D Raghunadharao
Professor of Medical Oncology
Nizam’s Institute of Medical Sciences
Hyderabad 500 082 India
Tel: 91 40 23489368 Fax: 91 40 23371747
Mobile: 91 9246571537 Email: [email protected]
ACHIEVEMENTS:
Established the 1st Medical Oncology Department and a comprehensive cancer care
center for the State – 1989
Established a Hospital Cancer Registry -1989
Established a subsidised cancer pharmacy – 1992
Established a Clinical Research Facility – 1992
Pioneered phase 1 trials in Cancer new cancer drugs: completed over 80 clinical
trials since 1993 in all phases
First ACRP Certified Clinical Research Physician in India 2004
Started a DM Medical Oncology Course in 2005
Founded the Medical Oncologists Forum for the State – 2005
Started the Twin Cities Cancer Club – 2004
INDOX Collaboration – funding from the University of Oxford for an early phase
cancer clinical trials unit –Facilities, training and personnel - 2005
Started the 1st hematopoietic stem cell transplant unit – 2003
Started the Childhood Cancer Study Group – 2007
Established the 1st Hospital Based Cancer Registry in AP (ICMR – NCRP)– 2011
Established the 1st Population based Cancer Registry in AP (ICMR – NCRP)- 2012
National Coordinator for training government doctors in the country in Cancer
Screening and Prevention under the National Rural Health Mission’s Noncommunicable disease program – 2011 – 2013
Collaboration with Breast International Group, Osmania University, Central
University, NIN, CCMB and ICRISAT in pre-clinical & clinical research
EDUCATION
DM (Medical Oncology Fellowship) 1987-89: Cancer Institute, University
of Madras, India
MD (Internal Medicine Residency) 1982-85: Post Graduate Institute of
Medical Education & Research, Punjab University, Chandigarh, India
MBBS: 1976-81: Andhra Medical College, Andhra University,
Visakhapatnam, India
ADVANCED TRAINING
Experimental Biotherapeutics: Gene and Cell Transfer therapy – Course
at the University of Oxford, UK 1 – 11 November 2011
National Assessment and Accreditation Council, University Grants
Commission, Bengaluru – Training in Assessment and Accreditation of
Institutes imparting Medical Education – Nov 2010
Statistics for Randomised Clinical Trials – University of Oxford, UK
May 2007
Phase 1 Clinical Trials Workshop at the University of Oxford, UK May
2006
Certified Clinical Trial Investigator of the Association of Clinical Trial
Investigators 2004 [Re-certified]
CERTIFIED MEMBER of the European Society for Medical Oncology 1998
USMLE Certification by ECFMG, USA 1996 (Parts 1 & 2)
ICRETT Fellowship, International Union Against Cancer 1998:
Training in Palliative Chemotherapy of Gynaecologic Cancers and Hospice
Care at the Institute for Cancer Studies, University of Birmingham,
Birmingham, UK.
ICRETT Fellowship, International Union Against Cancer 1993:
Advanced Training in Allogenic Bone Marrow Transplantation at the Princess
Margaret Hospital, Toronto, Canada.
Training in DNA diagnostics & Molecular Biology Techniques for the
clinician – Atomic Energy Commission of India 1992
PROFESSIONAL EXPERIENCE
Feb 2003 – till date Professor of Medical Oncology, Nizam's Institute
of Medical Sciences, Hyderabad
1998 - 03: Additional Professor, Medical Oncology, Nizam's Institute
of Medical Sciences, Hyderabad. This Autonomous Health Sciences
University Hospital caters to a population of 80 million, with 31 clinical and
para- clinical departments. It is the apex referral hospital for the State. The
institute has a comprehensive cancer care center with medical, radiation
and surgical oncology divisions. The average patient load is 2000 new
patients.
1998: UICC/ ICRETT Fellow at the Cancer Research Campaign's Institute
for Cancer Studies, University of Birmingham, U. K, in Gynaecologic Oncology
& Palliative Care, under Dr. Christopher J Poole.
1989-98: Assistant and later Associate Professor in Medical
Oncology, at the Nizam’s Institute of Medical Sciences, Hyderabad, India.
1985-87: Senior Resident (Registrar) in Medical Oncology at the Tata
Memorial Hospital, Bombay, India, under Dr. S. H. Advani. Learnt basics of
oncology. Witnessed allogenic and autologous BMT. Learnt elements of
cytochemistry, cytogenetics, flowcytometry and long term leukemic cell
culture.
1983 – 85 Lady Tata Trust Senior Research Fellow: worked on Mode of
acquisition of Clostridium difficile in neonates. MD Thesis
1983: Senior Research Fellow of the Indian Council of Medical Research,
under Prof. Sehgal, PGIMER, Chandigarh – Immunophenotyping of
lymphomas
POST DOCTORAL
1 Jan 2011 to 31 Dec 2012:
a. Monitoring Minimal Residual Disease and drug resistance in Chronic
Myeloid Leukemia
b. Xenobiotic Metabolising enzyme polymorphism and breast cancer
susceptibility
PhD guide:
1. Evaluation of vitamin A status using conjunctival impression cytology
(awarded and published)
2. The Effect of TPMT genotype on 6MP metabolism and toxicity in children with
ALL (Awarded & Published)
3. Evaluation of MDR1 gene expression profile in acute myeloid leukemia by RQPCR at diagnosis and at relapse (Completed)
4. Assessment of Aflatoxin Exposure among Indian Populations (Awarded &
published)
5. Genetic Polymorphism of CYP-2D6 and susceptibility to hematological
malignancies (Awarded & published)
6. Glutathione S Transferase polymorphism in acute leukemias (Awarded &
published)
7. Apolipoprotein E Polymorphisms in breast cancer (Awarded & publidhed)
Doctor of Medicine:
1. Identification of hematological malignancies by scatter plots and histograms
using VCS Technology of automated cell counter – Co guide for MD Pathology
Thesis 2012
2. A clinical profile of Superior vena caval obstruction syndrome – MD General
Medicine, Nizam’s Institute of Medical Sciences, Hyderabad. 2002
3. Ocular changes in chronic myeloid leukemia – MD Ophthalmology, University
of Health Sciences, Andhra Pradesh. 2000
4. Immunophenotyping of bone marrow in Hodgkin’s Lymphoma – MD
Pathology, Nizam’s Institute of Medical Sciences, Hyderabad. 2000
5. An Analysis of Acute Promyelocytic Leukemia treated with all-trans retinoic
acid – MD Medicine – Nizam’s Institute of Medical Sciences, Hyderabad. 2000
6. Chemotherapy induced bone marrow changes. MD Pathology from Nizam’s
Institute of Medical Sciences, Hyderabad. 1996
7. A Survey of attitudes of health care givers towards cancer. M Sc Dietetics of
the Avinashalingam University, Coimbatore. 1995
8. Ototoxicity of cDDP. MS (ENT) of Osmania University, Hyderabad. 1992
9. cDDP induced peripheral neuropathy. DM (Neurology) of the Nizam’s Institute
of Medical Sciences, Hyderabad. 1992.
