CONFIDENTIAL
BEP 2011 Grant Call Pre-Proposal (POC)
AGENCY FOR SCIENCE, TECHNOLOGY & RESEARCH
BIOMEDICAL ENGINEERING PROGRAMME
A Healthcare & Lifestyle Programme Office Initiative
Pre-Proposal for Proof-of-Concept (POC) Project
<To fill in the title of the proposed idea>
SUBMITTED BY:
<To insert organization logo of the
Clinical Lead-PI (To be filled in by
Clinical Lead-PI from the
Hospital/Specialist Centre/Medical
School)>
<Fill in >
Name of Clinical Lead-Principal
Investigator
Healthcare Organisation
Department
Designation
Email Address
<To insert organization logo of the
Technical Lead-PI (To be filled in by
Technical Lead-PI from A*STAR
SERC/BMRC RI OR Non-A*STAR
Institutes: Universities, Polytechnics,
Publicly-funded Institutes)>
<Fill in >
Name of Technical Lead-Principal
Investigator
SERC/BMRC RI/
University/Polytechnic/other publiclyfunded Institutes
Department
Designation
Email Address
Pre-Proposal Number*:
Submission Date* :
* To be completed by the Healthcare and Lifestyle (H&L) Programme Office
CLOSING DATE: 10th Jan 2012 (Tuesday) at 5pm, SST
Nov 2011
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CONFIDENTIAL
BEP 2011 Grant Call Pre-Proposal (POC)
Co-Investigator (Co-I)
Email & Organisation:
Co-Investigator (Co-I)
Email & Organisation:
Co-Investigator (Co-I)
Email & Organisation:
Collaborator
Email & Organisation:
Collaborator
Email & Organisation:
* Please add in more rows depending on the number of Co-Is or Collaborators
SUBMISSION DETAILS
IMPORTANT: EVERY SECTION AND FIELD MUST BE COMPLETED.
PLEASE INDICATE ‘NA’ WHERE A PARTICULAR SECTION OR FIELD IS
NOT APPLICABLE. INCOMPLETE APPLICATIONS WILL BE REJECTED.
Softcopy submission must comprise both the Word document (without
signatures) and the PDF format (with Lead-PIs’ signatures and Host
Institutions’ signatures) and have to be submitted to:
[email protected] with the subject header “BEP 2011 Grant
Call Submission_(Name of Clinical Lead-PI’s Institution)_(Name of
A*STAR Research Institute OR Universities, Polytechnics, Publiclyfunded Institutes)”.
The deadline for softcopy submission is 10th Jan 2012 (Tue) at 5pm, SST.
All hardcopy proposals with signatures must be submitted through either the
Clinical Lead-PI’s or Technical Lead-PI’s respective Office Of Research /
Principal’s or Directors’ Office / Agency Headquarters / RI ED’s Office /
Institutes or equivalent.
Address for hardcopy submission:
Healthcare & Lifestyle Programme Office
61 Biopolis Drive
Proteos Building, #01-02
Singapore 138673
Attn: Dr. Denise Teoh
The deadline for hardcopy submission is 16th Jan 2012 (Mon) at 5 pm, SST.
For further enquiries, please feel free to email:
Dr. Denise Teoh at [email protected]
Nov 2011
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CONFIDENTIAL
BEP 2011 Grant Call Pre-Proposal (POC)
INTRODUCTION
The Biomedical Engineering Programme (BEP), administered out of
A*STAR’s Healthcare & Lifestyle Programme Office, is a competitive, multidisciplinary grant programme aimed at engaging the local clinical community
with engineers and scientists to develop cost-effective innovations through a
needs-driven approach that will improve patient care.
The BEP 2011 Grant Call is funded by the Science and Engineering Research
Council (SERC) and seeks to foster Clinical-Engineer collaborations to
develop medical devices and solutions for clinical problems. The BEP
supports collaborative research projects with emphasis on devices,
procedures, diagnosis, and clinical systems.
Projects will have to be driven by needs identified by Clinicians that are
matched to a potential technological solution from the A*STAR
SERC/BMRC Research institutes (RIs) or Non-A*STAR Institutes
