LOC284058
PITX1
SYTL1
EEF1G
EEF1G
LOC222171
MOBKL2C
LOC23117
TPM4
TPM4
TPM4
TPM4
SPA17
SPA17
SPA17
SPA17
PDGFRL
PVRL3
PVRL3
PVRL3
ENSP00000316042
ENSP00000225941
ENSP00000252816
ENSP00000362179
ENSP00000362179
ENSP00000362179
ENSP00000376248
ENSP00000381783
ENSP00000381783
ENSP00000381783
ENSP00000381783
ENSP00000381783
ENSP00000322396
ENSP00000322396
ENSP00000322396
ENSP00000322396
ENSP00000322396
ENSP00000322396
ENSP00000277540
ENSP00000377845
ENSP00000379879
ENSP00000379879
ENSP00000379879
ENSP00000379879
ENSP00000303129
ENSP00000315906
ENSP00000315906
ENSP00000315906
ENSP00000315906
ENSP00000361410
ENSP00000375785
ENSP00000375785
ENSP00000375785
ENSP00000377117
ENSP00000377117
ENSP00000265340
ENSP00000363171
NP_001395.1
NP_001395.1
ENSP00000317836
ENSP00000379586
NP_569731.1
ENSP00000384985
ENSP00000384985
ENSP00000384985
ENSP00000384985
ENSP00000227135
ENSP00000227135
ENSP00000227135
ENSP00000227135
ENSP00000381149
ENSP00000321514
ENSP00000321514
ENSP00000321514
269
169
138
204
273
551
174
29
32
42
99
245
12
127
178
198
279
362
57
191
30
38
192
237
217
5
44
155
261
267
22
76
95
93
262
143
41
275
354
128
6
673
11
132
153
215
95
111
120
138
2
77
290
471
25945
4723
89822
89822
55276
55276
55276
6838
6838
11054
11054
1016
1016
1016
1016
9915
9915
9915
9915
9915
59338
5970
8572
5064
5064
5064
5064
10067
51187
51187
51187
51187
8509
8509
8509
84219
84219
85007
85007
85007
166614
166614
166614
166614
166614
166614
1632
2145
2145
2145
2145
2145
6184
6184
PVRL3
NDUFV1
KCNK17
KCNK17
PGM2
PGM2
PGM2
SURF6
SURF6
OGFR
OGFR
CDH18
CDH18
CDH18
CDH18
ARNT2
ARNT2
ARNT2
ARNT2
ARNT2
PLEKHA1
RELA
PDLIM4
PALM
PALM
PALM
PALM
SCAMP3
C15orf15
C15orf15
C15orf15
C15orf15
NDST2
NDST2
NDST2
WDR24
WDR24
MGC15875
MGC15875
MGC15875
DCAMKL2
DCAMKL2
DCAMKL2
DCAMKL2
DCAMKL2
DCAMKL2
DCI
EZH1
EZH1
EZH1
EZH1
EZH1
RPN1
RPN1
ENSP00000321514
ENSP00000322450
ENSP00000362328
ENSP00000362328
ENSP00000371393
ENSP00000371393
ENSP00000371393
ENSP00000361092
ENSP00000361092
ENSP00000349686
ENSP00000349686
ENSP00000371710
ENSP00000371710
ENSP00000371710
ENSP00000371710
ENSP00000378190
ENSP00000378190
ENSP00000378190
ENSP00000378190
ENSP00000378190
ENSP00000386800
ENSP00000384273
ENSP00000368303
ENSP00000379262
ENSP00000379262
ENSP00000379262
ENSP00000379262
ENSP00000347540
ENSP00000260443
ENSP00000260443
ENSP00000260443
ENSP00000260443
ENSP00000299641
ENSP00000299641
ENSP00000299641
ENSP00000293883
ENSP00000293883
ENSP00000377128
ENSP00000377128
ENSP00000377128
ENSP00000377578
ENSP00000377578
ENSP00000377578
ENSP00000377578
ENSP00000377578
