CURRICULUM VITAE Corey A. Siegel, MD WORK ADDRESS Dartmouth-Hitchcock Medical Center Section of Gastroenterology One Medical Center Drive Lebanon, NH 03756 Phone 603-650-8101 E-mail [email protected] DATE OF BIRTH: June 15, 1971 PLACE OF BIRTH: Hackensack, NJ HOME ADDRESS 5 Carriage Lane Hanover, NH 03755 603-643-1218 EDUCATION 2007-2009 1994-1998 1989-1993 M.S., Clinical/Health Services Research, The Dartmouth Institute for Health Policy and Clinical Practice, Dartmouth Medical School, Hanover, New Hampshire M.D., Tufts University School of Medicine, Boston, Massachusetts B.S., Tufts University College of Liberal Arts, Medford, Massachusetts POSTDOCTORAL TRAINING 2004-2005 2002-2005 2001-2002 1999-2001 1998-1999 Advanced Fellowship in Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts Mentors: Dr. Bruce E. Sands & Dr. Joshua R. Korzenik Fellow in Gastroenterology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire Chief Medical Resident, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire Resident, Internal Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire Intern, Internal Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire ACADEMIC APPOINTMENTS 2012-present Associate Professor of Medicine and of the Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine at Dartmouth, Hanover, NH 2012-present Adjunct faculty, White River Junction VA Outcomes Group 2010-2012 Assistant Professor, Dartmouth Institute for Health Policy & Clinical Practice, Geisel School of Medicine at Dartmouth, Hanover NH 2005-2012 Assistant Professor of Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH 2004-2005 Clinical and Research Fellow in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA HOSPITAL APPOINTMENTS 2012-present Medical Director, Medical Infusion Services, Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH 2011-present Director, Gastroenterology Research Program, Section of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 2005-present Director, Inflammatory Bowel Disease Center, Section of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 2001-present Physician, Medical Service, Department of Veterans Affairs, WRJ, VT LICENSURE New Hampshire, license #11395 BOARD CERTIFICATION Gastroenterology, 2005 ABIM, 2001 USMLE Part III, 1999 USMLE Part II, 1998 USMLE Part I, 1996 PROFESSIONAL SOCIETY MEMBERSHIPS American College of Gastroenterology American Gastroenterological Association Crohn’s and Colitis Foundation of America COMMITTEES National Chair, Quality Improvement Task Force, National Scientific Advisory Board, Crohn’s and Colitis Foundation of America, 2012-present Co–Chair, National Professional Education Committee, National Scientific Advisory Board, Crohn’s and Colitis Foundation of America, 2008 – 2011 Crohn’s and Colitis Foundation, Quality Improvement Committee, 2009-2011 Grant Review Study Section, Crohn’s and Colitis Foundation of America, 2008 – present AGA, IBD subcommittee for Clinical Practice Planning Committee for DDW, 2010present MKSAP Board Review Committee, Gastroenterology section IBD Support Foundation, Medical Advisory Board Data safety and monitoring board (DSMB) member on multiple clinical trials Regional Chapter Medical Advisory Committee, Crohn’s and Colitis Foundation of America, New England Chapter, 2005-present Institutional Infusion Services Committee, Dartmouth-Hitchcock Medical Center, 2012-present Clinical Trials Office, Principal Investigators’ Advisory Committee, Dartmouth-Hitchcock Medical Center, Lebanon, NH 2011-present Data Warehouse Committee, Dartmouth-Hitchcock Medical Center, Lebanon, NH, 20102011 Translational Research and Education Committee, Dartmouth-Hitchcock Medical Center, Lebanon, NH, 2008-2010 Section of Gastroenterology and Hepatology Internal Review Committee for Research Protocols, Dartmouth-Hitchcock Medical Center, Lebanon, NH, 2006-present Intern Selection Committee, Dartmouth-Hitchcock Medical Center, Lebanon, NH, 20012002, 2005-present RESEARCH GROUP/CONFERENCE ORGANIZATION International Organization for the Study of Inflammatory Bowel Disease (IOIBD). To be inducted March 2013. http://www.ioibd.org/ BRIDGe Group, 2007 - present. Founder of a group of 13 junior faculty IBD clinicians and clinical researchers. Collaborative research group, further details available at www.BRIDGeIBD.com Dartmouth-Hitchcock/CCFA Patient Education Symposium. Chairman of annual conferences 2006-2012. Current and Future Treatments of Inflammatory Disorders: Common Ground for IBD, Psoriasis and Rheumatoid Arthritis. Dartmouth-Hitchcock Medical Center, June 2007. Steering Committee member. JOURNAL EDITORIAL POSITIONS Alimentary Pharmacology & Therapeutics, International Editorial Board, 2011 - present Inflammatory Bowel Diseases, Associate Editor, 2009-present Inflammatory Bowel Diseases, Section Editor, Selected Summaries, 2006-2009 Gastroenterology and Hepatology, Editorial Board, 2007-current JOURNAL REVIEWER American Journal of Gastroenterology Alimentary Pharmacology and Therapeutics Annals of Internal Medicine Clinical Gastroenterology and Hepatology Cochrane Reviews Digestive Diseases and Sciences Gut Inflammatory Bowel Diseases Gastroenterology UpToDate MAJOR RESARCH INTERESTS Outcomes research in inflammatory bowel disease (IBD), risk prediction and risk communication for patients with Crohn’s disease, quality improvement in IBD RESEARCH SUPPORT Past Dartmouth-Hitchcock Medical Center, Department of Medicine Junior Faculty Research Development Award, 2005 Dartmouth Medical School, Hitchcock Foundation: A Novel Approach to Study the Association Between Mycobacterium Avium Complex and Crohn's Disease. January 2001 Crohn’s and Colitis Foundation of America. Career Development Award. July 2007-June 2010. Role: PI Foundation for Clinical Research in Inflammatory Bowel Disease. Patient knowledge and preferences in regards to colorectal cancer in the setting of ulcerative colitis. February 2007. Role: PI Present NIH K23 Career Development Award. 