Christopher V.E. Wright, D. Phil.
Curriculum Vitae January 2012
Nationality: British, PERMANENT U.S. RESIDENT (since June, 1992)
PRESENT POSITION:
July 1999 - present
Director, Vanderbilt University Program in Developmental Biology
July 1997 – present
Professor, Department of Cell and Developmental Biology
Vanderbilt University
July 2011 – July 2012
Vice-Chair, Faculty Affairs, Cell & Developmental Biology
Jan 2011 – present
Louise B. McGavock Endowed Chair, Cell & Developmental Biology
Member, Vanderbilt Cancer Center
Member, Vanderbilt Center for Stem Cell Biology
Member, Vanderbilt Diabetes Research Center
Member, Vanderbilt Reproductive Biology Center
Member, Vanderbilt School of Medicine Faculty Awards Committee
Member, Steering Committee, Beta Cell Biology Consortium
Chair, DEV-1 Study Section, Center for Scientific Review, NIH
PREVIOUS POSITIONS:
July 2009 - July 2010
July 2001 - 2010
Jan 1994 - June 1997
Jan 1990 - Dec 1993
Jan 1988 - Dec 1989
Jan 1987 - Dec 1987
Jan 1986 - Dec 1986
Jan 1985 - Dec 1985
Oct 1983 - Dec 1984
Vice-Chair for Faculty Affairs, Department of Cell and
Developmental Biology, Vanderbilt University
Molecular Diabetes Research (Endowed) Professor of Cell &
Developmental Biology. Vanderbilt University.
Associate Professor, Cell Biology, Vanderbilt University
Assistant Professor, Cell Biology, Vanderbilt University
American Cancer Society (California Division)
Senior Fellow (Mentor/Supervisor: E.M. De Robertis)
Postdoctoral Research Fellow, UCLA Biological Chemistry
Department (mentor/supervisor: E.M. De Robertis)
EMBO Long Term Postdoctoral Fellowship (Renewal)
EMBO Long Term Postdoctoral Fellowship
(ALTF-192-1984) Supervisor – E.M. De Robertis
Cancer Research Campaign Postdoctoral Fellowship
Supervisor – J.S. Knowland
HONORS & OTHER AWARDS:
2003
1989 - 1994
Sidney P. Colowick Award, For Research that Serves as a
Platform for Discovery in Diverse Areas.
Five year Royal Society Independent University Research
Biographical Sketch - Christopher V.E. Wright D.Phil.
2011 – present
SOCIETIES:
UNIVERSITY CAREER:
D. Phil.
B. Sc. (Hons., First class)
Lectureship (U.K.) [DECLINED, to take present position]
Louise B. McGavock Endowed Chair
Member, Society for Developmental Biology
Member, International Society for Stem Cell Research
Dept. of Biochemistry, University of Oxford
(Linacre College), U.K., 1980-1984
Mentored by John S. Knowland, D. Phil.
University of Warwick
Coventry CV4 7AL, U.K., 1977-1980
(including supervision by Alan Colman, and teaching from
Hugh Woodland, Liz Jones, and Bob Old.)
SCIENTIFIC ADVISORY BOARDS
2008 – present
2002 – 2010
2004 - 2006
Updated 7/13/17
Geron (CA)
ES Cell International (ESI) (Australia)
Berrie Cell Therapies of Diabetes, Naomi Berrie Diabetes
Center, Columbia University Medical Center (NY)
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Biographical Sketch - Christopher V.E. Wright D.Phil.
PUBLICATIONS (total 147 published to date):
1.
Wright CV, Wright SC, Knowland J. (1983) Partial purification of estradiol receptor from
Xenopus laevis liver and levels of receptor in relation to estradiol concentration. EMBO J. 2,
973-977 D. Phil. Graduate Research Project
2.
Knowland J, Theulaz I, Wright CV, Wahli W. (1984) Injection of partially purified estrogen
receptor preparation from Xenopus liver nuclei into oocytes activates the silent
vitellogenin locus. Proc. Natl. Acad. Sci. USA 81, 5777-5781
D. Phil. Graduate Research Project
3.
De Robertis EM, Fritz A, Goetz J, Martin G, Mattaj IW, Salo E, Smith GD, Wright CV, Zeller R.
(1985) The Xenopus homeo boxes. Cold Spring Harbor Symp. Quant. Biol. L, 271-275
Postdoctoral Fellow Research
4.
Wright CV, Cho KW, Fritz A, Buerglin TR, De Robertis EM (1987) A Xenopus laevis gene
encodes both homeobox-containing and homeobox-less transcripts. EMBO J. 6, 4083-4094
Postdoctoral Fellow Research
5.
Burglin TR, Wright, CV, De Robertis EM (1987) Translational control in homeobox
mRNAs? Nature 330, 701-702 Postdoctoral Fellow Research
6.
De Robertis EM, Buerglin TR, Fritz A, Wright CV, Jegalian B, Schnegelsberg P, Bittner D,
Morita E, Oliver G, Cho KW. (1988) Families of vertebrate homeodomain proteins. UCLA
Symp. 95 "DNA-Protein Interactions in Transcription" Ed. J.Gralla, 107-116
Postdoctoral Fellow Research
7.
Cho KW, Goetz J, Wright CV, Fritz A, Hardwicke J, De Robertis EM. (1988) Differential
utilization of the same reading frame in a Xenopus homeobox gene encodes two related
proteins sharing the same DNA-binding specificity. EMBO J. 7, 2139-2149
Postdoctoral Fellow Research
8.
Oliver G, Wright CV, Hardwicke J, De Robertis EM. (1988) Differential antero-posterior
expression of two proteins encoded by a homeobox gene in Xenopus and mouse embryos.
EMBO J. 7, 3199-3209 Postdoctoral Fellow Research
9.
Fritz AF, Martin G, Wright CV, De Robertis EM. (1988) Site-specific inversions in repeated
Xenopus laevis homeobox gene 2 sequences. Nucl. Acids Res. 16, 9058
Postdoctoral Fellow Research
10. De Robertis EM, Buerglin TR, Fritz A, Oliver G, Cho K, Wright, CV. (1988) Sequence
conservations in vertebrate homeobox mRNAs. Arch. Biol. Med. Exp. 21, 443-447
Postdoctoral Fellow Research
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Biographical Sketch - Christopher V.E. Wright D.Phil.
11. Oliver G, Wright CV, Hardwicke J, De Robertis EM. (1988) A gradient of homeodomain
protein in developing forelimbs of Xenopus and mouse embryos. Cell 55, 1017-1024.
Postdoctoral Fellow Research
12. Fritz AF, Cho KWY, Wright CV, Jegalian B, De Robertis EM. (1989).Duplicated homeobox
genes in Xenopus. Dev. Biol. 131, 584-588 Postdoctoral Fellow Research
13. Oliver G, Wright CV, Cho KW, De Robertis EM. (1988) Characterization and distributional
analysis of a homeobox-containing gene in Xenopus and mouse embryos. In: Cell to Cell
Signals in Mammalian Development, NATO ASI Series
Postdoctoral Fellow Research
14. Wright CV, Cho KW, Oliver G, De Robertis EM. (1989) Vertebrate homeodomain proteins:
Families of region-specific transcription factors. Trends Biochem. Sci. 14, 52-56
Postdoctoral Fellow Research
15. Wright CV, Schnegelsberg P, De Robertis E.M. (1989) XlHbox 8: a novel Xenopus homeo
protein restricted to a narrow band of the endoderm. Development 105, 787-794
Postdoctoral Fellow Research
16. De Robertis EM, Oliver G, Wright CV. (1989) Determination of axial polarity in the
vertebrate embryo: homeodomain proteins and homeogenetic induction. Cell 57, 189-191
Postdoctoral Fellow Research
17. Wright CV, Cho KW, Hardwicke J, Collins RH, De Robertis, EM. (1989) Interference with
function of a homeobox gene in Xenopus embryos causes transformation of the cervical
spinal cord. Cell 59, 81-93 Postdoctoral Fellow Research
18. Wright CV, Morita E, De Robertis EM. (1990) The Xenopus XlHbox 6 homeo protein, a
marker of posterior neural induction, is expressed in proliferating neurons. Development
109, 225-234 Postdoctoral Fellow Research
19. Molven A, Wright CV, Bremiller R, De Robertis EM, Kimmel CB. (1990) Expression of a
homeobox gene product in normal and mutant zebrafish embryos: evolution of the
tetrapod body plan. Development 109, 279-288 Postdoctoral Fellow Research
20. De Robertis EM, Oliver G, Wright, CV. (1990) Homeobox genes and the analysis of
vertebrate development. Scientific American, July 1990, 46-52
Postdoctoral Fellow Research
21. Cridland NA, Wright CV, McKenzie EA, Knowland J. (1990) Selective photochemical
treatment of estrogen receptor in a Xenopus liver extract destroys hormone binding and
transcriptional activation but not DNA binding. EMBO J. 9, 1859-1866
D. Phil. Graduate Research Project
Updated 7/13/17
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Biographical Sketch - Christopher V.E. Wright D.Phil.
