DETERMINATION OF CHANGE POINTS OF NON MONOTONIC FAILURE RATES Ramesh C. Gupta Robin Warren University of Maine, Department of Mathematits 5752 Neville Hall Orono, ME 04469-5752 U.S.A. R,~upta~tnaine.nlaine.edu and Statistics Survival and failure time date are frequently modeled by increasing or decreasing failure rate distributions. This may be inappropriate when the course of the disease is such that mortalny reaches a peak after some finite period and than declines slowly. For example, in a study of curability of breast cancer, Langlands et. al. (1979) found that the peak mortality occurred after about three years. Bennett (1983) analyzed the data from Veterans Administration lung cancer presented by Prentice (1973) and showed that the empirital rates for both low PS and high PS groups are non-monotonic. Therefore, it is important to analyze such data sets with appropriate models like log normal, inverse Gaussian log-logistic and Burr type X II, having non-monotonic failure rates. Sinte most of the failure rates have complex expressions because of the integral in the denominator, the determination of the monotonicity is not straightforward. To alleviate this difficulty Glaser (1980) presented a method to determine the monotonicity of the failure rate having one turning point. Glaser’s method uses the density function rather than the failure rate, which, in many cases, is much simpler-. Glaser’s method can be used in many complicated examples such as quadratic exponential family (Pham-Gia 1994), having generalized Rayleigh, half normal, gamma, Maxwell Boltzman, classical Rayleigh and Chi-square us special cases. Other examples include inverse Gaussian, log normal and weighted inverse Gaussian distributions, see Gupta and Akman (1995). In addition to these, Glaser’s method can be used to determine the monotonicity in certain mixture models having two components, see Gutland and Sethuraman (1994, 1995) and Al-Hussaini and Abd - El. Hakim (1989). This paper has been motivated by pooling two gamma distributions. the conjecture presented by Glaser is Glaser to models having two or more procedure helps us to identify failure by an interesting example of a failure rate obtained For certain values of the parameters it is found that not correct. This lead us to extend the results of turning points of the failure rate. The extended rates of more complex form, REFERENCES Al-Hussaini, EK. and Abd-El-Hakim, N.S. (1989). Failure rate of the inverse GaussianWeibull mixture model. Annals of the Institute of Statistical Mathematits 4 l(3 ), 617622. Bennett, S. (1983). Log-logistic 32(2), 165-171. regression models for survival data. Applied Statistics Glaser. R.E. (1980). Bathtub and related failure rate characterizations. American Statistical Association ‘75, 667-672. Journal of the Gupta R.C. and Akman, 0. (1995). On the reliability studies of a weighted inverse Gaussian model. Journal of Statistical Planning and Inference, 48, 69-83. Gurland, J. and Sethuraman, J. (1994). Reversal of increasing failure rates when pooling failure data. Technometrics 36(4), 416-4 18. Gurland, J. and Sethuraman, J. (1995). How pooling failure data may reverse increasing failure rate. Journal of the American Statistical Association, 90(432), 14 16 1423. Langlands, A.O. Pocock, SJ., Kerr, G.R. and Gore, S.M. (1979). Long term survival of patients with breast cancer: a study of curability of the disease. British Medieal Journal 2, 1247- 125 1. Pham-Gia, T. ( 1996). The hazard rate of the power-quadratic exponential distributions. Statistics and Probability Letters 20, 375-382. Prentice, R.L. ( 1973). Exponential Biometrits 60, 279-288. family of survivals with censoring and explanatory variables. ABSTRACT This paper was motivated by the problem of the determination of the change points of the failure rate of a mixture of two gamma distributions. For certain values of the parameters the existing methods are not applicable sinte, in this case, there are two turning points of the failure rate. Thus, we extend the results to models having two or more turning points of the failure fates. The extended procedure helps us to identify failure rates of more complex forms. Finally, the mixture gamma case is completely resolved employing theoretical, graphical and numerical techniques wherever necessary.
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