ORATIONS
K L Gupta Oration – Annual Conference of the Indian Association of Clinical
Biochemists – Tumour Markers in Cancer- Ranchi Feb 2013
ISMPO Oration – Indian Cancers, Indian Solutions - Mid Term Conference of the
Indian Society for Medical & Paediatric Oncology, Vizag 16 Feb 2012
Muthuswamy Naidu Memorial Oration on Breast Cancer, Sri Ramakrishna Institute of
Oncology and Research, Coimbattore – 20 September 2009
Dr. P S Ghatge Memorial Oration on The Role of General Practitioners in Prevention
and Treatment of Cancer Indian Medical Association, Hyderabad on Saturday, the
23rd of April 2005
Yellapragada Subbarao Commemorative Lecture on “Cancer: etiology, diagnosis and
prevention” at Bhimavaram, 12 January 2003
LICENSES AND CERTIFICATION: MRC no. 14000 Andhra
Editorial Board:
Indian J Cancer
Journal of ISMPO
JCO Indian Edition
South Asian Journal of Cancer
American Journal of Robotic Surgery
AWARDS & HONORS
Honorary Senior Research Fellow of the Department of Clinical Pharmacology,
University of Oxford, United Kingdom 2005 -2009
UICC/ICRETT Fellowship (1993 & 98)
ICMR Sr. Res. Fellowship (1983)
Lady Tata Senior Research Fellowship (1983) Honors in Chemistry (1977)
Rotary International Nitish Lahari Gold Medal (1979)
National Merit Scholarship (1972) State Merit Scholarship (1974)
CIVIC HONORS
2009 Dhanwantri Foundation – Sushruta Award for public service in medicine
2007 ANR Swarna kankanam for public service and professional excellence
2005 Madras Telugu Academy Samaikhya Bharat Gaurav Puraskar
2005 Ugadi Satkaramu [New Year Awards]: Megacity Navakala Vedika
2005 Kinnera - Sri Parthava Naama Ugadi Puraskaram
2005 Distinguished Couples of the Twin Cities
MEMBERSHIP TO PROFESSIONAL BODIES
Fellow & Life Member, International Union Against Cancer - UICC
Member, Selection Committee – Conquer Cancer Foundation Awards - American
Society for Clinical Oncology 2013-2015
Member, International Affairs Committee – American Society for Clinical Oncology
2007-2010
American Association for Cancer Research
Association of Physicians of India
Indian Society of Oncology
Indian Academy of Paediatrics
Indian Society for Medical Informatics
Association of Medical Physicists
Indian Association of Medical and
Of India
Pediatric Oncologists
Indian Association of Cancer Research
Indian Society for Clinical Research – Executive Member
European Society of Medical Oncology
Association of Clinical Research Professionals
Indian Cooperative Oncology Network
Indian Collaborative Clinical Research Organisation (Founder Trustee)
Founder – Medical Oncologists Forum, Twin Cities Cancer Club
Founder-Treasurer – Cancer Institute Alumni Association 2013
Founder-Member – Teen & Young Adult Oncology 2013
Founder & Managing Trustee – Digumarti Foundation
REFERENCES
1.
Professor David Kerr, CBE, MA MD DSc FRCP (Glas & Lon) F Med Sci
Rhodes Professor of Cancer Therapeutics and Clinical Pharmacology
Director, National Translational Cancer Research Network
Head of Department of Clinical Pharmacology, University of Oxford
Department of Clinical Pharmacology, Radcliffe Infirmary, Woodstock Road,
Oxford OX2 6HE UK
2. Prof. Ian Tannock, MD, FRCP(C), Ph D
Daniel Bergsagel Professor in Medical Oncology, Department of Medical
Oncology, Princess Margaret Hospital and the University of Toronto, Toronto,
Canada
PUBLICATIONS
2013
1. JAK2 V617F mutation: a marker for cml progression? Manjula G, Prajitha EM,
Sailaja K, Raghunadharao D, Anuradha C, Sugunakar V, Sandhya A,
Nageswara Rao S, Vishnupriya S. Journal of Cell and Tissue Research Vol.