22. Cho KW, Morita EA, Wright CV, De Robertis EM. (1991) Overexpression of a homeodomain
protein confers organizer activity to uncommitted Xenopus embryonic cells. Cell 65, 55-64
Postdoctoral Fellow Research
23. Blumberg B, Wright CV, De Robertis EM, Cho, KW. (1991) Organizer-specific homeobox
genes in Xenopus laevis embryos. Science 253, 194-196 Postdoctoral Fellow Research
24. Wright CV, Hogan B. (1991) Another hit for gene targeting. Nature 350, 458-459
25. Wright CV. (1991) Vertebrate homeobox genes. Current Opinion in Cell Biology 3, 976-982
26. Hogan B, Wright CV. (1992) The making of the ear. Nature 355, 494-495
27. Jones CM, Lyons KM, Lapan P, Wright CV, Hogan, BL. (1992) DVR-4 (Bone morphogenetic
protein-4) as a postero-ventralizing factor in Xenopus mesoderm induction. Development
115, 639-647
28. Wall NA, Jones CM, Hogan BL, Wright, CV. (1992) Characterization and modification of
Hox-2.1 protein in mouse embryos. Mech. Dev. 37, 111-120
29. Candia AF, Hu J, Crosby J, Lalley PA, Noden D, Nadeau J, Wright CV (1992) Mox-1 and Mox2 define a novel homeobox gene subfamily, and are differentially expressed during early
mesodermal patterning in mouse embryos. Development 116, 1123-1136
30. Jegalian B, Miller R, Wright CV, Blum M, De Robertis EM. (1992) A Hox-3.3-lacZ transgene
expressed in developing limbs. Mech. Dev. 39, 171-180
Postdoctoral Fellow Research
31. Wall NA, Blessing M, Wright CV, Hogan, BL. (1993) Biosynthesis and in vivo localization of
the Decapentaplegic-Vg related protein DVR-6 (Bone Morphogenetic Protein-6). J. Cell.
Biol. 120, 493-502
32. Gamer L, Wright CV. (1993) Murine Cdx-4 bears striking similarities to the Drosophila
caudal gene in its homeodomain sequence and early expression pattern. Mech. Dev. 43, 7181
33. Candia AF, Kovalik J-P, Wright CV. (1993) Sequence of Mox-2 and comparison to its
Xenopus and rat homologs. Nucl. Acids Res. 21, 4982
34. Wright CV. (1993) Hox genes and the hindbrain. Current Biology 3, 618-621
35. Lawler S, Candia AF, Ebner R, Lopez AR, Moses HL, Wright CV, Derynck, R. (1994) The
murine type II TGF- receptor has a coincident embryonic expression and binding
preference for TGF-1. Development 120, 165-175
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Biographical Sketch - Christopher V.E. Wright D.Phil.
36. Pierceall WE, Reale MA, Candia AF, Wright CV, Cho KR, Fearon ER. (1994) Expression of
Xenopus DCC (deleted in colon carcinoma) gene in the embryonic nervous system. Dev.
Biol. 166, 654-665
37. Barnes JD, Crosby J, Wright CV, Hogan BL. (1994) Embryonic expression of Lim-1, the
mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and
neurogenesis. Dev. Biol. 161, 168-178
38. Peshavaria M, Gamer LW, Henderson E, Teitelman G, Wright CV, Stein RW. (1994)
XlHbox8, an endocrine-specific Xenopus homeobox protein, is related to an insulin gene
transcription factor. Mol. Endocrinol. 8, 806-816
39. Guz Y, Montminy M, Stein R, Leonard J, Gamer LW, Wright CV, Teitelman G. (1994)
Expression of Stf-1, a putative insulin gene transcription factor, in duodenal epithelium and
islet cell ontogeny. Development 121, 11-18
40. Toyama R, O’Connell ML, Wright CV, Kuehn MR, Dawid IB. (1995) nodal induces ectopic
goosecoid and lim-1 expression and axis duplication in zebrafish. Development 121, 383391
41. Conlon FL, Wright CV, Robertson EJ. (1995) Effects of the T-Wis mutation on notochord
formation and mesodermal patterning. Mech. Develop. 49, 201-209
42. Gamer L, Wright, CV. (1995) Autonomous endodermal determination in Xenopus:
regulation of expression of the pancreatic gene XlHbox 8. Dev. Biol. 171, 240-251
43. Candia AF, Wright CV. (1995) The expression pattern of Xenopus Mox-2 implies a role in
initial mesodermal differentiation. Mech. Develop. 52, 27-36
44. Zhang X, Wright CV, Hanks SK. (1995) Cloning of Xenopus cDNA for focal adhesion kinase
(FAK) and expression during early development. Gene 160, 219-222
45. Jones CM, Kuehn MR, Hogan BL, Smith JC, Wright CV. (1995) Nodal-related signals induce
axial mesoderm and dorsalize mesoderm during gastrulation. Development 121, 36513662
46. Stoffel M, Stein R, Wright CV, Espinosa R, Le Beau MM, Bell GI. (1995) Localization of
human homeodomain transcription factor insulin promoter factor 1 (IPF1) to chromosome
band 13q12.1. Genomics 28, 125-126
47. Olson LK, Sharma A, Wright CV, Towle HC, Robertson RP, Stein R. (1995) Reduction of
Insulin Gene Transcription in HIT-T15  cells Chronically Exposed to a Supra-physiological
Glucose Concentration is Associated with Loss of STF-1 Transcription Factor Expression.
Proc. Natl. Acad. Sci. USA 92, 9127-9131
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Biographical Sketch - Christopher V.E. Wright D.Phil.
48. Offield M, Labosky P, Ray M, Jetton T, Magnuson M, Hogan BL, Wright, CV. (1996) Pdx-1
is required for pancreatic outgrowth and differentiation of the rostral duodenum.
Development 122, 983-995
49. Lowe LA, Su DM, Sampath K, Yokoyama T, Wright CV, Potter SS, Overbeek P, Kuehn M.
(1996) Conserved left-right asymmetry of nodal expression and alterations in murine situs
inversus. Nature 381, 158-161
50. Jones CM, Dale L, Hogan BL, Wright CV, Smith JC. (1996) Bone morphogenetic protein-4
(BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos.
Development 122, 1545-1554
51. Candia AF, Wright CV. (1996) Expression of Mox-1 and Mox-2 homeoproteins in
vertebrate embryos. Int. J. Dev. Biol. 40, 1179-1184
52. Fernandez A, King LC, Guz Y, Stein R, Wright CV, Teitelman G. (1997) Differentiation of
new insulin-producing cells is induced by injury in adult pancreatic islets. Endocrinology
138, 1750-1762
53. Peshavaria ML, Henderson E, Sharma A, Wright CV, Stein R. (1997) Functional
Characterization of the Transactivation Properties of the PDX-1 Homeodomain Protein.
Mol. Cell. Biol. 17, 3987-3996
54. Woychik R, Hogan B, Bryant S, Eichele G, Kimelman D, Noden D, Schoenwolf G, Wright, CV.
(1997) Pattern formation. Rep. Tox. 11, 339-344
55. Sampath K, Cheng A, Frisch A, Wright CV. (1997) Functional differences among Xenopus
nodal-related genes in left-right axis determination. Development 124, 3293-3302
56. Frisch A, Wright CV. (1998) XBMPRII: a novel Xenopus type II receptor mediating BMP
signaling in embryonic tissues. Development 125, 431-442
57. Wu K-L, Gannon M, Peshavaria M, Offield MF, Henderson E, Ray M, Marks A, Gamer LW,
Wright CV, Stein R. (1997). HNF3 is involved in pancreatic -cell-specific transcription of
the pdx-1 gene. Mol. Cell. Biol. 17, 6002-6013
58. Jetton TL, Moates JM, Lindner J, Wright CV, Magnuson MA. (1998) Targeted oncogenesis of
hormone-negative pancreatic islet progenitor cells. PNAS 95, 8654-8659
59. Sampath K, Rubinstein AL, Cheng AM, Liang JO, Fekany K, Solnica-Krezel, L, Korzh V,
Halpern ME, Wright CV. (1998) Induction of the zebrafish ventral floor plate requires
cyclops/nodal signaling. Nature 395, 185-189
60. Swift GH, Liu Y, Rose S, Bischof L, Steelman S, Buchberg A, Wright CV, MacDonald R.
(1998) An endocrine-exocrine switch in the activity of the pancreatic homeodomain
protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2).
Mol. Cell. Biol. 18, 5109-5120
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Biographical Sketch - Christopher V.E. Wright D.Phil.
61. Gannon M, Wright CV. (1998) Endodermal patterning and organogenesis. In “Cell Lineage
and fate determination” (S. Moody Ed.), San Diego: Academic Press, 583-615
62.
Wright CV. (1998) Lateral asymmetry in multicellular organisms.
Sem. Cell Dev. Biol. 9, 31-3
63. Dutta S, Bonner-Weir S, Montminy M, Wright CV. (1998) Regulatory factor linked to lateonset diabetes? Nature 392, 560
64. Erter CE, Solnica-Krezel L, Wright CV. (1998) Zebrafish nodal-related 2 encodes an early
mesendodermal inducer signaling from the extraembryonic YSL. Dev. Biol. 204, 361-372
65. Osada S, Wright CV. (1999) Xenopus nodal-related signaling is essential for
mesendodermal patterning during early embryogenesis. Development 126, 3229-3240
66. Mankoo BS, Candia AF, Wright CV, Rigby P, Pachnis V. (1999) Germline disruption of the
murine Mox-2 gene results in defects in mesodermal differentiation. Nature 400, 69-73
67. Lawson KA, Dunn NR, Roelin BA, Zeinstra LM, Davis AM, Wright CV, Korving JP, Hogan BL.
(1999) Bmp4 is required for the generation of primordial germ cells in the mouse embryo.
Genes and Development 13, 424-436
68. Gannon M, Gerrish K, Stein R, Wright CV. (1999) pdx-1 in pancreas development and
glucose homeostasis. American Diabetes Association, Proceedings of the Scottsdale
meeting on MODY genes. Pub. Karger Press. Eds. F. Matschinsky and M. Magnuson.
69. Kritzik MR, Jones E, Chen Z, Krakowski M, Krahl T, Good A, Wright CV, Fox H, Sarvetnick N.
(1999) Endocrine progenitor cells in the regenerating pancreas of the IFN transgenic
mouse. J. Endocrinology 163, 523-530
70. Song SY, Gannon M, Washington MK, Scoggins CR, Meszoely IM, Goldenring JR, Marino CR,
Sandgren EP, Coffey RJ, Wright CV, Leach SD. (1999) Expansion of Pdx1-expressing
pancreatic epithelium and islet neogenesis in transgenic mice overexpressing TGFa.