(Universities, Polytechnics, Publicly-funded Institutes). The philosophy is
to approach the needs, problems or gaps from a medical/healthcare point of
view, and not from a technology push perspective, right from the start.
It is critical that technical researchers can understand and appreciate, even at
a preliminary level, the motivation for the problem and the key features from a
non-technical perspective for a successful resolution. This includes
understanding the existing (even if unsatisfactory) solution in the current
situation, how the proposed solution will be tested and used in the clinical
setting as well as the likely impact of a successful implementation on the end
user/patient and/or healthcare organization.
Therefore, it is highly important that the clinical and technical collaborators
meet and comprehensively discuss both the clinical need and potential
technical solution to ensure there is value in such a collaboration.
The Pre-Proposal is structured in a way to elicit the necessary information that
will show full explanation of the clinical need with an outline of the potential
technical solution.
All projects must also demonstrate high potential for commercial outcome
and show a high likelihood of rapid impact on patient care. This is
essential because funded projects will need to show that they can be
commercialized and not remain as a pure science project.
The applications for this grant call are not restricted to a particular clinical
area but need to show a strong collaboration between the clinical and
technical partners to solve a specific clinical need.
There are two application categories: Proof-of-Concept (POC) and Proof-ofValue (POV).
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CONFIDENTIAL
BEP 2011 Grant Call Pre-Proposal (POC)
This application is for the Proof-of-Concept (POC) Category:
i.
ii.
iii.
iv.
v.
Concept generation – testing of a potential technology on the
clinical need
Building of prototype – can be a physical device, an IT system,
algorithm etc.; generate bench data
Estimated duration: 12 – 18 months
Estimated funding amount: $0.25 – $0.5M
Estimated number of funded POC projects: 10 projects
Definition of POC:
A POC application is for ideas that do not have an existing prototype or device
for a particular clinical need. The potential technology has only been identified
as a possible solution to the clinical need, without prior work being done. The
technology may have applications in other fields but have not been applied to
the clinical need in question.
The POC grant is to assess this potential technology as a solution to the
need. Therefore, it can constitute building a prototype and generating bench
data. No animal or human trials are needed at the POC phase.
INSTRUCTIONS
The following instructions serve as a guideline in completing this Pre-Proposal
and are by no means exhaustive.
For Sections A.1. – A.4, the originators of the Pre-Proposal are encouraged to
concisely articulate their responses in the boxes provided for each section
in Arial, font size 11 in a manner that may be easily understood by any
educated, but non-medically trained, individual. Note: Please do not extend
the size of the boxes provided.
Sections B – E are to be filled out according to instructions and additional
boxes/pages should be added if required.
SECTION
A.1.
DESCRIPTION
A.2.
CLINICAL NEED
POTENTIAL TECHNOLOGICAL SOLUTION
A.3.
POTENTIAL IMPACT OF SOLUTION
A.4.
AIMS OF PROJECT, OVERVIEW OF METHODS AND THE TEAM
B.
GRANT SUPPORT
C.
CURRICULUM VITAE
D.
DECLARATION AND ENDORSEMENT
E.
APPENDIX FOR REFERENCES
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CONFIDENTIAL
BEP 2011 Grant Call Pre-Proposal (POC)
A.1. CLINICAL NEED




