Addional file 2
S2 Graph:
Individual V-slope plots (n = 100)
This file includes individual V-slope plots of all the patients studied.
Details of VAT determination
Because multiple breakpoints were occasionally observed (cases: #9, #26, #40,
and #81), the first point of departure from S1was taken as the VAT. Occasionally
there were cases of apparent hyperventilation occurring near VAT, making the
determination of a VAT point difficult (cases: #3, #88, #90, and #95). When
VE/VCO2 increased and/or end-tidal CO2 decreased at the same time with the
break point of VE/VO2 and/or end-tidal O2 increase, this was considered to be
due to hyperventilation, not due to VAT. In addition, hyperventilation was
suspected when a V-slope broke away from S1 deflecting leftwards and upwards,
but returning to the S1 baseline after a short period. In principle the VAT point
also had to be below R of 1.0, since R never exceeds 1.0 in the absence of
lactate increase. When the average resting R value happened to be at or slightly
above 1.0 and the V-slope turned upwards breaking away from the R=1 line
with an angle > 45°almost immediately after the start of exercise, VAT had to
be judged to be at that break point of R of 1.0 or greater. This happened in 7
cases, resulting in very low values of VAT (cases: #11, #15, #18, #22, #41, #71,
and #86). When VAT occurred simultaneously with the respiratory
compensation point, it was still referred to as VAT. The actual VAT point was in
each case read off from the actual data point (a 10-s average point). Overall, the
VAT could not be determined in 5 cases (indicated as VAT, not detected.
#1
VAT = 476
V-slope
VCO2 (ml/min)
1000
500
0
0
500
VO2 (ml/min)
1000
#2
VAT=587
V-slope
VCO2 (ml/min)
1000
500
0
0
500
VO2 (ml/min)
1000
#3
VAT=873
V-slope
1000
VCO2 (ml/min)
Hyperventilation
500
0
0
500
VO2 (ml/min)
1000
VAT=713
#4
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
VAT=625
#5
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#6
VAT= 1 1 1 8
V- slope
2000
VC O2 (ml/min)
1500
1000
500
0
0
500
1000
VO2 (m//min)
1500
2000
#7
VAT= 6 0 7
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#8
VAT= 6 2 1
V- slope
1500
VC O2 (ml/min)
1000
500
0
0
500
1000
VO2 (m l/min)
1500
#9
VAT= 8 5 9
V- slope
1500
Multiple break points
VC O2 (ml/min)
1000
500
0
0
500
1000
VO2 (m l/min)
1500
#10
VAT= 6 8 4
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#11
VAT= 3 8 8
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#12
VAT=657
V- slope
1500
VC O2 (ml/min)
1000
500
0
0
500
1000
VO2 (m l/min)
1500
#13
VAT=560
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#14
VAT= 7 2 8
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#15
VAT= 3 6 3
V- slope
VC O2 (ml/min)
1000
500
0
1000
0
1000
0
0
500
VO2 (m l/min)
1000
#16
VAT= 3 6 9
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#17
VAT= 6 3 3
V- slope
1500
VC O2 (ml/min)
1000
500
0
0
500
1000
VO2 (m l/min)
1500
#18
VAT= 2 4 3
V- slope
(VC O2 ( m l/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#19
VAT= 3 9 0
V- slope
1500
VC O2 (ml/min)
1000
500
0
0
500
1000
VO2 (m l/min)
1500
#20
VAT- 5 8 0
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#21
VAT= 7 6 6
V- slope
1500
