Curriculum Vitae
What you are is God’s gift to you, what you make yourself is your gift to God.
Personal
Name
Dr. Farzana Latif Ansari (TI)
Father’s Name
Mohammad Latif Qureshi (Late)
Husband’s Name
Javed Siraj Ansari
Date & Place of Birth
20-02-1951, Rawalpindi.
Nationality
Pakistani
Occupation
University Teaching and Research
Present Position
Professor (TTS)
Mailing Address
Department of Chemistry, Quaid-i-Azam University (QAU)
Islamabad, Pakistan.
Phone
Permanent Address
051-90642109, 4833745 (R),
Fax:
051-90642241
E-mail:
<[email protected]>
03335122265 (M)
180-C, Sector 1, Khayaban-e-Sirsyed, Rawalpindi, Pakistan.
Academic Qualifications
Examination
Period
Ph.D.
Sep. 1986
Board/University
Eberhard-Karls University,
Tubingen,Germany.
Division/Grade
Magna cum laude
(very good)
M.Phil.
May 1978
Quaid-i-Azam University
1st
M.Sc.
Jan. 1976
Islamabad University
1st
B.Sc.
Dec. 1973
Punjab University
2nd
F.Sc.
Sep. 1971
Sargodha Board
1st
SSC
Sep. 1968
Sargodha Board
1st
1
Titles of Theses
M.Phil.
Studies on the Influence of Substituents on the Stability of Five-Membered Lactone
Rings.
Ein Topf Weg Zur Darstellung von Flour-, Amin-, Cyan, Nitrat und Sulfat Zuckern.
(One Pot Route to the Synthesis of Fluoro-, Amino-, Cyano-, Nitrate and Sulfate Sugars).
Ph.D.
German Language Examinations
1.
Grundstuffe I
April - May 1983
Göthe Institute, Mannheim,
Germany.
2.
Grundstuffe II
June - July 1983
Göthe Institute, Mannheim,
Germany.
3.
Mittelstuffe I
Aug. - Sep. 1983
Göthe Institute, Mannheim,
Germany.
4.
Comprehensive Examination.
Nov. 1983
Eberhand Karls University,
Tübingen, Germany
Languages
English, German, Arabic, Urdu
Distinctions


3rd position (M.Sc.)
2nd position (M.Phil.)
Honors and Awards
International

IUPAC Prize (Poster Competition), 2004

Shield from SAARC for displaying “Instructional Material for Secondary School Students” (1996).

DAAD Scholarship (Apr. 1983 - Dec. 1985).

Scholarship from Ministry of Science and Arts, Germany (Jan. 1986 to Sep. 1986).

DAAD-Fellowship (Jun - Aug. 1991).

DAAD-Fellowship (Jan. 19 – Apr. 1996).

DAAD Fellowship (Aug.12-Sep.22, 2010)

Woman of the Year, 1998, nomination by American Biographical Institute (ABI).

2000 Millennium Medal of Honor, nomination by ABI.
National

Tamgha-i-Imtiaz, 2000

Salam Prize Chemistry, 1990

3rd. Prize, All Pakistan Software Competition, 1994

1st Prize, Poster Competition, 2010

Merit Scholarship from Matric -Ph.D.
2

Shield from Pakistan Science Foundation for displaying “Educational Software” in Science
and Technology Fair-92.

Shield from Pakistan Science Foundation for displaying “Computer Aided Lessons on
Pericyclic Reactions” in Science and Technology Expo-93.
As External Examiner
All national universities (public and private)
As Subject Specialist in Selection Boards



DAAD Selection Committee
Federal Public Service Commission
Allama Iqbal Open University
Membership of Learned Bodies

IUPAC Fellow

Member Chartered Chemist (MRACI C Chem), The Royal Australian Chemical Institute Inc.

National Representative, IUPAC Chemical Nomenclature & Structure Representation Division

Fellow, The Chemical Society of Pakistan , CSP

Life Member, CSP

Whole Time Member, Third World Organization for Women in Science (TWOWS)

Honorary Member, Professional Women’s Advisory Board of American Biographical Institute (ABI).

Member, Tübingen University Alumni (TUA).

Member, German Alumni Forum Pakistan (GAFP)
Teaching and Research Experience
Post-Graduate/Post-Doctoral
June 77 - June 78
Research Officer (BPS 17), Pakistan Science Foundation (PSF) funded
Project, Department of Chemistry, Quaid-i-Azam University, Islamabad.
June 78 - Dec. 78
Lecturer (BPS 17), Govt. College for Women, Rawalpindi (appointed by the
Punjab Public Service Commission).
May 78
Completed M.Phil.
June 78
Ph.D. Scholar
Sep. 79 - Jan. 83
Teaching Research Associate (BPS 17), Department of Chemistry, Quaid-iAzam University, Islamabad.
July 80 - Jan. 82
Research Fellow (Honorary) in University Research Project.
April 83 - Dec. 85
DAAD-Fellow, West Germany.
Jan. 86 - Sep. 86
Ph.D. Scholar
Sep. 85 - April 86
Scientific Assistant conducted Biochemistry practicals (M.B.B.S. students) at
Physiologisch-chemisches Institut, Universität Tübingen, W. Germany.
Dec. 86 – Dec 88
Post-Doctoral Fellow, Quaid-i-Azam University, Islamabad, Pakistan.
Jan, 89-Jan 90 Post-Doctoral Fellow, University Grants Commission,
Islamabad
3
04.02.1990
Lecturer (BPS 17), Quaid-i-Azam University, Islamabad.
03.03.1994
Assistant Professor (BPS 18), Quaid-i-Azam University
27.11.1999
Associate Professor (BPS 19), Quaid-i-Azam University
10.01.2004
Professor (BPS-20), Quaid-i-Azam University
May 2006
Professor (BPS 21), Quaid-i-Azam University
31.05.2008
Professor (TTS), Quaid-i-Azam University
Dec. 86 – Dec. 88
Post-Doctoral Fellow, Quaid-i-Azam University, Islamabad, Pakistan.
Jan, 89-Jan 90
Post-Doctoral Fellow, University Grants Commission, Islamabad
June – Aug. 91
Post-Doc Fellow (DAAD), University of Tübingen, Germany.
Jan. – April 1996
Post-Doc Fellow (DAAD), University of Tübingen, Germany.
Aug. –Sep, 2010
Post-Doc Fellow (DAAD), FMP, Berlin, Germany.
Research Guidance
Report/Thesis
Completed
In Progress
M.Sc.
34
-
M.Phil.
26
3
Ph.D.
2+1
5
Postgraduate Teaching
M.Sc.
M.Phil. / Ph.D.






