DIPG Symposium, May 4-6, 2017, The Westin, 21 E 5th St, Cincinnati, Ohio, 45202, USA
www.dipg.org
Speaker's Note
All slide materials must be delivered
in final form no later than 7:30 the
day off the presentation to the
Garfield Room via flash drive. If you
would like to send your presentation
in advance, please email to
[email protected]
g.
CSN Medical Advisory Council
Gavin Baumgardner, Chair
Nicholas Gottardo
Dannis vanVuurden
Alberto Broniscer
Cynthia Hawkins
Ancillary Meeting Rooms
Presentation Preparation Green Room - Garfield Room
Medical Advisory Council Meeting Room - McKinley Room
Hospitality Suite - Room 1604
Shana Coley
Daniel McPherson
Maryam Fouladi
Michelle Monje-Deisseroth
Attendee Legend
Open Attendance
Doctors and Collaborative Sponsors
Collaborative Sponsors
Family and Foundations
CSN Chapters
Special Ticket
Stewart Goldman
Roger J. Packer
DIPG Collaborative Symposium 2017 Agenda
Thursday, May 4
Alternate Location
19:00-20:30
Foundational Software Workshop Hospitality Suite 1604 (CSN Chapters
Only - OPTIONAL)
19:00-19:45
The Cure Starts Now Chapter Dinner Fountain Room (CSN Chapters Only)
19:45-21:00
The Cure Starts Now Chapter Dinner,
Finding Your Passion - Fountain Room
(CSN Chapters Only)
20:30-22:00
Hospitality Suite Open - Room 1604
Friday, May 5
7:30-8:00
8:00-8:20
Presidential Room I
Alternate Location
DIPG Collaborative Foundations Dinner Fountain Room (Collaborative Sponsor
Foundations Only)
Presidential Room II
BREAKFAST SERVED IN LOBBY
Welcome and Introductions
Keith Desserich (DIPG Collaborative and The Cure Starts Now
Foundation)
8:20-8:40
Review of Current Funded Research Results and Progress (Moderated by Gavin
Baumgardner, The Cure Starts Now Foundation)
Characterizing Resistance Mechanisms to Radiation Therapy and
Adjuvant Chemotherapy in DIPG – Rameen Beroukhim, Dana-Farber
Cancer Institute
8:40-8:55
An Early Phase 2 Study of LEE011, a CDK4/6 Inhibitor, Following
Radiation Therapy in Children – Mariko DeWire, Cincinnati Children’s
Hospital Medical Center
8:55-9:10
Intra-tumoral Heterogeneity in DIPG and Midline High-grade Gliomas –
Cynthia Hawkins, SickKids Research Institute
9:10-9:25
Sequential Phase I Studies of Nivolumab Monotherapy and Nivolumab
in Combination with Ipilimumab – Ira Dunkel, Memorial Sloan Kettering
Cancer Center
Tentative DIPG Collaborative Schedule 2017 Published 4-27-17.xlsx
Page 2 of 10
Presidential Room III
Alternate Location
DIPG Collaborative Symposium 2017 Agenda
9:25-9:40
Discovering Novel Epigenetic Dependencies in DIPG – Mariella Filbin,
Dana-Farber Cancer Institute
9:40-9:55
Mitochondrial DNA Alterations and Their Potential as a Novel
Therapeutic Target in DIPG – Cynthia Hawkins, SickKids Research
Institute
BREAK
9:55-10:10
10:10-10:25
Liquid Biopsies for the Monitoring of DIPG – Esther Hulleman, VU
University Medical Center
10:25-10:40
The Evolutionary Dynamics of DIPG – Chris Jones, Institute of Cancer
Research
10:40-10:55
Targeting DIPGs through Super-activation of Steroid Receptor Coactivators – Xiao-Nan Li, Texas Children’s Hospital
10:55-11:10
Panobinostat Ultrasound Delivery Across the Blood Brain Barrier –
Jacques Grill, Gustave Roussy Cancer Campus
11:10-11:25
Evaluating TORC1/2 Kinase Inhibition in Murine and Nonhuman
Primate (NHP) Models – Javad Nazarian, Children’s National Hospital
11:25-11:40
Comprehensive Molecular-Based Cross-Species Comparison of DIPG
Biology – Javad Nazarian, Children’s National Hospital
11:40-11:55
Enabling Epigenetic Therapies by Exploring DIPG Chromatin
Sensitivities – Jamie Anastas, Boston Children's Hospital
11:55-12:10
Towards T-cell Based Immunotherapy for DIPG – Karin Straathof, UCL
Institute of Child Health
Tentative DIPG Collaborative Schedule 2017 Published 4-27-17.xlsx
Page 3 of 10
DIPG Collaborative Symposium 2017 Agenda
LUNCH AVAILABLE IN LOBBY (Continues into next session)
12:10-12:25
WORKING LUNCH - Snap Grant (Moderated by Gavin Baumgardner)
12:25-13:00
13:00-13:15
Presentation of 6 prospective novel research protocols (4 minutes each) with funding of $50,000 to
the top 2 winners as decided by the Medical Advisory Council.
