Jeopardy
Factors
affecting wound
healing
Heritable
Diseases
Specific
Tissues
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Phases of
Wound Healing
Treatment
Final Jeopardy
$100 Question from H1
Name the three phases
of wound healing.
$100 Answer from H1
a. Hemostasis and inflammation
b. Proliferation
c. Maturation and remodeling
$200 Question from H1
In the hemostasis phase, these are
the first infiltrating cells to enter
the wound site, peaking at 24 to 48
hours.
$200 Answer from H1
PMNs
$300 Question from H1
In the proliferation phase, these cells
proliferate extensively and participate
in the formation of new capillaries?
$300 Answer from H1
Endothelial cells
$400 Question from H1
They couple with proteins to form
proteoglycans, and compromise a large
portion of the “ground substance” that
makes up granulation tissue.
$400 Answer from H1
Glycosaminoglycans
$500 Question from H1
Breaks down collagen in the maturation
and remodeling phase.
$500 Answer from H1
Matrix metalloproteinases (MMPs)
$100 Question from H2
Genetic defect is in an extracellular protein,
fibrillin, and presents with tall stature,
arachnodactyly, lax ligaments, pectus
excavatum, and aneurysms.
$100 Answer from H2
Marfan’s Syndrome
$200 Question from H2
Defect in collagen formation. Thin, friable
Skin with prominent veins. Associated with
GI problems
$200 Answer from H2
Ehler-Danlos Syndrome
$300 Question from H2
Mutation in Type I collagen, four major
subtypes, dermal thining and increased
bruisability.
$300 Answer from H2
Osteogenesis Imperfecta
$400 Question from H2
Classified into 3 major subtypes.
impairment in tissue adhesion within the
epidermis, basement membrane, or dermis,
resulting in tissue separation.
$400 Answer from H2
Epidermolysis Bullosa
$500 Question from H2
An autosomal recessive disease of children
that causes an inability to absorb sufficient
zinc from breast milk or food. Impaired
granulation tissue formation.
$500 Answer from H2
Acrodermatitis Enteropathica
$100 Question from H3
The early integrity of a bowel anastamosis is
dependent on formation of a fibrin seal on the
serosal side, which achieves watertightness,
and on the suture-holding capacity of the
intestinal wall, particulary which layer?
$100 Answer from H3
Submucosal layer
$200 Question from H3
With a nerve injury, these cells ensheathe
and help in remyelinating the regenerating
axons.
$200 Answer from H3
Schwann cells
$300 Question from H3
What is the main characteristic that
distinguishes the healing of fetal wounds
from that of adult wounds?
$300 Answer from H3
Scar formation
$400 Question from H3
Cartilage consists of these cells, surrounded
by an extracellular matrix made up of
several proteoglycans, collagen fibers, and
water.
$400 Answer from H3
Chondrocytes
$500 Question from H3
The fetal wound is characterized by excessive
and extended production of what
glycosaminoglycan?
$500 Answer from H3
Hyaluronic Acid
$100 Question from H4
This medication inhibits the inflammatory
phase of wound healing and the release of
lysosomal enzymes.
$100 Answer from H4
Steroids
$200 Question from H4
The best known of the metabolic disorders
contributing to increased rates of wound
infection and failure.
$200 Answer from H4
Diabetes Mellitus
$300 Question from H4
What perioperative measure can be taken
to decrease wound infection rate by 66%?
$300 Answer from H4
Prophylactic antibiotics
$400 Question from H4
This deficiency impairs wound healing,
while supplement benefits wound healing
in nondeficient humans and animals.
$400 Answer from H4
Vitamin A
$500 Question from H4
With this deficiency, there is decreased
fibroblast proliferation, decreased collagen
synthesis, impaired overall wound strength,
and delayed epithelialization.
$500 Answer from H4
Zinc
$100 Question from H5
This dressing uses negative pressure to
increase the rate of wound healing by
increasing blood flow to subcutaneous tissues.
$100 Answer from H5
V.A.C. Dressing
$200 Question from H5
List a complication of sulfamylon
treatment.
$200 Answer from H5
Metabolic acidosis
$300 Question from H5
This is a serious complication of
Silvadene application.
$300 Answer from H5
Leukopenia and Neutropenia
$400 Question from H5
This treatment has a serious complication
of hyponatremia and methemoglobinemia.
$400 Answer from H5
Siver nitrate
$500 Question from H5
These two concepts are critical in
selecting appropriate dressing.
$500 Answer from H5
Occlusion and absorption
Final Jeopardy
Who were the first people to differentiate
between infected and diseased wounds
compared to noninfected wounds?
Final Jeopardy Answer
The Egyptians