ENSP00000377578
ENSP00000301729
ENSP00000264646
ENSP00000264646
ENSP00000264646
ENSP00000264646
ENSP00000264646
ENSP00000296255
ENSP00000296255
519
36
175
330
333
360
410
87
260
283
384
89
158
371
640
57
119
271
276
565
350
452
206
4
175
193
360
287
5
57
73
94
588
697
813
258
771
125
187
297
40
184
207
302
397
608
61
140
201
254
506
714
89
465
10392
10392
10392
10392
10392
10392
10392
1807
1807
1807
1807
1621
1621
1621
64794
64794
2542
2542
7020
7020
7020
51203
51203
51203
51203
51203
7597
27342
27342
27342
27342
27342
7205
7205
79651
79651
79651
79651
79651
1027
1027
1027
23769
23769
2801
2801
2801
9550
10768
10768
10539
10539
10539
10539
CARD4
CARD4
CARD4
CARD4
CARD4
CARD4
CARD4
DPYS
DPYS
DPYS
DPYS
DBH
DBH
DBH
DDX31
DDX31
SLC37A4
SLC37A4
TFAP2A
TFAP2A
TFAP2A
NUSAP1
NUSAP1
NUSAP1
NUSAP1
NUSAP1
ZBTB25
RABGEF1
RABGEF1
RABGEF1
RABGEF1
RABGEF1
TRIP6
TRIP6
RHBDL6
RHBDL6
RHBDL6
RHBDL6
RHBDL6
CDKN1B
CDKN1B
CDKN1B
FLRT1
FLRT1
GOLGA2
GOLGA2
GOLGA2
ATP6V1G1
AHCYL1
AHCYL1
TXNL2
TXNL2
TXNL2
TXNL2
ENSP00000222823
ENSP00000222823
ENSP00000222823
ENSP00000222823
ENSP00000222823
ENSP00000222823
ENSP00000222823
ENSP00000276651
ENSP00000276651
ENSP00000276651
ENSP00000276651
ENSP00000376776
ENSP00000376776
ENSP00000376776
ENSP00000361228
ENSP00000361228
ENSP00000350203
ENSP00000350203
ENSP00000368933
ENSP00000368933
ENSP00000368933
ENSP00000260359
ENSP00000260359
ENSP00000260359
ENSP00000260359
ENSP00000260359
ENSP00000378204
ENSP00000370208
ENSP00000370208
ENSP00000370208
ENSP00000370208
ENSP00000370208
ENSP00000200457
ENSP00000200457
ENSP00000374410
ENSP00000374410
ENSP00000374410
ENSP00000374410
ENSP00000374410
ENSP00000379629
ENSP00000379629
ENSP00000379629
ENSP00000246841
ENSP00000246841
ENSP00000342692
ENSP00000342692
ENSP00000342692
ENSP00000363162
ENSP00000377238
ENSP00000377238
ENSP00000357633
ENSP00000357633
ENSP00000357633
ENSP00000357633
70
142
208
830
937
942
948
57
143
205
461
248
286
393
345
350
206
211
2
6
12
44
132
171
220
316
204
4
273
274
321
346
10
224
6
52
443
657
772
73
134
172
155
489
33
218
570
34
17
147
67
231
253
308
8623
8623
8623
8623
56143
56143
414301
7278
7278
55250
9181
9181
9181
9181
6871
6871
84324
84324
10783
23729
9862
9862
9862
9862
9862
9862
9862
9862
79048
79048
79048
79048
648
648
84167
84167
84167
84167
84167
84167
9686
55758
55758
55758
55758
55758
5082
6195
6195
6195
6195
6195
6195
6195
ASMTL
ASMTL
ASMTL
ASMTL
PCDHA5
PCDHA5
DDI1
TUBA2
TUBA2
STATIP1
ARHGEF2
ARHGEF2
ARHGEF2
ARHGEF2
TADA2L
TADA2L
CIP29
CIP29
NEK6
CARKL
THRAP4
THRAP4
THRAP4
THRAP4
THRAP4
THRAP4
THRAP4
