Anti-Monocyte Chemoattractant Protein-1 Gene Therapy
Attenuates Left Ventricular Remodeling and Failure After
Experimental Myocardial Infarction
by Shunji Hayashidani, Hiroyuki Tsutsui, Tetsuya Shiomi, Masaki Ikeuchi, Hidenori
Matsusaka, Nobuhiro Suematsu, Jing Wen, Kensuke Egashira, and Akira Takeshita
Circulation
Volume 108(17):2134-2140
October 28, 2003
Copyright © American Heart Association, Inc. All rights reserved.
Figure 1. Cumulative percent survival of MI (n=48) and 7ND-transfected MI (MI+7ND; n=31) mice
shown by Kaplan-Meier method.
Shunji Hayashidani et al. Circulation. 2003;108:2134-2140
Copyright © American Heart Association, Inc. All rights reserved.
Figure 2. Time-dependent changes of LV end-diastolic diameter (A) and percent fractional
shortening (B) in sham (○; n=12), sham+7ND (□; n=12), MI (•; n=12), and MI+7ND (▪; n=12) mice.
Shunji Hayashidani et al. Circulation. 2003;108:2134-2140
Copyright © American Heart Association, Inc. All rights reserved.
Figure 3. M-mode echocardiograms obtained from sham-operated (A), MI (B), and 7NDtransfected MI (C) mice 28 days after operation.
Shunji Hayashidani et al. Circulation. 2003;108:2134-2140
Copyright © American Heart Association, Inc. All rights reserved.
Figure 4. Low-power (A through C) and high-power (D through F) photomicrographs of Massontrichrome-stained LV cross-sections obtained from sham (A and D), MI (B and E), and MI+7ND (C
and F) mice 28 days after operation.
Shunji Hayashidani et al. Circulation. 2003;108:2134-2140
Copyright © American Heart Association, Inc. All rights reserved.
Figure 5. A, Time-dependent changes (1, 3, 7, 14, and 28 days after ligation) in the number of
interstitial MOMA-2-positive macrophages in the LV of MI (n=3 each) and MI+7ND (n=3 each)
mice.
Shunji Hayashidani et al. Circulation. 2003;108:2134-2140
Copyright © American Heart Association, Inc. All rights reserved.
Figure 6. A, Time-dependent changes of cytokine gene expression assessed by multiprobe
ribonuclease protection assays from sham, MI, and MI+7ND mice.
Shunji Hayashidani et al. Circulation. 2003;108:2134-2140
Copyright © American Heart Association, Inc. All rights reserved.