DERBY-BURTON LOCAL CANCER NETWORK
FILENAME
Dox_Endo.DOC
CCPG B193
CONTROLLED DOC NO:
CSIS Regimen Name:
DOX_ENDO
Single Agent Doxorubicin
Available for Routine Use in
N/A
Derby in-patient

Derby day-case
N/A
Derby outreach
chemotherapy clinic
Derby out-patient
Burton in-patient
Burton day-case
Burton outreach
chemotherapy clinic
Burton out-patient
Indication
Treatment Intent
Anti-Emetics
Day 1
Advanced Endometrial Cancer
Palliative
Pre-chemotherapy
3
Post-chemotherapy
C
75mg/m2
Doxorubicin
Frequency & duration:
Notes:
1.

Intravenous bolus
every 21 days for a maximum of 6 cycles
Prior to commencing each cycle of chemotherapy the following parameters must
be met
 Platelets ≥ 100 x 109/L
 Absolute neutrophil count ≥ 1.5 x 109/L
 tBil < 20 micromol/L (see below for suggested dose modification if elevated)
2.
Doses should be capped at 2.2m2 body surface area
3.
For patients with a reduced performance status, consider reducing dose to 50
mg/m2
4.
Doxorubicin doses may be dose banded as per local policy
5.
Maximum cumulative dose Doxorubicin = 450 - 550mg/m2. A baseline MUGA
scan should be performed where the patient is considered at risk of having
significantly impaired cardiac contractility. If ejection fraction is less than 50%,
an alternative regimen should be given. MUGA scan should be repeated if there
is suspicion of cardiac toxicity at any point during treatment
DATE OF ISSUE 07.07.15
REVIEWED BY C.Ward
REVIEW DATE 07.07.17
AUTHORISED BY: Dr M Persic
*** VALID ON DATE OR PRINTING ONLY ***
VERSION 2
PAGE 1 of 2
DERBY-BURTON LOCAL CANCER NETWORK
FILENAME
6.
Dox_Endo.DOC
CCPG B193
CONTROLLED DOC NO:
CSIS Regimen Name:
DOX_ENDO
Dose Modifications
 Haematological toxicity
If platelets < 100 x 109/L or absolute neutrophil count < 1.5 x 109/L,
defer treatment for 1 week.
If blood counts recover, recommence at full dose


Hepatic impairment
tBilirubin (micromol/L)
<20
20-50
51-85
>85
Doxorubicin Dose
Full dose
50% of dose
25% of dose
Omit
Other Toxicities
Mucositis: Grade 3 or 4, reduce dose to 80%
Nausea & Vomiting: Grade 4 despite optimal use of antiemetics, reduce
dose to 80% or STOP
Neutropenic Fever (with ANC less than 0.5 x 109/L): Once counts have
recovered, reduce dose to 80%
References:
1.
DATE OF ISSUE 07.07.15
REVIEWED BY C.Ward
REVIEW DATE 07.07.17
AUTHORISED BY: Dr M Persic
*** VALID ON DATE OR PRINTING ONLY ***
VERSION 2
PAGE 2 of 2