Curriculum Vitae
Nome
Posizione
Sivlia Middei
Ricercatore presso Istituto di Biologia Cellulare e
Neurobiologia (Consiglio Nazionale delle Ricerche)
Roma, Italia
FORMAZIONE
Titolo
Istituto
1
Anni
Campo
Universita’ "La Sapienza", Roma
Italia
Facolta’ di Psicologia
Laurea
(110/110 cum laude)
1993-1998 Psicologia
Sperimentale, memoria
umana
Universita’ "Tor Vergata", Roma
Italia
Facolta’ di Medicina
PhD in Neuroscienze
2001-2005 Neuroscienze,
memoria, Malattie
neurodegenerative
Trinity College Institute of
Neuroscience,
Dublino, Irlanda
Post Doc
2005-2007 Neuroscienze,
memoria,
elettrofisiologia
Cosiglio Nazionale delle Ricerche
Post Doc
2007-2011 Neuroscienze, Morbo
di Alzheimer
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Biographical Sketch Silvia Middei
A. Posizioni
2011- oggi: Ricercatore, Consiglio Nazionale delle Ricerche, Istituto di Biologia cellular e Neurobiologia,
Roma (Italia)
2007-2011: Ricercatore, Fondazione Santa Lucia, Roma (Italia)
2005-2007: Post Doc, Trinity College Institute of Neuroscience Dublino (Irlanda)
2000-2004: Dottorando, Fondazione Santa Lucia, Roma (Italia)
Onori
2005-2007: Irish Research Council for Science Engineering and Technology Grant (Irlanda)
B. Pubblicazioni
1. Restivo L., Passino E., Middei S., Ammassari-Teule M. The strain-specific involvement of nucleus
accumbens in latent inhibition might depend on differences in processing configural- and cue-based
information between C57BL/6 and DBA mice. Brain Research Bullettin. 2002, 57: 35-39
2. Passino E., Middei S., Restivo L., Bertaina.Anglade V., Ammassari-Teule M. Genetic approach to
variability of memory systems: analysis of place vs. response learning and fos-related expression in
hippocampal and striatal areas of C57BL/6 and DBA/2 mice. Hippocampus, 2002, 12: 63-75
3. Aversano M., Ciamei A., Cestari V., Passino E., Middei S., Castellano C. Effects of MK-801 and
ethanol combinations on memory consolidation in CD1 mice: involvement of GABAergic
mechanisms. Neurobiology of Learning Memory 2002, 77: 327-37
4. Ammassari-Teule M., Middei S., Passino E., Restivo L. Enhanced procedural learning following
beta-amyloid protein (1-42) infusion in the rat. Neuroreport, 2002,13:1679-82
5. Restivo L., Middei S., Mingfu L., Reggio R., Passino E., Formisano R., Ammassari-Teule M.
Potentiation of ischemia-related behavioural alterations by electro-acupuncture in gerbils.
Functional Neurology, 2004, 19: 19-23
6. Middei S., Restivo L., Sgobio C., Passino E., Ammassari-Teule M.Reversible inactivation of
hippocampus and dorsolateral striatum in C57BL/6 and DBA/2 inbred mice failed to show
interaction between memory systems in these genotypes. Behavioural Brain Research, 2004, 154:
527-34
7. Middei S., Geracitano R., Caprioli A., Mercuri N.B., Ammassari-Teule M. Preserved fronto-striatal
plasticity and enhanced procedural learning in a transgenic mouse model of Alzheimer Disease
overexpressing mutant hAPPswe. Learning and Memory, 2004, 11: 447-52
8. Ognibene E., Middei S., Daniele S., Adriani W., Ghirardi O., Caprioli A., Laviola G. Aspects of
spatial memory and behavioral disinhibition in Tg2576 transgenic mice as a model of Alzhemer’s
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Biographical Sketch Silvia Middei
Disease. Behavioural Brain Research, 2005, 156:225-32
9. Middei S., Daniele S., Caprioli A., Ghirardi O., Ammassari-Teule M. Progressive cognitive decline
in a transgenic mouse model of Alzheimer disease overexpressing mutant hAPPswe. Genes Brain
and Behavior, 2006, 5:249-56.
10. Middei S., Vetere, G., Sgobio, C.A., Ammassari-Teule M. Landmark-based orientation but not
vestibular-based orientation elicits mossy fiber synaptogenesis in the mouse hippocampus.
Neurobiology of Learning and Memory, 2007, 87:174-80
11. Bellenchi G.C., Gurniak C.B., Perlas E., Middei S., Ammassari-Teule M., Witke W. N-cofilin is
associated with neuronal migration disorders and cell cycle control in the cerebral cortex.
Genes and Development, 2007, 21: 2347-57
12. Middei S., Restivo, L., Caprioli A., Aceti M., and Ammassari-Teule M. Region-specific changes in
the microanatomy of single dendritic spines over time might account for selective memory
impairments in ageing hAPPsweTg2576 mice, a mouse model for Alzheimer Disease.
