DOC/LP/00/28.02.02
LESSON PLAN
LP- BT6402
LP Rev. No: 00
Sub Code & Name : BT6402/ APPLIED THERMODYNAMICS
FOR BIOTECHNOLOGISTS
Branch: BIOTECHNOLOGY
Date: 30-12-14
Page 1 of 7
Semester : IV
OBJECTIVE:
At the end of this course, the students would have learnt about classical thermodynamics.
This subject will facilitate the students by providing basic concepts for courses like
bioprocess principles, heat transfer, etc.
SCOPE:
Applied thermodynamics for biotechnologists enlists thermodynamic properties of fluids
for both ideal and non-ideal solutions and understanding phase equilibria and chemical
reaction equilibria. This course will also help the student to take up course in Bioprocess
principles and an advanced elective course like Molecular modeling and Drug design. At
the industry level, students will gain knowledge about thermodynamic analysis of
processes.
DOC/LP/00/28.02.02
LP- BT6402
LESSON PLAN
LP Rev. No: 00
Date: 30-12-14
Sub Code & Name : BT6402/ APPLIED THERMODYNAMICS
FOR BIOTECHNOLOGISTS
Unit : I
Branch: BIOTECHNOLOGY
Page 2 of 7
Semester :
IV
Unit syllabus: THERMODYNAMIC LAW AND PROPERTIES OF FLUIDS 9 hrs
First Law of Thermodynamics, a generalized balance equation and conserved quantities,
Volumetric properties of fluids exhibiting non ideal behavior; residual properties;
estimation of thermodynamic properties using equations of state; calculations involving
actual property exchanges; Maxwell’s relations and applications.
Session
No
Topics to be covered
Time
(min)
Ref/Page Numbers
Teaching
Aids
LCD/BB
1
Introduction to Thermodynamics, Classification of
Thermodynamic properties.
50
2
Volumetric properties of pure fluids-PVT behavior, Virial
equation and its application, various correlations, Simple
problems.
Residual properties-Gibbs energy, Thermodynamic
diagrams.
50
TB 1 (1-15)
&
TB 2 (188-189)
TB 1 (52-59)
50
TB 1 (190-202)
LCD/BB
4
Equations of state-Maxwells equation, Clapeyron equation,
Entropy heat capacity equations.
50
TB 2 (193-197)
LCD/BB
5
Effect of temperature, pressure and volume on U, H and S,
CP-CV relationship, Problems.
50
TB 2 (202-209)
LCD/BB
6
Joule-Thomson Coefficient, Gibbs-Helmholtz Equation.
50
TB 2 (214-216)
LCD/BB
7
8
Problems involving actual property exchanges.
Maxwell’s relations and applications, Additional problems
in Unit 1
Review of unit 1 and giving assignment for students from
Unit 1 problems.
50
50
TB 2 (248-252)
TB 1 (182-190)
LCD/BB
LCD/BB
50
-
BB
3
9
LCD/BB
DOC/LP/00/28.02.02
LP- BT6402
LESSON PLAN
LP Rev. No: 00
Date: 30-12-14
Sub Code & Name : BT6402/ APPLIED THERMODYNAMICS
FOR BIOTECHNOLOGISTS
Unit: II
Branch: BIOTECHNOLOGY
Page 3 of 7
Semester :
IV
Unit syllabus: SOLUTION THERMODYNAMICS
9 hrs
Partial molar properties; concepts of chemical potential and fugacity; ideal and non-ideal
solutions; concepts and applications of excess properties of mixtures; activity coefficient;
composition models; Gibbs Duhem equation.
Topics to be covered
Session
No
Time
(min)
Ref
Teaching
Aids
TB1 (315-316)
TB2 (254-264)
TB3 (333 – 342)
TB1 (317-319)
TB2 (265-268)
TB3 (343-346)
TB1 (332-346)
TB 2 (269-274)
TB3 (353 – 359)
LCD/BB
TB1 (347-348)
TB2 (274-275)
TB3 (360 – 365)
TB1 (349-351)
TB2 (298-299)
TB3 (366 – 370)
TB2 (278-282)
TB3 (347 – 349)
TB2 (283-287)
TB3 (349-352)
TB 1 (360-365)
TB 2(303-308)
LCD/BB
-
BB
1
Partial molar properties-physical meaning of partial molar
properties, determination of partial molar properties.