1K23DK078678-01A1. 2008-2013. Role: PI. Award $797,220 Crohn’s and Colitis Foundation of America, Quality of Care Initiative. January 2011-Dec 2011. Role: Co-PI with Dr. Thomas Ullman and Dr. Gil Melmed. Award $180,000 Foundation for Clinical Research in IBD. Pilot Study of Hyperbaric Oxygen for Ulcerative Colitis. July 2012. Role: Co-investigator. Award $40,000. R01. 1R01HS021747-01. Evaluating a prediction tool and decision aid for patients with Crohn’s disease. September 2012-August 2017. Role: PI. Award $2,278,000. Under Review Implementation strategies for a risk prediction tool for patients with Crohn’s disease – PCORI Pilot Projects Grant – submission July 2012 AWARDS Dartmouth-Hitchcock Department of Medicine Excellence in Teaching Award, 2009 Crohn’s and Colitis Foundation of America (CCFA) Young IBD Investigator Award, May 2008. San Diego, CA. Research Excellence in GI and Liver (REGAL) Award recipient, October 2006, Chicago, IL INVITED PRESENTATIONS Regional “Shared Decision Making in IBD”, Medical Grand Rounds, Androscogin Valley Hospital, Androscogin NH, May 2012 The times they are a-changin’ - Crohn’s diagnosis & treatment in 2011, Medical Grand Rounds, Valley Regional Hospital, Claremont, NH, January 2011 Communicating the benefits and risks of Crohn’s disease therapy to patients. Combined Medical and Pediatric Grand Rounds, Maine Medical Center, March 2011 “The times they are a-changin’ – Crohn’s diagnosis and treatment in 2009. Medical Grand Rounds, Dartmouth-Hitchcock Medical Center, Lebanon, NH, April 2009. “Choosing the right medications for you.” Crohn’s and Colitis Foundation of America, New England Chapter Patient Education Symposium, Lebanon, NH, May 2008. “Inflammatory Bowel Disease 101.” Anthem, Blue-Cross/Blue-Shield. Manchester, NH, June 2008. “Inflammatory Bowel Disease: Diagnosis and Treatment 2008” Medical Grand Rounds, Lakes Region General Hospital, Laconia, NH, April 2008. “Inflammatory Bowel Disease: Diagnosis and Treatment 2008” Boston University Northeast Regional Nurse Practitioner Conference. April 2008. “Understanding Your Choices about Current Treatment and Looking Towards the Future” Crohn’s and Colitis Foundation of America, New England Chapter, Baystate Medical Center Patient Education Symposium. October 2007. “Making and Evaluating Choices about IBD Medications” Crohn’s and Colitis Foundation of America, New England Chapter Patient Education Symposium, Burlington, MA, March 2008. “Infections in IBD” Crohn’s and Colitis Foundation of America, National Research Conference. Aventura, FL, December 2007. “Side-Effects of IBD Medications: Putting Risk Into Perspective.” Crohn’s and Colitis Foundation of America, New England Chapter Patient Education Symposium, Lebanon, NH, May 2007. “New Discoveries and the Future of IBD Treatment.” Crohn’s and Colitis Foundation of America, New England Chapter Patient Education Symposium, Lebanon, NH, May 2007. “State of the Art of IBD in 2007.” Key note lecture at the Maine Gastroenterology Society Meeting, Freeport, ME, April 2007. “Risks of IBD Medications: Should we be concerned?” Crohn’s and Colitis Foundation of America, New England Chapter Patient Education Symposium, Burlington, MA, March 2007. “Hot Topics in Inflammatory Bowel Disease.” Medical Grand Rounds, New London Hospital, New London, NH, October 2006. “Hot Topics in Inflammatory Bowel Disease.” Medical Grand Rounds, Catholic Medical Center, Manchester, NH, June 2006 “New Treatments for Inflammatory Bowel Disease.” Crohn’s and Colitis Foundation of America, New England Chapter Patient and Family Education Symposium, Lebanon, NH, June 2006 “Weighing the Risks and Benefits of Therapy for IBD.” Crohn’s and Colitis Foundation of America, New England Chapter Patient and Family Education Symposium, Lebanon, NH, June 2006 “Hot Topics in Inflammatory Bowel Disease.” Medical Grand Rounds, Mt. Ascutney Hospital, Windsor, VT, May 2006. “Hot Topics in Inflammatory Bowel Disease.” Medical Grand Rounds, Manodnock Community Hospital, Peterborough, NH, April 2006. “Understanding the Risks and Benefits of Biologic Therapy for IBD.” Crohn’s and Colitis Foundation Patient and Family Education Symposium. Burlington, MA, March 2006. “Hot Topics in Inflammatory Bowel Disease.” Medical Grand Rounds, Central Vermont Regional Hospital, Berlin, VT, March 2006. “Update in the Treatment of IBD.” Medical Grand Rounds, Rutland Regional Hospital, Rutland, VT, February 2006. “Inflammatory Bowel Disease: Easy Questions, Difficult Answers.” Dartmouth-Hitchcock Medical Center, December 2005. “Anorectal disorders.” Gastroenterology in Primary Care. Woodstock, VT, Febuary 2004 “Crohn’s Disease.” Gastroenterology in Primary Care. Bedford, NH, June 2003 National “Balancing the benefits and risks of IBD therapy” Crohn’s and Colitis Foundation of America, Physician Education Program, Memphis, Tennessee, August 2012 “Risk of IBD Therapy” Digestive Disease Week, Postgraduate Course, San Diego, California. May 2012 “Improving Quality of Care for Patients” Internal Medicine Update, Keynote Speaker, Boca Raton Regional Hospital, Boca Raton, Florida, March 2012 “Communicating the risks and benefits of IBD therapy to our patients”. Mt. Sinai School of Medicine, GI Grand Rounds, New York, New York. February 2012 “Do IBD therapies cause cancer?” Crohn’s and Colitis Foundation of America National Research Conference, Hollywood, FL, December 2011. “Optimizing biologic therapy” Crohn’s and Colitis Foundation of America National Research Conference, Hollywood, FL, December 2011. “Communicating with the IBD patient: How to convey benefits and risks” American