13(1) 3439-3443 (2013)
2. An Open-Label Study of the Safety and Tolerability of Pazopanib in
Combination with FOLFOX6 or CapeOx in Patients with Colorectal Cancer
(accepted for publication in Investigational New Drugs)
3. Association of E-cadherin single nucleotide polymorphisms with the increased
risk of breast cancer: A study in south Indian women (submitted for
publication in Genetic Testing and Molecular Biomarkers)
2012
,
1. Phase 1 Dose Escalation Study of Rigosertib by 2-, 4-, or 8-hour Infusion
Twice Weekly in Patients with Advanced Cancer (Accepted for publication in
Indian Journal of Cancer manuscript number IJC_223_12)
2. Jorge Cortes, Jeff H. Lipton, Delphine Rea, Raghunadharao Digumarti,
Charles Chuah, Nisha Nanda, Annie-Claude Benichou, Adam R. Craig,
Mauricette Michallet, Franck E. Nicolini and Hagop Kantarjian. Phase 2 study
of subcutaneous omacetaxine mepesuccinate after TKI failure in patients with
chronic-phase CML with T315I mutation. Blood 2012-03-415307; published
ahead of print August 15, 2012, doi:10.1182/blood-2012-03-415307
3. B H Srinivas, T Roshni Paul, Shantveer G Uppin, Megha S Uppin, Rachel T
Jacob & D Raghunadharao. Morphologic Changes in the Bone Marrow in
Patients of Chronic Myeloid Leukemia (CML) treated with Imatinib Mesylate
Indian J Hematol Blood Transfus 2012, 28:162-169
4. Ruth Pettengell, Bertrand Coiffier, Geetha Narayanan, Fernando Hurtado de
Mendoza, Raghunadharao Digumarti, Henry Gomez, Pier Luigi Zinzani,
Gary Schiller, David Rizzieri, Giles Boland, Paul Cernohous, Lixia Wang,
Christine Kuepfer, Igor Gorbatchevsky, Jack W Singer: Pixantrone dimaleate
versus other chemotherapeutic agents as a single-agent salvage treatment in
patients withrelapsed or refractory aggressive non-Hodgkin lymphoma: a
phase 3, multicentre, open-label, randomised trial. Lancet Oncology May 30,
2012 DOI:10.1016/S1470-2045(12)70212-7
5. Patchva Dorababu & Shaik Mohammad Naushad & Vijay Kumar Kutala &
Raghunadharao Digumarti. Impact of age, gender and haplotypes of
thiopurine methyltransferase (TPMT) and inosine triphosphate
pyrophosphatase (ITPA) genes on 6-mercaptopurine toxicity in children with
acute lymphoblastic leukemia European Journal of Clinical Pharmacology:
Volume 68, Issue 5 (2012), Page 885-886
6. Dorababu P, Nagesh N, Linga VG, Gundeti S, Kutala VK, Reddanna P,
Digumarti R. Epistatic interactions between thiopurine methyltransferase
(TPMT)
and
inosine
triphosphate
pyrophosphatase
(ITPA)
variations
determine 6-mercaptopurine toxicity in Indian children with
lymphoblastic leukemia. Eur J Clin Pharmacol. 2012;68(4):379-87.
acute
7. Dorababu P, Naushad SM, Linga VG, Gundeti S,
Nagesh N, Kutala VK,
Reddanna P, Digumarti R. Interaction between thiopurine and folate
metabolic pathway genetic variants determines 6-MP mediated hematological
toxicity in children with acute lymphoblastic Leukemia. Pharmacogenomics
Journal. [In press, 2012].
2011
1. Dunna NR, Anuradha C, Vure S, Sailaja K, Surekha D, Raghunadharao D,
Rajappa S, Vishnupriya S. NQO1*2 [NAD(P)H: quinone oxidoreductase 1]
polymorphism and its influence on acute leukemia risk Biology and Medicine,
Vol 3 (3): 19-25, 2011
2. Naushad Shaik Mohammad, Pavani Addepalli, Rupasree Yedluri, Shree Divyya
Parvathaneni, Deepti Sripurna, Digumarti Raghunadharao, Gottumukkala
Suryanarayana Raju, Prayaga Aruna, Kutala Vijay Kumar. Association of
aberrations in one-carbon metabolism with molecular phenotype and grade of
breast cancer (MS# MC-11-0287), accepted for publication in Molecular
Carcinogenesis
3. S. Anitha, F. Waliyar, A. S. Reddy, Ratna Rao, Raghunadharao D and P.
Lava Kumar. The development of a simple enzyme-linked immunosorbent
assay for quantitative estimation of aflatoxin B1 albumin adduct in humans.