Gastrenterology 117, 1416-1426
71. Kofron M, Demel T, Xanthos J, Lohr J, Sive H, Osada S-I, Wright CV, Wylie C, Heasman J.
(1999) Mesoderm induction in Xenopus is a zygotic event regulated by maternal VegT via
TGF growth factors. Development 126, 5759-5770
72. Ishimaru Y, Yoshioka H, Tao H, Thisse B, Thisse C, Wright CV, Hamada H,
Ohuchi H, Noji S. (2000) Asymmetric expression of antivin/lefty-1 in the early chick
embryo. Mech. Dev. 90, 115-118
73. Gerrish K, Gannon M, Shi D, Henderson E, Stoffel M, Wright CV, Stein R. (2000) Pancreatic 
cell-specific transcription of the pdx-1 gene: The role of conserved upstream control
regions and their HNF3 sites. J. Bio. Chem. 275, 3485-3492
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Biographical Sketch - Christopher V.E. Wright D.Phil.
74. Gannon M, Ray MK, Van Zee K, Rausa F, Costa RH, Wright CV. (2000) Maintained
expression of HNF6 in islet endocrine cells leads to disrupted islet architecture and loss of
beta cell function. Development 127, 2883-2895
75. Cheng AM, Thisse B, Thisse C, Wright CV. (2000) The lefty-related factor Xatv acts as a
feedback inhibitor of nodal signaling in mesoderm induction and L-R axis development in
Xenopus. Development 127, 1049-1061
76. Thisse B, Wright CV, Thisse C. (2000) Activin-and Nodal-related factors control anteroposterior patterning of the zebrafish embryo. Nature 403, 425-427
77. Gannon M, Shiota C, Postic C, Wright, CV, Magnuson MA. (2000) Analysis of the Cremediated recombination driven by rat insulin promoter in embryonic and adult mouse
pancreas. genesis 26, 139-141
78. Gannon M, Herrera PL, Wright CV. (2000) Mosaic Cre-mediated recombination in
pancreas using the pdx-1 enhancer/promoter. genesis 26, 143-144
79. Osada S-I, Saijoh Y, Frisch A, Yeo C-Y, Adachi H, Watanabe M, Whitman M, Hamada H,
Wright CV. (2000) Activin/Nodal responsiveness and asymmetric expression of a Xenopus
nodal-related gene converge on a FAST-regulated module in intron 1. Development 127,
2503-2514
80.
Gonzalez EM, Fekany-Lee K, Carmany-Rampey A, Erter CE, Topczewski J, Wright CV,
Solnica-Krezel L. (2000) Head and trunk development in zebrafish arise via coinhibition of
BMP signaling bozozok and chordino. Genes and Development 14, 3087-3092
81. Dutta S, Gannon MA, Peers B, Wright CV, Bonner-Weir S, Montminy M. (2001) PDX:PBX
complexes are required for normal proliferation of pancreatic cells during development.
PNAS 98, 1065-1070
82. Hui H, Wright CV, Perfetti R. (2001) GLP-1 induces differentiation of IDX-1 positive
pancreatic ductal cells into insulin secreting cells. Diabetes 50, 785-796
83. Wright CV, Cheng AM, Osada S-I, Hamada H. (2001) “Negative feedback inhibiting Nodal
signaling during asymmetrical morphogenesis. HFSP Workshop 10 Report.
84. Wright CV. (2001) Mechanisms of Left-Right Asymmetry: What's Right and What's Left?
Developmental Cell 1 (August), 1-20
85. Gannon M, Gamer LW, Wright CV. (2001) Regulatory regions driving developmental and
tissue-specific expression of the essential pancreatic gene pdx1. Developmental Biology 238,
185-201
86. Erter CE, Wilm TP, Basler N, Wright CV, Solnica-Krezel L. (2001) Wnt8 is required in lateral
mesendodermal precursors for neural posteriorization in vivo. Development 128, 3571-3583
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Biographical Sketch - Christopher V.E. Wright D.Phil.
87. Chytil A, Magnuson MA, Wright CV, Moses HL. (2002) Conditional inactivation of the TGFbeta type II receptor using Cre:Lox. genesis 32, 73-75
88. Brissova M, Shiota M, Nicholson WE, Gannon M, Knobel SM, Piston DW, Wright CV, Powers
AC. (2002) Reduction in pancreatic transcription factor PDX-1 impairs glucose stimulated
insulin secretion. J Biol. Chem. 277, 11225-11232
89. Shih DQ, Heimesaat M, Kuwajima S, Stein R, Wright CV, Stoffel M. (2002) Profound defects in
pancreatic b cell function in mice with combined heterozygous mutations in pdx1, hnf1, and
hnf3. PNAS 99, 3818-1823
90. Schumpert B, Keefer A, Wright CV, Swalla BJ. (2000) Evolution of Left-Right Asymmetry:
Expression of Ascidian Nodal. Amer. Zool. 39:77A #456
91. Kushner JA, Ye J, Schubert M, Burks DJ, Dow MA, Flint CL, Dutta S, Wright CV, Montminy
MR, White MF. (2002) Pdx1 restores ß cell function in Irs2 knockout mice. J. Clin. Invest.
109, 1193-1201
92.
Samaras SE, Cissell MA, Gerrish K, Wright CV, Gannon M, Stein R. (2002) Conserved
sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in
pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6. Mol Cell Biol. 22,
4702-4713
93.
Kawaguchi Y, Cooper B, Gannon M, Ray M, MacDonald R, Wright CV. (2002) The role of the
transcriptional regulator PTF1a in converting intestinal to pancreatic progenitors. Nature
Genetics 32, 128-134
94.
Wright CV, Halpern ME. (2002) Specification of left-right asymmetry. [in “Pattern
Formation in Zebrafish”, ed. L. Solnica-Krezel. Pub. Springer.] Results Probl Cell Differ. 40,
96-116
95.
Nakae J, Biggs WH, Kitamura T, Cavanee WK, Wright CV, Arden KC, Accili D. (2002)
Regulation of insulin action and pancreatic -cell function by mutated alleles of the gene
encoding forkhead transcription factor Foxo1. Nature Genetics 32, 245-253
96.
Kitamura T, Nakae J, Kitamura Y, Kido Y, Biggs WH, Wright CV, White MF, Arden KC,
Accili D. (2002) The forkhead transcription factor Foxo1 links insulin signaling to Pdx1
regulation of pancreatic beta cell growth. J Clin Invest. 110,1839-1847
97.
Means AL, Ray KC, Singh AB, Washington MK, Whitehead RH, Harris RC, Wright CV,
Coffey RJ, Leach SD. (2003) Overexpression of heparin-binding EGF-like growth factor in
mouse pancreas results in fibrosis and epithelial metaplasia. Gastroenterology 124,
1020-1036
98.
Suzuki R, Tobe K, Terauchi Y, Komeda K, Kubota N, Eto K, Yamauchi T,
Azuma K, Kaneto H, Taguchi T, Koga T, German MS, Watada H, Kawamori R,
Wright CV, Kajimoto Y, Kimura S, Nagai R, Kadowaki T. (2003) Pdx1 expression in Irs2deficient mouse beta-cells is regulated in a strain-dependent manner. J Biol Chem 278,
43691-43698
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Biographical Sketch - Christopher V.E. Wright D.Phil.
99.
Mankoo BS, Skuntz S, Harrigan I, Grigorieva E, Candia A, Wright CV,
Arnheiter H, Pachnis V. (2003) The concerted action of Meox homeobox genes is
required upstream of genetic pathways essential for the formation, patterning and
differentiation of somites. Development 130, 4655-4664
100.
Hingorani SR, Petricoin EF, Maitra A, Rajapakse V, King C, Jacobetz MA,
Ross S, Conrads TP, Veenstra TD, Hitt BA, Kawaguchi Y, Johann D, Liotta
LA, Crawford HC, Putt ME, Jacks T, Wright CV, Hruban RH, Lowy AM, Tuveson DA. (2004)
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse.
Cancer Cell 4, 437-450
101.
Mead PE, Parganas E, Ohtsuka S, Morishita K, Gamer L, Kuliyev E, Wright CV, Ihle JN.
(2005) Evi-1 expression in Xenopus. Gene Expression Patterns 5, 601-608
102.
Nomura S, Settle SH, Leys CM, Means AL, Peek RM, Leach SD, Wright CV, Coffey RJ,
Goldenring JR. (2005) Evidence for repatterning of the gastric fundic epithelium
associated with Ménétrier’s Disease and TGF overexpression. Gastroenterology 128,
1292-1305
103.
Jepeal LI, Fujitani Y, Boylan MO, Wilson CN, Wright CV, Wolfe MM. (2005) Cell-specific
expression of glucose-dependent insulinotropic polypeptide (GIP) is regulated by the
transcription factor pdx-1. Endocrinology 146, 383-391
104.
Means AM, Chytil A, Moses HL, Coffey RJ, Wright CV, Taketo MM, Grady WM. (2005)
Keratin 19 gene drives Cre recombinase expression throughout the early
postimplantation mouse embryo. genesis 42, 23-27
105.
Zhang H, Fujitani Y, Wright CV, Gannon M. (2005) Efficient recombination in pancreatic
islets by a tamoxifen-inducible Cre-recombinase. genesis 42, 210-217.
106.
Brissova M, Blaha M, Spear C, Nicholson W, Radhika A, Shiota M, Charron MJ, Wright CV,
Powers AC. (2005) Reduced pdx-1 expression impairs islet response to insulin resistance
and worsens glucose homeostasis. Am. J. Physiology – Endocrinology and Metabolism 288,
E707-E714
107.
Means AL, Meszoely IM, Suzuki K, Miyamoto Y, Rustgi AK, Coffey RJ, Wright CV, Stoffers
DA, Leach SD. (2005) Pancreatic epithelial plasticity mediated by acinar cell
transdifferentiation and generation of nestin-positive intermediates. Development 132:
3767-3776
108.
