Supplemental table 3: Characteristics of the 48 “DRT” case reports (6 unpublished cases from the EVALJEU cohort and 42 already published case
reports)
Sex
(M/F)
Age
(years)
PD onset
(years)
History of
SUD
Current comorbidities
Favorite type of game
Severity of GD
(DSM-IV)
GD onset after
DRT prescription
GD resolution after
DRT discontinuation
Case 1
M
59
54
Nicotine,
alcohol
No
Pure chance games
5/10
Yes (a few years)
Yes
Probability that GD is
due to DRT
(Naranjo imputability)
Possible
Case 2
M
66
62
Nicotine
No
Pure chance games
6/10
Yes
Yes
Possible
Case 3
M
61
53
Nicotine
MD, agoraphobia, PTSD
Pure chance games
4/10
Yes
NS
Possible
Case 4
Case 5
Case 6
Seedat et al., 2000 (4)
Molina et al., 2000 case 1
(5)
Molina et al., 2000 case 2
(5)
Molina et al., 2000 case 3
(5)
Molina et al., 2000 case 4
(5)
Molina et al., 2000 case 5
(5)
Molina et al., 2000 case 6
(5)
Molina et al., 2000 case 7
(5)
Molina et al., 2000 case 8
(5)
Molina et al., 2000 case 9
(5)
Molina et al., 2000 case 10
(5)
Molina et al., 2000 case 11
(5)
F
F
M
F
F
67
52
69
59
44
55
41
68
47
36
No
No
No
No
No
No
No
No
No
MD
Pure chance games
Pure chance games
Pure chance games
Pure chance games
NS
6/10
4/10
5/10
Pathological
NS
Yes
Yes
Yes
Yes (2 years)
Yes
No
No
NS
NS
NS
Possible
Possible
Possible
Possible
Possible
M
42
32
Alcohol
Compulsions
NS
NS
Yes
Yes (reduced doses)
Possible
M
66
54
No
Compulsion
NS
NS
Yes
NS
Possible
M
68
60
No
MD
NS
NS
Yes
NS
Possible
M
65
59
No
Binge-eating
NS
NS
Yes
NS
Possible
M
52
44
Alcohol
MD
NS
NS
Yes
NS
Possible
M
49
37
Alcohol
MD
NS
NS
NS
NS
Doubtful
M
50
40
Alcohol
No
NS
NS
Yes
NS
Possible
M
63
53
No
MD
NS
NS
Yes
NS
Possible
M
65
57
No
No
NS
NS
Yes
NS
Possible
M
53
33
No
MD, anxiety disorder
NS
NS
Yes
NS
Possible
Molina et al., 2000 case 12
(5)
Montastruc et al., 2003 (49)
Kurlan et al., 2004 case 1
(50)
Kurlan et al., 2004 case 2
(50)
Avanzi et al., 2004 case 1
(7)
Avanzi et al., 2004 case 2
(7)
Larner et al., 2006 (51)
Bandini et al., 2007 case 1
(42)
Bandini et al., 2007 case 2
M
49
35
Alcohol
Anxiety disorder
NS
NS
NS
NS
Doubtful
F
M
61
NS
50
48
No
NS
Depressive syndrome
NS
Pure chance games
Pure chance games
NS
NS
Yes
Yes
NS
NS
Possible
Possible
F
NS
53
NS
Depression
Pure chance games
NS
Yes
No
Possible
M
64
52
No
No
Pure chance games
Pathological
Yes
No
Possible
M
60
48
No
Depression
NS
Pathological
NS
Yes (reduced doses)
Possible
M
M
42
43
40
39
NS
No
NS
Pure chance games
NS
Pathological
Yes
Yes
Yes
Yes (reduced doses)
Possible
Possible
M
51
46
NS
Depression
Moderate Depression
Insomnia
Moderate Depression
Pure chance games
Pathological
Yes
Yes (reduced doses)
Possible
1
(42)
Wong et al., 2007 case 1
(52)
Wong et al., 2007 case 2
(52)
Wong et al., 2007 case 3
(52)
Wong et al., 2007 case 4
(52)
Wong et al., 2007 case 5
(52)
Wong et al., 2007 case 6
(52)
Wong et al., 2007 case 7
(52)
Wong et al., 2007 case 8
(52)
Ferreira Garcia et al., 2007
(45)
Bostwick et al., 2009 case 1
(44)
Bostwick et al., 2009 case 2
(44)
Bostwick et al., 2009 case 3
(44)
Bostwick et al., 2009 case 4
(44)
Bostwick et al., 2009 case 5
(44)
Tschopp et al., 2010 case 1
(47)
Tschopp et al. 2010 case 2
(47)
Bosco et al., 2012 case 1
(43)
Bosco et al., 2012 case 2
(43)
Bosco et al., 2012 case 3
(43)
Pignatti et al., 2012 (46)
Wilson et al., 2013 (48)
M
45
33
No
DDS
Anxiety
NS
7/10
Yes
Yes
Possible
M
58
49
No
No
NS
8/10
Yes
Yes
Possible
M
56
52
No
MD
Chance games with
pseudo-skills
8/10
Yes
Yes
Possible
F
54
49
No
No
Pure chance games
8/10
Yes
Yes
Possible
F
53
47
No
No
Pure chance games
3/10
Yes
No
Possible
M
59
52
No
No
Chance games with
pseudo-skills
7/10
Yes
Yes
Possible
M
54
49
No
Anxiety
(On-line Poker)
7/10
Yes
Yes
Possible
M
78
63
No
Depression
(On-line Poker)
5/10
Yes
Yes
Possible
F
41
18
No
No
Pure chance
Pathological
Yes (6 months)
Yes
Probable
M
52
41
NS
Compulsive lawn care
Casino (no more specific)
Pathological
Yes
Yes
Possible
M
68
65
NS
Hypersexuality
Casino (no more specific)
Pathological
Yes
Yes
Possible
F
53
NS
NS
NS
Casino (no more specific)
Pathological
Yes
Yes
Possible
M
69
55
NS
Hypersexuality
Casino (no more specific)
Pathological
Yes
Yes
Possible
M
49
41
NS
NS
Pathological
Yes
Yes
Possible
F
49
47
No
Pure chance games
Pathological
Yes
NS
Possible
M
71
66
NS
Pure chance games
Pathological
Yes
No
Possible
M
44
39
No
Hypersexuality
Bipolar disorder
Hypersexuality
Compulsive internet use
Hypersexuality
Compulsive overeating
No
Pure chance games
Pathological
Yes (6 months)
No
Possible
M
51
47
Alcohol
MD
Pure chance games
Pathological
Yes (6 months)
No
Possible
M
43
40
Alcohol
Pure chance games
Pathological
Yes (3 months)
No
Possible
F
M
42
32
34
29
No
NS
MD
Hypersexuality
No
No
Pure chance games
Pure chance games
Pathological
Pathological
Yes (2 years)
NS
NS
Yes
Possible
Possible
DDS: Dopamine Dysregulation Syndrome; DRT: Dopamine Replacement Therapy; GD: Gambling Disorder; MD: Major Depression; NS: Not Specified; PD: Parkinson’s Disease; SUD: Substance Use Disorder
2