Introduction to organic chemistry as a fascinating science
Reaction Mechanism
Chemistry of Heterocycles
Biochemistry
Lab. courses involving analytical techniques
Multistep organic synthesis of pharmaceutically important compounds




Medicinal Chemistry
Pericyclic Reactions
Physical Organic Chemistry including
Theoretical and Computational Chemistry & CADD.
Undergraduate Teaching
The following lectures were delivered at different schools and colleges for introducing chemistry as an interesting
and fascinating science:
4

Questions Children Often Ask

Frontiers of Chemistry

Low Cost Activity in Chemistry

Hands-on-Chemistry  OHP Laboratory

Chemistry for Kids

The Quran and Chemistry
Experience in Software Development
A software comprising a number of Computer Aided Lessons (CALS) on Pericyclic Reactions has been developed.
These lessons are a supplement to the book Electrocyclic Reactions – from Fundamentals to Research, which is
published by Wiley-VCH. The developed CALS are being used in the department as teaching aid which has greatly
facilitated the comprehension of the seemingly cumbersome subject of pericyclic reactions.
Computer Assisted Drug Designing (CADD)
Work has also been carried out in the direction of Computer Assisted Drug Designing (CADD) and a CADD lab has
been established. A number of software namely Molecular Operating Environment (MOE) VMD, Accelrys etc. are
being used for carrying out in silico design and synthesis of small drug like molecules of potential pharmacological
interest.
Medicinal Chemistry
Various facets of medicinal chemistry are being explored both in wet and dry labs by synthesizing
pharmacologically active compounds (solution and solid phase). Positional scanning protocol is used for the
identification of leads in different combinatorial libraries of small drug like molecules. These concepts are also used
in class room teaching by offering a course on medicinal to M.Phil/Ph.D. students.
Dissemination of Chemical Knowledge
National Level
Extensive efforts have been made to popularize chemistry by delivering lectures at different schools and colleges on
topics ranging from introducing chemistry as a fascinating science, building molecular models for facilitating
comprehension of difficult concepts, low cost activity and demonstration of difficult concepts on Overhead Projector
(OHP). The OHP demonstrations in the classroom, quite common in the western world, have not yet been practiced
in Pakistan. These activities have helped in developing scientific attitudes and logical thinking in students both at
undergraduate and postgraduate level. Efforts have been made to exploit Computer Assisted teaching by developing
computer aided lessons and their display in different workshops, science exhibitions and in different universities of
Pakistan and by writing chemistry books and reports on state of science education in Pakistan.
International level
As part of a six-member delegation of scientists, visited different German universities and research institutions with
a view to strengthen the existing, and establishing new linkages, in the field of Medicinal Chemistry, Bioinformatics
and Molecular Biology. The visit was jointly sponsored by the Higher Education Commission (HEC) and the
Deutscher Forschungs Gemeinschaft (DFG). As a result thereof, MoU’s were signed with University of Hamburg,
University of Göttingen and Free University, Berlin to promote mutual collaboration with the scientists at both ends.
In continuation to these efforts, the visit of a German professor-a reputed Medicinal Chemist (Prof. Rademann from
Berlin) was organized under FFHP of HEC and a workshop in combinatorial chemistry was organized. This
workshop paved the way to the establishment of medicinal chemistry at QAU. Further, the visit of a well-known
organic chemist (Prof. Langer from University of Rostock) was organized and preliminary work was carried out for
establishing a Center for Synthetic and Medicinal Chemistry at QAU with support from DAAD and HEC. In this
connection a mega proposal has already been submitted to DAAD. The proposal is still in its infancy.
5
Organization of Conferences/Seminars/Workshops

2nd DAAD Follow-up Seminar held in Islamabad (Mar.11-13, 1991), Organizing Secretary.

3rd DAAD Follow-up Seminar held in Islamabad (Sep. 29-Oct.2, 1991), Member, Organizing Committee.

4th DAAD Follow-up Seminar, held in Islamabad (April 28-May 1, 1999), Organizing Secretary.

10th National Chemistry Conference, held in Islamabad (Oct. 2823, 1999), Member, Organizing
Committee.

National Seminar on Frontiers of Chemistry held at Islamabad (Dec. 12, 2002), Organizing Secretary.

Annual Day Celebration in the years 2007, 2008, 2009, Organizing Secretary.

1st Chemistry Alumni Meeting & One Day Seminar on Frontiers of Chemistry (May 15-16, 2009),
Organizing Secretary.

Workshop on Combinatorial Chemistry held in Islamabad (May 07-13, 2004) Coordinator.


5th International & 15th National Chemistry Conference held in Islamabad (Nov, 2004), Organizing
Secretary.
8th International and 20th National Chemistry Conference (February 15-17, 2010), Organizing Secretary.