College of Gastroenterology Postgraduate Course, National Harbor, Maryland, October 2011 “Cochrane symposium – evidence based algorithm for the treatment of ulcerative colitis,” Digestive Disease Week, Chicago, IL, May 2011 “When is it time to start anti-TNF therapy,” Digestive Disease Week, Chicago, IL, May 2011 “Meet the professor – management of Crohn’s disease,” Digestive Disease Week, Chicago, IL, May 2011 “Quality of care in IBD,” Digestive Disease Week, Canadian trainee program, Chicago, IL, May 2011 “Communicating the Risks and Benefits of Crohn’s Disease Therapy to our Patients,” GI Grand Rounds, Rhode Island Hospital, Providence, RI, February 2011 “From inception to implementation: Development of the Crohn’s Disease Risk Prediction Model”, GI Research Conference, Rhode Island Hospital, Providence, RI, February 2011 “Communicating the Risks and Benefits of Crohn’s Disease Therapy to our Patients,” GI Grand Rounds, Beth Israel Medical Center, New York, New York, February 2011 “Communicating the Risks and Benefits of Crohn’s Disease Therapy to our Patients,” Case University Hospitals, Cleveland, OH, January 2011 “Communicating the Risks and Benefits of Crohn’s Disease Therapy to our Patients,” University of Miami, Miami, FL, January 2011 “Quality of care in IBD”, Crohn’s and Colitis Foundation of America National Research Conference, Hollywood, FL, December 2010. “IBD patients who never had IBD”, Crohn’s and Colitis Foundation of America National Research Conference, Hollywood, FL, December 2010. “Communicating Risk of Inflammatory Bowel Disease Therapy,” Scripps Annual IBD Symposium, La Jolla, September 2010 “Dealing with the risks of IBD therapy,” Digestive Disease Week, Postgraduate Course, New Orleans, LA, May 2010 “Cancer in IBD Therapy,” Digestive Disease Week, Clinical Symposium, New Orleans, LA, May 2010 “Communicating Risks and Benefits of IBD Therapy,” NYU Annual GI Update, New York, NY, April 2010 “Communicating the Risks of IBD Therapy to Patients and their Parents,” Childrens’ Hospital, Boston, MA, April 2010 “Communicating risks of IBD therapies to patients and their parents” Crohn’s and Colitis Foundation of American National Research Conference, Hollywood, FL, December 2009. “Introduction to Quality Improvement in IBD” Crohn’s and Colitis Foundation of American National Research Conference, Hollywood, FL, December 2009. “Risk and Risk Communication in IBD” Cleveland Clinic, Annual George Rankin Lecture, Cleveland, OH, November 2009 “How to discuss risks of IBD therapies with your patients without scaring them” Mt. Sinai School of Medicine IBD Symposium. New York, NY. September 2009. “Risks and Benefits of IBD Treatments” University of North Carolina IBD Day. Chapel Hill, NC. September 2009. “IBD Update” CCFA Physicians’ Dinner. Minneapolis, MN. June 2009. “Prevention of Infectious in IBD” Boston IBD Symposium, Boston, MA, April 2009 “When and How to Use Biologic Therapy for the Treatment of IBD” ACG Regional Meeting, Las Vegas, NV, March 2009 “Personalized Treatment for Patients with Crohn’s Disease” Walter Reed/ACG GI Symposium, Tysons Corner, VA, March 2009 “Communicating Risks and Benefits to IBD Patients” Crohn’s and Colitis Foundation of American National Research Conference, Hollywood, FL, December 2008. “Diagnosis, Treatment and Prevention of Infectious Complications of IBD” Crohn’s and Colitis Foundation of American National Research Conference, Hollywood, FL, December 2008. “Infections in IBD” Massachusetts General Hospital Annual IBD Course, Boston, MA October 2008. “Are biologic safe?” American College of Gastroenterology Annual Meeting, Orlando, Florida, October 2008. “Risks and Benefits of the Treatment of Crohn’s Disease.” Cedars-Sinai Medical Center Annual Update. Lake Tahoe, CA, September 2008. “Risks in Crohn’s disease: Balancing the risks of the disease against the risks of the drugs” AGA forum, Digestive Disease Week, San Diego, CA, May 2008. “Microscopic colitis” Meet-the-professor, Digestive Disease Week, San Diego, CA, May 2008. “Balancing the Risks and Benefits of IBD Therapy: What Should we Tell our Patients?” Visiting Professor, Yale University Section of Gastroenterology. New Haven, CT. April 2008. “Short and Long Term Risk of IBD therapy” 3rd Biannual Clinical Advances in Gastroenterology and Hepatology (Jefferson Medical College). San Juan, Puerto Rico, March 2008. “Balancing Efficacy and Risk: What do we tell our patients?” American College of Gastroenterology, Symposium Talk, Philadelphia, PA. October 2007. “Risk and Risk Communication for the Treatment of IBD.” Visiting Professor, University of Michigan, Ann Arbor, MI, September 2007. “Meet-the-Professor, Microscopic Colitis.” Digestive Disease Week, Washington, DC, May 2007. “How to weigh the risks and benefits of treatment for IBD: Gaining perspective” Crohn’s and Colitis Foundation of America, Los Angeles Chapter Patient Education Program, Los Angeles, CA, March 2007. “Safety of Immunomodulation in IBD: What is the evidence and what should we tell our patients?” Crohn’s and Colitis Foundation of America, Los Angeles Chapter Physician Education Program. Los Angeles, CA, March 2007. “Side Effects of IBD Medications: How and what do we tell our patients?” Crohn’s and Colitis Foundation of America, National Research Conference. Miami, FL, December 2006. “Safety of Biologic Therapy: What is the Evidence?” Physician Symposium, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN). Orlando, FL, October 2006. “Risk and Risk Communication in the Treatment of Inflammatory Bowel Disease.” Mayo Clinic, Rochester, MN, October 2006. “Risk and Benefits of Infliximab in the Treatment of Crohn’s Disease.” REGAL awards, Chicago, IL, October 2006. “Risks and Benefits of Infliximab for the Treatment of Crohn’s Disease.” Digestive Disease