VC O2 (ml/min)
1000
500
0
0
500
1000
VO2 (m l/min)
1500
#22
VAT= 2 4 1
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#23
VAT= 5 2 6
V- slope
2000
VC O2 (ml/min)
1500
1000
500
0
0
500
1000
VO2 (m l/min)
1500
2000
#24
VAT= 7 2 8
V- slope
1500
VC O2 (ml/min)
1000
500
0
0
500
1000
VO2 (m l/min)
1500
#25
VAT= 5 3 3
V- slope
1500
VC O2 (ml/min)
1000
500
0
0
500
1000
VO2 (m l/min)
1500
#26
VAT= 1 3 6 3
V- slope
3000
2500
Multiple break points
VC O2 (ml/min)
2000
1500
1000
500
0
0
500
1000
1500
2000
VO2 (m l/min)
2500
3000
#27
VAT= 9 6 9
V- slooe
1500
VC O2 (ml/min)
1000
500
0
0
500
1000
VO2 (m l/min)
1500
#28
VAT= 4 5 8
V- slope
1500
VC O2 (ml/min)
1000
500
0
0
500
1000
VO2 (m l/min)
1500
#29
VAT= 6 5 8
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#30
VAT= 5 2 8
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#31
VAT= 6 2 0
V- slope
1500
VC O2 (ml/min)
1000
500
0
0
500
1000
VO2 (m l/min)
1500
#32
VAT= 6 1 8
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#33
VAT= 6 8 4
V- slope
1500
VC O2 (ml/min)
1000
500
0
0
500
1000
VO2 (m l/min)
1500
#34
VAT= 5 0 7
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#35
VAT= 6 6 6
V- slope
1500
VC O2 (ml/min)
1000
500
0
0
500
1000
VO2 (m l/min)
1500
#36
VAT= 1 0 0 6
V- slope
1500
VC O2 (ml/min)
1000
500
0
0
500
1000
VO2 (m l/min)
1500
#37
VAT= 5 6 8
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#38
VAT= 6 2 1
V- slope
1500
VC O2 (ml/min)
1000
500
0
0
500
1000
VO2 (m l/min)
1500
#39
VAT= 4 7 0
V- slope
VC O2 (ml/mn)
1000
500
0
0
500
VO2 (m l/min)
1000
#40
VAT= 8 4 1
V- slope
2000
VC O2 (ml/min)
1500
Multiple break points
1000
500
0
0
500
1000
VO2 (m l/min)
1500
2000
#41
VAT= 3 0 2
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#42
VAT= 6 2 1
V- slope
VO2 (m l/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#43
VAT= 6 1 2
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#44
VAT= 9 8 2
V- slope
2000
VC O2 (ml/min)
1500
1000
500
0
0
500
1000
VO2 (m l/min)
1500
2000
#45
VAT= 3 9 2
V- slope
1500 0
1500
VC O2 (ml/min)
1000
500
0
0
500
1000
VO2 (m l/min)
1500
#46
VAT: not detected
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#47
VAT= 6 9 0
V- slope
1500
VC O2 (ml/min)
1000
500
0
0
500
1000
VO2 (m l/min)
1500
#48
VAT= 6 3 7
V- slope
1500
VC O2 (ml/min)
1000
500
0
0
500
1000
VO2 (m l/min)
1500
#49
VAT=563
V- slope
1500
VC O2 (ml/min)
1000
500
0
0
500
1000
VO2 (m l/min)
1500
#50
VAT= 8 3 0
V- slope
1500
VC O2 (ml/min)
1000
500
0
0
500
1000
VO2 (m l/min)
1500
#51
VAT= 6 2 1
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#52
VAT= 5 2 5
V- slope
1500
VC O2 (ml/min)
1000
500
0
0
500
1000
VO2 (m l/min)
1500
#53
VAT= 8 7 0
V- slope
2000
VC 2 (ml/min)
1500
1000
500
0
0
500
1000
VO2 (m l/min)
1500
2000
#54
VAT= 5 6 4
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#55
VAT= 1 4 3 3
V-slope
2000
VCO2 (ml/min)
1500
1000
500
0
0
500
1000
VO2 (ml/min)
1500
2000
#56
VAT= 7 1 9
V-slope
1500
VCO2 (ml/min)
1000
500
0
0
500
1000
VO2 (ml/min)
1500
#57
VAT= 4 3 7
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#58
VAT= 5 4 1
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#59
VAT= 3 7 6
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#60
VAT= 4 3 9