DAAD Alumni Seminar, Islamabad, Oct. 29– 31, 2010, Member, Organizing Committee.
Collaboration

Prof.Dr.K.Koehler
Abteilung Anorganische Chemie
Technische Universität München
Lichtenbergstraße 4
85747 Garching, Germany

Prof. Dr. J. Rademann,
Universität Leipzig, Medicinal Chemistry, Institute of Pharmacy
Brüderstr. 34, 04103 Leipzig, Germany

Prof. Dr. P. Langer
Institüt für Chemie, Universität Rostock
Albert-Einstein Straße 9a , 18059 Rostock, Germany
Co-curricular activities







Convener, Seminar Committee
Member , Ph.D. Admission Committee
Member, Maintenance Committee
Member, University Discipline Committee
Member, Academic Council
Member, Board of Faculty
Chairperson, Girls Hostel Discipline Committee
Extra-curricular activities:
Compilation of the following books
 Science magazine
 Illustrative Thesaurus
 Echoes of a mother
 A star is born
 Kids chemistry
 Yeh Batee kis ki Baytee hay (Whose daughter is she)?
6
References

Prof. Dr. Dr. W. Völter,
Leiter der Abteilung für Physikalische Biochemie
Physiologisch-chemisches Institut der
Universität Tübingen, Hoppe-Seyler Str. 4
Germany – Tubingen 72706.
Prof. Dr. J. Rademann,
Universität Leipzig, Medicinal Chemistry,
Institute of Pharmacy,
Brüderstr. 34, 04103 Leipzig, Germany

Ph.D. Theses Supervised
Name
Title
Year
Palladium leaching dependent on reaction parameters in SuzukiMiyaura coupling reactions catalyzed by Palladium supported on
alumina
2009
Design, synthesis, bio-evaluation and computational studies on small
drug-like molecules.
2010
Umer Rashid
Dihydropyrimidines as potential drug candidates-Design, synthesis,
bioevaluation and computational studies.
Thesis under
evaluation
Maj.Baseer Khan
Solution and solid phase synthesis of some chalcones and the derived
heterocycles of pharmacological significance.
(public
defense already
done)

Saeeda Shahid
Soomro (as CoSupervisor)

Samina Nazir


M.Phil. Theses Supervised (1-21 as Supervisor, 22-24 as Co-Supervisor)
S.No.
Name
Title
Year
1.
Ijaz-ur-Rehman
1
.
A triflate mediated coupling of sugars with aza-heterocycles.
1992
2.
Nasir
2
A. Kazmi
.
Synthesis of nucleoside analogs.
1994
3.
Sajid
3
H. Awan
.
Different methods for the coupling sugars with heterocyclic
bases.
1994
4.
Muhammad
4
Naeem
.
Synthesis of some sugar substrates and their coupling with
heterocycles.
2000
5.
Naveeda
5
Shaheen
.
Synthesis and characterization of chiral sugar substrates.
2000
6.
Sumera
6
Umbreen
.
Synthesis and reactions of pharmaceutically important
heterocycles.
2000
7
7.
Shazia
7
Saghir
.
Synthesis and reactions of carbohydrates and benzothiazepine
derivatives as potential surfactants.
2001
8.
Shahid
8
Ameen
Synthesis and characterization of glycosylamides as potential
surfactants.
2003
9.
Latif
9
Hussain
.
Combinatorial synthesis and pharmacological screening of 7membered benzothiazepines.
2003
10.
Saima
1
Nasir
0
.
Synthesis and characterization of small drug-like heterocycles
2004
11.
Sajida
1
Sultana
1
.
Synthesis of some sugar substrates and their reactions with azaheterocycles, anilines and phenols.
2005
12.
Samina
1
Nazir
2
.
Combinatorial solution phase synthesis of molecular libraries of
chalcones as potential antibacterial and cytotoxic agents.
2005
13.
Ihsan
1
ullah
3
.
Synthesis and biological screening of combinatorial libraries of
small drug like molecules .to establish structure activity
relationship.
2006
14.
Rasheed
1
Ahmed
Khera
4
.
Combinatorial synthesis and biological screening of small druglike molecules.
2006
15.
Fatima
1
Iftikhar
5
.
Solution and solid phase synthesis of small drug like molecules.
2007
16.
Sana
1
Qureshi
6
.
Design and synthesis of some novel semicarbazones as potential
anticancer and anticonvulsant agents.
2007
17.
Saima
1
Kalsoom
7
.
Design, synthesis and theoretical & computational studies on
heteroazepinone semicarbazones as potential anticonvulsants
and antioxidants.
2008
18.
Iram
1
Batool
8
.
Synthesis, bioevaluation and computational studies on 3,4dihydropyrimidines
2008
19.
Sobia
1
Shaheen
9
.
Design and synthesis of triazoles based on 1,3-dipolar
cycloadditions
2009
20.
S.
2 Aaliya Shehzadi
0
.
Triazoles at a click-synthesis, bio-evaluation and computational
studies.
2009
21.
Zahra Ali
Click synthesis and characterization of pharmaceutically
significant mono-& bis-triazoles.
2010
Shahida Shujat
Synthesis and characterization of biologically significant
nucleosides and their derivatives (in collaboration).
1995
Humaira Y. Gondal
Preparations and reactions of some medicinally important azaheterocycles (in collaboration).
1999
Humaira Noureen
Biological activities of chalcones and their libraries
2006
22.
23.
24.
(in collaboration).
8
Research Projects
No.
1.
Title
Funding
Agency
Duration
Designation
Dec. 86 to
Principal Investigator
1 Synthesis of Benzimidazole-glycosides.
.
URF
2 A Triflate-mediated Approach to
. Synthesis of Nucleoside Analogs.
URF
Dec. 87 - Dec.
88
Principal Investigator
4.
3 On the Writing of a Book entitled
. “Pericyclic Reactions-Fundamentals to
Research” (Part-I).
URF
Jan. 92 - Dec. 92
Principal Investigator
5.
4 On the writing of a Book entitled
. “Pericyclic Reactions-Fundementals to
Research” (Part-II).
URF
Apr. 93- Dec. 93
Principal Investigator
6.
5 Fluorocarbohydrates in the Synthesis of
. Anti-AIDS Nucleosides.
URF
Feb. 94 - Jan. 95
Principal Investigator
7.
6 Phase Transfer Catalysis of Glycosides.
.
URF
1995
Principal Investigator
8.
7 Epoxysugars as substrates for the
synthesis of Nucleosides
URF
1996
Principal Investigator
9.
9 Synthesis of Carbohydrate Building
. Blocks and Bioactive Natural Products.
URF
1997-98
Principal Investigator
10.
9 Epoxy sugars as Chiral Building Blocks.
0
.
URF
1998-99
Principal Investigator
11.
1 Synthesis of Carbohydrate Building
0 Blocks.
.
1998-2002
Principal Investigator
2.
Dec. 87
3.
DAAD
Germany
(4060.11 DM)
12.
1 Synthesis and Reactions of
1 Carbohydrate Building Blocks.
.
URF
2000-01
Principal Investigator
13.
1 Synthesis of Carbohydrate derived
2 Surfactants and Studies on their Liquid
. Crystal Properties.
URF
2001
Principal Investigator
14.
1 Enantioselective Synthesis of
3 Carbohydrate Building Blocks and
Bioactive Natural Products.
PSF
2001 -6
Principal Investigator
2004 -6
Principal Investigator
URF
2010
Principal Investigator
HEC
2007
Principal Investigator
15.
16.
17.
1 Synthesis and biological screening of
4 combinatorial libraries of small drug. like molecules to establish structure
activity relation and drug development.
Synthesis and bioevaluation of some
novel anthraquinone sulfonamides
1 Computer Assisted Drug Designing
5
(Rs.1,900,000)
HEC
(Rs.1,693,000)
9
18.
19.
.
(Rs. 868,185)
1 Computer aided design and synthesis of
6 IL2 inhibitors as immunomodulating
. agents.
(Rs.3,558,295)
1 Computer aided identification and
7 synthesis of α-glucosidase inhibitors.
.
(Rs.1,978,882)
HEC
PSF
2010 -2012
Principal Investigator
2010 -2012
Principal Investigator
Scientific Meetings
Conferences/Seminars (with presentations)
1.
19th. All Pakistan Science Conference held in Islamabad (Sep. 1-6, 1979). Title of paper presented:
Synthesis of Benzimidazoles as Potential Therapeutic
Agents-I
2.
20th. All Pakistan Science Conference held in Karachi (Aug. 21-27, 1981). Title of paper presented:
Synthesis of Benzimidazoles as Potential Therapeutic Agents-II.
3.
21st. All Pakistan Science Conference held in Bahawalpur (Dec. 31, 1982-Jan. 4, 1983). Title of paper
presented: Studies on the Influence of Substituents on the Mechanism of Hydrolysis of -Lactones.
4.
3rd. International Symposium and Pakistan-US Bi-national Workshop on Natural Products
Chemistry held in Karachi (Jan. 9-14, 1988). Titles of papers presented:
5.