Week, Oral Presentation, Los Angeles, CA, May 2006 “Crohn’s Colitis and Colorectal Cancer.” Digestive Disease Week, Oral Presentation, Los Angeles, CA, May 2006 “How to Get Started in an Academic IBD Career.” American Gastroenterological Association Investing in the Future Program, Los Angeles, CA, May 2006 “Discussing Risks of Treatment with Patients: A Review of Common Medications and Major Side Effects.” Crohn’s and Colitis Foundation Medical Symposium, Chicago, IL, February 2006. “New Biologics: The Choices and the Risks.” Crohn’s and Colitis Foundation Medical Symposium, Chicago, IL, February 2006. “Risks and Benefits of Infliximab for the Treatment of Crohn’s Disease.” Crohn’s and Colitis Foundation National Research Conference, Miami, FL, December 2005. “Difficult IBD Cases.” Dartmouth-Hitchcock Update in Gastroenterology and Hepatology, Manchester, NH, May 2005. “Risk/Benefit Analysis of Infliximab in Crohn’s Disease.” Massachusetts General Hospital Research Retreat, Boston, MA, January 2005. International Canterbury Bowel & Liver Trust Visiting IBD Professor “Communicating the risks and benefits of therapy to IBD patients”, Annual Immune Mediated Inflammatory Disease Conference, Nelson, New Zealand, September 2012 Canterbury Bowel & Liver Trust Visiting IBD Professor “Personalized Medicine for Inflammatory Bowel Disease Patients”, Annual Immune Mediated Inflammatory Disease Conference, Nelson, New Zealand, September 2012 “Communicating the risks and benefits of therapy to patients with Crohn’s disease” University of Western Ontario. GI Grand Rounds. London, Ontario, April 2012 “Do IBD therapies cause cancer,” United European Gastroenterology Week (UEGW), Stockholm, Sweden, October 2011 “Explaining the risk of IBD therapy to our patients,” Austrian National IBD Meeting (ÖGGH), Mondsee, Austria, September 2011 “Does every patient with Crohn’s disease need immunomodulator and/or anti-TNF therapy?” Austrian National IBD Meeting (ÖGGH), Mondsee, Austria, September 2011 “Safety of anti-TNF therapy and effective risk communication to patients,” Greek IBD Society National Meeding, Kalamata, Greece, May 2011 “Can long-term outcomes be predicted,” St. Vincent’s Hospital IBD Symposium, Melbourne, Australia, April 2011 “The risk versus benefit of combination therapy,” St. Vincent’s Hospital IBD Symposium, Melbourne, Australia, April 2011 “Is colonoscopic surveillance necessary in Crohn’s disease?” St. Vincent’s Hospital IBD Symposium, Melbourne, Australia, April 2011 “Modeling outcomes in Crohn’s disease?” St. Vincent’s Inaugural Paediatric IBD Symposium, Melbourne, Australia, April 2011 “Benefit/Risk of treatments in IBD: the patients’ perspective,” SNFGE-AGA Cosponsored IBD Symposium, Paris, France, March 2011 “Detection and prevention of dysplasia in ulcerative colitis,” SNFGE-AGA Cosponsored IBD Symposium, Paris, France, March 2011 “Extraintestinal Cancer in IBD,” European Crohn’s and Colitis Organization Annual Meeting, Dublin, Ireland, February 2011 “Communicating the Risks and Benefits of Crohn’s Disease Therapy to our Patients,” GI Grand Rounds, Hospital for Sick Kids, Toronto, ON, Canada, November 2010 “Communicating the Risks and Benefits of Crohn’s Disease Therapy to our Patients,” GI Grand Rounds, McMaster University, November 2010 “Lymphoma Risk of Inflammatory Bowel Disease Therapy,” IBD Ahead Symposium, Brussels, Belgium, September 2010 “Exercising patient choice: Communicating Benefits and Risks of IBD Therapy,” British Society of Gastroenterology, Liverpool, UK, March 2010 “Risk and Risk Communication in IBD”, University of British Columbia, Vancouver, BC, Canada, January 2010 “When to use early anti-TNF therapy for Crohn’s disease”, University of Calgary, Alberta, Canada, January 2010 “Communicating risks of IBD therapies” United European Gastroenterology Week, London, UK, November 2009 “Balancing Risks and Benefits of IBD Therapy” IBD Ahead Symposium, St. Julians, Malta, April 2009 “Risk and Risk Communication in IBD” GI Grand Rounds, University of Manitoba, Winnipeg, Manitoba, October 2008. “Risk Assessment with IBD Therapeutics: What do we know and what should we tell our patients?” Western Canada IBD Symposium, Banff, Albert, CA. November 2007. BIBLIOGRAPHY Original Publications Cheifetz AS, Melmed GY, Spiegel B, Talley J, Devlin SM, Raffals L, Irving PM, Jones J, Kaplan GG, Kozuch P, Sparrow M, Velayos F, Baidoo L, Bressler B, Siegel CA. Setting priorities for comparative effectiveness research in inflammatory bowel disease: Results of an international provider survey, expert RAND panel, and patient focus groups. Inflamm Bowel Dis 2012; Epub ahead of print. Ha C. Ullman TA, Siegel CA, Kornbluth A. Patients enrolled in randomized clinical trials do not represent the inflammation bowel disease patient population. Clin Gastroenterol Hepatol 2012; Epub ahead of print Lacy BE, Everhart KK, Weiser KT, Delee R, Strobel S, Siegel C, Croweel MD. IBS patients’ willingness to take risks with medications. Am J Gastroenterol 2012;107(6):804809. Siegel CA, Finlayson SR, Sands BE, Tosteson AN. Adverse events do not outweigh benefits of combination therapy for Crohn’s disease in a decision analytic model. Clin Gastroenterol Hepatol. 