CURRENT SCIENCE, VOL. 101, NO. 7, 10 OCTOBER 2011
4. Anantabhushan A Ranade, Shona Nag, Ranjan Mahopatra, Suresh H Advani, P
P Bapsy, D Raghunadharao, Vinod Raina, Anish Maru, K Sambhasiviah,
Purvish M Parikh, V P Gangadharan, Chanchal Goswami, J S Shekhon,
Shekhar Patil and Ashish Bakshi. A multicenter phase II study of cremophor
free, polymeric Nanoparticle formulation of Paclitaxel in locally advanced and
/or metastatic breast cancer submitted to Breast Cancer Research MS
ID 6693975345885539
5. Raghunadharao Digumarti, Yenyun Wang, Ganapathi Raman, Dinesh C.
Doval, Suresh H. Advani, Pramod K. Julka, Purvish M. Parikh, Shekhar Patil,
Shona Nag, Jayaprakash Madhavan, Ajay Bapna, Annantbhushan A. Ranade,
Atul Varadhachary, and Rajesh Malik. A randomized, double-blind, placebo-
controlled Phase 2 study of single agent oral talactoferrin in patients with
locally advanced or metastatic non-small cell lung cancer that had progressed
following previous chemotherapy. J Thorac Oncol. 2011; 6: 1098–1103
6. Raghunadharao D and Senthil J Rajappa. Management of Aspergillosis
Fungal Facts Volume 7 July 2011
7. Pragnya Coca, Sadashivudu G., Shantiveer Uppin, Raghunadharao D
Metastatic adenocarcinoma in a young male, 12 years after treatment of
primary nonseminomatous germ cell tumor. IJMPO 2011, 32: 115 - 117
2010
1. D Surekha, K Sailaja, D Nageswararao, T Padma, Raghunadharao D, S
Vishnupriya Association of a CYP17 Genen Polymorphism with development of
Breast Cancer in India Asian Pacific J Cancer Prevention, Vol 11, 2010, 1653-
1657
2. D Surekha, K Sailaja, D Nageswararao, T Padma, D Raghunadharao and S
Vishnupriya. CYP2D6*4 polymorphisms and breast cancer risk. Biology and
Medicine, Vol 2 (4): 49-55, 2010
3. Nageswararao Dunna, Senthil Rajappa, Raghunadharao Digumarti, Sugunakar
Vure, Sailaja Kagiata, Surekha Damineni, V R Rao, Satish Kumar Yadav,
Rajsekhar Reddy Ravuri, Vishnupriya Satti. Fms like tyrosine kinase (FLT3)
and Nucleophosmin 1 (NPM1) mutations in de novo normal karyotype acute
myeloid leukemia (AML) Asian Pacific J Cancer Prev, 11, 1- 6
4. Shaik Mohammad Naushad, Addepalli Pavani, Raghunadha Rao Digumarti,
Suryanarayana Raju Gottumukkala, Vijay Kumar Kutala Epistatic interactions
between loci of one-carbon metabolism modulate susceptibility to breast
cancer Mol Biol Rep 2010 DOI 10.1007/s11033-010-0631-z
5. Naushad Shaik Mohammad, Rupasree Yedluri, Pavani Addepalli,
Suryanarayana Raju Gottumukkala, Raghunadha Rao Digumarti, Vijay Kumar
KutalaAberrations in one-carbon metabolism induce oxidative DNA damage in
sporadic breast cancer Mol Cell Biochem DOI 10.1007/s11010-010-0670-8
6. Rajender Singh, Francis Amrithraj, Pooja Singh, Krupakar Nallala, Surekha
Damineni, Gopal Reddy, D Raghunadharao, Lakshman Rao, S Ramachandra,
S Vishnupriya, K Ramalingam, K Satyamoorthy, Kumaraswamy Thangaraj CAG
repeat length polymorphism in the androgen receptor gene and breast cancer
risk: data on Indian women and survey from the world Breast Cancer
Research and Treatment 2010 Nov; 1263:10
7. Nageswararao D, Manjulla G, Sailaja K, Surekha D, Raghunadharao D, Senthil
R and Vishnupriya S. Association of CYP2D6*4 polymorphism with acute
leukemia J of Cell and Tissue Research 2010 10 (2): 2201 – 2205 – Best
paper award
8. Purvish M. Parikh, MD, A.A. Ranade, MD, Ashok Vaid, MD, Suresh H. Advani,
MD, Raghunadharao Digumarti, DM, Jayaprakash Madhavan, MD, Shona Nag,
MD, Ajay Bapna, MD, Jagdev Singh Sekhon, MD, Shekhar Patil, DM, Preeti M.
Ismail, PhD, MBA, Yenyun Wang, MD, Atul Varadhachary, MD, PhD, Rajesh
Malik, MD. A randomized, double-blind, placebo-controlled Phase 2 study of
single agent oral talactoferrin in patients with locally advanced or metastatic
non-small cell lung cancer that had progressed following previous
chemotherapy (Submitted for publication to JCO)
9. An Open-Label Pharmacokinetic Study Of The Safety And Tolerability Of
Votrient In Combination With FOLFOX6 Or CapeOx In Patients With Colorectal
Cancer (Submitted for publication to Annals of Oncology)
10. A. U. Buzdar, B. Xu, R. Digumarti, L. Goedhals, X. Hu, V. Semiglazov, S.
Cheporov, E. Gotovkin, S. Hoersch, K. Rittweger, D. W. Miles, J.
O’Shaughnessy and S. Tjulandin on behalf of the NO16853 trial group. Part I:
Randomized phase II non-inferiority study (NO16853) of two different doses
of capecitabine in combination with docetaxel for locally advanced/metastatic
breast cancer. Annals of Oncology (Submitted for publication)
11. T Roshni Paul, Shantiveer G Uppin, Megha S Uppin, Rachel T Jacob, D
Raghunadharao and Senthil J Rajappa Evaluation of cytopenias occurring in
imatinib treated chronic myeloid leukemia (CML) patients Indian J of Hemat &
Blood Transfusion 2010 Nov
12. Jadhav MP, Bamba A, Shinde VM, Gogtay N, Kshirsagar NA, Bichile LS, Mathai
D, Sharma A, Varma S, Digumarti R. Liposomal amphotericin B
(FungisomeTM) for the treatment of cryptococcal meningitis in HIV/AIDS
patients in India: A multicentric, randomized controlled trial J Postgrad Med
2010; 56: 71-5
2009
1. Ashwani Tandon, Sundaram Challa, M. Shanmugam, Swarnalatha Gopalan,
Roshni T. Paul, Raghunadharao Digumarthi. Epstein-Barr virus as a
possible etiologic agent in primary central nervous system lymphoma in
immunocompetent individuals. Neurology India; Jan-Feb 2009, 57: 36-40
2. Surekha D, Sailaja K, Rao D Nageswara, Padma T, Raghunadharao D,
Vishnupriya S Association of CYP1A1*2 Polymorphisms with breast cancer
risk : A case control study. Ind J of Medical Research. 2009; 63: 10 - 17
2008
1. Peter G. Pappas,Coleman M. F. Rotstein, Robert F. Betts, Marcio
Nucci,1Deepak Talwar,Jan J. De Waele,Jose A. Vazquez, Bertrand F.