Hoshino M, Nakamura S, Mori K, Kawauchi T, Terao M, Nishimura YV, Fukuda A, Fuse T,
Matsuo N, Sone M, Watanabe M, Bito H, Terashima T, Wright CV, Kawaguchi Y, Nakao K,
Nabeshima Y-I. (2005) Ptf1a, a bHLH Transcriptional Gene, Defines GABAergic Neuronal
Fates in Cerebellum. Neuron 47: 201-213
109.
Chea HK, Wright CV, Swalla BJ. (2005) Nodal signaling and the evolution of
deuterostome gastrulation. Developmental Dynamics 234: 269-278
Updated 7/13/17
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Biographical Sketch - Christopher V.E. Wright D.Phil.
110.
Pedersen JK, Nelson SB, Jorgensen MC, Henseleit KD, Fujitani Y, Wright CV, Sander M,
Serup P; Beta Cell Biology Consortium. (2005) Endodermal expression of Nkx6 genes
depends differentially on Pdx1. Dev Biol. 288:487-501
111.
Glasgow SM, Henke RM, Macdonald RJ, Wright CV, Johnson JE. (2005) Ptf1a determines
GABAergic over glutamatergic neuronal cell fate in the spinal cord dorsal horn.
Development 132:5461-5469.
112.
Takahashi S, Onuma Y, Yokota C, Westmoreland JJ, Asashima M, Wright CV. (2006)
Nodal-related gene Xnr5 is amplified in the Xenopus genome. genesis 44: 309-321
113.
Miyatsuka T, Kaneto H, Shiraiwa T, Matsuoka TA, Yamamoto K, Kato K, Nakamura Y, Akira
S, Takeda K, Kajimoto Y, Yamasaki Y, Sandgren EP, Kawaguchi Y, Wright CV, Fujitani Y.
(2006) Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia
through Stat3 activation. Genes Dev. 20:1435-1440
114.
Fukuda A, Kawaguchi Y, Furuyama K, Kodama S, Horiguchi M, Kuhara T, Koizumi M,
Boyer DF, Fujimoto K, Doi R, Kageyama R, Wright CV, Chiba T. (2006) Ectopic pancreas
formation in Hes1 -knockout mice reveals plasticity of endodermal progenitors of the gut,
bile duct, and pancreas. J Clin Invest. 116:1484-1493
115.
Fukuda A, Kawaguchi Y, Furuyama K, Kodama S, Kuhara T, Horiguchi M, Koizumi M,
Fujimoto K, Doi R, Wright CV, Chiba T. (2006) Loss of the major duodenal papilla results
in brown pigment biliary stone formation in pdx1 null mice. Gastroenterology 130:855867
116.
Fujitani Y, Fujitani S, Boyer DF, Gannon M, Kawaguchi Y, Ray M, Shiota M, Stein RW,
Magnuson MA, Wright CV. (2006) Targeted deletion of a cis-regulatory region reveals
differential gene dosage requirements for Pdx1 in foregut organ differentiation and
pancreas formation. Genes Dev. 20:253-266
117.
Ripley AN, Osler ME, Wright CV, Bader D. (2006) Xbves is a regulator of epithelial
movement during early Xenopus laevis development. PNAS 103:614-619
118.
Cha YR, Takahashi S, Wright CV. (2006) Cooperative non-cell and cell autonomous
regulation of Nodal gene expression and signaling by Lefty/Antivin and Brachyury in
Xenopus. Dev Biol. 290:246-264
119.
Hruban RH, Rustgi AK, Brentnall TA, Tempero MA, Wright CV, Tuveson DA. (2006)
Pancreatic cancer in mice and man: the Penn Workshop 2004. Cancer Res. 66:14-17
120.
Fujitani Y, Fujitani S, Luo H, Qiu F, Burlison J, Long Q, Kawaguchi Y, Edlund H, Macdonald
RJ, Furukawa T, Fujikado T, Magnuson MA, Wright CV. (2006) Ptf1a determines
horizontal and amacrine cell fates during mouse retinal development. Development 133:
4439-4450
Updated 7/13/17
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Biographical Sketch - Christopher V.E. Wright D.Phil.
121.
Boyer DF, Fujitani Y, Gannon M, Powers AC, Stein RW, Wright CV. (2006) Complementation
rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cisregulatory sequences in pancreatic and duodenal expression. Dev. Biol. 298: 616-631
122.
Ohi Y, Wright CV. (2006) Anteriorward shifting of asymmetric Xnr1 expression and
contralateral communication left-right specification in Xenopus. Dev. Biol. 301: 447-463
123.
Ijichi H, Chytil A, Gorska AE, Aakre ME, Fujitani Y, Fujitani S, Wright CV, Moses HL.
(2006) Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific
blockade of transforming growth factor-beta signaling in cooperation with active Kras
expression. Genes & Dev. 20:3147-3160
124.
Westmoreland JJ, Takahashi S, Wright CV. (2007) Xenopus Lefty requires proprotein
cleavage but not N-linked glycosylation to inhibit nodal signaling. Dev. Dynamics 236:
2050-2061
125.
Wiebe PO, Kormish JD, Roper VT, Fujitani Y, Alston NI, Zaret KS, Wright CV, Stein RW,
Gannon M. (2007) Ptf1a binds to and activates area III, a highly conserved region of the
Pdx1 promoter that mediates early pancreas-wide Pdx1 expression. Mol Cell Biol 27;
4093-4104
126.
Morton JP, Mongeau ME, Klimstra DS, Morris JP, Lee YC, Kawaguchi Y, Wright CV, Hebrok
M, Lewis BC. (2007) Sonic hedgehog acts at multiple stages during pancreatic
tumorigenesis. PNAS 104: 5103-5109
127.
Pascual M, Abasalo I, Mingorance-Le Meur A, Martinez A, Del Rio JA, Wright CV, Real FX,
Soriano E. (2007) Cerebellar GABAergic progenitors adopt an external granule cell-like
phenotype in the absence of Ptf1a transcription factor expression. PNAS 104; 5193-5198
128.
Jarikji ZH, Vanamala S, Beck CW, Wright CV, Leach SD, Horb ME. (2007) Differential
ability of Ptf1a and Ptf1a-VP16 to convert stomach, duodenum and liver to pancreas. Dev
Biol. 304: 786-799
129.
Keller DM, McWheeney S, Arsenilis A, Drouin J, Wright CV, Wang H, Wollheim CB, White
P, Kaestner KH. (2007) Characterization of pancreatic transcription factor Pdx-1 binding
sites using promoter microarray and serial analysis of chromatin occupancy. J. Biol. Chem
282: 32084-32092
130.
Gannon M, Ables ET, Crawford L, Lowe D, Offield MF, Magnuson MA, Wright CV. (2008)
pdx-1 function is specifically required in embryonic  cells to generate appropriate
numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol 314: 406417
131.
Burlison JS, Long Q, Fujitani Y, Wright CV, Magnuson, MA. (2008) Pdx-1 and Ptf1a
concurrently determine fate specification of pancreatic multipotent progenitor cells. Dev
Biol 316: 74-86
Updated 7/13/17
Page 13
Biographical Sketch - Christopher V.E. Wright D.Phil.
132.
Dokmanovic-Chouinard M, Chung WK, Chevre JC, Watson E, Yonan J, Wiegand B,
Bromberg Y, Wakae N, Wright CV, Overton J, Ghosh S, Sathe GM, Ammala CE, Brown KK,
Ito R, LeDuc C, Solomon K, Fischer SG, Leibel RL. (2008) Positional cloning of “LischLike”, a candidate modifier of susceptibility to type 2 diabetes in mice. PLoS Genetics
4(7): e 1000137
133.
Fukuda A, Kawaguchi Y, Furuyama K, Kodama S, Horiguchi M, Kuhara T, Kawaguchi M,
Terao M, Doi R, Wright CV, Hoshino M, Chiba T, Uemoto S. (2008) Reduction of Ptf1a
gene dosage causes pancreatic hypoplasia and diabetes in mice. Diabetes 57: 2421-2431
134.
Yang YP, Wright CV. (2009) Chemicals turn human embryonic stem cells towards beta
cells. Nature Chemical Biology 5: 195-196
135.
Skuntz S, Mankoo B, Nguyen M-T T, Hustert E, Nakayama A, Tournier-Lasserve E, Wright
CV, Pachnis V., Bharti K, Arnheiter H. (2009) Lack of the mesodermal homeodomain
protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the craniocervical joints of the axial skeleton. Developmental Biology 332: 383-395 PMC2898144
136.
Anderson KR, Tores CA, Solomon K, Becker TC, Newgard CB, Wright CV, Hagman J, Sussel
L. (2009) Cooperative transcriptional regulation of the essential pancreatic islet gene
NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. Journal of Biological Chemistry 284:
21236-31248 PMC2781522
137.
Betley JN, Wright CV, Kawaguchi Y, Erdélyi F, Szabó G, Jessell TM, Kaltschmidt JA. (2009)
Stringent specificity in the construction of a GABAergic presynaptic inhibitory circuit.
Cell 139: 161-174 PMC2812434
138.
Wang S, Yan J, Anderson DA, Xu Y, Kanal MC, Cao Z, Wright CV, Gu G. (2010) Neurog3
gene dosage regulates allocation of endocrine and exocrine cell fates in the developing
mouse pancreas. Developmental Biology 338: 28-37 PMC2824035
139.
Marjoram LT, Wright CV. (2010) Rapid differential transport of Nodal and Lefty on
sulfated proteoglycan-rich extracellular matrix regulates left-right asymmetry in Xenopus.
Development 138: 475-485 PMID: 21205792
140.
Pan FC, Wright C. (2011) Pancreas organogenesis: from bud to plexus to gland.
Developmental Dynamics 240: 530-565 PMID: 21337462
141.