2012;10(1):46-51. PMID 21963958 Ashworth LA, Billett A, Mitchell P, Nuti F, Siegel C, Bosvaros A. Lymphoma risk in children and young adults with inflammatory bowel disease; Analysis of a large singlecenter cohort. Inflamm Bowel Dis 2012;18(5):838-43. Van Assche G, Lewis JD, Lichtenstein GR, Loftus EV, Ouyang Q, Panes J, Siegel CA, Sandborn WJ, Travis SP, Colombel JF. The London position statement of the world congress of gastroenterology on biological therapy for IBD with the European Crohn’s and Colitis Organization: Safety. Am J Gastroenterol 2011;106(9):1594-602 D'Haens GR, Panaccione R, Higgins PD, Vermeire S, Gassull M, Chowers Y, Hanauer SB, Herfarth H, Hommes DW, Kamm M, Löfberg R, Quary A, Sands B, Sood A, Watermayer G, Lashner B, Lémann M, Plevy S, Reinisch W, Schreiber S, Siegel C, Targan S, Watanabe M, Feagan B, Sandborn WJ, Colombel JF, Travis S. The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD With the European Crohn's and Colitis Organization: When to Start, When to Stop, Which Drug to Choose, and How to Predict Response? Am J Gastroenterol, 2011;106:199-212. Siegel CA, Siegel LS, Hyams JS, Kugathasan S, Markowitz J, Rosh JR, Leleiko N, Mack DR, Crandall W, Evans J, Keljo DJ, Otley AR, Oliva-Hemker M, Farrior S, Langton CR, Wrobel IT, Wahbeh G, Quiros JA, Silber G, Bahar RJ, Sands BE, Dubinsky MC. A Real-time tool to display the predicted disease course and treatment response for children with Crohn's disease. Inflamm Bowel Dis 2011; 17:30-8. Johnson FR, Hauber B, Ozdemir S, Siegel CA, Hass S, Sands BE. Are gastroenterologists less tolerant of treatment risks than patients? Benefit risk preferences in Crohn’s disease management. J Manag Care Pharm. 2010;16:616. Melmed GY, Spiegel BM, Bressler B, Cheifetz AS, Devlin SM, Harrell LE, Irving PM, Jones J, Kaplan GG, Kozuch PL, Velayos FS, Baidoo L, Sparrow MP, Siegel CA. The appropriateness of concomitant immunonomodulators and anti-TNF agents for Crohn’s disease: One size does not fit all. Clin Gastroenterol Hepatol 2010; 8:655. Baars JE, Siegel CA, Van’t Spijker A, Markus T, Kuipers EJ, van der Woude CJ. Inflammatory bowel disease patients are insufficiently educated about the basic characteristics of their disease and the associated risk of colorectal cancer. Dig Liver Dis 2010; Epub ahead of print Siegel CA, Schwartz LM, Woloshin S, Cole EB, Rubin DT, Vay T, Baars J, Sands BE. When should ulcerative colitis patients undergo colectomy for dysplasia? Mismatch between patient preferences and physician recommendations. Inflamm Bowel Dis 2010;16:1658-62. Rubin DT, Dubinksy MC, Panaccione R, Siegel CA, Binion DG, Kane SV, Hopper J. The impact of ulcerative colitis on patients’ lives compared to other chronic diseases: A patient survey. Dig Dis Sci. 2010; 55:1044. Wilcox AR, Dragnev C, Darcey CJ, Siegel CA. A new tool to measure the burden of Crohn’s disease and its treatment: Do patient and physician perceptions match? Inflamm Bowel Dis 2010;16:645. Awais D, Siegel CA, Higgins PD. Modeling dysplasia detection in ulcerative colitis: Clinical implications of surveillance intensity. Gut 2009;58:1498. Siegel CA, Marden SM, Persing SM, Larson RJ, Sands BE. Risk of Lymphoma Associated with Combination Anti-TNF and Immunomodulator Therapy for the Treatment of Crohn’s Disease: A Meta-Analysis. Clinical Gastroenterology and Hepatology 2009;7:874. *NOTE – this manuscript was in the “Top 10” most cited manuscripts in this journal from 2008-2010. Courville EL, Siegel CA, Vay T, Wilcox AR, Suriawinata AA, Srivastava A. Isolated Asymptomatic Ileitis Does Not Progress To Overt Crohn's Disease On Long Term Follow Up Despite Features Of Chronicity In Ileal Biopsies. Am J Surg Pathol 2009;33:1341. Baars JE, Siegel CA, Kuipers EJ, van der Woude CJ. Patient’s perspectives important for early anti-tumor necrosis factor treatment in inflammatory bowel disease. Digestion 2009;79:30-35. Rubin DT, Siegel CA, Kane SV, Binion DG, Panaccione R, Dubinsky MC, Loftus EV, Hopper J. Impact of ulcerative colitis from patients’ and physicians’ perspectives: Results from the UC: NORMAL survey. Inflamm Bowel Dis. 2009 Apr;15(4):581-8.. Johnson FR, Ozdemir S, Mansfield C, Hass S, Siegel CA, Sands BE. Are adult patients more tolerant of treatment risks than parents of juvenile patients? Risk Analysis 2009;29(1):121-136. Spiegel BM, Ho W, Esrailian E, Targan S, Higgins P, Siegel CA, Dubinsky M, Melmed G. Controversies in ulcerative colitis: A survey comparing decision making of experts versus community gastroenterologists. Clin Gastroenterol Hepatol 2008;7(2):169-74. Siegel CA, Levy LC, Mackenzie, Sands BE. Patient perceptions of the risks and benefits of infliximab for the treatment of inflammatory bowel disease. Inflamm Bowel Dis 2008;14(1): 1-6. Johnson FR, Ozdemir S, Mansfield C, Hass S, Miller DW, Siegel CA, Sands, BE. Crohn's Disease Patients' Benefit-Risk Preferences: Serious Adverse Event Risks versus Treatment Efficacy. Gastroenterology 2007;133(3):769-79. Siegel CA, Hur C, Korzenik JR, Gazelle, GS, Sands BE. Risks and benefits of infliximab for the treatment of Crohn’s disease. Clinical Gastroenterology and Hepatology 2006;4:1017-1024. Siegel CA, Sands BE. Risk factors for colorectal cancer in Crohn’s colitis: A case-control study. Inflammatory Bowel Diseases 2006;12:491-496. Reddy D, Siegel CA, Sands BE, Kane S. Possible association between isotretinoin and inflammatory bowel disease. Am Journal Gastroenterol 2006;101:1569-1573. Review articles Devlin SM, Cheifetz AS, Siegel CA, on behalf of the BRIDGe Group. Patient-specific approach to combination versus monotherapy with the use of antitumor necrosis factor α agents for inflammatory bowel disease. Gastroenterol Clin North Am 2012;41(2):411.28. Feuerstein JD, Cheifetz AS, Siegel CA. Comparative effectiveness research in inflammatory bowel disease: prospects and challenges. Expert Rev Gastroenterol Hepatol 2012;6:405-407. Levy LC, Siegel CA. Commentary: diagnostic medical radiation exposure in inflammatory bowel disease. Aliment Pharmacol Ther. 2012;35(8):959-60. Siegel CA. Shared decision making in inflammatory bowel disease: helping patients understand the tradeoffs between treatment options. Gut 2012;61(3):459-65. Siegel CA. Review article: explaining risks of inflammatory bowel disease therapy to patients. Aliment Pharmacol Ther. 2011;33:23-32. Levy LC, Siegel CA. Endoscopic mucosal healing in ulcerative colitis. Aliment