Dupont, David L. Horn,Luis Ostrosky-Zeichner,Annette C. Reboli, Byungse
Suh, Raghunadharao Digumarti, Chunzhang Wu, Laura L. Kovanda, Leah
J. Arnold, and Donald N. Buell. Micafungin versus Caspofungin for Treatment
of Candidemia and Other Forms of Invasive Candidiasis. Clinical Infectious
Diseases 2007; 45:883–93
2. Surekha D, Vishnupriya S, Sailaja K, Nageswara Rao D and Raghunadharao
D Influence of Apolipoprotein E Gene Polymorphism on the Risk for Breast
Cancer. Int J Hum Genet, 8(3): 277-282 (2008)
3. Luc Yves Dirix, Jorge Ignacio, Shona Nag, Poonamally Bapsy, Henry Gomez,
Digumarti Raghunadharao, Robert Paridaens, Stephen Jones, Silvia
Falcon, Marina Carpentieri, Antonello Abbattista, and Jean-Pierre Lobelle.
Treatment of Advanced Hormone-Sensitive Breast Cancer in
Postmenopausal Women With Exemestane Alone or in Combination With
Celecoxib. J Clin Oncol 26:1253-1259
4. Rajappa S, Gundeti S, Talluri M and Digumarti R. Chemotherapy for
advanced lung cancer – A 5-year experience. Ind J Cancer 2008; 45: 20 – 26.
5. Senthil Rajappa ; Lalit Varadpande; Tara Paul ; Rachel Jacob;
Raghunadharao Digumarti. Imatinib mesylate in early chronic phase chronic
myeloid leukemia: Experience from a developing country. Leukemia and
Lymphoma,2008; 49:3, 554 – 558
6. Surekha, D, Vishnupriya, S, Sailaja, K., Nageswararao, D, Padma, T and
Raghunadharao, D Role of GSTP1 gene polymorphism in the development
of breast cancer: a case control study. Journal of Cell and Tissue Research
Vol. 8(3) 1613-1616 (2008)
2007
1. Senthil Rajappa, Norman Bethune, Sadasivudu G, Lalit Varadpande,
Raghunadharao Digumarti. Acute coronary syndrome as the presenting
feature of Cardiac rhabdomyosarcoma. J Clin Oncol. 2007 Feb 1; 25(4):
449-51
2. PM Parikh, AA Ranade, AK Vaid, SH Advani, D Raghunadharao, S Nag,
Oral talactoferrin extends survival in patients with recurrent NSCLC in a
randomized placebo-controlled Phase 2 trial.A Varadhachary, JP
Madhavan, LF0201 Group, Y Wang. ASCO Proceedings 2007
3. Senthil Rajappa, Norman Bethune, Shantiveer Uppin, Aruna Prayaga,
Rupam Borgohain, D Raghunadharao. Reversible paraneoplastic
syndrome as the presenting feature of ovarian teratoma-A
clinicopathological correlate. Annals of the Indian Academy of Neurology
2007:10; 52-4
4. Senthil Rajappa, Shantiveer Uppin, D Raghunadharao. Testicular relapse
of Primary central nervous system lymphoma. Leukemia and Lymphoma;
46 (5): 1023 – 1025.
5. Senthil Rajappa, Satish Rao, Mahendra Parage, D Raghunadharao.
Primary Renal Lymphoma Presenting as Paraneoplastic Limbic
Encephalitis. J Clin Oncol 2007; 25(24): 3783-3785
6. Senthil Rajappa, Lalit Varadpande, Roshni Paul, Raghunadharao
Digumarti. Immune Thrombocytopenia with Imatinib Mesylate. Leukemia
and Lymphoma 2007
7. Senthil Rajappa, Lalit Varadpande, Roshni Paul, Rachel Thomas Jacob, D
Raghunadharao. Sub optimal responses of Indian patients with chronic
phase chronic myeloid leukemia to imatinib mesylate. National Medical
Journal of India
8. Senthil Rajappa, Krishna Mohan, Shantveer Uppin, D Raghunadharao.
Gastrointestinal Stromal Tumor: A single institution experience of 50
cases. Indian Journal of Gastroenterology
9. Phase III study of pemetrexed plus cisplatin versus gemcitabine plus
cisplatin in chemonaive patients with locally advanced or metastatic nonsmall cell lung cancer (NSCLC). ECCO conference in Barcelona, Spain
September 23-27, 2007. Submitted for publication in NEJM 2007 [under
review]
10. Ernst-Rüdiger Kuse, Ploenchan Chetchotisakd, Clovis Arns da Cunha,
Markus Ruhnke, Carlos Barrios, Digumarti Raghunadharao, Jagdev Singh
Sekhon, Antonio Freire, Venkatasubramanian Ramasubramanian, Ignace
Demeyer, Marcio Nucci, Amorn Leelarasamee,Frédérique Jacobs, Johan
Decruyenaere, Didier Pittet, Andrew J Ullmann, Luis Ostrosky-Zeichner,
Olivier Lortholary, Sonja Koblinger,Heike Diekmann-Berndt, Oliver A
Cornely, for the Micafungin Invasive Candidiasis Working Group L.
Micafungin versus liposomal amphotericin B for candidaemia and invasive
candidosis: a phase III randomised double-blind trial ancet April 26, 2007
DOI:10.1016/S0140-6736 (07) 60605-9
11. Digumarti Raghunadharao, Jagdev Singh Sekhon, Antonio Freire,
Venkatasubramanian Ramasubramanian, Ignace Demeyer, Marcio Nucci,
Amorn Leelarasamee,Frédérique Jacobs, Johan Decruyenaere, Didier
Pittet, Andrew J Ullmann, Luis Ostrosky-Zeichner, Olivier Lortholary, Sonja
Koblinger,Heike Diekmann-Berndt, Oliver A Cornely, for the Micafungin
Invasive Candidiasis Working Group. Micafungin versus caspofungin for
candidemia and other forms fo invasive candidiasis. Clinical Infectious
Diseases 15 Sep 2007
12. H. W. Hirte, D. Raghunadharao, T. Baetz, S. Hotte, S. Rajappa, A.
Iacobucci, S. Sharma, H. Parikh, S. Kulkarni, S. Patil, M. Padigaru, S.