12:27
Advanced RNAi Therapeutics for DIPG – Miguel Sena-Esteves, University
of Massachusetts Medical School
12:32
Investigating the Role of BMI-1 – Satarupa Sengupta or Rachid Drissi,
Cincinnati Children's Hospital Medical Center
12:37
Novel Next Generation Mapping of DIPG Genome – Javad Nazarian,
Children's National Medical Center
12:42
Targeting PDGFR Alterations in DIPG – Carl Koschmann, University of
Michigan Medical School
12:47
Characterization and Validation of Non-Invasive Biomarkers – Maura
Massimino, IRCCS Istituto Nazionale dei Tumori Via Venezian
12:52
Cellular Cybercriminals – Michelle Monje-Deisseroth, Stanford
University
Review of Current Funded Research Results and Progress - CONTINUED
(Moderated by Gavin Baumgardner)
Fenretinide, a Novel Agent Targeting RTK/PI3K/AKT Network for the
Treatment of DIPG – Maria Tsoli, Children’s Cancer Research
Tentative DIPG Collaborative Schedule 2017 Published 4-27-17.xlsx
Page 4 of 10
DIPG Collaborative Symposium 2017 Agenda
13:15-13:30
Allele Specific Antisense Therapy – Adrian Krainer, Cold Spring Harbor
Laboratory
13:30:13:45
Exploring the Interactome of H3K27M to Find Therapeutic Targets for
DIPG – Cynthia Hawkins, SickKids Research Institute
13:45-14:00
Radiosensitisation Modulating Glucose – Han Shen, Children’s Cancer
Institute
14:00-14:15
Targeting Neuronal Activity-regulated DIPG Infiltration – Michelle
Monje-Deisseroth, Stanford University
14:15-14:25
Summary – Gavin Baumgardner, Chair Medical Advisory Council, The
Cure Starts Now
14:25-14:45
Review of Snap Grant Funding (Moderated by Gavin Baumgardner)
Increased Tenascin-C (TNC) Protein Expression in Tumor Tissue and CSF
in DIPG patients – Amanda Saratsis, Ann and Robert H. Lurie Children’s
Hospital of Chicago
14:45-15:00
Tumor Associated Microglia in DIPG – Michelle Monje-Deisseroth,
Stanford University
15:00-15:15
MRI Guided Focused Ultrasound: Targeted Drug Delivery in DIPG –
Saira Alli, SickKids Research Institute
Tentative DIPG Collaborative Schedule 2017 Published 4-27-17.xlsx
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Legacy Project - Jen Gault, The Cure
Starts Now Foundation (McKinley Room)
DIPG Collaborative Symposium 2017 Agenda
BREAK
15:15-15:30
15:30-15:45
DIPG International Registry Update - Maryam Fouladi, Cincinnati Children’s
Hospital Medical Center
15:45-16:00
DIPG Registry SIOPe – Dannis van Vuurden, VU University Medical Center
New Members and Families – How the
DIPG Collaborative Works – Heidi
Feyerherm-Smith, The Cure Starts Now
and The Love, Chloe Foundation
CSN BOD Meeting - McKinley Room
16:00-16:30
Networking Dinner – Via Vite Restaurant
- reservation only, space limited
16:30-20:00
(Presentation of Snap Grant Recipients,
Collaborative Researcher of the Year and
Research Innovator of the Year at 17:00)
20:00-22:30
Hospitality Suite Open - Room 1604
Tentative DIPG Collaborative Schedule 2017 Published 4-27-17.xlsx
Page 6 of 10
DIPG Collaborative Symposium 2017 Agenda
Saturday, May 6
Presidential Room I
7:45-8:15
Presidential Room III
Alternate Location
BREAKFAST SERVED IN LOBBY
6:45-7:15
7:00-7:45
Presidential Room II
DIPG Registry Workshop - Maryam
Fouladi, Cincinnati Children's Hospital
Medical Center; Dannis vanVuurden,VU
University Medical Center
DIPG Workshop - Maryam Fouladi,
Cincinnati Children's Hospital Medical
Center
8:15-8:45
Collaborative Organizational Session Heidi Feyerherm-Smith, The Cure Starts
Now; Tamara Ekis, Reflections of Grace
Collaborative Strong - Tim Hayden, JTHF;
Tamara Ekis, Reflections of Grace; Nettie
CSN Making Supporters Into Investors and Brad Boivin, Courage for Cures
Brooke Desserich and Michelle
Bjornberg, The Cure Starts Now
Foundation Brainstorm (Ideas and
Foundation
Fundraising Suggestions)- Heidi
Feyerherm-Smith, The Cure Starts Now
and The Love, Chloe Foundation
BREAK
8:45-9:00
9:00-9:30
Survivorship and DIPG – Alberto
Broniscer, St. Jude Children's Research
Hospital; Lindsey Hoffman, Children’s
Hospital of Colorado
9:30-9:50
Research Jazz – A Paradigm Shift Moderated by Barrie Littlefield, Cure
Brain Cancer Foundation
GBM Agile - Carrie Treadwell,
National Biomarker
Development Alliance
Tentative DIPG Collaborative Schedule 2017 Published 4-27-17.xlsx
CSN State of Foundation - Brooke
Desserich, The Cure Starts Now
Foundation
Review of Past DIPG Research Trends
and International Treatments - Trent
Hummel, Cincinnati Children’s Hospital
Medical Center
Identifying Upcoming Research Trends Trent Hummel, Cincinnati Children’s
Hospital Medical Center
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Proton Therapy Center Tour - Offsite
tour of CCHMC’s Proton Therapy Center at
the Liberty Campus. Meet in hotel lobby at
7:15 am for transport. 30 minute
transportation with introduction of facility.