50
2
Chemical potential, Effect of temperature and pressure on
Chemical potential.
50
3
Fugacity and Fugacity coefficient for pure species and
species in solution, Generalized correlations for Fugacity
coefficient, Problems involving Fugacity and Fugacity
coefficient.
Ideal and non-ideal solutions, Raoult’s law, Henry’s law,
Problems.
50
5
Concepts and applications of excess properties of mixtures
50
6
50
7
Activity, Activity coefficient, Effect of temperature and
pressure on Activity coefficient, Problems.
Gibbs Duhem Equation and problems related to it.
8
Additional problems in unit 2
50
9
Tutorial –I
50
4
50
50
LCD/BB
LCD/BB
LCD/BB
LCD/BB
LCD/BB
BB
DOC/LP/00/28.02.02
LP- BT6402
LESSON PLAN
LP Rev. No: 00
Date: 30-12-14
Sub Code & Name : BT6402/ APPLIED THERMODYNAMICS
FOR BIOTECHNOLOGISTS
Unit: III
Branch: BIOTECHNOLOGY
Page 4 of 7
Semester :
IV
Unit syllabus: PHASE EQUILIBRIA
9 hrs
Criteria for phase equilibria; v-l-e calculations for binary and multi component systems;
liquid-liquid equilibria and solid-solid equilibria.
Session
No
Topics to be covered
Time
(min)
Ref
Teaching
Aids
Criteria of Phase equilibria-Constant U and V, Constant T
and V, Constant P and T.
Criterion of stability, Vapor-liquid equilibria, Phase
diagram for binary solutions, Problems.
50
LCD/BB
3
Vapor-liquid equilibria for multicomponent system,
Problems.
50
4
Binary liquid-liquid equilibria, Diagrams, Problems.
50
5
Multicomponent liquid-liquid equilibria, Diagrams,
Problems
50
TB2 (310-312)
TB3 (383 – 386)
TB1 (501-507)
TB 2 (312-314,
326-330)
TB3 ( 387- 390)
TB1 (516-525)
TB 2 (362-366)
TB3 (391 – 395)
TB 2 (381,
384-386)
TB3 (449 – 453)
TB 2 (382-386)
6
Solid- Solid equilibria
50
LCD/BB
7
Additional problems in unit 3
50
TB1 (526-535)
TB3 (454-455)
TB1 (555-558)
TB2 (386-397)
8
Review of unit 3 and giving assignment for students from
Unit 3 problems.
50
-
BB
9
Tutorial - II
50
-
BB
1
2
50
LCD/BB
LCD/BB
LCD/BB
LCD/BB
LCD/BB
DOC/LP/00/28.02.02
LP- BT6402
LESSON PLAN
LP Rev. No: 00
Date: 30-12-14
Sub Code & Name : BT6402/APPLIED THERMODYNAMICS
FOR BIOTECHNOLOGISTS
Unit : IV
Branch: BIOTECHNOLOGY
Page 5 of 7
Semester :
IV
Unit syllabus: CHEMICAL REACTION EQUILIBRIA
9 hrs
Equilibrium criteria for homogeneous chemical reactions; evaluation of equilibrium
constant; effect of temperature and pressure on equilibrium constant; calculation of
equilibrium conversion and yields for single and multiple reactions.
Session
No
Topics to be covered
Time
(min)
Ref
Teaching Aids
1
Equilibrium criteria for homogeneous chemical reactions
and its applications, Standard Gibbs energy.
50
LCD/BB
2
Equilibrium constant, effect of temperature and pressure
on equilibrium constant, Problems.
50
3
Evaluation of equilibrium constant, Problems.