Gaston. A phase 1 study of selective cyclin dependent kinase inhibitor
P276-00 in patients with advanced refractory neoplasms. 2007 AACRNCI-EORTC International Conference
2006
1. D. Raghunadharao. Invasive Fungal Infections in the Neutropenic Cancer
Patient Abstract cum Souvenir Book, 6th National Conference of SIHAM, Jan
2006. p 54-59
2. D. Raghunadharao. Clinical Trials in Complementary and Alternate Systems of
Medicine. 4th International Seminar on Complementary Therapies in Cancer
Management. Feb 2006. p 29-32
3. D Nageswararao, S Vishnupriya, D Surekha, K Sailaja and D. Raghunadharao.
Genetic Polymorphism of CYP-2D6 and susceptibility to hematological
malignancies. International Symposium at the Dept of Genetics, 8-11 Jan
2006
4. D Nageswararao, S Vishnupriya, D Surekha, K Sailaja and D. Raghunadharao
Glutathione S Transferase polymorphism in acute leukemias. International
symposium on Human Genomics and Public Health & 31 Annual Conference of
ISHG. JNU, New Delhi Feb 27- 1 Mar 2006
5. Raghunadharao D, Senthil J Rajappa, Anjna Surath and Srihari Uppalapati. A
retrospective analysis of epidemiology and treatment patterns for gastric
cancer at a tertiary health care centre in India. ASCO 2006, Atlanta, Abstract
46
6. D. Raghunadharao. Invasive Fungal Infections in the Neutropenic Cancer
Patient Abstract cum Souvenir Book, 6th National Conference of SIHAM, Jan
2006. p 54-59
7. D. Raghunadharao. Clinical Trials in Complementary and Alternate Systems of
Medicine. 4th International Seminar on Complementary Therapies in Cancer
Management. Feb 2006. p 29-32
8. Schlingensiepen, R., Bogdahn U., Mahapatra, A.K., Sasthry, A., Mouli, Ch.,
Venkataramana, N.K., Sharma, A, Nair, S, Raghunadhrao, D, Parfenov, V.,
Oliushine, V., Schlingensiepen, K.-H. Antisense Therapy for Recurrent or
Refractory Malignant Glioma: Results of a Phase Iib Study. 55th Annual
Conference of the Neurological Society of India (December 20th - 23rd 2006,
Madurai
9. Senthil Rajappa, Anjna Surath, S. Uppalapati, R. Digumarti. A retrospective
analysis of epidemiology and treatment patterns for gastric cancer at a tertiary
care center in India. Journal of Clinical Oncology, 2006 ASCO Annual Meeting
Proceedings (Post-Meeting Edition). 24, No 18S (June 20 Supplement),
2006: 4086
2005
1. Lalit Kumar, V P Gangadharan, D. Raghunadharao, Tapan Saikia, Sandip
Shah, Hemant Malhotra, P P Bapsy, Kavita Singh, Raman Rao. Nat Med J
India 2005; 18 (2):66-70 Safety and efficacy of an indigenous recombinant
interferon alpha-2b in patients with chronic myelogenous leukaemia: Results
of a multicentre trial from India.
2. Senthil Rajappa, Unni Krishnan, Satish Rao, D. Raghunadharao, Anjna Surath,
Aruna Prayaga, Renal metastasis from Primary hepatocellular carcinoma - A
case report- Indian Journal of Medical and Pediatric Oncology 2005,Vol 26;No
2:37-39
3. Senthil Rajappa, Anand Loya, Satish Rao, D. Raghunadharao, Anjna Surath,
U.Srihari, Metastasis to oral cavity - A report of 2 cases and review of
literature, Indian Journal of Medical and Pediatric Oncology 2005, Vol 26;No
2: 43-46
4. Senthil Rajappa, Satish Rao, D. Raghunadharao, Anjna Surath, C. Sundaram,
Uma Devi, Melanotic Progonoma – A case report and review of literature
Indian Journal of Medical and Pediatric Oncology 2005,Vol 26;No 2: 33-36
5. Senthil Rajappa, Shantveer Uppin, D. Raghunadharao, Anjna Surath, Satish
Rao, Isolated Central Nervous system blast crisis in Chronic myeloid leukemiaA case report – Hematological Oncology 2005 published online in Wiley Inter
Science (in press)
6. Senthil Rajappa, Sirisha Senthil, D. Raghunadharao. Choroidal metastasis
from lung cancer-A case report and review of literature. Indian Journal of
Medical and Pediatric oncology 2005 Vol 26,No.3.44-46
7. Senthil Rajappa, D. Raghunadharao, Prabhakar Rao. Avascular necrosis in
chronic myeloid leukemia on imatinib mesylate. Hematological Oncology 2005
(under review)
8. D. Raghunadharao, P. Koralewski, P. Servatowski, A Gruszfeld, K Lakshmaiah,
A Szczesna, M Savin, K Yen, D Magnuson, A Bhatnagar and M R Green. A
randomized phase 2 study of Pivanex and Docetaxel compared to docetaxel
monotherapy in patients with previously treated advanced NSCLC. World
Conference on Lung Cancer, Barcelona, Spain
9. RT Jacob, Manu Goyal, T Roshni Paul, K Gayathri and D. Raghunadharao.
Evaluation of cytognetic and haematological response to therapy in chronic
myeloid leukemia. Proceedings of the IX ADNAT and XXX ISHG [Poster O66]