45 minute tour. Will return by 9:00 am.
Limited spaces - must register at check-in by
16:00, 5-5-17.
DIPG Collaborative Symposium 2017 Agenda
9:50-10:05
10:05-10:20
10:20-10:40
10:40-11:00
11:00-11:15
Mebendazole and Its Impact
– Greg Riggins, Johns Hopkins
Medicine
DIPG Formation and
Response to Bromodomain
Inhibition – Amanda Saratsis,
Ann and Robert H. Lurie
Children’s Hospital of Chicago
Misdiagnoses and the Role of DIPG Maryam Fouladi, Cincinnati Children’s
Hospital Research Center
Imaging Diagnosis of DIPG:
Concordance Amount
Radiologists – James Leach,
Cincinnati Children’s Hospital
Medical Center
DIPG Diagnosis: Standardization and
WHO Classification Changes – Cynthia
Hawkins, SickKids Research Hospital
Tentative DIPG Collaborative Schedule 2017 Published 4-27-17.xlsx
Survivorship and DIPG - Alberto
Broniscer, St. Jude Children's Research
Hospital; Lindsey Hoffman, Children’s
Hospital of Colorado
Trial Design and Methodology
Workshop (A Primer on Protocol
Structures) – Arzu Onar-Thomas, St. Jude
Hospital and the Pediatric Brain Tumor
Consortium
Club 22 - Lisa Hill, The Cure Starts Now
Foundation (sponsored by Lauren's Fight
for Cure Foundation)
The FDA and Strategy Towards DIPG and
Rare Cancers - Joohee Sul, National
Cancer Institute
Page 8 of 10
DIPG Collaborative Symposium 2017 Agenda
11:15-11:30
Is ACVR1 the Right Target to
Treat Children with DIPG? – Moderated
by Oren Becher, Northwestern University
Novel ACVR1 Inhibitors in
Patient-Derived DIPG Models
– Chris Jones, The Institute of
Cancer Research
11:30-11:45
11:45-12:00
Targeting of ACVR1 in DIPG;
both a success and a failure Mark Kieran, Dana-Farber
Cancer Institute
Evaluating ACVR1
Inhibitors Using Genetic
Models of DIPG – Oren
Becher, Northwestern
University
Club 22 - Lisa Hill, The Cure Starts Now
Foundation (sponsored by Lauren's Fight
for Cure Foundation)
Biopsy as a Standard of Care – Lindsay
Kilburn, Children’s National Hospital
LUNCH SERVED IN LOBBY
12:00-12:30
CED Developments and Applications –
Moderated by Katherine Warren,
National Cancer Institute
12:30-12:55
Alternative CED
Combinations – Steven Gill,
University Hospital Bristol
Tentative DIPG Collaborative Schedule 2017 Published 4-27-17.xlsx
Compassionate Use Navigation - Erin
Benson, Kids v. Cancer Foundation
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DIPG Collaborative Symposium 2017 Agenda
12:55-13:15
13:15-13:45
CED and Image Based
Monitoring – Sabine Mueller,
University of California San
Francisco
Advocacy Challenges - Moderated by
Barrie Littlefield, Cure Brain Cancer
Foundation
Cavatica and CBTTC Initiatives - Javad
Nazarian, Children’s National Hospital;
Adam Resnick, Children's Hospital of
Philadelphia
BREAK
13:45-14:00
14:00-14:30
CSN Practical Applications for Success Rick Merk and Michelle Bjornberg, The
Cure Starts Now Foundation
Closing Session – Gavin Baumgardner, The Cure Starts Now Foundation
CSN Best Ideas - Rick Merk and Michelle
Bjornberg, The Cure Starts Now
Foundation
14:30-15:30
15:30-17:30
The Cure Starts Now “Once in a
Lifetime Gala” 10-Year Superhero
Celebration, featuring an exclusive
performance by TOBYMAC (6 Time
Grammy Winning Artist with Over
10 Million Albums Sold) – Duke
Energy Convention Center
(approximately 2 blocks west of
hotel) - Ticket only
17:30-23:45
CSN’s flagship national event.
Join nearly 1,200 other
supporters of brain cancer
research for a once in a
lifetime experience!
Tentative DIPG Collaborative Schedule 2017 Published 4-27-17.xlsx
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