Willet S, Wright CV. (2011) Pancreatic plasticity and reprogramming – novel directions
towards disease therapy. Nuclear Reprogramming and Stem Cells. Pub: Springer. Eds: J
Ainscough, S Yamanaka, T Tada.
142.
Dorrell C, Grompe MT, Pan FC, Zhong Y, Canaday PS, Shultz LD, Greiner DL, Wright CV,
Streeter PR, Grompe M. (2011) Isolation of mouse pancreatic alpha, beta, duct and acinar
populations with cell surface markers. Mol Cell Endocrinol. 339:144-150 PMID:
21539888
Updated 7/13/17
Page 14
Biographical Sketch - Christopher V.E. Wright D.Phil.
143.
Yang, YP, Thorel F, Boyer DF, Herrera PL, Wright CV. (2011) Context-specific -to- cell
reprogramming by forced Pdx1 expression. Genes Dev. 25:1680-1685 PMID: 21852533
144.
Ijichi H, Chytil A, Gorska AE, Aakre ME, Bierie B, Tada M, Mohri D, Miyabayashi K, Asaoka
Y, Maeda S, Ikenoue T, Tateishi K, Wright CV, Koike K, Omata M, Moses HL. (2011)
Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse
model of pancreatic ductal adenocarcinoma. J. Clin. Invest. 121:4106-4117 PMC: 3195452
145.
Potter LA, Choi E, Hipkens SB, Wright CV, Magnuson MA. (2011) An RMCE-derived cyan
fluorescent protein reporter allele for Pdx1. genesis (in press) PMID: 21913313
146.
Kopinke D, Brailsford M, Pan FC, Magnuson MA, Wright CV, Murtaugh LC. (2012)
Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas.
Developmental Biology 362: 57-64 PMC3254730
147.
Ahnfelt-RØnne J, JØrgensen MC, Klinck R, Jensen JR, Füchtbauer EM, Deering T,
MacDonald RJ, Wright CV, Madsen OD, Serup P. (2012) Ptf1a-mediated control of Dll1
reveals an alternative to the lateral inhibition mechanism. Development 139: 33-45 PMC3231770
Updated 7/13/17
Page 15
Biographical Sketch - Christopher V.E. Wright D.Phil.
GRADUATE AND POSTDOCTORAL TRAINEES:
Pre-doctoral Trainees earning Ph.D.
1. Albert F. Candia (1990-1994) Research Focus: Mesoderm specifications in Vertebrates.
Postdoctoral fellow at University of California-Irvine, then research scientist at Arbor Vita
Corp., now with Angiogenix Inc.
2. Laura W. Gamer (1990-1994) Research Focus: Homeobox Genes in Vertebrates Embryonic
Endoderm. Currently a tenured research scientist at The Forsyth Institute and faculty
member at Harvard (Boston, MA).
3. Martin Offield (1991-1996) Research Focus: Homeobox Genes in Pancreatic Development.
Postdoctoral Fellow at University of Virginia (VA); now faculty member at Liberty
University, Texas.
4. Amanda Frisch (1994-1998) Research Focus: Homeobox Genes, Growth Factors and
Endodermal Determination. Currently a Resident at Seattle after finishing M.D. at
Vanderbilt University Medical School (Nashville, TN).
5. Caroline Erter Burns (1996-2000) Research Focus: Mesendodermal and Neural patterning
by Nodal-related Signalling in Zebrafish. Currently an Assistant Professor and CoPrincipal Investigator, Cardiovascular Research Center, Massachusetts General Hospital
and Harvard Medical School (Charlestown, MA)
6. Abby Cheng (1996-2001) Research Focus: Anatagonism of Nodal Signals in Mesendodermal
Formation and Left-Right Axis Specification. Previously a Postdoctoral Fellow, Sean
Coughlin Labo, UCSF (2002-2008). Currently the Newton Site Coordinator, Science Club
for Girls (Cambridge, MA)
7. Young-Ryun Cha (2000-2006) Research Focus: Regulation of Nodal Intercellular Signaling.
Currently a Postdoctoral Fellow, Brant Weinstein Lab, Molecular Genetics, NICHD
8. Daniel Boyer (2001-2006) Research Focus: Pancreas Transcription Factors and Endocrine
Differentiation. Currently a Clinical and Anatomical Pathology Resident, Massachusetts
General Hospital and Harvard Medical School (Charlestown, MA)
9. Yuki Ohi (2001 -2006) Research Focus: Long-range Nodal Signaling in Vertebrate L-R
Specification. Currently a Postdoctoral Fellow, Miguel Ramalho-Santos Lab, Stanford
University
10. JJ Westmoreland (2001-2007) Research Focus: Long-range Nodal Signaling in Vertebrate LR Specification. Currently a Postdoctoral Fellow in the Beatriz Sosa-Pineda lab. Genetics
& Tumor Cell Biology, St. Jude Children’s Research Hospital, Memphis, TN.
11. Lindsay Bramson (2005-2010) Research Focus: Long-range Nodal Signaling in Vertebrate
L-R Specification. Currently a Postdoctoral Fellow in the Michel Bagnat Lab, Duke
University.
Current Pre-doctoral Trainees
Angela Halstead
Spencer Willet
Eric Bankaitis
Jessica Sweatt
Updated 7/13/17
(2007-present)
(2007-present)
(2010-present)
(2010-present)
Page 16
Biographical Sketch - Christopher V.E. Wright D.Phil.
Postdoctoral Trainees
1. Karuna Sampath (1995-1996) Growth Factors in Endodermal Determination. Currently:
Senior Principal Investigator at Temasek Lifesciences Laboratory (Singapore)
2. Shin-ichi Osada (1995-1999) Mechanisms of Endodermal Determination and
Regionalization. Currently: Assistant Professor, Akita University (Japan)
3. Maureen Gannon (1996-2000) The Role of pdx-1 Homeobox Gene in Pancreatic
Development and Islet Differentiation. Currently: Associate Professor of Medicine, Cell
and Developmental Biology, and Molecular Physiology and Biophysics at Vanderbilt
University Medical Center (Nashville, TN)
4. Yoshiya Kawaguchi (1999-2002) Transcription Factor Regulation of Exocrine and
Endocrine Pancreatic Cell Lineages. Currently: Researcher, Department of Surgery, Kyoto
University Graduate School of Medicine (Kyoto, Japan)
5. Shuji Takahashi (2002-2004) Nodal signaling in Xenopus embryos. Currently: Research
Fellow at Tokyo University (Tokyo, Japan)
6. Yoshio Fujitani (2000-2005) Influence of upstream conserved sequences on pdx1 function
in vivo. Currently: Research Scientist, First Department of Medicine, Kyoto Prefectural
University of Medicine (Kyoto, Japan)
7. Daniel Boyer (2006-2009) Pancreas Transcription Factors and Endocrine Differentiation,
Currently a Clinical and Anatomical Pathology Resident, Massachusetts General Hospital
and Harvard Medical School (Charlestown, MA)
8. Stuart Hobbs (2009-2011) Nodal vs. Actin as fill inducers of bona fide endoderm. Currently:
a Research Scientist, United States Army
Current Postdoctoral Trainees
Fong Cheng Pan (2007-present)
Pdx1 in mammalian pancreatic development
Yu-Ping Yang (2007-present)
Pdx1 in mammalian pancreatic development
Matthew Bechard (2010-present)
Pdx1 in mammalian pancreatic development
Sebastian Rieck (2011-present)
Epigenetics of pancreas endocrine differentiation
Other Lab personnel:
Michael Ray (1992 – present)
Ashley Burnett (2004-2005)
Kim Crowder (2005-2006)
Xavier Stein (2006-2007)
Eric Bankaitis (2007 – 2009) now a graduate student in the lab
Updated 7/13/17
Page 17
Biographical Sketch - Christopher V.E. Wright D.Phil.
Tim Shehan (2009 – 2010)
Justin Wells (2009 – 2011)
Clayton Ulrey (2009 – 2011)
Joseph Toplon (2011 – present)
Jeff Duryea (2011 – present)
Summer and other short-term students:
Amanda Hall-Walker (Smith) (2004-2005)
Melanie Warnes (2008)
Updated 7/13/17
Page 18
Biographical Sketch - Christopher V.E. Wright D.Phil.
RESEARCH SUPPORT - CUMULATIVE GRANTS (as of 2/16/2011):
ACS
DB-53
“Mox genes in vertebrate mesoderm specification”
7/01/93-6/30/96
$216,000 total direct costs
NIH
RO1HD28062 - Disability Supplement
“Homeobox genes in vertebrate embryonic endoderm”
5/01/94-4/30/96
$40,160 total direct costs
NIH
RO1 HD28062
“Homeobox genes in vertebrate embryonic endoderm”
5/01/94-4/30/97
$642,808 total direct costs
NIH
PO1DK42502 (M. Magnuson, P.I, C.V.E. Wright, Project 4 P.I.)
“Genes of glucose homeostasis and diabetes”
Project 4 - pdx-1 in mammalian pancreatic development
7/01/95-6/30/00
$625,053 total direct costs for project 4
RENEWED - 7/01/00-6/30/05
$669,838 total direct costs for project 4
THIS GRANT WAS RECENTLY ALTERED INTO A U-19 ASSOCIATED WITH THE
INCORPORATION INTO THE BETA CELL BIOLOGY CONSORTIUM.
This led to the extension of the specific aims of the grant and a significant increase in
annual funding – currently ~$300,000/year direct costs.
RENEWED: 08/01/05-07/31/10
Project 4 – Transcriptional networks of pancreas endocrine cell differentiation
$1,187,565 total direct costs for project 4
NIH
P01DK42502 (M. Magnusson, P.I., S. Leach, Core Manager (2000) C.V.E. Wright,
Core Manager, (2001-2005)
“Pancreatic Morphology Core, Core D, Genes of Pancreatic Function and Development”
7/01/00-06/30/05
$280,695 total directs
PI change from Steven Leach to C.V.E. Wright effective March 2001
NIH
1 S10 RR15682-01 (David Miller, PI)
“Zeiss LSM 510 Confocal Microscope”
04/01/2001
Updated 7/13/17
Page 19
Biographical Sketch - Christopher V.E. Wright D.Phil.
NIH
T32 HD07502 (B. Hogan, P.I. (1997-2001) C.V.E. Wright, P.I. (2001-present)
“Training Program in Developmental Biology”
5/01/97-4/30/02
$841,975 total directs (5 pre-doctoral trainees)
PI change from Brigid Hogan to C.V.E. Wright effective March 2001
RENEWED: 5/01/02-4/30/07
$1,098,000 total direct costs (5 pre-doctoral trainees)
RENEWED: 5/01/07-4/30/12
$1,338,068 total direct costs (5 pre-doctoral trainees, 1 postdoctoral trainee)
NIH
RO1 DK56211 (S. Leach, P.I.; Wright, 4% effort 1999-2000; terminated on S.L.
move to Johns Hopkins)
“Surgical studies of pancreatic stem cells”
8/1/99-7/31/04
$183,964 total direct costs
NIH
RO1 GM56238 (C.V.E. Wright, PI)
“Biological roles of nodal-related genes in embryogenesis”
7/01/97-6/30/01
$863,294 total direct costs
RENEWED: 7/01/01-6/30/05
$820,000 total direct costs
RENEWED: 7/01/07-6/30/12
$1,250,000 total direct costs
JDRF 35-2008-626 (H. Semb, PI, C.V.E. Wright, Project 1 PI)
hESC Network Grant – Directed differentiation of human ES cells into bona fide beta cell
progenitors
Project 1: Nodal vs. Actin as full inducers of bona fide endoderm
9/01/08 – 8/31/11
9/01/11 - 8/31/12 No cost extension
$594,000 total direct costs for Project 1
NIH
U01 DK089570-01 (C.V.E. Wright, PI, C.V.E. Wright, Project 1 PI)
“Architecture and communication controlling the efficient generation of beta cells”
9/15/10 - 6/30/14
$1,368,955 annual total project costs
$294,902 annual project 1 direct costs
Updated 7/13/17
Page 20
Biographical Sketch - Christopher V.E. Wright D.Phil.
DEPARTMENTAL/UNIVERSITY ACTIVITIES:
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21.
22.
23.
Vice-Chair, Cell & Developmental Biology Faculty Affairs, VUMC
(2011-present)
Vice-Chair, Cell & Developmental Biology Faculty Affairs, VUMC
(2009-2010)
Chair, Faculty Search Committee, Developmental Neurobiology
(2003-2007)
Director, Developmental Biology Program, VUMC
(1998-present)
Interim V-C Research, Cell Biology Department, VUMC,
(1998-2000)
Planning committee, Medical Research Building III
(1998-present)
Member, Transinstitutional Educational Initiatives Committee
(1998)
Task Force Basic Science Initiatives
(1996)
IGP Executive Committee, Cell Biology Representative
(1994-1998)
Graduate Education Committee for the Medical School
(1994-1998)
Cell Biology IGP Student Recruitment Committee
(1993-1998)
Basic Science Seminar Series Coordinator
(1992-1993)
Cell Biology Course Review Committee
Secondary Faculty Annual Review Committee, Cell Biology Department
Director, Developmental Biology Journal Club
Recruitment, David Miller, David Greenstein, Peter Kolodjiez, various others
Supervisor, in situ/IHC core lab
Cell Biology Renovation committees
CBMS Training Grant Executive Committee (1993-1998)
Highly active support and participation in Cell Biology Journal Club and Research
Seminar
Invited Advisory Committee Member, Mentored Clinical Scientist Development Award
(Bahaa Fadel)
Cell and Developmental Biology Department Recruitment Committee
Cell and Developmental Biology Department Space Planning Committee
FACULTY MENTORING COMMITTEES:
Current Vanderbilt Committees
2005 – present Stacey Huppert, Ph.D. (currently: Assistant Professor, Cell and Developmental
Biology) Committee Chair
2002 - present Guoqiang Gu, Ph.D. (previously: Assistant Professor, Cell and Developmental
Biology, currently: Associate Professor, Cell and Developmental Biology)
2004 – present
Committee Chair
Matt Tyska, Ph.D. (previously: Assistant Professor, Cell and Developmental
Biology, currently: Associate Professor, Cell and Developmental Biology)
Committee Chair
2008 – present
2010 – present
Updated 7/13/17
Kevin Ess, M.D., Ph.D. (currently: Assistant Professor, Neurology, Pediatrics,
and Cell and Developmental Biology) Committee Chair
Wenbiao Chen , Ph.D. (currently: Assistant Professor of Molecular Physiology
& Biophysics)
Page 21
Biographical Sketch - Christopher V.E. Wright D.Phil.
Previous Vanderbilt Committees
2002-2009
Daniela Drummond-Barbosa, Ph.D. (previously: Assistant Professor, Cell and
Developmental Biology, currently: Associate Professor, department of
Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of
Public Health, Baltimore MD) Committee Chair
2009-2010
Trish Labosky, Ph.D. (previously: Associate Professor, Cell and
Developmental Biology, currently: Associate Professor, Cell and Developmental
Biology) Committee Chair
Previous International Mentoring Committees
2010
Anne Grapin-Botton, Ph.D. (Professor, ISREC Institute, Ècole Polytechnique
Fèderalè De Lausanne, Lausanne, Switzerland) Mid-term External Advisor and
Evaluator, Tenure Review Committee
PROFESSIONAL ACTIVITIES OUTSIDE OF VANDERBILT:
(i)
(ii)
(iii)
(iv)
(v)
(vi)
(vii)
(viii)
(ix)
(x)
(xi)
(xii)
(xiii)
(xiv)
(xv)
(xvi)
(xvii)
(xviii)
(xix)
(xx)
(xxi)
(xxii)
Member, Society for Developmental Biology
(1990-present)
Ad hoc member, NIH Biol-2 study section
(1994, 1995)
Site visit, NSF RTG,
(1994)
Baylor Interdisciplinary Graduate Program in Developmental Biology
Site visit, Holland Laboratory (Red Cross)
(1994)
Advisory Committee ad hoc member
Full Member, NIH Biol-2 study section for RO1 and F32 grants
(1995-2000)
Ad hoc reviewer: NSF (Developmental Biology & Neuroscience)
(1996-present)
NIH (Molecular Biology)
Consultant, Genetics Institute
(1996-1997)
JDRF/NASA Strategic Planning Workshop on b cell replacement”
(1997)
Scientific Advisory Board: Ontogeny, Inc., Cambridge, Mass.
(1997-2000)
Editorial Advisory Board, “Developmental Biology”
(1998-present)
Guest Editor, Seminars in Cell and Developmental Biology,
“Lateral Asymmetry in Multicellular Organisms”
(1998)
NIH RFA Study Section “Approaches to Euglycemia”
(1998)
Invited panel member
CSHL zebrafish meeting, attendee/poster presentations,
(1998)
Speaker, American Diabetes Association, MODY meeting, Scottsdale
(1998)
Speaker, Focus on Diabetes, Erice, Sicily, Invited panel member
(1998)
Editorial Advisory Board, “Development”
(1999-present)
Editorial Board, “Genesis”
(1999-present)
Ad Hoc review study section: Genome Study Section Nov 2000
(2000)
NIH study section site visit team, U.Penn PPG (NIDDK; P.I. Dr. M. Lazar)
(2000)
Editorial Board, “TheScientificWorld” web publishing forum
(2001-present)
Ad hoc reviewer CDF4 March 2001
(2001)
Chair, RFA NIH study section for Xenopus Genetics Initiative
(2001)
Updated 7/13/17
Page 22
Biographical Sketch - Christopher V.E. Wright D.Phil.
(xxiii) Ad hoc review; Genome Study Section; and several other study sections for
(2001)
NIDDK and general study sections.
(xxiv) Steering Committee, “NIH Beta Cell Biology Consortium”
(2001- 2005)
Chair, Transgenic Mouse and Gene Inactivation Committee
(xxv) Full Member, NIH DEV-1 Study Section
(2005 - present)
(xxvi) Chair, NIH-DEV-1 Study Section
(2006 - 2008)
(xxvii) CAMB Review Board Member, Univ. Pennsylvania Graduate Program
(2008)
(xxviii) Journal Reviewing:
Cell, Developmental Cell, Neuron, Nature, Science, Genes and Development,
Development, Developmental Biology, Proc. Natl. Acad. Sci. USA, Mechanisms of
Development, Journal of Cell Biology, Gene, Molecular and Cellular Biology,
Experimental Cell Research, J. Biol. Chem., Nature Medicine
Updated 7/13/17
Page 23
Biographical Sketch - Christopher V.E. Wright D.Phil.
PRESENTATIONS/MEETING ORGANIZATIONS/MISCELLANEOUS:
May 1991
October 1991
January 1992
June 1992
August 1992
November 1992
May 1993
June 1993
June 1993
April 1994
November 1994
November 1994
December 1994
February 1996
June 1996
1996
1996
May 1997
June 1997
June 1997
June 1997
November 1997
Updated 7/13/17
Session Chair and Invited Speaker, Southeast Regional Developmental
Biology Conference
Guest Lecturer, Genetics short course, University of Michigan, Ann Arbor
“Molecular genetics of pattern formation in Drosophila (other lecturers: T.
Schupbach, M. Levine, W. McGinnis, S. L. Zipursky) “The role of homeobox
genes in vertebrate development”
Invited Seminar, University of Virginia, Charlottesville (host, Rob Grainger)
Poster Presentation, 4th International Xenopus Conference, Asilomar,
Monterey, California
Invited Speaker, Gordon Conference, Kimball Union Academy, Meriden
N.H., “Peptide Growth Factors”
Invited Participant, NIEHS workshop “Pattern formation”, NIEHS, RTP, N.C.