THRAP4
SECISBP2
SECISBP2
SECISBP2
SECISBP2
PCGF4
PCGF4
FLJ21742
FLJ21742
FLJ21742
FLJ21742
FLJ21742
FLJ21742
VGLL4
RCOR3
RCOR3
RCOR3
RCOR3
RCOR3
PDCL
RPS6KA1
RPS6KA1
RPS6KA1
RPS6KA1
RPS6KA1
RPS6KA1
RPS6KA1
ENSP00000370718
ENSP00000370718
ENSP00000370718
ENSP00000370718
ENSP00000367366
ENSP00000367366
ENSP00000302805
ENSP00000382982
ENSP00000382982
ENSP00000316051
ENSP00000357298
ENSP00000357298
ENSP00000357298
ENSP00000357298
ENSP00000377915
ENSP00000377915
ENSP00000337632
ENSP00000337632
ENSP00000377749
ENSP00000225519
ENSP00000377684
ENSP00000377684
ENSP00000377684
ENSP00000377684
ENSP00000377684
ENSP00000377684
ENSP00000377684
ENSP00000377684
ENSP00000364965
ENSP00000364965
ENSP00000364965
ENSP00000364965
ENSP00000365909
ENSP00000365909
ENSP00000221671
ENSP00000221671
ENSP00000221671
ENSP00000221671
ENSP00000221671
ENSP00000221671
ENSP00000384705
ENSP00000355972
ENSP00000355972
ENSP00000355972
ENSP00000355972
ENSP00000355972
ENSP00000377826
ENSP00000383967
ENSP00000383967
ENSP00000383967
ENSP00000383967
ENSP00000383967
ENSP00000383967
ENSP00000383967
259
314
409
563
123
651
213
40
401
723
236
439
595
800
14
235
28
73
141
100
2
7
29
156
182
328
386
984
207
527
544
700
73
88
6
65
129
149
192
529
62
42
74
267
304
325
114
44
54
198
349
621
642
697
10133
10133
10133
10133
10133
10133
10133
10133
26271
26271
26271
26271
3500
2232
3326
3326
3326
6122
6122
6122
9325
9325
9325
9325
9325
51552
51552
4542
4542
4542
2026
2026
2026
2026
8835
9684
10635
10635
10635
51478
515
84970
284004
284004
10013
10013
51514
51514
51514
51514
51514
51514
51514
143630
OPTN
OPTN
OPTN
OPTN
OPTN
OPTN
OPTN
OPTN
FBXO5
FBXO5
FBXO5
FBXO5
IGHG1
FDXR
HSPCB
HSPCB
HSPCB
RPL3
RPL3
RPL3
TRIP4
TRIP4
TRIP4
TRIP4
TRIP4
RAB14
RAB14
MYO1F
MYO1F
MYO1F
ENO2
ENO2
ENO2
ENO2
SOCS2
LRRC14
RAD51AP1
RAD51AP1
RAD51AP1
HSD17B7
ATP5F1
C1orf94
FLJ23825
FLJ23825
HDAC6
HDAC6
DTL
DTL
DTL
DTL
DTL
DTL
DTL
MGC20470
ENSP00000368022
ENSP00000368022
ENSP00000368022
ENSP00000368022
ENSP00000368022
ENSP00000368022
ENSP00000368022
ENSP00000368022
ENSP00000356210
ENSP00000356210
ENSP00000356210
ENSP00000356210
ENSP00000374991
ENSP00000293195
ENSP00000360709
ENSP00000360709
ENSP00000360709
ENSP00000385762
ENSP00000385762
ENSP00000385762
ENSP00000261884
ENSP00000261884
ENSP00000261884
ENSP00000261884
ENSP00000261884
ENSP00000362946
ENSP00000362946
ENSP00000344871
ENSP00000344871
ENSP00000344871
ENSP00000229277
ENSP00000229277
ENSP00000229277
ENSP00000229277
ENSP00000376831
ENSP00000292524
ENSP00000309479
ENSP00000309479
ENSP00000309479
ENSP00000348664
ENSP00000358736