Some Recent Synthetic, Isolation and Structural Studies in Natural Products.

Synthesis of 3,4-Dideoxy-3,4-cynomethylene pyranosides.
4th. International Symposium on Natural Products Chemistry held in Karachi (Jan. 26-Feb. 3, 1990).
Titles of papers presented.

Synthesis of some Sugar Derivatives of potential Biochemical Interest.

Synthesis and Spectroscopic Studies on some Aza-Heterocycles.
6.
2nd. DAAD Follow-up Seminar held in Islamabad (Mar. 11-13, 1990). Title of paper presented: One pot
Route to the Synthesis of Sugar Derivatives through Nucleophilic Substitution Reactions.
7.
2nd. National Chemistry Conference held in Karachi (Dec. 28-31, 1990). Title of paper presented:
Synthesis and Spectral Studies of some Sugar Sulphates.
8.
4th. International Conference on CD held in Germany. Title of paper presented: Circular Dichorism of
Carbohyrate-Metal Complexes.
9.
5th. National Chemistry Conference (Oct. 27-29, 1993) held in Islamabad. Title of papers presented:

A Triflate mediated Coupling of Sugars with Aza-Heterocycles.

Computer Aided Lessons on Pericyclic Reactions.
10.
19th. IUPAC Symposium on the Chemistry of Natural Products organized by HEJ Research Institute of
Chemistry, Karachi (Jan. 16-20, 1994). Title of Poster/Software displayed: Computer Aided Lessons on
Pericyclic Reactions.
11.
Spectroscopy for Material Analysis, 2nd. National Symposium on Modern Trends in Contemporary
Chemistry, Islamabad (April 4-6, 1995). Title of presentation Synthesis and NMR Spectral Studies of
some Nucleosides and their Analogs.
12.
8th. National Chemistry Conference held in Lahore (Sep. 2-4, 1997). Title of paper presented: Regio-,
and Stereoselective Ring Opening of some Epoxypranosides through Titanium Isopropoxide and Sm I2- A
facile Route to Iododeoxy Sugars.
13.
9th National Chemistry Conference held in Karachi (Dec. 6-8, 1998). Title of paper presented A
Convenient Regioselective Synthesis of 3-Deoxy-3-Chloro and 3-Deoxy-3-allylhexapyranosides.
10
14.
4th DAAD Follow-up Seminar, held in Islamabad (April 28-May 1, 1999). Title of paper presented
Synthesis of 3-C-Alkyl Derivatives of some Hexopyranosides.
15.
1st International and 11th National Chemistry Conference held in Peshawar (April 10-14, 2001).

