Lecture 1a
Motivation
• Why do students take chemistry labs?
• Most lecture courses provide a theoretical background
in general chemistry and in organic chemistry but
usually do not consider the practical aspects of the
experiment much
• Conducting an experiment in lab is often times much
more complicated than chemistry conducted on paper
because many details have a significant impact on the
overall outcome of the experiment
• Performing an actual experiment in the lab is a learning
experience on how to combine many theoretical and
practical aspects together (i.e., theory of the reaction,
Le Châtelier Principle, polarity, acidity, kinetics, etc.)
Learning Goals
• At the end of the class you should be able to
• Be able to perform basic laboratory techniques i.e., setting
up and running reactions, perform purifications (extraction,
recrystallization, chromatography)
• Be able to operate equipment used in the lab correctly
i.e., infrared and UV-Vis spectrophotometer, rotary
evaporator, polarimeter, etc.
• Analyze spectra and chromatograms of your compounds
(IR, NMR, UV-Vis, GC/MS, HPLC)
• Understand why things happen in the lab
• Be able to perform literature research and write a report
that takes literature results into account in the discussion
• Be familiar with safety regulations
Course Overview II
• Experiments and Activities
• Meeting 1-8: Synthesis of Jacobsen’s Catalyst and Chiral
Epoxidation of an Unknown Alkene
NH 2 HOOC
R1
OH
O
R2
+
NH 2 HOOC
R3
OH
R4
NaOCl
H 2O/AcOH
NH 3
NH 3
+
-
+
-
OO C
OO C
OH
OH
N
R3
R4
N
O
1. Mn(OAc)2*4 H2O
OH
2
R2
OH
2 K2CO3
CHO
R1
N
OH
2 Air
3. LiCl
Mn
N
Cl
O
Course Overview III
• Experiments and Activities
• Meeting 9-11: Synthesis of Lidocaine
• Meeting 12-14: Synthesis of Nitrobiphenyls
• Meeting 15-18: Synthesis of Acetyl ferrocene and Ferrocene
derivatives
FeCl2 +
2 K +Cp-
-2 KCl
Fe
(CH3CO)2O
H3PO4
CH3
Fe
O
?
Administrative Issues
• Make sure that you arrive on time to your first in-lab meeting
because if you are more than 15 minutes late, you will lose
your spot in the course. Excuses do not count later on
i.e., “I did not think that the lab meets during meeting 1”
or “I did not find the lab”! (Hint: Only the elevator in the
east wing goes all the way up to the 6th floor!)
• Wait-listed students will be accommodated if spaces become
available during the first meeting of the section: chemistry>
biochemistry> other majors >> extension students, priority
in within a group will be given to seniority
• If the student is added to the roster, the instructor will report
the student to the department to been enrolled (usually at the
end of the first week and not on the same day!)
Textbooks/Readers
• The course reader bundle (= main reader (purple) and exam
collection (light purple), $36) is mandatory while the Survival
Kit reader (=SKR, orange, $29) is highly recommended.
All readers are available from Course Reader Materials
(1081 Westwood Blvd). It is highly advisable to have the
latest version (Winter 2016) because this is the reference for
the experiments, the quizzes and the final exam.
• Recommended: Mohrig et al., Techniques in Organic
Chemistry (online: $45.99 for a 180 day subscription for
the 4th edition via coursesmart), most students usually have
a copy already if they were enrolled in Chem 30BL recently
• Organic textbook for reference i.e., Brown and Foote,
Mc Murry, Wade, Vollhardt and Schore, etc.
Preparation for in-lab meeting
• Pre-lab: title, purpose, introduction, balanced chemical equations,
detailed procedure, safety information of all chemicals used (review
the MSDS for each compound used in the experiment), spectroscopic
information (Xerox copy if available, if not the numbers will do fine
as well), answers to pre-lab questions (posted on course website), a
sample pre-lab can be found on page 9 in Survival Kit Reader
(=SKR)
• Consult the appropriate reading assignments to get a better in-depth
understanding of the material. It could not hurt to review the
techniques used in the project as well before entering the lab
• Bottom line: The better you understand what you are about to do,
the easier it will be in the lab. If you put in the time beforehand,
you will be less stressed in the lab. Copying reports from friends
or room mates, etc. might safe time, but it will show in the end
(=final exam), where many of these students have experienced a
Waterloo.
Grades
• In-lecture quiz (20 points, seven total, schedule to be announced,
lowest score dropped)
• Pre-lab (5 points) and post-lab (5 points, no post-lab questions!)
• Formal report for epoxidation project (20 points draft (due: January 22, 2016
at 4:30 pm), 60 point final version (due: February 5, 2016 at 4:30 pm)
• Proposal and oral presentation for Ferrocene project (20 points each)
• Product evaluations (2*20 points=40 points)
• TA/Instructor evaluation (10 points per meeting, average student 7-8 points)
• Lab notebook (20 points, due immediately after final exam)
• Final Exam (200 points, March 17, 2016, 8:00-11:00 pm), no make-up
exam
• Bottom line: Both the in-lab portion and the final exam have to be passed
to pass the course. In order to get a high grade in the course, the student
has to perform very well in both portions, not just in one portion.
Instructor
• Office: Young Hall 3077E
• Office hours: MWF 10-11 am, M 3-4 pm and TR 11-12 pm in YH 3077 or
by appointment (please do not schedule an appointment before 8 am or
after 4:30 pm, if you do make an appointment, make sure to show up on
time!)
• Email: [email protected]
• Course website: www.chem.ucla.edu/~bacher (Note that the instructor does
not use the CCLE website!)
• Course discussion board: www.piazza.com/ucla/winter2016/chem30cl
• The course discussion board has to be used for general chemistry
questions only. This means that you cannot post homework
questions!
• Sign up for Scifinder before the first in-lab meeting