Background of Problem: What is the problem observed? Why is this a problem that
warrants significant attention?
Treatment options: What are the current treatment options? What are the shortcomings
of the current treatment options?
Define unmet need: What is needed to address the problem and/or treatment gap
identified above?
Market Size: Who is/are the target patients? What is the incidence and/or prevalence?
What is the total amount spent per year to address the problem faced by these target
patients?
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CONFIDENTIAL
BEP 2011 Grant Call Pre-Proposal (POC)
A.2. POTENTIAL TECHNOLOGICAL SOLUTION




Solution Overview: Provide an overview of the solution
Technology: Provide a summary of the core technology and how it works.
Competitive Analysis: How is the proposed solution better than existing/emerging
competing technologies?
Include necessary references (in Appendix)
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CONFIDENTIAL
BEP 2011 Grant Call Pre-Proposal (POC)
A.3. POTENTIAL IMPACT OF SOLUTION

Value Proposition: How does the proposed solution benefit various stakeholders
(patients, physicians, payers)? This can be from both clinical and economical
perspectives.
A.4. AIMS OF PROJECT, OVERVIEW OF METHODS AND THE TEAM



Aims of project: List briefly the key aims/objectives of the project
Overview of Methods: Provide an overview of the methods that will be employed
The Team: Provide brief background of each team member.
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CONFIDENTIAL
BEP 2011 Grant Call Pre-Proposal (POC)
B. GRANT SUPPORT
Provide the details for all currently held or applied grants by the two Lead-PIs
and Co-Is. These include those supported by / applied to A*STAR, NMRC,
NRF, Universities, Clusters and other public funding agencies.
<Name of Clinical Lead PI>
Title of Research
Funding
Agency
Amount of Fund
Amt
Balance
approved /
Available
Amt
($)
received ($)
Support
Period
(Year)
Expiry Date
of the Grant
Amount of Fund
Amt
Balance
approved /
Available
Amt
($)
received ($)
Support
Period
(Year)
Expiry Date
of the Grant
Amount of Fund
Amt
Balance
approved /
Available
Amt
($)
received ($)
Support
Period
(Year)
Expiry Date
of the Grant
<Name of Technical Lead PI>
Title of Research
Funding
Agency
<Name of Co-Investigator No. 1>
Title of Research
Funding
Agency
<insert additional boxes if necessary>
C. CURRICULUM VITAE
In no more than 1 page, please provide the following information on each
Lead-PI and Co- Investigator:







Name
Current position and past employment history (Please provide full
details, eg, joint appointments, percentage of time spent in Singapore
every year, if applicable)
Academic qualifications (indicate institution’s name and year degree
awarded)
Latest 10 publications
Patents held (related or unrelated to study)
Recent awards (Scientific awards)
Research outcomes from other grants (e.g. publications, patents,
awards, etc.)
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CONFIDENTIAL
BEP 2011 Grant Call Pre-Proposal (POC)
D. DECLARATION AND ENDORSEMENT
We declare that the facts stated in this application and the
accompanying information are true and that this is an original and latest
version of the Pre-Proposal.
*Lead Co-PIs and Co-Is from any of the A*STAR institution will require endorsement by
Executive Direction of the host institution to verify official affiliation.
Clinical Lead-Principal Investigator
Name
<Originator>
Signature
Date
To be completed by the Head of Department (or his nominee) of the Hospital/ Specialist
Centre/ Medical School (for clinical Lead-PI)
Specific Comments:
The Hospital/ Specialist Centre/ Medical School, supports / does not support
this version of the Pre-Proposal.
Name:
Designation:
Signature:
Nov 2011
Date:
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CONFIDENTIAL
BEP 2011 Grant Call Pre-Proposal (POC)
Technical Lead-Principal Investigator
Name
<Originator>
Signature
Date
To be completed by the Executive Director of the A*STAR Host Institution (or nominee)
OR the Head of Department (or nominee) of the Universities, Polytechnics, Publicly
Funded Institutes (for Non-A*STAR Technical Lead-PI)
Specific Comments:
The Research Institute/ University/ Publicly Funded Institute supports/ does
not support this version of the Pre-Proposal.
Name:
Designation:
Signature:
Date:
Other Co-Investigators
Name
Institution/Department
Signatory Approval from
A*STAR RI ED
(if applicable)
Key participants from
other publicly funded
institutions e.g.
universities/hospitals
(add rows if necessary)
Note: Co-Investigators can receive funding
Other Collaborators (no signature required)
Name
Institution/Department
Key participants from other publicly
funded institutions e.g.
universities/hospitals
(add rows if necessary)
Note: Collaborators do not receive funding
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CONFIDENTIAL
BEP 2011 Grant Call Pre-Proposal (POC)
E. APPENDIX FOR REFERENCES

Include only necessary references
Nov 2011
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