Modification of the cysteine residues in IκBα kinase and
NF-κB (p65) by xanthohumol leads to suppression of NFκB–regulated gene products and potentiation of apoptosis
in leukemia cells
by Kuzhuvelil B. Harikumar, Ajaikumar B. Kunnumakkara, Kwang S. Ahn, Preetha
Anand, Sunil Krishnan, Sushovan Guha, and Bharat B. Aggarwal
Blood
Volume 113(9):2003-2013
February 26, 2009
©2009 by American Society of Hematology
XN potentiates the TNF-induced apoptosis in chronic myeloid leukemia cells.
Kuzhuvelil B. Harikumar et al. Blood 2009;113:2003-2013
©2009 by American Society of Hematology
XN down-regulates the TNF-induced gene products linked to proliferation, apoptosis, and
invasion of chronic myeloid leukemia cells.
Kuzhuvelil B. Harikumar et al. Blood 2009;113:2003-2013
©2009 by American Society of Hematology
XN down-regulates the TNF-induced NF-κB activation induced by different agents and in
different cell lines.
Kuzhuvelil B. Harikumar et al. Blood 2009;113:2003-2013
©2009 by American Society of Hematology
XN down-regulates the TNF-induced NF-κB activation through inhibition of IκBα kinase.
Kuzhuvelil B. Harikumar et al. Blood 2009;113:2003-2013
©2009 by American Society of Hematology
XN down-regulates the TNF-induced NF-κB activation through modification of p65 subunit of NFκB.
Kuzhuvelil B. Harikumar et al. Blood 2009;113:2003-2013
©2009 by American Society of Hematology
XN down-regulates the NF-κB reporter activity induced by TNF and TNF-signaling components.
Kuzhuvelil B. Harikumar et al. Blood 2009;113:2003-2013
©2009 by American Society of Hematology
XN down-regulates the TNF-induced NF-κB activation through FXR-independent mechanism.
Kuzhuvelil B. Harikumar et al. Blood 2009;113:2003-2013
©2009 by American Society of Hematology