Figure 1. Evaluation point and enrollment of subjects
analyzed in this study
A. Evaluation point
Hospitalization
(10 or more days)
Outpatient division
A
B
2 to 4 weeks
Last outpatient
Second day of
check-up
hospitalization
before hospitalization
Outpatient division
C
2 to 4 weeks
D
Last examination First outpatient
before discharge follow-up
from the hospital after discharge
B. Enrollment
1) Hospitalization for ten or more days in Tokushima University Hospital
2) Eating more than 90% of served hospital foods
3) No significant infection, organ failure, gastrointestinal bleeding or malignancy
Reference group (REF group)
1) All of the blood examination of serum
albumin and hemoglobin
concentration at A, B, C, and D were
performed.
2) Proteinuria was less than 30 mg/dl
by dipstick urine test.
3) Estimated glomerular filtration rate
was
over 45 ml/min/1.73m2.
Low proteinuria with
glucocorticoid group
(LPG group)
1) Less than
1 g/gCreatinine
proteinuria
2) Glucocorticoid
only/and
immunosuppressant
treatment
during hospitalization
Chronic kidney disease group
All of the blood and urine examination of
serum albumin, hemoglobin
concentration and urine protein, creatine
at A, B, C, and D were performed.
HIgh proteinuria without
glucocorticoid group
(HP group)
1) 1 or more
g/gCreatinine
proteinuria
2) No glucocorticoid
/immunosuppressant
treatment
HIgh proteinuria with
glucocorticoid group
(HPG group)
1) 1 or more g/gCreatinine
proteinuria
2) Glucocorticoid
only/and
immunosuppressant
treatment
during hospitalization
3) Minimal change
nephrotic syndrome patients
were excluded
Figure 2. Serum albumin and hemoglobin
concentration in the reference group
A
B
*
Hemoglobin
Serum albumin
*
4
3
2
1
A
B
C
*
5
D
**
(g/dL)
P = 0.21
(B and C)
*
(g/dL)
22
20
18
16
14
12
10
8
6
A
B
C
D
Figure 3. Serum albumin, hemoglobin concentration and proteinuria
in chronic kidney disease patients with low proteinuria (LPG group)
A
B
*
*
*
4
Hemoglobin
Serum albumin
5
3
2
1
B
A
C
D
(g/gCreatinine)
*
Urine protein/creatinine
P = 0.20
(C and D)
1.00
0.75
0.50
0.25
0.00
A
B
C
22
20
18
16
14
12
10
8
6
P =0.06
(A and B)
A
C
**
**
(g/dL)
D
**
(g/dL)
B
C
D
Figure 4. Serum albumin, hemoglobin concentration and
proteinuria in chronic kidney disease patients with high
proteinuria without glucocorticoid therapy (HP group)
*
B
*
*
*
(g/dL)
(g/dL)
4
Hemoglobin
Serum albumin
5
3
2
1
B
A
C
D
C
(g/gCreatinine)
*
Urine protein/creatinine
*
*
20
15
10
5
0
A
B
C
*
P = 0.34 (A and C)
D
*
A
P = 0.21
(B and C)
22
20
18
16
14
12
10
8
6
A
B
C
D
Figure 5. Serum albumin, hemoglobin concentration and
proteinuria in chronic kidney disease patients with high
proteinuria with glucocorticoid therapy (HPG group)
*
**
**
*
*
(g/dL)
B
(g/dL)
4
Hemoglobin
Serum albumin
5
3
2
1
B
A
C
D
C
(g/gCreatinine)
*
Urine protein/creatinine
*
P = 0.38
(C and D)
20
15
10
5
0
A
B
C
*
A
D
**
P = 0.31
(C and D)
22
20
18
16
14
12
10
8
6
A
B
C
D
Figure 6. Time course of systolic blood pressure
A
B
250
225
200
175
150
125
100
75
B
A
(mmHg)
**
Systolic blood pressure
Systolic blood pressure
P = 0.37
(B and C)
C
**
250
225
200
175
150
125
100
75
D
B
A
C
C
D
D
*
*
**
250
225
200
175
150
125
100
75
A
B
C
*
(mmHg)
Systolic blood pressure
(mmHg)
Systolic blood pressure
*
*
*
(mmHg)
D
P = 0.17
(B and C)
250
225
200
175
150
125
100
75
A
B
C
*
D