Synthesis of Aryl C-glycosides.

Hands on Chemistry – OHP Laboratory.
16.
2nd International & 12th National Chemistry Conference held in Jamshoro (Feb.4-6, 2002). Title of
paper presented: Synthesis, Separation and Conformational Analysis of Diastereomeric Benzothiazepines.
17.
7th Eurasia Conference on Chemical Sciences held at HEJ, Karachi (Mar.9-12, 2002). Title of paper
presented: Pharmaceutically important Benzothiazepines, Synthesis, Separation and XRD analysis of
Diastereomeric 1,5-Benzothiazepines.
18.
National Seminar on Frontiers of Chemistry held at Islamabad (Dec. 12, 2002), Title of paper presented,
Computational Chemistry - Trends in Education and Research.
19.
Plenary Lecture delivered at 3rd International & 13th National Chemistry Conference held in Karachi
(Dec.28-31, 2002). Title of paper: Computational Chemistry and Mechanism of No-Mechanism Reactions.
20.
Plenary Lecture delivered at 4th International & 14th National Chemistry Conference held in Lahore
(May 16-18, 2004). Title of paper: Pericyclic Reactions on the Road to Computational Chemistry.
21.
5th International & 15th National Chemistry Conference held in Islamabad, (Nov, 2004). Titles of
presentations

Combinatorial Synthesis of Chalcone Libraries as Potential Antibacterial agents (IUPAC Poster Prize
in Organic Chemistry).

Regiocontrolled Synthesis of Benzyl 3-Deoxy-3-Halo-and Benzyl 3-Deoxy-3-C-Allyl Pentopyranosides
(Poster).

Discovery of New Nickel Metalocentre spanning Inhibitors of Urease (Oral).
th
22.
11 Asian Chemical Congress and 13th General Assembly held in Seoul, Korea (Aug.23-26, 2005),
Title of paper presented, Combinatorial Synthesis and Antibacterial Studies on an Indexed Chalcone
Library.
23.
10th International Symposium on Natural Product Chemistry, held in Karachi, (Jan. 06-09, 2006). Title
of presentation, Synthesis and Brine Shrimp Lethality Studies on Index Chalcone Libraries.
24.
6th International & 16th National Chemistry Conference held in Multan, (April 6-8, 2006). Title of
presentation: Synthesis and antitumor activities of a parallel library of aryl and heteroaryl Chalcones.
25.
Drug Design amongst the Vines (Dec. 03-07, 2006), RACI, Australia, Title of presentation,
Combinatorial synthesis and antitumor studies on a chalcone library using positional scanning protocol
and CoMFA based 3DQSAR.
26.
11th International Symposium on Natural Product Chemistry, Karachi, Pakistan, (Oct 29-Nov.01 2008,
Titles of posters presented:

In silico studies on 2,3-dhydro-1,5-benzothiazepines as cholinesterase inhibitors.

Comprehensive 3D-QSAR studies on an array of cytotoxic chalcones
27.
5th international Symposium on Biotechnology (ISB-09), Jamshoro, Pakistan. (Oct. 4-7, 2009)
In silico studies on anticonvulsant drugs.
28.
34th International Nathiagali Summer College on Physics & Contemporary Needs, Islamabad (Jun 22Jul 4, 2009), Introduction to computer aided drug designing.
29.
19th National Chemistry Conference (Jun, 2009), Baragali, Plenary lecture, An excursion through wet
and dry labs.
8th International and 20th National Chemistry Conference (Feb.15-17, 2010), Islamabad, Pakistan
30.
11





