Flowchart to consider points while prescribing Abacavir/Lamivudine
Considering prescribing
Abacavir/Lamivudine
New
Patient
History of (suspeceted)
hypersensitivity to
Abacavir
HLA-B*5701
Screening
Positive
Negative
No
Do not start
treatment
with
Abacavir/
Lamivudine
HLA-B*5701
status
Existing patient
Start treatment with
Abacavir/Lamivudine
Alert card
No events
reported
Continue
treatment
with
Abacavir/
Lamivudine
Patient counselling
Patient reports
suspected HSR
Start treatment
with Abacavir/
Lamivudine and
follow protocol as
for HLA-B*5701
negative patient
Immediatlely stop treatement with
Abacavir/Lamivudine.
Advise the patient to return / dispose the
unused medicine
Yes
Dont start
treatment
with
Abacavir/
Lamivudine
Positive
Dont start
treatment
with
Abacavir/
Lamivudine
Negative
Restart
treatment in a
setting where
medical
assistance is
available
Unknown
Test the
patient for
HLA-B*5701
Follow the
protocol as
for HLAB*5701
status
positive or
negative