Invited Speaker and Session Chair, S. E. Regional Developmental Biology
Society meeting, Univ. of Georgia, Athens
Invited Seminar, NIH/FDA (host, Milan Jamrich)
Invited Seminar, U. Illinois at Chicago (host: Karen Colley, Biochemistry)
Session Chair, S. E. Regional Developmental Biology Society meeting, Duke
University
Saint Jude Children’s Research Hospital, Memphis (host, Jim Ihle). “A
homeobox gene is required for pancreatic development and insulin gene
activation”, Invited Speaker
Invited Seminar, Genetics Institute, Boston (host, Gordon Wong)
Invited Seminar, UCLA (host, Eddy De Robertis)
Co-organizer, Keystone Symposium, Hilton Head, South Carolina
Co-organizer, 1996 Society for Developmental Biology National Meeting,
Vanderbilt University
Session Chair/Speaker, CSHL Mouse Genetics Meeting
Invited Seminars (non-conference), Duke (Dan Kiehart), UTSW (Ray
MacDonald), UCSF (Michael German)
Invited Speaker, Joslin Diabetes Center, Boston, MA (host, Mary Loeken)
Invited Speaker, UCSF Dev Biology Program Mini-symposium
Invited Speaker, CSHL Quant Biology Symposium “Pattern Formation”
Invited Speaker, 74th Endocrinology Society meeting, San Diego (declined)
Invited Participant, CSHL/Banbury Center Conference on L-R Asymmetry
Page 24
Biographical Sketch - Christopher V.E. Wright D.Phil.
Spr/Summer 1997 Invited Guest Editorship, Seminars in Developmental Biology
April 1998
October 1998
November 1998
December 1998
1998
March 1999
March 1999
March 1999
April 1999
June 1999
June 1999
September 1999
Summer 2000
August 2000
March 2000
March 2000
Fall 2000
Fall 2000
Fall 2000
Fall 2000
Fall 2000
Fall 2000
2000
August 2000
Updated 7/13/17
Invited Seminar, Annual Mondy-Carroll Lectureship, Williams Baptist
College, Walnut Ridge, Arkansas. “Knockout genes”
Invited Seminar, Blaffer Lecture Series, M.D. Anderson Cancer Center,
Houston. “Pdx-1 regulates pancreas differentiation and b cell function”
Invited Speaker, “ADA: MODYs as Paradigms of the Pathogenesis of Type 2
Diabetes”
Invited Speaker, Erice, Italy. Conference: “Focus on Diabetes”
CSHL Zebrafish meeting attendee and poster presentation
Invited Speaker, Frontiers of Amphibian Biology Conference, Hiroshima
Invited Lecture, Kyoto University (host, Yoshiki Sasai)
Invited Lecture, Osaka University (host, Hiroshi Hamada).
Invited Lecture, University of Pennsylvania Diabetes Grand Rounds
(host, Franz Matschinsky).
Invited Speaker, SDB National Meeting, Charlottesville, VA
Invited Speaker, Developmental Biology Gordon Conference
Invited Speaker, Massachusetts General Hospital Grand
Invited Participant, HFSP Workshop 10, HFSP, Strasbourg, France
“Vertebrate Patterning”
Poster Presentation “Asymmetric Xnr1 expression controlled by an intron
enhancer”, 8th Annual International Xenopus Conference (August 2000
Poster Presentation, NIH Workshop “Stem Cells and the Pancreas”
Invited seminar, Purdue University, host Dr. Steve Konieczny “PDX1 and
pancreas development and function”
Plenary lecture, Human Cell Biology Meeting, Kyoto University and
International Conference Center. Dr. M. Imamura, organizer. “PDX1 and
pancreas development and function”
Invited seminar, Tokyo University, host Dr. M. Asashima “Nodal
signaling and antagonism in Xenopus embryogenesis”
Invited seminar, Tokyo University, host Dr. M. Taira “Nodal signaling
and antagonism in Xenopus embryogenesis”
Invited seminar, Tokyo University, Diabetes Group, host Dr. Kadowaki
“Pdx1 and pancreas development and function”
Invited seminar, Osaka University, host Dr. Hamada “Nodal signaling and
antagonism in Xenopus embryogenesis”
Invited seminar, Osaka Diabetes Group, host Dr. Y. Kajimoto “Pdx1 and
pancreas development and function”
Invited participant: Trans-NIH Xenopus community workshop
Poster presentation, 8th Annual International Xenopus Conference
Page 25
Biographical Sketch - Christopher V.E. Wright D.Phil.
Dec 2000
Invited seminar, Fox Chase Cancer Center, PA. Host Dr. K. Zaret,
Dr. J. Burch “pdx1 and pancreas differentiation and function”
May 2001
June 2001
Plenary Lecture, Pancreatic Cancer Symposium, Vanderbilt University
Invited participant, Juan March Institute meeting, Madrid on “Vertebrate LR asymmetry”
Reviewer, JDRF Center for Islet Transportation at Harvard Medical School
(Newport, RI)
Discussion and Session Leader, “Axis Development and Early Patterning”,
Gordon Research Conference on Developmental Biology (Andover, NH)
Invited Workshop Organizer and participant, “L-R asymmetry.” Society for
Developmental Biology National Meeting, U.W. Seattle
Invited Speaker, “Transcription factor regulation of pancreas
organogenesis”, Department of Cell Biology, Emory University (Atlanta,
GA). Host: Dr. K. Moses
NIDDK “Pancreatic Development, Proliferation, and Stem Cells,” Invited
participant:
Invited Speaker, “Global and tissue-specific requirements for transcription
factors in differentiated pancreatic cells and precursor populations”,
Cincinnati Children’s Hospital, OH. Host: Dr. Michael Bates
June 2001
June 2001
July 2001
September 2001
October 2001
November 2001
January 2002
April 2002
April 2002
May 2002
May 2002
July 2002
August 2002
August 2002
Sept 2002
Updated 7/13/17
Invited Speaker, “Global and tissue-specific requirements for transcription
factors in differentiated pancreatic cells and precursor populations”, Joslin
Diabetes Center Diabetes (MA). Host: Dr. Susan Bonner-Weir
Invited Speaker, “ Global and tissue specific requirements for transcription
factors during pancreas organogenesis and cell type specific differentiation
and maintenance”, 102nd Annual Congress of Japan Surgical Society (Osaka,
Japan)
Keynote Speaker, “Plasticity of pancreatic development”, Mid-Atlantic
Regional SDB Meeting (Washington, DC)
Invited Speaker, UCLA Genetics Seminar Series (CA). Host: Shuo Lin
Invited Speaker, COE Symposium “Replication, Maintenance and
Expression of Genomic Information”, (Osaka, Japan). Host: Dr. Hisato
Kondoh
Instructor, “Gene Inactivation & Lineage Labeling Studies of Pancreas
Formation”, Cold Spring Harbor Labs “Stem Cell” course (4 student contact
hours)
Invited Speaker, ISREC/EMBO “Endoderm” conference (Arolla,
Switzerland)
Invited Speaker, 9th International Xenopus Conference (Cambridge, UK)
Invited Speaker, 14th International Symposium on Regulatory Peptides
(Boston, MA)
Page 26
Biographical Sketch - Christopher V.E. Wright D.Phil.
Oct 2002
Oct 2002
Oct 2002
Nov 2002
Invited Speaker, Markey Special Emphasis Pathway in Human
Pathobiology, Heart Failure course, Washington University (St. Louis, MO)
2 hours student contact
St Louis DRTC Seminar Program, Invited Seminar
Invited Speaker, Rachmiel Levine Memorial Symposium “Advances in Islet
Cell Biology: From Stem Cell Differentiation to Clinical Tranplantation”,
“Differentiation of Embryonic Stem Cells to Insulin-Secreting Structures”
(Anaheim, CA).
Presentation and Breakout Session Leader, Beta Cell Biology Consortium
Investigator Retreat (Anaheim, CA)
Title: “Transcription factor regulation of pancreas development and function”
for all 2003 talks unless noted otherwise
Feb 2003
Feb 2003
Mar 2003
Mar 2003
Apr 2003
Apr 2003
Apr 2003
May 2003
May 2003
May 2003
June 2003
June 2003
July 2003
July 2003
Sept 2003
Updated 7/13/17
Invited Speaker, “Lineage Tracing Studies of Transcription Factors in
Pancreas Development”, UC Irvine (CA) Host: Ken Cho
Reviewer, JDRF Center for Beta Cell Therapy - Europe (Brussels, Belgium)
Invited Speaker, “Pancreatic Ontogeny: The Role of Transcription Factors”,
the 6th International Congress of the Cell Transplant Society (Atlanta, GA)
Invited Speaker, UC San Francisco (CA). Associated with application to
direct UCSF’s new Stem Cell Institute – I withdrew my name from this search
U.C. Denver (host: Lori Sussel), invited seminar
Invited Speaker, University Colorado at Boulder (CO) Host: Jackie Lee
Keynote Lecture, Center for Molecular Liver Studies in Digestive and Liver
Disease 4th Annual Retreat, “Lineage Tracing Studies of Transcription
Factors in Pancreas Development”, (Philadelphia, PA) Host: Ken Zaret
Participant, Joslin Diabetes Center 2003 Symposium “Evading Beta Cell
Death in Diabetes: Prevention and Transplantation” (Boston, MA)
Invited Speaker, Banting and Best Diabetes Center 14th Annual Scientific
Day, “Lineage Tracing Studies of Transcription Factors in Pancreas
Development” (University of Toronto) Host: Daniel Drucker
Invited Speaker, AGA at Digestive Disease Week 2003, ”Transcriptional
Control of Pancreas Organogenesis and Function” (Orlando, FL)
Invited Speaker and Conference Summation, Instituto Juan March des
Estudios Workshop on Developmental Mechanisms in Vertebrate
Organogenesis (Madrid, Spain)
Invited Speaker, “Pancreatic Progenitor Cells”, American Diabetes
Association 63rd Annual Meeting (New Orleans, LA)
Reviewer, JDRF Summer 2003 Stem Cell Center Review (New York, NY)
Participant, Society for Developmental Biology 62nd Annual Meeting
(Boston, MA) Candidate for 2004 Southeast SDB Representative
Invited Speaker, Northwester University Pancreatic Development and
Disease Modeling Conference (Chicago, IL)
Page 27
Biographical Sketch - Christopher V.E. Wright D.Phil.