Peptide heterocycles: new classes of drug like molecules by ligation of peptides (oral).
Prediction of interacting modes of Anticancer drugs with DNA using cyclic voltametric, UV visible
spectroscopic and the molecular docking techniques (oral).
Synthesis, bioevaluation and docking studies on antidiabetic chalcones (Poster, 1st Prize, Organic
Chemistry).
Synthesis and bio-evaluation of derivatives of 1,4-disubstituted-1,2,3-triazoles (poster).
In silico design and synthesis of dihydropyrimidines as a new class of urease inhibitors (poster).
31.
11th Tetrahedron Symposium , Beijing, China (Jun. 22-25, 2010), in silico modeling on specific
inhibitory potential of thiophen-2,3-dihydro, 1,5-benzothiazepines against BChE in formation of β-amyloid
plaques associated with Alzheimer’s disease (Poster).
32.
11th Eurasia Conference on Chemical Sciences, Aman, Jordan (Oct. 6-10, 2010), Triazoles at a clickRegioselective synthesis of 1,4-disubstituted-1,2,3-mono- and bis-triazoles by Cu(I) catalyzed [3+2]
cycloaddition.
33.
DAAD Alumni Seminar, Pakistani and German Universities – Joining Forces for a Better Future,
Islamabad, Oct. 29-31, 2010, Title of presentation: Exploring various facets of medicinal chemistry.
Workshops/Expos
34.
National Science and Technology Fair for Self Reliance, 1992 held in Islamabad. Title of Exhibit,
Educational software for students from Class I to M.Phil.
35.
Workshop on Theoretical and Computational Chemistry, organized by National Academy of Higher
Education, Islamabad (Feb. 6-11, 1993). Title of paper and Exhibit, Mechanism of No Mechanism
Reactions.
36.
All Pakistan Software Competition (July 29-31, 1993). Title of Exhibit: Computer Aided Lessons on
Pericyclic Reactions.
37.
Science and Technology Expo-93 (Sep. 19-24, 1993). Title of Display, Educational Software for
Chemistry Students.
38.
Workshop on Applications of Computers to Chemistry organized by National Academy of Higher
Education, Islamabad. (Jan. 1-6, 1994). Resource Person, Title of presentation, HMO and Pericyclic
reactions.
39.
Workshop on “Die Grenzorbital (FMO), Theorie und ihre Anwendvng in der organischen Chemie” held in
Tübingen, Germany (Feb. 8-12, 1996), Title of presentation, Pericyklische Reaktionen und Ihre
Mechanismus.
40.
SAARC Workshop on the Development and Production of Instructional Material in Science
Education at Secondary Level, Islamabad (Oct. 8-10, 1996). Title of Display: Instructional Material for
Secondary School Students.
Conferences/Workshops (attended)
41.
First International Conference on Scientific Miracles of Quran and Sunnah held in Islamabad (Oct.
18-21, 1987).
42.
DAAD-Follow-up Seminar held in Islamabad (Mar. 27-30, 1988).
43.
3rd. DAAD Follow-up Seminar held in Islamabad (Sep. 29-Oct.2, 1991).
44.
10th National Chemistry Conference, held in Islamabad (Oct. 2823, 1999).
45.
Information handling for promotion of E-Business, Workshop for Middle Management Women held at
PASTIC, Islamabad (Jul 30 -–Aug. 4, 2001).
12
46.
Seminar on Chromatography held in Islamabad (Mar 13, 2002) organized by Varian, We Brothers.
47.
One- Day Seminar on NMR Spectroscopy held in Islamabad (Sep.22, 2003).
48.
International Workshop on Wealth Generation through Research organized by PSF and NUST in
Islamabad (Dec.03, 2003).
49.
Workshop on Combinatorial Chemistry held in Islamabad (May 07-13, 2004).
50.
Workshop on Computational Chemistry and its Applications, (June 24-27, 2006), Karachi.
51.
1st Joint Status Seminar of the Screening Unit (FMP) and Network of Drug Discovery and
Development, Berlin, Germany (Jun 4, 2008).
13
Publications
Books/Chapters
1
F. Latif Ansari, R. Qureshi, M.L. Qureshi, Electrocyclic Reactions - from Fundamentals to Research,
Supplemented by Computer Aided Lessons, Wiley-VCH, Weinheim, Germany, ISBN 3-7785-2569-7, 1999.
www.wiley-vch.de/books/tis/index.html).
2
F. Latif Ansari, R. Qureshi, State of Science Education in Pakistan, Annual Review, 2002-03, Social
Policy and Development Center, ISBN 969-8407-01-4.
3
F. Latif Ansari, S. Umbreen, L. Hussain, T. Makhmoor, S.A.Nawaz, M.A.Lodhi, S.N.Khan, F. Shaheen,
M.I. Chaudhry and Atta-ur-Rahman, Syntheses and Biological Activities of Chalcone and Benzothiazepine
Derivatives: Promising New Free Radical Scavengers, and Cholinesterases, Urease, and α-Glucosidase
Inhibitors, Essays on Science, Felicitation Volume (in honor of Prof. Dr. W. Voelter, Germany), Hamdard
Foundation, Pakistan, 8, 2006, 197-218.
Research Papers
1
M. Hasan, N. Khan and F. Latif, Influence of Substituents on the Stability of Five-Membered Lactone
Rings, Islamabad J. Sci., 1978, 5 (1-2), 35-37.
2
M. Hasan, M.U. Zubair and F. Latif, Preparation of Benzimidazoles as Potential Therapeutic Agents-I,
Islamabad J. Sci., 1979, 6 (1-2), 34-39.
3
M. Hasan, F. Latif and M. Amjad, Preparation of New Benzimidazoles as Potential Therapeutic
