ULM School of Pharmacy
GENERAL TOXICOLOGY: TOXI 4011- 61305-201660
Spring 2016
COURSE SYLLABUS
I. CONTACT INFORMATION: Dr. Sharon A. Meyer
Office: Rm 262 Bienville CoP Bldg
Ph: 342-1685
Office hours: M - T 9:30AM - 12:00PM
email: [email protected] (preferred means of communication)
II.
COURSE DESCRIPTION: Biochemical basis of chemical toxicity including toxicodynamics,
biotransformation, toxicokinetics, mutagenicity, carcinogenicity, teratogenicity and toxicity testing.
III.
COURSE PREREQUISITES: BIOL3011; grade of C or better in TOXI 1001
IV.
COURSE OBJECTIVS:
A. Objective 1 - to demonstrate general background knowledge on how chemicals and physical agents
interact with biological systems to elicit adverse effects.
B. Outcome 2 – to demonstrate and apply knowledge of toxicological principles and compound-specific
effects to enable rational, thoughtful evaluation of toxicological risk to human health and the
environment.
V.
COURSE TOPICS: See Lecture Schedule
VI.
INSTRUCTIONAL METHODS AND ACTIVITIES: Material will be presented through lectures and inclass discussions. Lectures will be illustrated with projected Powerpoint slides. Powerpoint lecture
slides and class announcements will be posted to Moodle. Student oral presentations will be presented
by student teams using Powerpoint.
VII.
EVALUATION AND GRADE ASSIGNMENT:
 Exams: There will be 3 exams given during the semester. Each exam will emphasize material since
the last exam, but incorporate general toxicological principles subsequent to their presentation in the
semester. See Lecture Schedule for the dates and lectures emphasized in each exam.
 Student presentations: Students will be grouped to debate the pros and cons of a contemporary
toxicological problem. This will entail accessing Web-based resources and preparation of a succinct
(~20 min) PowerPoint presentation. Topics for presentations will be assigned during the first week of
class.
 Grading:
a) 3 exams given within the semester @ 100 point/each = 300 pts
b) Student oral presentation = 100 pts
TOTAL = 400 pts
The final grade will be based upon the sum of points from the exams and presentation as follows:
A = 400 - 360
B = 359 - 320
C = 319 - 280
D = 279 - 240
F  239
Note: Undergraduate mid-term grades will be posted on-line for students to view via Banner. Mid-term
grades indicate a student’s status at mid-semester only and do not indicate the final performance outcome
of a student.
VIII.
CLASS POLICIES AND PROCEDURES: All policies stated in the current ULM Student Policy Manual &
Organizational Handbook should be followed (see http://www.ulm.edu/studentpolicy/). Additional class
policies include:
A. Textbook(s) and Materials: Required readings are the appropriate chapters of the textbook,
Casarett & Doull's Toxicology: The Basic Science of Poisons, 8th ed (Klaassen, C.D., ed.), 2013.
Supplemental readings may be assigned from additional class handouts as provided.
B. Attendance Policy: Classes start promptly at 12:30PM and end at 1:45PM. Attendance will be
monitored and only verifiable absences, as defined in the ULM Student Policy Manual
(www.ulm.edu/studentpolicy/), will be accommodated. Excusal of absences requires verification by
provision of a health practitioner note, an obituary, etc. tp the instructor-of-record.
C. Make-up Policy: It is the student's responsibility to arrange in advance, if possible, for completion of
make-up work necessitated by excused absences. Make-up exams should be completed within 10
days of the scheduled exam date.
ULM School of Pharmacy
Spring 2016
TOXI411-01 – Course Syllabus, Con’t
Class Policies and Procedures: Con’t
D. Academic Integrity: Faculty and students must observe the ULM published policy on Cheating And
Plagiarism (see Page 7 in ULM Student Policy Manual - www.ulm.edu/studentpolicy/).
E. Course Evaluation Policy: Students are expected to complete the on-line course evaluation.
F. Student Services: Information about ULM student services, such as Student Success Center
(http://www.ulm.edu/studentsuccess/), Counseling Center (http://www.ulm.edu/counselingcenter/),
Special Needs (http://www.ulm.edu/studentaffairs) and Student Health Services
(http://www.ulm.edu/shs/), is available at the following Student Services web site
http://ulm.edu/studentaffairs/
ULM Student Mental Wellness Resources: Students having experiencing emotional, behavioral, or
social problems, and who would like to talk with a caring, concerned professional, please call one of
the following: ULM Counseling Center 342-5220; Marriage & Family Therapy Clinic 342-9797;
Community Counseling Center 342-1263.
All services are offered free to faculty, staff, and students, and all are strictly confidential.
Library homepage is http://www.ulm.edu/library/reference.html.