Neurobiology of Learning and Memory, 2008, 90: 467-471
13. Giampà C*., Middei S*., Patassini S., Bernardi G., Ammassari-Teule M., Fusco F.R.
Phospphodiesterase 4 inhibition prevents sequestration of CREB binding protein, protects striatal
parvalbumin interneurons, and rescues from motor deficits in the R6/2 mouse model of Huntington
disease. European Journal of Neuroscience, 2009, 25: 902-910, * equal contribution
14. Vergni D., Castiglione F., Briani M., Middei S., Alberdi E., Reymann K.G., Natalini R., Volontè C.,
Matute C., Cavaliere F. A model of ischemia-induced Neuroblast activation in the adult
subventricular zone. PLoS One. 2009;4(4):e5278
15. Marchetti C, Tafi E, Middei S, Rubinacci MA, Restivo L, Ammassari-Teule M, Marie H. Synaptic
adaptations of CA1 Pyramidal Neurons induced by a Highly Effective Combinational
Antidepressant therapy. Biol Psychiatry. 2010 Jan 15;67(2):146-54
16. Middei S, Roberto A, Berretta N, Panico MB, Lista S, Bernardi G., Mercuri NB, Ammassari Teule
M, Nisticò R.Learning discloses abnormal structural and functional plasticity at hippocampal
synapses in the APP23 mouse model of Alzheimer Disease. Learning and Memory 2010 Apr
19;17(5):236-40
17. D'Amelio M, Cavallucci V, Middei S, Marchetti C, Pacioni S, Ferri A, Diamantini A, De Zio D, Carrara
P, Battistini L, Moreno S, Bacci A, Ammassari-Teule M, Marie H, Cecconi F. Caspase-3 triggers early
synaptic dysfunction in a mouse model of Alzheimer's disease. Nat Neurosci. 2011 Jan;14(1):69-76.
18. Middei S, Spalloni A, Longone P, Pittenger C, O'Mara SM, Marie H, Ammassari-Teule M. CREB
selectively controls learning-induced structural remodeling of neurons. Learn Mem. 2012 Jul
18;19(8):330-6.
19. Pignatelli M, Vollmayr B, Richter SH, Middei S, Matrisciano F, Molinaro G, Nasca C, Battaglia G,
AmmassariTeule M, Feligioni M, Nisticò R, Nicoletti F, Gass P.Enhanced mGlu5-receptor
dependent long-term depression at the Schaffer collateral-CA1 synapse of congenitally learned helpless
rats. Neuropharmacology. 2013 Mar; 66:339-47
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Biographical Sketch Silvia Middei
20. Middei S, Houeland G, Cavallucci V, Ammassari-Teule M, D’Amelio M, and Marie H. CREB is
necessary for synaptic maintenance and learning-induced changes of the AMPA receptor GluA1
subunit.
Hippocampus, 2013 Jun; 23:488-499
21. Pignataro A., Middei S., Borreca A., Ammassari-Teule M. Indidtinguishable pattern of amygdala and
hippocampus rewiring following tone or contextual fear conditioning in C57BL/6 mice. Front Behav
Neurosci 2013 Oct; 7: 156.
22. Errico F, Nisticò R, Di Giorgio A, Squillace M, Vitucci D, Galbusera A,Piccinin S, Mango D, Fazio
L, Middei S, Trizio S, Mercuri NB, Teule MA, Centonze D, Gozzi A, Blasi G, Bertolino A, Usiello A.
Free D-aspartate regulates neuronal dendritic morphology, synaptic plasticity, gray matter volume and
brain activity in mammals. Transl Psychiatry. 2014 Jul 29;4:e417.
23. Middei S, Ammassari-Teule M, Marie H. Synaptic plasticity under learning challenge. Neurobiol
Learn Mem. 2014 Nov;115:108-15.
24. Oddi D, Subashi E, Middei S, Bellocchio L, Lemaire-Mayo V, Guzmán M, Crusio WE, D'Amato FR,
Pietropaolo S. Early Social Enrichment Rescues Adult Behavioral and Brain Abnormalities in a Mouse
Model of Fragile X Syndrome. Neuropsychopharmacology. 2015 Mar; 40: 1113-22
25. Pignataro A, Borreca A. Ammassari-Teule M, Middei S. CREB Regulates Experience-Dependent
Spine Formation and Enlargement in Mouse Barrel Cortex. Neural Plasticity 2015 (in stampa)
C. Finanziamenti
Consiglio Nazionale delle Ricerche
Progetto Invecchiamento
Periodo: 2014-2015.
Ruolo nel progetto: Coordinatore
Alzheimer Association Grant (USA)
Periodo: 2013-2015.
Ruolo nel progetto: Coordinatore sezione “studio del comportamento”, Co-PI (PI Cristina Marchetti)
Alzheimer Association Grant (USA)
Periodo: 2010-2012.
Ruolo nel progetto: Coordinatore sezione “studio del comportamento”, Co-PI
(PI: Marcello D’Amelio).
CNRS-CNR Collaboration Grant Project (France-Italy).
Periodo: 2010-2012. Ruolo nel progetto: Coordinatore sezione “studio della plasticita’ sinaptica”
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Biographical Sketch Silvia Middei