10. D Nageswararao, S Vishnupriya, P Himabindu, AR Poongothai, D Surekha, K
Sailaja and D. Raghunadharao. Evaluation of oxidative stress in acute
leukemia using MDA assay [Poster O87]. Proceedings of the IX ADNAT and
XXX ISHG
11. D Surekha, S Vishnupriya, K Sailaja, D Nageswararao, Poongothai AR, D.
Raghunadharao and G Suryanarayanaraju. A case control study of plasma
fibrinogen with clinical parameters in breast case. [Poster O88] Proceedings
of the IX ADNAT and XXX ISHG
12. K Sailaja, S Visnupriya, Surekha D, D Nagewararao, Poongothai AR and D.
Raghunadharao. Effect of clinical variables on Malondialdehyde levels in
Chronic Myeloid Leukemia [Poster O98] Proceedings of the IX ADNAT and
XXX ISHG
2004
1. Raghunadharao Digumarti, Senthil J Rajappa, A Surat, Lakshmi Srinivas
Maddali. A retrospective analysis of the clinical profile and induction outcome
for acute myeloid leukemia at a tertiary care centre in a developing country
[Poster 607] Proceedings of the ESMO 2004 Vienna, Austria
2. D Surekha, S Vishnupriya, P Himabindu, K Sailaja, Poongothai AR, D.
Nageswararao, D. Raghunadharao and G Suryanarayanaraju. Association of
Apolipoprotein E Polymorphism with Breast cancer [Poster 36] Proceedings of
the International Conference on Human Genome Update. 28-30 August 2004
page 77
3. D. Nageswararao, S Vishnupriya, P Himabindu, S Poongothai, D Surekha, K
Sailaja and D Raghunadharao. Quantitative variations of Malondealdehyde
levels in acute leukemias. [Poster 38] Proceedings of the International
Conference on Human Genome Update. 28-30 August 2004 page 79
4. K Sailaja S Vishnupriya, P Himabindu, Ponngothai AR, Surekha D, D
Nageswararao and D Raghunadharao. Study of Fibrinogen levels in chronic
myeloid leukemia. [Poster 37] Proceedings of the International Conference on
Human Genome Update. 28-30 August 2004 page 78
5. Poongothai AR, Vishnupriya S, Reddy PP and D. Raghunadharao. Variation in
spontaneous sister chromatid exchanges in leukeimas: a family study.
Proceedings of the International Conference on Human Genome Update. 2830 August 2004 page 76
6. Sundaram Challa, Aruna Kumari Prayaga, Lakshmi Vemuri, Jaishankar
Sadasivan, Murali Krishna Murthy Jagarlapudi, Raghunadharao Digumarti,
Rajagopal Prabhala. Fungal Endocarditis: An autopsy study. Asian
Cardiovascular and Thoracic Annals 2004; 12: 95-98.
7. Arani Chatterjee, D. Raghunadharao , Rao N V S Mamidi, Kasiram Katneni,
Vijay V Upreti, Anjna Surath, Maddali L Srinivas, Srihari Uppalapati, Sangeeta
Jiwatani, Swaminathan Subrahmanyam and Nuggehally R Srinivas. Safety,
Tolerability, Pharmacokinetics and Pharmacodynamics of an orally active
novel camptothecin analog, DRF-1042, in refractory cancer patients in a
Phase I dose escalation study. J Clin Pharmacol Jul 2004; 44: 723-736.
8. P P Babpsy, D. Raghunadharao, A Majumdar, S Ganguly, A Roy, G Uppal, R
Mukherjee, A Burman, N Saha. DO/NDR/02 A novel polymeric nanoparticle
paclitaxel: Results of a phase I dose escalation study. Abstract No: 2026.
ASCO 2004. Proc Am Soc Clin Oncol Annual Meeting. Category:
Developmental Therapeutics Sub-category – Cytotoxic Chemotherapy
Pharmacology/Pharmacokinetics.
9. D. Raghunadharao, Doval DC, Majumdar A, Raoy A, Ganguly S, Uppal G,
Mukherjee R, Burman A R, Saha N. Phase I dose escalation study on DRF
7295: A novel peptide based anticancer drug, in patients with advanced,
metastatic adenocarcinomas: Final results. Abstract No: 3094. ASCO 2004.
Annual Meeting. Category: Developmental Therapeutics – Molecular
Therapeutics. Sub-category: Antiangiogenic or antimetastatic agents
10. D. Raghunadharao. Guidelines for the use of tumor markers. Physicians
Digest. Vol 13 (1) April-May 2004: 54-62
2003
1. L. Y. Dirix, J. Ignacio, S. Nag, P. Bapsy, H. Gomez, D. Raghunadharao, R.
Paridaens, S. Jones, S. Falcon, G. Massimini, for the Exemestane and Celecoxib
Study Group Final results from an open-label, multicenter, controlled study of
exemestane +/- celecoxib in postmenopausal women with advanced breast
cancer (ABC) progressed on tamoxifen (T). Abstract No: 77. Proc Am Soc Clin
Oncol 22: page 20, 2003 (abstr 77).
2. R Digumarti, Gangadharan V P, T Saikia, S Shah, L Kumar, H Malhotra, P B
Padmanabhan, K Singh. Pichia pastoris derived human recombinant interferon
alpha 2b in chronic myeloid leukemia patients: results of a phase 3 multicentric
trial. Abstract no.: 735, Proc Am Soc Clin Oncol 2003: Page 183
2002
1. D Raghunadharao. Cytogenetic Profile of Chronic Myeloid Leukemias. Ind J of
Cancer Vol 39 (Jun 2002): 61-65.
2. D. Raghunadharao. Clinical trial documentation and Follow-up in Indian setting.
Medicine Update 2002 Proceedings of APICON 2002. Vol 12, 1345-6.
3. Raghunadharao D & Sudhavani Tummala. MALT Lymphoma of thyroid. JAPI 50,
2002.
4. A randomised multicentre comparative study of Peginterferon alfa-2a (40 KD)
versus interferon alfa-2a in patients with treatment-naïve chronic myelogenous
leukaemia. Proceedings of American Society of Hematology Annual Conference.
