Karyotype/Pedigree Review
Name __________________________________
________________________________
1.
________________________________
Label the diagrams above as either: PEDIGREE or KARYOTYPE on the lines provided.
2. Which diagram would show you a person affected with a trisomy?
PEDIGREE
KARYOTYPE
BOTH
3. Which diagram would show you a pattern of inheritance?
PEDIGREE
KARYOTYPE
BOTH
4. Which diagram can show you the sex of an individual?
PEDIGREE
KARYOTYPE
BOTH
5. Which diagram is used to show specific genetic traits?
PEDIGREE
KARYOTYPE
BOTH
6. Which diagram is used to show chromosome disorders?
PEDIGREE
KARYOTYPE
BOTH
7. Which diagram is used to show the number of autosomes?
PEDIGREE
KARYOTYPE
BOTH
1. What type of trait is portrayed in Pedigree A?
Autosomal
Sex-Linked
2. What type of trait is portrayed in Pedigree B?
Autosomal
Sex-Linked
3. What is the dominance pattern of the trait depicted in Pedigree A?
Dominant
Recessive
4. What is the dominance pattern of the trait depicted in Pedigree B?
Dominant
Recessive
5. What do the squares represent?
_____________________________________
6. What do the circles represent?
_____________________________________
7. What do the ‘shaded’ shapes represent?
_____________________________________
8. What do the ‘half shaded’ shapes represent?
_____________________________________
9. Looking at Pedigree A, suppose male 12 had children with a female carrier. How many children will be affected
with the trait?
10. Looking at Pedigree B, suppose female 8 had children with a man who was hybrid for widow’s peak. What are the
possible genotypes of their offspring?
Sex-Linked Review
1.
Name __________________________________
A colorblind mother and a normal father have four daughters. What is the chance that the girls are colorblind just
like their mother?
2. A normal man has two sons-one with normal blood clotting and one with hemophilia. What would the genotype
of the mother be?
Genotype of mother? ____________________________
3. A carrier mother and a normal father have children. What is the chance that their daughter will be color blind?
Chance of daughters who are colorblind? ____________________________
4. A hemophiliac father and a carrier mother are planning to have children. What is the chance that their children
will have hemophilia? What is the chance that the hemophilia gene would be passed onto their grandchildren?
% of offspring affected?
___________
% of grandchildren that may carry the gene? __________
Genetic Disorders: Recessive/Dominant Review
1.
Name __________________________________
Cystic Fibrosis shows a genetically recessive inheritance pattern. How many offspring are likely to be affected by
cystic fibrosis if both parents are carriers of the disorder?
2. Marfan syndrome is an autosomal dominant disorder that causes abnormal growth and development in humans.
Which are the following genotypes would be affected by Marfan’s syndrome?
NN = _____________________ Nn = _____________________ nn = _____________________
3. Huntington’s disease is a progressive brain disorder caused by an autosomal dominant gene on chromosome 4.
What is the chance that a hybrid mother and a normal father would have a child also affected with Huntington’s
disease?
Chance: _____________________
4.
The Tay-Sachs gene is carried by 1 in 30 Ashkenazi Jews. It is a recessive disorder that causes blindness within the
first 5 months of life followed by death by the age of four.
a. What is the likelihood that the Tay-Sachs gene would affect an offspring from a carrier mom and a normal
homozygous father?
b. What is the likelihood that the Tay-Sachs gene would affect OR be carried in the grandchildren of these
parents?
% of offspring affected?
___________
% of grandchildren that may carry the gene? __________
Co-Dominant/ Incomplete Dominance Review
Name __________________________________
1. Black shows incomplete dominance to white in cats. Determine the expected phenotypes of the offspring from a
grey father and a white cat.
Expected Phenotypes: ________________________________________
2.
Find a cross of two parents that produce offspring with all four different blood types.
Cross of parents: _______________________________________
3. A carrier mother has a son with sickle cell anemia. What would the genotype of the father been if his sister was
normal?
Father’s genotype: _____________________________________
4. A mother with type A blood crossed with a man, they had children that have every blood type EXCEPT for blood
type O. What is the genotype of the father?
Father’s genotype: _______________________________________
5. How many genes for blood?
_____________________________
6. How many blood types?
_____________________________
7. Gene combinations for people with type A blood?
_____________________________
8. Gene combinations for people with type B blood?
_____________________________
General Genetics Review
Name __________________________________
GETTING THE ‘GIST’ OF HUMAN GENECTICS
What is the difference between the following terms?
Sex-Linked: ____________________________________________________________________
Autosomal: ___________________________________________________________________
Determine whether the following traits are sex-linked or autosomal?
_____________________________Color blindness
_____________________________Hemophilia
_____________________________Cystic Fibrosis
_____________________________Huntington’s’ disease
_____________________________Male patterned baldness
_____________________________Blood Type
What is the pattern of inheritance? COMPLETE DOMINANCE, INCOMPLETE DOMINANCE, CODOMINANCE
_____________________________Sickle Cell Anemia
_____________________________Blood clotting (Hemophilia)
_____________________________Huntington’s’ disease
_____________________________Blood Type
_____________________________Color vision
Using the codes below, complete the following crosses for the scenarios on the back side of this page.
BLOOD CLOTTING
N = Normal
n = hemophila
HUNTINGTON’S DISEASE
H = Affected
h = normal
COLOR VISION
N = Normal
n = colorblind
CYSTIC FIBROSIS
N = Normal
n= affected
1. A hemophiliac mother with a normal father:
2. A father heterozygous for Huntington’s disease, and a normal mother:
3. A mother who is a carrier for color blindness and a normal father:
4. A father with cystic fibrosis and a pure normal mother: