Specific combinations of donor and recipient KIR-HLA
genotypes predict for large differences in outcome after
cord blood transplantation
by Takuya Sekine, David Marin, Kai Cao, Li Li, Pramod Mehta, Hila Shaim, Catherine
Sobieski, Roy Jones, Betul Oran, Chitra Hosing, Gabriela Rondon, Abdullah
Alsuliman, Silke Paust, Borje Andersson, Uday Popat, Partow Kebriaei, Muharrem
Muftuoglu, Rafet Basar, Kayo Kondo, Yago Nieto, Nina Shah, Amanda Olson, Amin
Alousi, Enli Liu, Anushruti Sarvaria, Simrit Parmar, Darius Armstrong-James,
Nobuhiko Imahashi, Jeffrey Molldrem, Richard Champlin, Elizabeth J. Shpall, and
Katayoun Rezvani
Blood
Volume 128(2):297-312
July 14, 2016
©2016 by American Society of Hematology
Effect of recipient HLA-C genotype on clinical outcome after CBT in the 110 patients in the
discovery cohort.
Takuya Sekine et al. Blood 2016;128:297-312
©2016 by American Society of Hematology
KIR2DL2/L3/S2-expressing NK cells dominate the reconstituting NK repertoire after CBT. (A)
Representative fluorescence-activated cell sorter plots of reconstituting KIR2DL1/S1 and
KIR2DL2/L3/S2 expressing NK cells in PBMCs from 7 HLA-C1/C1, 9 HLA-C1/C2, and...
Takuya Sekine et al. Blood 2016;128:297-312
©2016 by American Society of Hematology
One-year cumulative incidence of relapse and probability of OS in the 80 HLA-C1/x patients
grouped according to the KIR-HLA genotype of the donor CB graft.
Takuya Sekine et al. Blood 2016;128:297-312
©2016 by American Society of Hematology
HLA-C2 homozygous patients receiving a CB graft with the combined HLA-C2-KIR2DL1/S1
genotype have a lower 1-year cumulative incidence of relapse and better probability of OS. We
combined HLA-C2 homozygous patients in the discovery and validation cohorts (n ...
Takuya Sekine et al. Blood 2016;128:297-312
©2016 by American Society of Hematology
Prognostic impact of key HLA and KIR genotypes emerging from multivariate analysis.
Takuya Sekine et al. Blood 2016;128:297-312
©2016 by American Society of Hematology
NK response post CBT. Recovering NK cells from CB units with a combined HLA-C1KIR2DL2/L3/2DS2 genotype express more CD107a (A) and interferon-γ (B) in response to
stimulation with K562 targets than those from CB units that were either predicted to be unlic...
Takuya Sekine et al. Blood 2016;128:297-312
©2016 by American Society of Hematology