F-statistics study material
 read and digest the following text
 use the text and the appropriate equations
within to solve the problem at the end
Problem:
Calculate FST , FIS and FIT for case 1 and case 2. Start by calculating allele frequencies for A1 (p) and A2 (q) in each row. The given numbers are observed
frequencies of genotypes in the populations. In case 1 the allele frequencies are equal among subpopulations. Also, in case 1, subpopulation 1 is in H-W
equilibrium. In case 2, both subpopulations are in H-W equilibrium.
case 1
subpopulation 1
subpopulation 2
A1A1
0.25
0.35
A1A2
0.5
0.3
A2A2
0.25
0.35
p
q
case 2
subpopulation 1
subpopulation 2
FST =
FST =
FIS =
FIS =
FIT =
FIT =
A1A1
0.25
0.49
A1A2
0.5
0.42
A2A2
0.25
0.09
p
q