Optimization and design modeling for continuous roll compaction granulation
Presenter: Shrikant Swaminathan
Participants: Shrikant Swaminathan, Simseok A. Yuk, Petrus Geldenhuis, Ariel R. Muliadi, Carl Wassgren, Jim Litster
II. Experimental Setup
I. Motivations and Scientific Goals
Motivations
•
•
Bulk powder behavior during compaction in our
FEM model is described using porous-plasticity
model (Drucker-Prager Cap model).
Literature
data
for
DPC
parameters
of
pharmaceutical blends are insubstantial.
a) Diametrical compression
(compact breaking) test
III. Powder properties derivations
b) Uniaxial compression
(compact breaking) test
f
2P

 Dt
diametrical
compression
test
Project goals
c) Die Compression test
• Develop an experimentally-validated 3D
computational model for predicting the roll
compaction process.
• Understand the separate and combined influence
of formulation and device design on process
outputs.
Cohesion
b)
• Model-driven engineering to evaluate
modifications to existing roll compactor
geometry for improving homogeneity of ribbons.
• Develop accurate lower order models for
first stage design and control purposes.
c)
a)
S
S
d
 c f

13  2
Internal friction angle

tan    
 c  2 T
σT
Die
Compression
test
3  c  d 
c
Die
Compression
test
IV. Experimental Setup
Pressure sensor on die
S
S
•
V. Results Highlights
Load cell on
upper punch
Cap evolution parameters
Load cell on
lower punch
1
1
where, p   T  2 rad  q   T   rad 
2
3
The Compaction simulator is mounted on a MTS
pb  pa  R  d  pa tan    
810 universal testing machine.
•
•
Cap eccentricity parameter
The axial stress is measured using the load cells
mounted on the upper and lower punch.
The radial stress is measured by the pressure
sensor. The stress is measured by direct contact
with the powder
VI. Future Work
•
•
•
Understand the influence of punch speed on
Drucker-Prager Cap properties on powder
compaction
Measure the Drucker-Prager Cap powder
properties for common pharmaceutical blends.
Develop computational model for predicting
stress distribution at roll entry region.
Die
Compression
test
•
Material – Avicel PH 102, PH 101, PH 200
•
Punch Speed 5mm/min for loading and unloading with no dwell time.
•
All powder properties qualitatively match the trend of Cunningham
et al.’s data and the trend of Han et al.’s data.
The compression properties of MCC is insensitive to particle size.
•
Die
Compression
test
Young’s modulus (E) & Poisson’s ration (v)
σrad