ENSP00000381121
ENSP00000337854
ENSP00000337854
ENSP00000365804
ENSP00000365804
ENSP00000355958
ENSP00000355958
ENSP00000355958
ENSP00000355958
ENSP00000355958
ENSP00000355958
ENSP00000355958
ENSP00000369531
196
223
246
267
333
340
378
429
2
18
237
243
157
70
53
148
275
231
245
260
70
128
256
402
576
35
140
15
776
881
54
105
197
228
87
456
165
228
252
3
177
67
186
337
138
553
241
397
437
600
652
669
671
158
143630
84733
84733
84733
84733
84733
5328
5328
5510
5510
55619
55619
55619
55619
55619
55619
55619
55619
55619
55619
55619
6251
6251
22885
22885
51163
3268
3268
10456
22895
149371
149371
149371
55249
55249
55249
55249
55249
55249
200576
200576
55295
60496
60496
60496
54905
54905
147015
29091
29091
85360
85360
85360
10113
MGC20470
CBX2
CBX2
CBX2
CBX2
CBX2
PLAU
PLAU
PPP1R7
PPP1R7
DOCK10
DOCK10
DOCK10
DOCK10
DOCK10
DOCK10
DOCK10
DOCK10
DOCK10
DOCK10
DOCK10
RSU1
RSU1
ABLIM3
ABLIM3
DBR1
HRBL
HRBL
HAX1
RPH3A
EXOC8
EXOC8
EXOC8
YY1AP1
YY1AP1
YY1AP1
YY1AP1
YY1AP1
YY1AP1
PIP5K3
PIP5K3
FLJ11078
AASDHPPT
AASDHPPT
AASDHPPT
CYP2W1
CYP2W1
MGC23280
STXBP6
STXBP6
SYDE1
SYDE1
SYDE1
PREB
ENSP00000369531
ENSP00000308750
ENSP00000308750
ENSP00000308750
ENSP00000308750
ENSP00000308750
ENSP00000361847
ENSP00000361847
ENSP00000385466
ENSP00000385466
ENSP00000386392
ENSP00000386392
ENSP00000386392
ENSP00000386392
ENSP00000386392
ENSP00000386392
ENSP00000386392
ENSP00000386392
ENSP00000386392
ENSP00000386392
ENSP00000386392
ENSP00000367145
ENSP00000367145
ENSP00000377875
ENSP00000377875
ENSP00000260803
ENSP00000300176
ENSP00000300176
ENSP00000329002
ENSP00000374036
ENSP00000355605
ENSP00000355605
ENSP00000355605
ENSP00000385390
ENSP00000385390
ENSP00000385390
ENSP00000385390
ENSP00000385390
ENSP00000385390
ENSP00000384356
ENSP00000384356
ENSP00000300976
ENSP00000278618
ENSP00000278618
ENSP00000278618
ENSP00000344178
ENSP00000344178
ENSP00000378361
ENSP00000379928
ENSP00000379928
ENSP00000341489
ENSP00000341489
ENSP00000341489
ENSP00000384032
172
131
146
153
157
191
129
217
47
91
368
560
603
705
1306
1441
1637
1640
1702
1928
2164
224
282
2
163
511
7
173
215
642
266
545
698
73
234
425
638
684
716
6
94
476
6
96
185
30
363
319
4
66
89
169
444
107
10113
10113
10113
10113
6525
6525
140735
51177
51177
10391
10391
55166
55166
4675
4675
4675
4675
4675
4675
9751
11274
11274
11274
11274
201456
144699
7086
7086
7086
1267
23759
23759
23759
4208
51310
57697
57697
57697
57697
57697
57697
57697
57697
55718
79085
2167
2167
129807
3854
3854
220965
220965
220965
91133
PREB
PREB
PREB
PREB
SMTN
SMTN
Dlc2
CKIP-1
CKIP-1
CORO2B
CORO2B