Pharmacol Ther. 2011;33:1254-5. Loew BJ, Siegel CA. Foam preparations for the treatment of ulcerative colitis. Current Drug Delivery 2011. Epub ahead of print. Siegel CA. What options do we have for induction therapy for Crohn’s disease. Digestive Diseases 2010;28:543-7. Siegel CA. Should mucosal healing be a primary endpoint in clinical trials of Crohn’s disease? Pro. AGA Perspectives, Oct/Nov 2010. Siegel CA. Lost in translation: Helping patients understand the risks of inflammatory bowel disease therapy. Inflamm Bowel Dis 2010;16:2168. Siegel CA. Creating quality measures in IBD. Gastroenterology & Hepatology 2010;6:218. Siegel CA. Accidentally ASCENDing into comparative effectiveness research for inflammatory bowel disease; Gastroenterology 2009;137:1880. Siegel CA. Risk of lymphoma in inflammatory bowel disease. Gastroenterology and Hepatology 2009;5(11):1. Siegel CA, Marden S, Sands BE. Response to: Insufficient evidence to conclude whether anti-TNF therapy increases the risk of lymphoma in Crohn’s disease. Clin Gastroenterol and Hepatol 2009;7:1139. Siegel CA, Melmed GY, Ullman TA. Quality of care in inflammatory bowel disease: A STEEEP challenge. Inlamm Bowel Dis. 2009;16:134. Johnson FR, Hauber AB, Ozdemir S, Hass S, Siegel C, Sands B. Quantitative benefitrisk tradeoff preferences for Crohn’s disease treatments - Implications for regulatory decision making and disease management. Int J Med Biol Front 2009;15(5/6):457-466 Siegel CA, Melmed GY. Review: Predicting response to anti-TNF agents for the treatment of Crohn’s disease. Therapeutic Advances in Gastroenterology 2009; 2:245. Siegel CA. Making therapeutic decisions in IBD: The role of patients. Current Opinion in Gastroenterology 2009;25:334. Siegel CA, Macdermott RP. Is chronic pain an extraintestinal manifestation of IBD? Inflamm Bowel Dis. 2009; 15:769. Marden SM, Siegel CA. Give me prednisone and give me death. Inflamm Bowel Dis. 2009; 15:1119. Sparrow MP, Irving PM, Baidoo L, Bressler B, Cheifetz AS, Devlin SM, Harrell LE, Jones J, Kozuch PL, Melmed GY, Velayos FS, Siegel CA. Current controversies in Crohn’s disease: A roundtable discussion of the BRIDGe group. Gastroenterology & Hepatology 2008; 4(10):713-720. Siegel CA. Communicating the risks of inflammatory bowel disease medications to patients. Inflamm Bowel Dis Monit;2008(3):78-83. Siegel CA. Patient perspectives on therapeutic options for IBD. Gastroenterology and Hepatology 2007; 3(12):909-911. Hanauer SB, Kane SV, Plevy SE, Siegel CA. A case-based discussion of managing Crohn’s disease: Integrating the new generation of anti-TNF therapies. Gastroenterology and Hepatology 2007; 3(12):3-14. Siegel CA. Guide to discussing the risks of immunomodulator and anti-TNF therapy with inflammatory bowel disease patients. Practical Gastroenterology 2007; XXXI (11): 1424. Siegel CA. Embracing the internet for progress in shared decision making. Inflamm Bowel Dis 2007;13(12):1579-1580. Levy LC, Siegel CA. Adherence issues in the treatment of ulcerative colitis. Medscape Internal Medicine. Available at: http://www.medscape.com/viewarticle/563408 Siegel CA, Rubin DT. American College of Gastroenterology Annual Scientific Meeting 2006 Review. Inflammatory Bowel Disease Monitor 2007;7(3):121-124. Siegel CA, Bensen, S, Ely P. Should rare complications of treatment influence decisionmaking in ulcerative colitis? Inflammatory Bowel Diseases 2007;13:242. Siegel, CA. Safe and Effective Use of Immunomodulators for Inflammatory Bowel Disease. Practical Gastroenterology 2006;7:31-44. Siegel, CA. As if mothers don’t have enough to worry about…Inflamm Bowel Dis. 2006;12(2):146-147. Siegel CA, Sands BE. Review article: practical management of inflammatory bowel disease patients taking immunomodulators. Alimentary Pharmacology & Therapeutics 2005;22 (1):1-16. Siegel CA, Silas AE, Suriawinata AA, van Leeuwen DJ. Liver Biopsy 2005: When and How? Cleveland Clinic Journal of Medicine 2005;72(3):199-224. Siegel CA. Take two prednisone and don’t call me in the morning. Inflamm Bowel Dis. 2005;11(2):206-7. Siegel CA, Book Review of Gastrointestinal Symptoms in Advanced Cancer Patients. Journal of Palliative Care 2004;7:89. Siegel CA, Robertson DJ. Print and Media Review of Gastroenterology and Hepatology for the Primary Care Provider: Principles, Practice and Guidelines for Referral. Gastroenterology 2003;124:1160-1161. Book Editor Irving PM, Siegel CA, Rampton DS, Shanahan F, eds. Inflammatory Bowel Disease: New Challenges (second edition). 2011. Oxford: Wiley-Blackwell Book Chapters Siegel CA (2011). Balancing benefits and risks of biologic therapy. In: Bayless TM, Hanauer SB, eds. Advanced Therapy in Inflammatory Bowel Disease. (pp. 723-728). Shelton, Connecticut: People’s Medical Publishing House. Siegel CA (2011). The risks of immunomodulators and biologics: what should we tell patients? In: Irving PM, Siegel CA, Rampton DS, Shanahan F, eds. Inflammatory Bowel Disease: New Challenges. (pp. 140-143). Oxford: Wiley-Blackwell Korzenik JR, Siegel,CA (2011). The limitations of applying evidence based medicine to inflammatory bowel disease: what we do not learn from clinical trials. In: Lichtenstein G, ed. Ulcerative Colitis: The complete guide to medical management. (pp. 71-78). Thorofare: Slack incorporated. Korzenik JR, Siegel,CA (2011). The limitations of applying evidence based medicine to inflammatory bowel disease: what we do not learn from clinical trials. In: Lichtenstein G, ed. Crohn’s disease: The complete guide to medical management. (pp. 69-76). Thorofare: Slack incorporated. Levy LC, Siegel CA (2011). State of the art medical treatment for the adult patient with IBD: The mesalamine based therapies. In: Cohen R, ed. Inflammatory bowel disease diagnosis and therapeutics – 2nd edition (pp. 59-71). New York: Humana