Computing Center Help Desk is accessed at http://www.ulm.edu/computingcenter/helpdesk
Disabilities Policy and Services: The University of Louisiana at Monroe strives to serve students with
special needs through compliance with Sections 504 of the Rehabilitation Act of 1973 and the
Americans with Disabilities Act. These laws mandate that postsecondary institutions provide equal
access to programs and services for students with disabilities without creating changes to the
essential elements of the curriculum. While students with special needs are expected to meet our
institution's academic standards, they are given the opportunity to fulfill learner outcomes in
alternative ways. Examples of accommodations may include, but are not limited to, testing
accommodations (oral testing, extended time for exams), interpreters, relocation of inaccessible
classrooms, permission to audiotape lectures, note-taking assistance, and course substitutions.
Current college’s policies on serving students with disabilities can be obtained on the ULM website:
http://ulm.edu/counselingcenter/
If you need accommodation because of a known or suspected disability, you should contact the
Director for Disabled Student Services at:



Voice phone: 318-342-5220
Fax: 318-342-5228
Walk-In: ULM Counseling Center, 1140 University Avenue (this building and room are
handicapped accessible).
If you have special needs to compensate for disabilities affecting class performance, you should
contact the instructor-of-record within the first two days of class.
G. Sexual Harassment or Gender-Based Discrimination: Title IX of the Education Amendments of 1972
prohibits sex discrimination against any participant in an educational program or activity that receives
federal funds, including federal loans and grants. Furthermore, Title IX prohibits sex discrimination to
include sexual misconduct, sexual violence, sexual harassment and retaliation. If you encounter sexual
harassment or gender-based discrimination, please contact the Title IX Coordinator at 318-342-1004;
you may also file a complaint online, 24 hours a day, at: www.ulm.edu/titleix.
ULM School of Pharmacy
Spring 2016
TOXI411-01 – Course Syllabus, Con’t
Class Policies and Procedures: Con’t
H. Emergency Procedures: See attached Emergency Evacuation Plan. University Police: Call 1-911
from land lines and 342-5350 from cell phones
Emergency Evacuation Plan
Meet in front of
Band building
*
ULM School of Pharmacy
V. TOXI 4011: GENERAL TOXICOLOGY
Spring 2016
LECTURE SCHEDULE - Spring 2016
12:30 - 1:45 PM Tu/Th
Room 259 Sugar Hall
Coordinator:
Dr. Sharon A. Meyer
Office: Rm 262 Bienville CoP Bldg.
Ph: 342 - 1685
email: [email protected]
Introduction to Toxicology:
1. Tu Jan 19 History & Scope - Meyer
2. Th Jan 21 General Principles - Meyer
3. Tu Jan 26 General Mechanisms of Toxicity – Meyer
Disposition:
4. Th Jan 28 - Biotransformation of Toxicants; Part 1 - Mehendale
5. Tu Feb 2 Absorption, Distribution, Elimination – Salley
6. Th Feb 4 Toxicokinetics - Meyer
///////////// Tu Feb 9 -- NO CLASS -- Mardi Gras Break ////////////////////////////
7.
Th Feb 11 - Biotransformation of Toxicants; Part 2 – Mehendale
8. Tu Feb 16 Biotransformation of Toxicants; Part 3 – Mehendale
****** Th Feb 18 FIRST EXAM (Lectures 1 – 8) ******
Toxic Effects:
9. Tu Feb 23 Genetic Toxicology – Meyer
10. Th Feb 25 Chemical carcinogenesis-I – Meyer
11. Tu Mar 1
Chemical carcinogenesis-II – Meyer
Classes of Toxicants
12. Th Mar 3
Solvents & Vapors - Mehendale
13. Tu Mar 8
Metals – Mehendale
14. Th Mar 10 Natural Toxins – Meyer
15. Pesticides – Meyer --- No classroom session; Will be posted to Moodle as online
lecture via Camtasia
SOT Mar 13-17
16. Th Mar 17
Developmental Toxicants – Baer
****** Tu Mar 22 SECOND EXAM (Lectures 9-16) ******
17. Th Mar 24 Chemical Weapons of Mass Destruction – Meyer
//////////// Tu, Th Mar 29, Mar 31 -- NO CLASS -- Spring Break -- /////////////////
18. Tu Apr 5
Air, Water and Soil Toxicants - Meyer
Student presentations – Groups 1, 2 & 3, Topics 1-3; FOR
Student presentations – Groups 4, 5 & 6, Topics 1-3; AGAINST
Student presentations – Group 7 -Topic 4 FOR; Group 8 -Topic 4 AGAINST
– Group 9 – Decision FOR/AGAINST; Topics 1-3;
Science-based Management of Risk:
19. Tu Apr 19 Risk Assessment of Health Effects -- R. Gentry, Environ
20. Th Apr 21 Testing for Toxicity – Meyer
21. Tu Apr 26 Epidemiology – Meyer
22. Th Apr 28 Exposure Assessment – Meyer
23. Tu May 3
Risk Perception & Communication – Meyer
Th Apr 7
Tu Apr 12
Th Apr 14
*** Th May 5 THIRD EXAM (Lectures 17 – 23; Student Presentations)***
Textbook: Casarett & Doull's Toxicology: The Basic Science of Poisons, 8th ed (Klaassen,
C.D.), 2013. Available on Moodle under Pharmacy Library Resources; AccessPharmacy Database
Additional readings from class handouts may supplement the required text.