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#61
VAT= 5 8 9
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#62
VAT= 3 6 5
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#63
VAT= 7 3 6
V-slope
1500
VCO2 (ml/min)
1000
500
0
0
500
1000
VO2 (ml/min)
1500
#64
VAT= 7 6 7
V-slope
1500
VCO2 (ml/min)
1000
500
0
0
500
1000
VO2 (ml/min)
1500
#65
VAT= 6 2 6
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#66
VAT= 8 2 0
V-slope
1500
VCO2 (ml/min)
1000
500
0
0
500
1000
VO2 (ml/min)
1500
#67
VAT= 5 0 9
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#68
VAT= 6 0 2
V-slope
1500
VCO2 (ml/min)
1000
500
0
0
500
1000
VO2 (ml/min)
1500
#69
VAT= 4 8 7
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#70
VAT= 6 1 4
V-slope
1500
VCO2 (ml/min)
1000
500
0
0
500
1000
VO2 (ml/min)
1500
#71
VAT= 3 8 5
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#72
VAT: n ot de te c te d
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#73
VAT= 6 1 5
V- Slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#74
VAT= 6 7 3
VSlope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#75
VAT: n ot de te c te d
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#76
VAT= 4 3 7
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#77
VAT= 7 5 0
V-slope
1500
VCO2 (ml/min)
1000
500
0
0
500
1000
VO2 (ml/min)
1500
#78
VAT= 4 1 6
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#79
VAT: n ot de te c te d
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#80
VAT= 8 0 0
V-slope
1500
VCO2 (ml/min)
1000
500
0
0
500
1000
VO2 (ml/min)
1500
#81
VAT= 7 0 2
V-slope
1500
Multiple break points
VCO2 (ml/min)
1000
500
0
0
500
1000
VO2 (ml/min)
1500
#82
VAT= 4 6 8
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#83
VAT= 2 9 2
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#84
VAT= 6 1 2
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#85
VAT= 1 2 2 3
V-slope
2000
VCO2 (ml/min)
1500
1000
500
0
0
500
1000
VO2 (ml/min)
1500
2000
#86
VAT= 2 8 2
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#87
VAT= 6 0 5
V-slope
1500
VCO2 (ml/min)
1000
500
0
0
500
1000
VO2 (ml/min)
1500
#88
VAT= 5 4 4
V- slope
VC O2 (ml/min)
1000
Hyperventilation
500
0
0
500
VO2 (m l/min)
1000
#89
VAT= 7 1 8
V-slope
1500
VCO2 (ml/min)
1000
500
0
0
500
1000
VO2 (ml/min)
1500
#90
VAT= 6 5 0
V- slope
1000
VC O2 (ml/min)
Hyperventilation
500
0
0
500
VO2 (m l/min)
1000
#91
VAT= 9 7 6
V-slope
2000
VCO2 (ml/min)
1500
1000
500
0
0
500
1000
VO2 (ml/min)
1500
2000
#92
VAT= 7 7 0
V-slope
1500
VCO2 (ml/min)
1000
500
0
0
500
1000
VO2 (ml/min)
1500
#93
VAT= 7 0 4
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#94
VAT: n ot de te c te d
V- slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000
#95
VAT= 4 8 3
V- slope
VC O2 (ml/min)
1000
Hyperventilation
500
0
0
500
VO2 (m l/min)
1000
#96
VAT= 9 2 0
V-slope
1500
VCO2 (ml/min)
1000
500
0
0
500
1000
VO2 (ml/min)
1500
#97
VAT= 9 3 7
V-slope
1500
VCO2 (ml/min)
1000
500
0
0
500
1000
VO2 (ml/min)
1500
#98
VAT= 7 7 8
V-slope
2000
VCO2 (ml/min)
1500
1000
500
0
0
500
1000
VO2 (ml/min)
1500
2000
#99
VAT= 5 1 3
V-slope
1500
VCO2 (ml/min)
1000
500
0
0
500
1000
VO2 (ml/min)
1500
#100
VAT= 4 3 2
V-slope
VC O2 (ml/min)
1000
500
0
0
500
VO2 (m l/min)
1000