Poster presentation. 2002.
5. Fungal Endocarditis – an autopsy study. Asian Cardiovascular and Thoracic
Annals. 2002
6. Promyelocytic Leukemias – clinical, morphological and cytogenetic profile.
Proceedings of IAPM AP Chapter 2002. Oral Presentation. Gold Medal for Best
Paper.
7. Post radiation sarcomas -a presentation of 3 cases. Proceedings of AROI 2002.
Poster Presentation.
8. Acute myeloid Leukemia after Breast cancer: an increased risk or effect of
therapy? Proceedings of ISO/ISMPO 2002. Poster Presentation.
9. A Phase 2 study of nano-particle paclitaxel in metastatic breast cancer.
Proceedings of ASCO 2002. Poster presentation.
10. A Phase 2 study of Farnesyl transferase inhibitor in relapse, resistant acute
myeloid leukemia. Proceedings of ASCO 2002. Poster Presentation.
11. A Phase 1 study of a DRF 1042, a novel orally effective Camptothecin analogue.
Proceedings of ASCO 2002. Poster presentation.
2001
1. Spectrum of monoclonal gammopathies in Andhra Pradesh. Ind J Clin Biochem
2001, 16 (1), 52- 59.
2. Cytology of extramedullary myeloid cell tumours (EMCTs). Proceedings of the
Indian Association of Cytopathologists. 31st Annual Conference. 2001
3. Cytogenetic response to Interferon in Chronic Myeloid Leukemia: A common
denominator of treatment outcome. J Tumor Marker Oncology 2001 14 (4): 359360
2000
1. Marrow Mesenchymal Stem Cells. Editorial in Clin Proc NIMS, Vol. 15 (2) Sept.
2000 p 1-3.
1999
Co-authored a chapter entitled Monitoring and Follow-up of patients treated
with chemotherapy for ovarian cancer in 'Effective Management of Ovarian
Cancer' Edited by A B MacLean, Published by the Royal College of Obstetricians &
Gynaecologists, London, UK.
1. Retrospective analysis of ALL: Prognostic features and role of less intensive
short term chemotherapy Dec 1999 Proceedings of Asia Pacific Cancer Congress,
Chennai.
2. Mitoxanterone induction in acute myeloid leukemia, NIMS experience-7 years
study. Dec 1999 Proceedings of Asia Pacific Cancer Congress, Chennai.
3. Clinical profile, treatment and outcome of gestational trophoblastic disease in a
tertiary care center. Dec 1999 Proceedings of Asia Pacific Cancer Congress,
Chennai.
1998
1. Analysis of Data of the Tumor Registry. Clin Proc NIMS 1998; 13:12-18
2. Squamous Cell Carcinoma of the Scalp with Lung Metastases - A Case Report.
Clin Proc NIMS1998; 13: 33-34
3. Management
of
Malignancies of Haemopoietic System. Chapter in
Musculoskeletal System - Imaging and Management. Published by the Nizam's
Institute of Medical Sciences, Hyderabad. Pages 173-178.
4. Role of biochemical and cytogenetic markers in acute leukemias. Oral
Presentation. 8th Asia Pacific Conference of Clinical Biochemistry.
1997
1. Familial Mosaic Turner’s Syndrome in Siblings with Ovarian Malignancy – a Case
Report. Clin Proc NIMS 1997, 12(2): 41-42.
2. Nephrotic Syndrome with Chronic Myeloid Leukemia. Clin Proc NIMS 1997, 12(1):
43-44.
3. Chromosomal Abnormalities in Acute Non-Lymphoblastic leukemia. Clin Proc
NIMS, 1997, 7 (3): 12-15.
4. Role of Radiation Therapy in Thymomas -NIMS Experience and Review of
literature. Clin Proc NIMS, 1997, 7 (3): 16-18.
5. An Effective and Affordable Chemotherapy Protocol for Hodgkin’s Disease. Clin
Proc NIMS 1997, 12(4): 7-8.
6. All-Trans Retinoic Acid - Drug Profile and NIMS Experience. Clin Proc NIMS 1997,
12 (4) 9-11.
7. 5-Fluorouracil Induced Encephalopathy - A Case Report. Clin Proc NIMS1997,
12(4): 25.
1996
1. Sickle beta thalesemia with AML-M4 and orbital chloromas. IJMPO 1996, 17:107110.
2. Hodgkin’s disease with atypical mycobacteriosis. Clin Proc NIMS 1996, 11(1): 5758.
3. Carcinoma Breast with submandibular lymphnode metastases. Clin Proc NIMS
1996,11(1): 59-60.
4. Chemotherapy of retinoblastoma. Clin Proc NIMS 1996; 11(3): 5-7
1995
1. Management of drug resistant CML in blast crisis with homeopathic drugs. J
Assoc Homeopath Ind.
1994
1. Tumor lysis syndrome. Clin Proc NIMS 1994, 9(4): 62-64.
2. Spinal extradural tumor metastasizing intradurally. Neurol Ind. 1994, 42: 237238.
3. Chemoprevention. Clin Proc NIMS 1994; 9(2):61
4. Carcinoma Breast - Choroidal Metastases. Clin Proc NIMS 1994; 9 (4): 36-37.
5. Familial Breast Cancer. Clin Proc NIMS 1994; 9(2): 52
6. Prevalence of Hepatitits C Virus in Liver Diseases and other High Risk Groups.
Clin Proc NIMS 1994; 9(3): 40-42.
1990
1. Importance of serum alpha-fetoprotein in a case of primary mediastinal germ cell
tumor (teratoma). Clin Proc NIMS 1990, 5(1): 52-55.
1989
1. Intrathecal methotrexate toxicity. JAPI 1989, 37:5.
1987
1. INH induced antinuclear antibodies. JAPI 1987, 35: 113-115.