Neuronal Nitric Oxide Reduces Sympathetic Excitability by
Modulation of Central Glutamate Effects in Pigs
by Johannes Zanzinger, Jürgen Czachurski, and Horst Seller
Circulation Research
Volume 80(4):565-571
April 1, 1997
Copyright © American Heart Association, Inc. All rights reserved.
Variation of glutamate responses by NO. Original tracings show changes in BP, RSNA, and HR.
L-NNA (0.3 mmol/L) and SNAP (100 μmol/L) were administered by short-term ICV infusion.
Johannes Zanzinger et al. Circ Res. 1997;80:565-571
Copyright © American Heart Association, Inc. All rights reserved.
Modulation of the pressor effects (ΔMAP) and sympathoexcitatory responses (% RSNA) to
glutamate by NO within the brain stem.
Johannes Zanzinger et al. Circ Res. 1997;80:565-571
Copyright © American Heart Association, Inc. All rights reserved.
Effects of NO on somatosympathetic reflex responses.
Johannes Zanzinger et al. Circ Res. 1997;80:565-571
Copyright © American Heart Association, Inc. All rights reserved.
Effects of intracerebroventricular (i.c.v.) or intravenous (i.v.) treatment with sham control, 7-NI (1
mmol/L i.c.v., 20 mg/kg i.v.), L-NNA (0.3 mmol/L i.c.v.), L-NAME (20 mg/kg i.v.), and SNAP (100
μmol/L i.c.v., 2 μg·kg−1·min−1 i.v.) (n=8, i.c.v.; n=6, i.v.) (A) or sham control, MeTC (0.1 mmol/L
i.c.v.), l-arginine (L-Arg, 3.0 mmol/L i.c.v.), and SNAP (100 μmol/L i.c.v.) (n=5) (B) on the
responses of mean BP (ΔMAP) and RSNA (% RSNA) to electrical stimulation of the left greater
sciatic nerve (10 to 20 V, 1-millisecond pulse duration, 30 Hz for 20 seconds every 2 minutes).
*P<.05, **P<.01 vs control values.
Johannes Zanzinger et al. Circ Res. 1997;80:565-571
Copyright © American Heart Association, Inc. All rights reserved.