Role of In Vivo Vascular Redox in Resistance
ArteriesNovelty and Significance
by Rob H.P. Hilgers, and Kumuda C. Das
Hypertension
Volume 65(1):130-139
December 10, 2014
Copyright © American Heart Association, Inc. All rights reserved.
A, Expression of thioredoxin (Trx) in mesenteric artery of wild-type (WT), Trx-Tg, and dnTrx-Tg
mice.
Rob H.P. Hilgers, and Kumuda C. Das Hypertension.
2015;65:130-139
Copyright © American Heart Association, Inc. All rights reserved.
A, Depolarization (60 mmol/L K+ Krebs-Ringer buffer)-induced and (B) phenylephrine-induced
contraction in mesenteric arteries (MAs) derived from wild-type (WT; white bars), Trx-Tg (blue
bars), and dnTrx-Tg (red bars) mice.
Rob H.P. Hilgers, and Kumuda C. Das Hypertension.
2015;65:130-139
Copyright © American Heart Association, Inc. All rights reserved.
A, Endothelium-dependent hyperpolarization (EDH)–mediated responses in the presence of the
selective intermediate-conductance KCa (IK1) channel blocker TRAM-34 in mesenteric arteries
(MAs) derived from wild-type (WT; circles), Trx-Tg (upward triangles), and dnTrx-Tg (downward
triangles) mice.
Rob H.P. Hilgers, and Kumuda C. Das Hypertension.
2015;65:130-139
Copyright © American Heart Association, Inc. All rights reserved.
A, NS309-mediated relaxing responses in endothelium-intact (+E, open symbols) and
endothelium-denuded (-E, closed symbols) mesenteric arteries (MAs) derived from wild-type
(WT; circles), Trx-Tg (upward triangles), and dnTrx-Tg (downward triangles) mice.
Rob H.P. Hilgers, and Kumuda C. Das Hypertension.
2015;65:130-139
Copyright © American Heart Association, Inc. All rights reserved.
NS309-mediated relaxing responses in mesenteric arteries (MAs) derived from wild-type (WT;
circles), Trx-Tg (upward triangles), and dnTrx-Tg (downward triangles) mice.
Rob H.P. Hilgers, and Kumuda C. Das Hypertension.
2015;65:130-139
Copyright © American Heart Association, Inc. All rights reserved.
A, Cumulative concentration–response curves to diamide and dithiothreitol (DTT) in mesenteric
arteries (MAs) derived from wild-type (WT) mice.
Rob H.P. Hilgers, and Kumuda C. Das Hypertension.
2015;65:130-139
Copyright © American Heart Association, Inc. All rights reserved.
A, In a subset of mesenteric arteries (MAs), relaxing responses to H2O2 were analyzed.
Rob H.P. Hilgers, and Kumuda C. Das Hypertension.
2015;65:130-139
Copyright © American Heart Association, Inc. All rights reserved.
A, The baseline blood pressure of 12-week-old mice was measured as described in the Methods.
Rob H.P. Hilgers, and Kumuda C. Das Hypertension.
2015;65:130-139
Copyright © American Heart Association, Inc. All rights reserved.
A schematic diagram presenting the role of thioredoxin (Trx) system in regulation of
endothelium-derived hyperpolarization (EDH) response and consequent blood pressure control.
Rob H.P. Hilgers, and Kumuda C. Das Hypertension.
2015;65:130-139
Copyright © American Heart Association, Inc. All rights reserved.