Press. Sands BE, Siegel CA (2010). Crohn’s Disease. In: M Feldman, LS Friedman, LJ Brandt, eds. Sleisenger and Fordtran’s Gastrointestinal and Liver Disease, 9th edition (pp.1941 -1973). Philadelphia: Saunders/Elsevier. Siegel CA (2010). Comprehensive approach to patient risk. Risk versus benefit of biologics and immune suppressants. In: SR Targan, F Shanahan, LC Karp, eds. Inflammatory bowel disease: Translating basic science into clinical practice (pp. 678692). Oxford, UK: Wiley-Blackwell. Siegel CA (2010). Risks and complications of biologic therapy. In: D Baumgart, ed. Biologic therapy for inflammatory bowel disease (pp. 64-73). Bremen: UNI-MED. Siegel CA, Sands BE (2010). The first visit. In: SJ Bickston, RS Bloomfeld, eds. Handbook of inflammatory bowel disease (pp. 1-8). Baltimore: Wolters Kluwer/Lippincott Williams and Wilkins. Siegel CA (2010). The risks of biologic therapy for inflammatory bowel disease. In: CN Bernstein, ed. The inflammatory bowel disease yearbook, volume 6 (pp.89-108). London, UK: Remedica. Levy LC, Siegel CA (2009). What are the risks of biologic therapies and how do you communicate this to patients? In: DT Rubin, FA Farraye, S Friedman, eds. Curbside Consultations in Gastroenterology (pp. 27-32). Thorofare: Slack incorporated. Siegel CA (2009). Inflammatory bowel disease in the current world: Controversies in Management. In: MC Dubinsky, EJ Scherl, eds. The life cycle and IBD: A focus on special populations (pp. 231-244). Thorofare: Slack incorporated. Johnson FR, Hauber AB, Ozdemir S, Hass S. Siegel CA, Sands BE. Quantitative benefit-risk tradeoff preference for Crohn’s disease treatments – Implications for regulatory decision making and disease management. In: Crohn’s disease: Etiology, Pathogenesis and Interventions. In press. Siegel CA, Levy, LC. What tips should I give my surgical colleagues who are seeing patients with pouchitis? In: Cash B, ed. Curbside consultation of the colon: 49 clinical questions. In press. Abstracts Corey A. Siegel, Phillip Fleshner, Lori S. Siegel, Jerome Rotter, Marla Dubinsky, Eric Vasilauskas, Andy Ippoliti, David Shih, Gil Melmed, Carol Landers, Talin Haritunians, Stephan Targan, Kent Taylor, Dermot McGovern. Predicting Crohn’s disease postoperative recurrence using clinical, endoscopic, serologic and genetic factors. Digestive Disease Week, Chicago, IL, May 10, 2011 Corey A. Siegel, Sadie M. Marden, Lori S. Siegel, Marla C. Dubinsky, Annette M. O’Connor. Development of the first Crohn’s disease decision aid: helping patients make informed, preference-based decisions for their treatment. Digestive Disease Week, Chicago, IL, May 10, 2011 Lori Ann Ashworth, Amy Billett, Paul Mitchell, Federica Nut, Corey Siegel, Athos Bousvaros. Lymphoma risk in children and young adults with inflammatory bowel disease: analysis of a large single center cohort. Digestive Disease Week, Chicago, IL, May 9, 2011 Corey Siegel, Sadie Marden, Courtney Kozlowski, Burr Loew, Campbell Levy, Steve Bensen. Crohn’s disease patients report their definitions of “rare” adverse events, remission and the importance of mucosal healing: what patients REALLY think. Digestive Disease Week, Chicago, IL, May 9, 2011 Christina Ha, Thomas Ullman, Corey A. Siegel, Asher Kornbluth. Are patients enrolled in randomized controlled trials (RCTs) representative of the general Inflammatory Bowel Disease (IBD) patient population? Digestive Disease Week, Chicago, IL, May 9, 2011 Anderson P, King L, Landers C, McGovern D, Kane E, Taylor K, Melmed G, Kelly V, Wilcox A, Srivastava A, Siegel CA. Serologic and genetic profiles of patients with incidental asymptomatic ileitis. Digestive Disease Week, New Orleans, LA. May 4, 2010. White LC, Spangler C, Rosenblum J, Sweeney S, Homan E, Bensen S, Levy LC, Dragnev MC, Moskalenko-Locke K, Siegel CA. A quality improvement project significantly increased the vaccination rate for immune suppressed IBD patients. Digestive Disease Week, New Orleans, LA. May 4, 2010. Siegel CA, Finalyson SR, Sands BE, Tosteson. AN. A decision analysis to define the thresholds at which the risks of combination azathioprine and infliximab therapy outweigh its benefits. American College of Gastroenterology , San Diego, CA, Oct 27, 2009. Siegel CA, Sands BE, Feagan B, Sandborn WJ, Hass S, Niecko T. Natalizumab reduces the rate of hospitalization in moderate to severe Crohn’s patients: Data from the ENACT and ENCORE Trials. American College of Gastroenterology, San Diego, CA, Oct 27, 2009. Melmed G, Spiegel B, Bressler B, Cheifetz A, Devlin S, Harrell L, Irving P, Jones J, Kaplan G, Kozuch P, Velayos F, Baidoo L, Sparrow M, Siegel, C. When is it appropriate to use concomitant immunomodulators with anti-TNF agents for the treatment of Crohn’s disease? Results of a RAND appropriateness panel. American College of Gastroenterology, San Diego, CA, Oct 26, 2009 – Presidential Poster Award Lacy, BE, Everhart KK, Weiser KW, De Lee R, Strobel, S, Siegel CA, Cowell, MD. Medication Risk Taking Behavior in IBS Patients. American College of Gastroenterology, San Diego, CA, October 25, 2009, Presidential Poster Award Siegel CA, Siegel LS, Hyams J, Kugathasan S, Markowitz J, Rosh J, Leleiko N, Mack D, Crandall W, Evans J, Keljo D, Otley A, Oliva-Hemker M, Langton C, Wrobel IT, Wahbeh G, Quiros A, Silber G, Bahar R, Sands BE, Dubinsky MC. A Prediction Tool to Help Children with Crohn's Disease and their Parents Understand Individualized Risks of Disease Complications and Response to Therapy. Digestive Disease Week, Chicago, IL. June 3, 2009. Sweeney S, King A, Bihrle M, Ortego A, Siegel CA. Do Barriers to Access of Care Impact Outcomes in Patients with Crohn’s Disease? Digestive Disease Week, Chicago, IL. May 31, 2009. Mahadevan U, Siegel CA, Abreu M. Certolizumab use in pregnancy: Low levels detected in cord blood. Digestive