C6orf139
C6orf139
NAP1L3
NAP1L3
NAP1L3
NAP1L3
NAP1L3
NAP1L3
SNPH
USP18
USP18
USP18
USP18
FBXO15
FBXL14
TKT
TKT
TKT
CNP
PPIL2
PPIL2
PPIL2
MEF2C
SLC22A17
FANCM
FANCM
FANCM
FANCM
FANCM
FANCM
FANCM
FANCM
POLR3E
SLC25A23
FABP4
FABP4
NEU4
KRT6B
KRT6B
FAM13C1
FAM13C1
FAM13C1
L3MBTL4
ENSP00000384032
ENSP00000384032
ENSP00000384032
ENSP00000384032
ENSP00000385265
ENSP00000385265
ENSP00000240343
ENSP00000358122
ENSP00000358122
ENSP00000378836
ENSP00000378836
ENSP00000360243
ENSP00000360243
ENSP00000362171
ENSP00000362171
ENSP00000362171
ENSP00000362171
ENSP00000362171
ENSP00000362171
ENSP00000386414
ENSP00000215794
ENSP00000215794
ENSP00000215794
ENSP00000215794
ENSP00000269500
ENSP00000344855
ENSP00000296289
ENSP00000296289
ENSP00000296289
ENSP00000377470
ENSP00000381812
ENSP00000381812
ENSP00000381812
NP_002388.2
ENSP00000380437
ENSP00000267430
ENSP00000267430
ENSP00000267430
ENSP00000267430
ENSP00000267430
ENSP00000267430
ENSP00000267430
ENSP00000267430
ENSP00000352140
ENSP00000334537
ENSP00000256104
ENSP00000256104
ENSP00000385149
ENSP00000252252
ENSP00000252252
ENSP00000362974
ENSP00000362974
ENSP00000362974
ENSP00000382976
126
127
188
297
50
131
5
152
187
5
94
4
130
135
203
217
231
304
453
290
3
152
240
288
85
42
6
241
543
261
3
180
450
391
306
136
178
209
530
1155
1316
1428
1510
498
177
22
53
476
338
436
324
396
427
2
91133
91133
91133
91133
5316
5316
8773
8773
81570
81570
81570
81570
8568
8568
54682
54682
8507
8877
5713
5713
5713
5713
5713
5713
26256
26256
26256
26256
23062
23062
23062
112476
23059
23059
23059
23059
55722
55722
9904
9904
9904
9904
9904
9904
9904
9904
9904
9904
55701
55701
55701
55701
55701
55701
L3MBTL4
L3MBTL4
L3MBTL4
L3MBTL4
PKNOX1
PKNOX1
SNAP23
SNAP23
CLPB
CLPB
CLPB
CLPB
D21S2056E
D21S2056E
MANSC1
MANSC1
ENC1
SPHK1
PSMD7
PSMD7
PSMD7
PSMD7
PSMD7
PSMD7
CABYR
CABYR
CABYR
CABYR
GGA2
GGA2
GGA2
LOC112476
CLUAP1
CLUAP1
CLUAP1
CLUAP1
Cep72
Cep72
RBM19
RBM19
RBM19
RBM19
RBM19
RBM19
RBM19
RBM19
RBM19
RBM19
FLJ10357
FLJ10357
FLJ10357
FLJ10357
FLJ10357
FLJ10357
ENSP00000382976
ENSP00000382976
ENSP00000382976
ENSP00000382976
ENSP00000291547
ENSP00000291547
ENSP00000380327
ENSP00000380327
ENSP00000340385
ENSP00000340385
ENSP00000340385
ENSP00000340385
ENSP00000383237
ENSP00000383237
ENSP00000379638
ENSP00000379638
ENSP00000306356
ENSP00000376285
ENSP00000219313
ENSP00000219313
ENSP00000219313
ENSP00000219313
ENSP00000219313
ENSP00000219313
ENSP00000382405
ENSP00000382405
ENSP00000382405
ENSP00000382405
ENSP00000311962
ENSP00000311962
ENSP00000311962
ENSP00000351608
ENSP00000344392
ENSP00000344392