50
4
50
50
TB1 (594-603)
LCD/BB
50
50
TB2 (422-428)
TB3 (493- 496)
TB 1 (604-611)
LCD/BB
7
Calculation of equilibrium conversion and yields for
single reaction and related problems.
Calculation of equilibrium conversion and yields for
multiple reaction and related problems.
Other factors affecting equilibrium conversion like inert
materials, excess of reactants, products etc.,
Additional problems in Unit 4
TB1 (564-567)
TB2 (399-403)
TB3 (470 – 474)
TB1 (565-567)
TB 2 (404-420)
TB3 (475-476)
TB1 (571-573)
TB3 (475-476)
TB1 (577-589)
8
Additional problems in Unit 4
50
TB 2 (441-450)
BB
9
Tutorial III
50
-
BB
5
6
LCD/BB
LCD/BB
LCD/BB
LCD/BB
DOC/LP/00/28.02.02
LP- BT6402
LESSON PLAN
LP Rev. No: 00
Date: 30-12-14
Sub Code & Name : BT6402/ APPLIED THERMODYNAMICS
FOR BIOTECHNOLOGISTS
Unit : V
Branch: BIOTECHNOLOGY
Page 6 of 7
Semester :
IV
Unit syllabus: THERMODYNAMIC DESCRIPTION OF MICROBIAL GROWTH
AND PRODUCT FORMATION
9 hrs
Thermodynamics of microbial growth stoichiometry thermodynamics of maintenance,
Calculation of the Operational Stoichiometry of a growth process at different growth
rates, including Heat using the Herbert-Pirt relation for Electron donor, thermodynamics
and stoichiometry of product formation.
Session
No
Topics to be covered
Time
(min)
Ref
Teaching Aids
1
Thermodynamics of microbial growth
50
Internet notes
LCD/BB
2
Stoichiometry thermodynamics of maintenance
50
Internet notes
LCD/BB
3
50
Internet notes
LCD/BB
4
Non-growth components and models for microbial
maintenance
Herbert Model & Pirt Model
50
Internet notes
LCD/BB
5
Compromise Model
50
Internet notes
LCD/BB
6
Relationship between three models
50
Internet notes
LCD/BB
7
Overall maintenance coefficient and Multi-Parameter
Sensitivity analysis
50
Internet notes
LCD/BB
8
Implications of microbial ecology modeling
50
Internet notes
LCD/BB
9
Tutorial IV
50
-
BB
DOC/LP/00/28.02.02
LP- BT6402
LESSON PLAN
LP Rev. No: 00
Date: 30-12-14
Sub Code & Name : BT6402/ APPLIED THERMODYNAMICS
FOR BIOTECHNOLOGISTS
Page 7 of 7
Branch: BIOTECHNOLOGY
Semester
: IV
COURSE DELIVERY PLAN:
Week
1
2
3
4
5
6
7
8
9
10
11
12
13
14
Units
I
II
III
IV
V
TEXT BOOK (TB):
1.
2.
3.
Smith J.M., Van Ness H.C., Abbot M.M. Chemical Engineering
Thermodynamics. 6th Edition. McGraw-Hill, 2001.
Narayanan K.V. A Text Book of Chemical Engineering Thermodynamics.
Prentice Hall India, 2001.
Gopinath Halder. Introduction to Chemical Engineering Thermodynamics, PHI,
2009.
REFERENCE BOOK (RB):
1.
2.
3.
Sandler S.I. Chemical and Engineering Thermodynamics. John Wiley, 1989.
Christiana D.Smolke, The Metabolic pathway engineering handbook
fundamentals, CRC Press Taylor & Francis Group, 2010.
Urs von Stockar, Thomas Maskow, Jingsong Liu, Ian W.Marison, Rodrigo Patino,
Thermodynamics of microbial growth and metabolism: an analysis of the current
situation (2006) Journal of Biotechnology, 121, 517-533.
Prepared by
Approved by
P. K. Praveen Kumar
Dr. Sulochana Somasundaram
Assistant Professor
Department of Biotechnology
Professor and HOD
Department of Biotechnology
30-12-2014
30-12-2014
Signature
Name
Designation
Date
15