Agents-II, J. Chem. Soc. Pak, 1981, 3, 111-113.
4
M. Amjad, F. Latif, M. Hasan and N. Khan, Synthesis and Mass Spectral Studies of
Benzimidazoles, J. Chem. Soc. Pak., 1984, 6(4) 235-238.
5
F. Latif, M. Hasan and S. Zulfiqar, Synthesis of New Benzimidazoles as Potential Therapeutic
Agents-III, Preparation of Bis-Benzimidazoles, J. Chem. Soc. Pak., 1984, 6 (3), 153-160.
6
M. Hasan, F. Latif and M.C.G. Alvarez, Reactions of Some Unsaturated Carboxylic Acids with oPhenylene Diamine in Acid Medium I, J. Chem. Soc. Pak., 1985, 7(4), 309-313.
7
N. Afza, A. Malik, F. Latif and W. Voelter, Synthesis of Sugar Nitrates by Nucleophilic Substitution,
Liebigs Ann. Chem., 1985, 1929-1934 (Renamed as European J.Org. Chem.).
8
F. Latif, A. Malik and W. Voelter, Expoxide Assisted Displacement of Trifyl Group by Flouride ion.
An Efficient Approach to Fluorodeoxy Sugars, Z. Naturforsch, 1985, 40b, 317-318.
9
M. Hasan, F. Latif and M.C.G. Alvarez, Preparation, Physical Properties and Nuclear Magnetic
Resonance Spectral Studies of Isomeric 2 (Hyroxypropyl)-Benzimidazoles, J. Chem. Soc. Pak., 1987,
9(1), 57-6
New
10 F. Latif, A. Malik and W. Voelter, Efficient High-Yielding Synthesis and NMR Spectroscopic Studies
of Some Fluorodeoxy sugars, Liebigs Ann. Chem., 1987, 617-620 (Renamed as European J.Org.
Chem.).
11 F. Latif, A. Malik and W. Voelter, Synthesis of New Amino- and Aziridino-Sugar Derivatives of
Potential Biochemical Interest, Liebigs Ann. Chem., 1987, 717-720 (Renamed as European J.Org.
Chem.).
12 M.S. Sheikhani, F. Latif, A. Fatima, A. Malik and W. Voelter, Synthesis of 3,4-Dideoxy-3, 4Cyanomethylene Pyranosides: A New Class of Cyclopropanated Sugars, J. Chem. Soc. Chem. Comm.,
1988, 1419-1420.
14
13 M. Hasan, F. Latif and J.V. Thuijil, Effect of Substituents on the Hydrolysis Mechanism of Lactones, Isl. J. Sci., 1990, 10 (1-2) 77-89.
14 F. Latif, M.S. Sheikhani and W. Voelter, Convenient Synthesis of Mono- and Cyclic Sulphates of
Carbohydrates via Triflate Displacement, J. Chem. Soc. Perkin Trans., 1990, 1, 1573-1575 (Renamed
as Org. & Biomol. Chem.).
15 A.Malik, F. Zaman, M. Akhtar, N. Naz A. Fatima, F. Latif and Y. Abed. Epoxysugars as
Intermediates in Carbohydrate Synthesis, Trends in Organic Chemistry, 1993, 4, 741-772, Ed. Atta-UrRahman, Harward Academic Publishers, The Netherlands, 1992, 12, 1.
16 N. Khan, Y-Al-Abed, F. Latif Ansari, H.J. Kohlbau, W. Voelter; Regio-und Stereoselselektive
Ringöffnug on Epoxypyranosiden durch Isopropoxytitan-Reagenzien und Sm I2 : Ein einfacher
Zugang zur Ioddesoxyzuckern. Z. Naturforsch., 1996, 51B, 1781-1789.
17 F. Ansari, C. Fedorchuk, M. Parvez, S. Umbreen S. Sagheer, Crystal Structure Report, Diastereomers
of 2-Phenyl--4(2-hydroxyphenyl)-2,3,4,5-Tetrahydro-1,5-Bezothizepines, Acta Cryst., 2002, E58,
0422-0425.
18 M. Parvez, S. Umbreen and F. Latif Ansari, Derivatives of 4-(2’- Hydroxyphenyl)-2,3-dihydro-1,5benzothiazepines, Acta Cryst,, 2003 , C59, 0298-0301.
19 M. Rauf, F. Latif Ansari, G. Bibi, Photocatalytic Degradation of some Azodyes, J. Fac. Sci., UAE
Univ., 2004, 13, 41-45 (Renamed as Int. J. Sci. Res. University of UAE).
20 F. Latif Ansari, S. Umbreen, L. Hussain, T. Makhmoor, S.A.Nawaz, M.A.Lodhi, S.N.Khan, F.
Shaheen, M.I. Chaudhry and Atta-ur-Rahman, Syntheses and Biological Activities of Chalcone and
Benzothiazepine Derivatives: Promising New Free Radical Scavengers, and Cholinesterases, Urease,
and α-Glucosidase Inhibitors, Chem. Biodiv, 2005, 2 (4), 487-96 .
21 F. Latif Ansari, L.Hussain, S.Nasir, Electron Ionization Fragmentation Mechanisms of Different
Substituted 2,3-Dihydo- and 2,3,4,5-Tetraihydro-1,5-Benzothiazepines, Rapid Commun. Mass
Spectrom. 2005, 19, 1-7.
22 F. Latif Ansari, S. Nazir, H. Naureen, B. Mirza, Combinatorial Synthesis and Antibacterial studies on
an lndexed Chalcone Library, Chem. Biodiiv .2005, 2, 1656- 64.
23 F. Latif Ansari , S. Sultana, Andrea M.Corrente, Masood Parvez,, 2,3,4,6-Tetra-O-acetyl-O-p-tertbutylphenyl-β-D-glucopyranoside, Acta Cryst, 2006, E62, 03139-03141.
24 A.Rahman, R. Qureshi,, M.Kiran, F. Latif Ansari, Electron Affinities, Solvation Energies and Redox
Potentials of some Chalcones: Substituents Effects and Correlation with semi Empirical MO Energies,
Turk. J. Chem, 2007, 30, 1-10.
25 Ahsan-Ullah, F. Latif Ansari, Ehsan-Ul-Haq, S. Nazir, B. Mirza, Combinatorial Synthesis and
Antitumour studies on an Aryl and Heteroaryl Chalcone Library using Positional Scanning Method,
Chem. Biodiv. 2007, 4, 203-214.
26 Sarfraz A. Nawaz, S.Umbreen, A.Khalid, F. Latif Ansari, Atta-ur-Rahman, M.I. Choudhry, Structural
insight into the inhibition of cholinesterase by 2,3,4,5-tetrahydro-1,5-benzothiazepines, J.Enzyme
Inhib. & Med.Chem., 2008, 23, 2, 206-12.
27 F. Latif Ansaria, Fatima Iftikhara , Ihsan-ul-Haqb, Bushra Mirzab Muhammad Baseera, Umer Rashida,
Solid phase synthesis and biological evaluation of a parallel library of 2,3-dihydrobenzothiazepines,