ENSP00000344392
ENSP00000344392
ENSP00000264935
ENSP00000264935
ENSP00000376344
ENSP00000376344
ENSP00000376344
ENSP00000376344
ENSP00000376344
ENSP00000376344
ENSP00000376344
ENSP00000376344
ENSP00000376344
ENSP00000376344
ENSP00000298694
ENSP00000298694
ENSP00000298694
ENSP00000298694
ENSP00000298694
ENSP00000298694
159
289
301
413
260
293
40
132
253
357
392
628
68
330
77
383
309
26
103
127
180
288
293
316
66
207
415
448
215
577
602
111
85
138
303
402
115
145
34
50
347
481
482
646
712
783
859
866
122
377
405
440
717
1178
55701
80174
80174
80174
80174
80174
80174
10227
10227
10227
4144
11133
4841
4841
4841
11319
11319
11319
11319
11319
11319
55040
23378
23378
10922
9112
9112
23291
8099
922
922
116224
27161
27161
27161
27161
27161
27161
27161
1160
1160
4007
4007
92703
92703
7251
51322
51322
51322
51322
115509
115509
56474
6175
FLJ10357
DRF1
DRF1
DRF1
DRF1
DRF1
DRF1
TETRAN
TETRAN
TETRAN
MAT2A
KPTN
NONO
NONO
NONO
HSGT1
HSGT1
HSGT1
HSGT1
HSGT1
HSGT1
EPN3
KIAA0409
KIAA0409
FASTK
MTA1
MTA1
FBXW11
CDK2AP1
CD5L
CD5L
C9orf42
EIF2C2
EIF2C2
EIF2C2
EIF2C2
EIF2C2
EIF2C2
EIF2C2
CKMT2
CKMT2
LMO6
LMO6
TMEM183A
TMEM183A
TSG101
WAC
WAC
WAC
WAC
ZNF689
ZNF689
CTPS2
RPLP0
ENSP00000298694
ENSP00000377178
ENSP00000377178
ENSP00000377178
ENSP00000377178
ENSP00000377178
ENSP00000377178
ENSP00000347619
ENSP00000347619
ENSP00000347619
ENSP00000386436
ENSP00000337850
ENSP00000362963
ENSP00000362963
ENSP00000362963
ENSP00000362070
ENSP00000362070
ENSP00000362070
ENSP00000362070
ENSP00000362070
ENSP00000362070
ENSP00000268933
ENSP00000254605
ENSP00000254605
ENSP00000352212
ENSP00000384180
ENSP00000384180
ENSP00000377393
ENSP00000261692
ENSP00000357156
ENSP00000357156
ENSP00000366492
ENSP00000220592
ENSP00000220592
ENSP00000220592
ENSP00000220592
ENSP00000220592
ENSP00000220592
ENSP00000220592
ENSP00000254035
ENSP00000254035
ENSP00000365487
ENSP00000365487
ENSP00000356211
ENSP00000356211
ENSP00000349721
ENSP00000364797
ENSP00000364797
ENSP00000364797
ENSP00000364797
ENSP00000287461
ENSP00000287461
ENSP00000369555
ENSP00000376299
1360
6
135
222
232
239
389
230
310
453
88
103
11
60
338
63
80
222
401
402
434
464
219
440
80
243
250
305
92
173
299
89
62
91
354
402
533
693
844
230
335
101
169
68
270
199
334
351
417
429
30
137
19
146
6175
9094
5859
5859
5859
5859
5859
5859
6187
23154
RPLP0
UNC119
QARS
QARS
QARS
QARS
QARS
QARS
RPS2
NCDN
ENSP00000376299
ENSP00000337040
ENSP00000307567
ENSP00000307567
ENSP00000307567
ENSP00000307567
ENSP00000307567
ENSP00000307567
ENSP00000341885
ENSP00000381017
297
57
80
166
205
292
394
740
74
663