Disease Week, Chicago, IL. June 3, 2009. Kreuter JD, Siegel CA, Gardner TB, Srivastava A, Suriawinata AA. Density of IgG4+ Plasma Cells in Ulcerative Colitis Correlates with the Degree of Inflammation and not with Extraintestinal Manifestations. United States and Canadian Academy of Pathology, Boston, MA, March 2009. Wilcox AR, Dragnev C, Darcey CJ, Siegel CA. A new tool to measure the burden of Crohn’s disease and its treatment: Do patient and physician perceptions match? Am Journal Gastroenerol 2008.103(S1):S425. Siegel CA, Siegel LS, Sands BE, Wrobel I, Wahbeh G, Quiros A, Silber G, Bahar R, Dubinsky MC. A prototype system dynamics model to communicate the risk of Crohn’s disease complications to patients and their predicted treatment response. Am Journal Gastroenerol 2008.103(S1):S451. Siegel CA, Marden SM, Persing SM, Larson RJ, Sands BE. Risk of lymphoma associated with anti-TNF agents for the treatment of Crohn’s disease: A meta-analysis. Gastroenterology 2008;134(4):A14. Awais D, Litt AK, Siegel CA, Higgins P. Modeling dysplasia detection in ulcerative colitis: clinical implications of surveillance sensitivity. Gastroenterology 2008;134(4):A34. Sands BE, Siegel CA, Spencer M, Hass S. Natalizumab reduces the hospitalization rate in moderate to severe Crohn’s disease patients: A pooled analysis of the ENACT-1 and ENCORE studies. Gastroenterology 2008;134(4):A154. Baars JE, Siegel CA, van’t Spijker A, Kuipers EJ, van der Woude CJ. Patients with inflammatory bowel disease are insufficiently educated about their disease and associated risks. Gastroenterology 2008;134(4):A200. Spiegel BM, Ho W, Esrailian E, Melmed GY, Higgins PD, Siegel CA, Dubinsky MC, Targan SR. Practice patterns of 5-ASA use in ulcerative colitis (UC): Results of a national vignette survey comparing experts vs. community providers. Gastroenterology 2008;134(4):A209. Spiegel BM, Ho W, Esrailian E, Melmed GY, Higgins PD, Siegel CA, Dubinsky MC, Targan SR. Experts and community providers have varying levels of beliefs about the appropriateness of colectomy for flat low-grade dysplasia (LGD) in ulcerative colitis UC). Gastroenterology 2008;134(4):A345. Siegel CA, Schwartz LM, Woloshin S, Cole EB, Rubin DT, Bunnag AP, Vay T, Baars JE, Sands BE. When should ulcerative colitis patients undergo colectomy for dysplasia? Mismatch between patient preferences and physician recommendations. Gastroenterology 2008;134(4):A346. Fingar EL, Vay T, Wilcox A, Siegel C, Suriawinata AA, Srivastava A. Isolated Asymptomatic Ileitis Does Not Progress to Crohn s Disease Despite Presence of Features of Chronicity in Ileal Biopsies. Modern Pathology, Vol 21 (Suppl 1; January) 2008; 118A. Runner-up, GI Pathology Best Abstract Prize. Baars JE, Siegel CA, van ‘t Spijker A, Kuipers EJ, van der Woude CJ. Patients with inflammatory bowel disease are insufficiently educated about their disease and associated risks. Presented at the European Crohn’s and Colitis Organization Congress Lyon, France 2008. Rubin DT, Siegel CA, Kane SV, Binion DG, Panaccione R, Dubinsky MC, Hopper J. Patient and Physician Perceptions on Living with Ulcerative Colitis: Results from Two Internet Surveys. American Journal of Gastroenterology 102: S310 527 Suppl. 2 SEP 2007. (Also presented as posters at Advances in IBD Miami FL 2007, CDDW 2008 Montreal Quebec Canada 2008) Rubin DT, Dubinsky MC, Panaccione R, Siegel CA, Binion DG, Kane SV, Hopper J. The impact of ulcerative colitis on patients’ lives compared with other chronic diseases: a survey of patients’ opinions. American Journal of Gastroenerology 102: S483 994 Suppl. 2 SEP 2007. (Poster presentations at Advances in IBD Miami FL 2007, BSG 2008 Birmingham UK, CDDW 2008 Montreal Quebec Canada 2008) Sands BE, Siegel CA, Johnson R, Ozdemir S, Hass S, Miller DW. Gastroenterologists’ Tolerance for Crohn’s Disease Treatment Risks. United European Gastroenterology Week, Paris, France, October 2007. Siegel CA, Van der Toorn P, Levy LC, Mackenzie T, Van der Woude C. International differences in patient perceptions of the benefits and risks of infliximab. Gastroenterology 2007;132(4,Suppl 2):A-515. Siegel CA, Levy LC, Mackenzie T, Sands BE. Patient perceptions of the risks and benefits of infliximab for the treatment of Crohn’s disease. Am J Gastroenterol 2006;101:S438. Siegel CA, Kamin I, Sands BE. Risk factors for colorectal cancer in Crohn’s colitis: A Case control study. Gastroenterology 2006;130(4):A2. Siegel CA, Hur C, Korzenik JR, Sands BE. Risks and benefits of infliximab for the treatment of Crohn’s disease. Gastroenterology 2006;130(4):A71. Sands B, Siegel C, Hass S, Miller D, White J, Johnson R, Ozdemir S. Crohn’s disease patients’ willingness to accept the risks of serious adverse events in exchange for clinical benefits. Gastroenterology 2006;130(4):A656. Siegel CA, Olenec CA, Wartman DG, Bensen SP, Ely P. Hemophagocytic syndrome: A complication of ulcerative colitis or side-effect of 6-MP therapy? The American Journal of Gastroenterology 2004;99(10):S134. Siegel CA, Bensen S, Marsh B, Robertson D, Wadell R, Hynes M, Kelly V, Cole B, Von Reyn CF. Skin Testing to Evaluate the Association Between Crohn’s Disease and Mycobacterial Infection. The American Journal of Gastroenterology 2001;97(9): S267. Gilbert RJ, Dillon S, Yakubovich M, Siegel C, Pothoulakis C, Lamont JT, Feig LA. Cytotoxicity Due To Clostridium Difficile Toxin B Is Associated With Modification Of The Small Molecular Weight GTP-Binding Protein rho A. Gastroenterology 1994. 106;A688. Gilbert RJ, Siegel C, Yakubovich M, Dillon S, Feig L, Pothoulakis C, Lamont JT. Clostridium Difficile Toxin B Inhibits ADP-Ribosylation Of rho A In Pancreatic Microsomal Membranes. Gastroenterology 1993;104: A706. Date updated: 11/27/12 By: Corey A. Siegel
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