Probabilistic Sensitivity Analysis and Cost-effectiveness Acceptability Curves for GERD Management
A, Probabilistic sensitivity analysis for GERD management. B, Cost-effectiveness acceptability curves for GERD management. The line segments in A
represent the base case cost-effectiveness of alternative ways of treating patients with heartburn using best estimates of treatment success rates, event
rates, and costs. The dots represent possible underlying true values of cost-effectiveness when fully accounting for uncertainty in these costs and
outcomes. Dollar amounts are Canadian dollars. In both A and B, inset graph labels A through F represent the following test groups: A, Intermittent PPI; B,
Maintenance PPI; C, Maintenance H2RA; D, Step-down maintenance PA; E, Step-down maintenance H2RA; F, Step-down maintenance PPI.
Source: Economic Analysis, Users' Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice, 3rd ed
Abbreviations: GERD, gastroesophageal reflux disease; H2RA, histamine2-receptor agonist; PA, prokinetic agent; PPI, proton-pump inhibitor.
Citation: Guyatt G, Rennie D, Meade MO, Cook DJ. Users' Guides to the Medical Literature: A Manual for Evidence-Based
Clinical Practice, 3rd ed; 2015 Available at: http://mhmedical.com/ Accessed: July 28, 2017
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