Bioorg. Med. Chem, 2008, 16, 7691-7697.
28 A. Shah, A.M. Khan, R. Qureshi, F. Latif Ansari, M.F. Nazar, S.S. Shah, Redox behavior of
anticancer chalcones on a glassy carbon electrode and evaluation of its interaction parameters with
DNA, Int, J. M .Sc. 2008, 9, 1424-1434.
29 F. Latif Ansari, Zaheer-ul-Haq,, A.Wadood, Ahsanullah, in silico studies on urease inhibitors to
explore enzyme-ligand interactions,. J.Enzyme Inhib. & Med.Chem., 2009, 24 (1), 151-156.
30 F. Latif Ansaria, Muhammad Baseera, Fatima Iftikhara , Saima Kulsooma, Ahsan Ullaha, Samina
Nazira, Awais Shaukata, Ihsan-ul-Haqb, Bushra Mirzab Microwave assisted synthesis, antibacterial
15
activity against Bordetella bronchiseptica of a library of 3'-hydroxy-aryl and heteroaryl chalcones and
molecular descriptors-based SAR, ARKIOVC 2009 (x) 318-332.
31 A. Shah, R. Qureshi, A. M. Khan, F. Latif Ansaria, S Ahmad, Determination of binding parameters
and the mode of Ferrocenyl Chalcone-DNA interaction, Bull. Chem. Soc. Jpn. (2009), 82 (4), 453-457.
32 A. Shah, R. Qureshi, R. A. Khera, F. Latif Ansari , Electrochemical behavior of 1-ferocenyl-3-phenyl2-propen-1-one on Glassy carbon electrodes and evaluation of its interaction parameters with DNA, J.
Braz. Chem. Soc, 2009, 0 (0), 1-5.
33 S.S.Soomro, F.Latif Ansari, K.A.Chatziapostol, k.Koehler, Palladium leaching dependenceon
reaction parameters in Suzuki-Miyaaura coupling reactions catalyzed by palladiums supported on
alumina under mild reaction conditions, J. Catalysis, 2010, 273, 138-146.
34 W. Khan, Zaheer-ul-Haq, , S. Kalsoom, F. Latif Ansari, In-silico modeling on specific inhibitory
potential of thiophene-2,3-dihydro-1,5-benzothiazepine against BChE in the formation of β-amyloid
plaques associated with Alzheimer's disease, Theor. Biol.Med. Model, 2010, 7, 1-26.
35 A. El-Dahshan, S.Nazir, Ahsanullah, F.Latif Ansari, J.Rademann, Peptide heterocycle chimera-new
class of more drug-like peptidomimetics by ligation of peptide bis-electrophiles with various bisnucleophiles. Eur.J.Org.Chem, 2010, 1-11.
Papers under review
1.
R. Qureshi, F. Perveen, S. Ahmad, N.K. Janjua, F.L. Ansari, S. Kalsoom, Prediction on interacting modes
of anticancer drugs with DNA using cyclic voltametric, UV-Visible spectroscopic and the molecular
docking techniques, Bioelectrochemistry, 2009.
2.
F. Latif Ansari, S. Kalsoom, Zaheer-ul-Haq, In silico Studies on 2,3-Dihydro-1,5-Benzothiazepines as
Cholinesterase Inhibitors, Chem. Biol. Drug Design, 2009.
3.
L. Jafri, F. Latif Ansari, M. Jamil, S. Kalsoom, S. Khurram, B. Mirza, Determination of Biological
Activities of Some semicarbazones, Chem. Biol. Drug Design, 2009.
4.
F. Latif Ansari, U.Rashid, I.Batool, Reaz-uddin, M.Ajmal, Zaheer-ul-Haq, Design of 3,4dihydropyrimidines as novel urease inhibitors using structure-based virtual screening of an inhouse
database, Chem. Biodiv. 2010.
5.
F. Latif Ansari, S.Shaheen, S, Aliya Shehzadi, F.Jabeen, H.Awan, Y.Niazi, B.Mirza, Triazoles at a clickRegioselective synthesis of 1,4-disubstituted-1,2,3-mono- and bis-triazoles by Cu(I) catalyzed [3+2]
cycloaddition., Aus. J. Chem, 2010.
6.
F. Latif Ansari, S. Nazir, H. Noureen, B. Mirza, Zaheer-ul-Haq, In Silico guided design and synthesis of
cytotoxic chalcones, Chem. Biodiv., 2010.
Conference Proceedings (Published)
1.
Proc. Nat. Pdt. Chem. Pak., 1988, 549-568,.Malik, A.Q. Khan, Z. Ahmed, N.H. Kazmi, K. Rehman, N.
Afza and F. Latif, Some Recent Synthetic, Isolation and Spectral Studies in Natural Products.
2.
International Congress on CD, Germany, 1991, 212-224.W. Voelter, A. Malik, F. Latif and J. Tschkert,
CD Studies on Carbohydrate Meal Complexes.
3.
Proc. Fifth. Nat. Chem. Conf., Pak, 1993, 238-241, F. Latif, I.U. Rehman, A. Malik, A Triflate Mediated
Coupling of Sugars with Aza-heterocycles,
4.
19th. IUPAC Symposium on Natural Product Chemistry, 1994, 9-13.F. Latif Ansari, R. Qureshi, M.
Qureshi and F.S. Qureshi, Computer Aided Lessons on Pericyclic Reactions.
5.
Proc. of the Conference “Spectroscopy for Material Analysis”, Islamabad, 1995, 469-473, F. Latif,
Ansari, S. H. Awan and N.H. Kazmi, Synthesis and NMR Spectral Studies of Some Nucleosides and their
Analogues.
16
6.
11th Asian Chemical Congress and 13th General Assembly, Korea (Aug.23-6, 2005), F. Latif Ansari, S.
Nazir, H. Naureen, B. Mirza, Combinatorial Synthesis and Antibacterial Studies on an Indexed Chalcone
Library.
7.
10th International Symposium on Natural Product Chemistry, Pakistan, (Jan. 06-09, 2006, F. Latif
Ansari, S. Nazir, H. Naureen, B. Mirza, Synthesis and Brine Shrimp Lethality Studies on an Indexed
Chalcone Library.
8.
Drug Design amongst the Vines, Australia, (Dec.03-07,2006), F. Latif Ansari, Ahsan-Ullah, Ehsan-UlHaq, S. Nazir, B. Mirza, Combinatorial Synthesis and Antitumor Studies on a Chalcone Library using
Positional Scanning Protocol and CoMFA based 3DQSAR.
17