Oct 2003
Invited Speaker, “Gene manipulation on the pdx-1 pancreatic homeobox
gene”, Inaugural International Stem Cell Conference “Stem Cells: From
Bench to Bedside” (Singapore, Japan)
Feb 2004
Invited Speaker, “Manipulation on the pdx1 and ptf1a pancreas
transcription factor genes”, Keystone Symposia “Signaling in Vertebrate
Organogenesis” (Santa Fe, NM)
Invited Speaker, “Gene Knockout and Lineage Studies of Pancreas
Transcription Factors”, Keystone Symposia “Diabetes Mellitus: Molecular
Signaling, Genes and Therapeutics/Molecular Control of Adipogenesis and
Obesity” (Banff, Canada)
Invited Speaker, “Manipulation on the pdx1 and ptf1a pancreas
transcription factor genes”, Developmental Biology Annual Symposium and
Genetics 2004 (Roslin Institute, Warwick, England)
Participant, JDRF “Beta Cell Regeneration Workshop” (New York, NY)
Keynote Speaker, “Transcription Factor Regulation of Pancreas
Organogenesis and Function”, 29th Annual Arnold Lazarow Memorial
Lecture, University of Minnesota Medical School (MN) Host: G. Eric Bauer
Organizer and Session Chair, Vanderbilt University Summer Conferences
“Frontiers in Genome Engineering: Building A Better Mouse” (Nashville, TN)
Invited Speaker, Society for Developmental Biology 63rd Annual Meeting,
University of Calgary (Alberta, Canada)
Invited Speaker, “Pancreas Specification and Linage Diversification: control
by the Pdx1 and Ptf1a transcription factors”, FASEB Summer Research
Conference, “Mechanisms of Liver Growth, Development, and Disease”
(Snowmass, CO)
Invited Speaker, “Model Development. Modifier and Marker Genes” Session,
“Pancreatic Cancer in Mice and Men: The Penn Workshop 2004”
(Philadelphia, PA)
Mar 2004
Mar 2004
Mar 2004
May 2004
June 2004
July 2004
August 2004
Dec 2004
June 2005
July 2005
August 2005
November 2005
Updated 7/13/17
Invited Speaker and Session Chair, “Pancreas Specification and Lineage
Diversification: Control by the Pdx1 and Ptf1a Transcription Factors”, 10th
US-Japan GI & Liver Meeting in 21st Century, (Kyoto, Japan)
Participant, Society for Developmental Biology 64th Annual Meeting (San
Francisco, CA)
Invited Speaker, “Pancreas Transcription Factors: Lineage Tracing and Cell
Fate Determination”, FASEB Summer Research Conference,
Gastrointestinal Tract XI: Innovations in GI Research & Therapy”
(Snowmass, CO)
Invited Speaker, “Development of efficient high-output methods for
identifying pancreas differentiation regulatory genes”, Russell and Angela
Berrie Cell Therapy Program in Diabetes (New York, NY)
Page 28
Biographical Sketch - Christopher V.E. Wright D.Phil.
November 2005
November 2005
February 2006
April 2006
May 2006
May 2006
June 2006
June-July 2006
September 2006
September 2006
October 2006
October 2006
November 2006
February 2007
March 2007
April 2007
Updated 7/13/17
Invited Speaker, “Lineage Tracing and genetic pathways of pancreas and
foregut differentiation”, Institut de Recherches Cliniques de Montreal
(IRCM) Pfizer Lecture Series (Montreal, Canada)
NCI NIH Site Team Visit Participant, Laboratory of Protein Dynamics and
Signaling (Frederick, MD)
Meeting Organizer, “Pancreatic Islets: From Development to
Transplantation”, Chair of Joint Plenary Session “Joint Session with the
Transplantation Meeting”, and Speaker “Analysis of Gene Networks
Regulating Zebrafish Pancreas Development”, Keystone Symposium, (Taos,
New Mexico)
Invited Speaker, Department of Biological Sciences, Tennessee State
University (Nashville, TN)
Participant, BCBC Workshop of Gene Regulatory Networks and
Bioinformatics and BCBC Investigator Retreat (Waltham, MA)
Keynote Speaker, UC-Irvine Cancer Center Developmental Biology Program
Retreat (Laguna Beach, CA)
Attendee, 65th Annual Society for Developmental Biology Meeting (Ann
Arbor, MI)
Attendee, The 4th Annual International Society for Stem Cell Research
Meeting (Toronto, Ontario, Canada)
Invited Speaker, “Anterior-ward shifting and unilateral expression of Xnr1
in L-R specification”, 11th International Xenopus Conference (Kisarazu,
Tokyo) Host: Masanori Taira
Invited Speaker, “Dissecting transcriptional networks regulating pancreas
development”, University of Tokyo, (Tokyo, Japan) Host: Yoshio Kawaguchi
Participant, BCBC Investigator Planning Meeting (Philadelphia, PA)
Invited Speaker, “Programming Pancreatic Beta Cells” EMBO/FEBS/JDRF
Workshop (El Perello, Spain)
Member, External Review Committee, Center for Developmental Genetics,
SUNY-Stonybrook (Stonybrook, NY)
Invited Speaker, “Transcription Factor Guidance of Pancreas Specification
and Lineage Diversification”, Duke University Medical Center (Durham NC)
Host: Brigid Hogan
Graduate Student Invited Speaker, “Transcription Factor Guidance of
Pancreas Specification and Lineage Diversification”, Developmental
Genetics Program, Skirball Institute (NYC, NY) Host: Ryan Cinalli (Student
Host)
Invited Speaker, “Left-Right field patterning & contralateral communication in
Xenopus”, Department of Molecular & Human Genetics Tuesday Noon Seminar
Series, Baylor College of Medicine (Houston, TX) Host: Milan Jamrich
Page 29
Biographical Sketch - Christopher V.E. Wright D.Phil.
May 2007
Mat 2007
July 2007
September 2007
September 2007
September 2007
October 2007
November 2007
November 2007
March 2008
March 2008
March 2008
April 2008
May 2008
May 2008
September 2008
November 2008
December 2008
Updated 7/13/17
Invited Speaker, “Transcriptional Control of Pancreas Specification and
Lineage Diversification”, Division of Developmental Biology, Cincinnati
Children’s Hospital (Cincinnati, OH) Host: Jim Wells
Speaker, “Threshold requirements for pdx1 in the maturation of beta cell
progenitors”, BCBC Investigator Retreat (Washington, DC)
Organizer, “Frontiers in Genome Engineering: Building A Better Mouse II”,
Vanderbilt University (Nashville, TN)
Invited Speaker, “Pancreas development: the frog leads the mouse”,
Symposium Programme honoring the 60th Birthday of Eddy De Robertis,
EMBL (Heidelberg, Germany) Host: Iain Mattaj
Invited Speaker, “Transcription Factor Control of Pancreas Specification
and Lineage Diversification “, Developmental Genetics/Centre for
Biomedicine, University of Basel (Basel, Switzerland) Host: Rolf Zeller
Speaker, “Stem Cells”, BCBC Investigator Planning Meeting (Boston, MA)
Invited Speaker, “Transcription Factor Control of Pancreas Specification
and Lineage Diversification “, 2nd Annual Developmental Biology Fall
Symposium, University of Georgia (Athens, GA) Host: Nancy Manley
Review Panel Member, CSR Open House Workshop: Integrated Biological II,
NIH (Bethesda, MD)
Keynote Speaker, “Transcription factor control of pancreas specification
and lineage diversification”, University of Pittsburgh Endocrinology and
Metabolism Basic Science Retreat (Pittsburgh, PA) Host: Donald Scott
Invited Speaker, “Transcriptional regulation of pancreas progenitors and
lineage diversification”, University of Nebraska Eppley Institute for Cancer
Research (Omaha, NE)
Graduate Student Invited Speaker, “Left-right asymmetry – long distance
signaling and tissue morphogenesis”, University of Pennsylvania
Department of Cell and Developmental Biology (Philadelphia, PA)
Invited Speaker, “Pancreas progenitor flux: control by Pdx1 and Ptf1a” ,
Fox Chase Cancer Center (Philadelphia, PA) Host: Ken Zaret
Keystone Symposia Meeting Organizer, “Islet and Beta Cell Development
and Transplantation” (Snowbird, UT)
Attendee, Upper Midwest Islet Club (meeting of many regional diabetes
research labs). Vanderbilt University (Nashville, TN)
Invited Lead-off Speaker, “Diabetes and cell therapy – developmental
biology and ES cells”, Training Course 2008 - Strategies in directed
differentiation of ES cells into mature cell types for therapy, JDRF Center
for Beta Cell Therapy in Diabetes (Copenhagen, Denmark)
Attendee, 12th International Xenopus Conference (Mosel, Germany)
Attendee, BCBC Investigator Retreat, University of Pennsylvania
(Philadelphia, PA)
Invited Speaker, “Pancreas progenitor flux: control by Pdx1 and Ptf1a”,
University of Western Ontario (London, Canada) Host: C. Pin
Page 30
Biographical Sketch - Christopher V.E. Wright D.Phil.
December 2008
Invited Speaker, “Pancreas progenitor flux: control by Pdx1 and Ptf1a”,
Columbia University (NYC, NY) Host: Lori Sussel
January 2009
Invited Speaker, “Ptf1a and Pdx1 regulation of progenitor flux in the main
phase of pancreatic organogenesis”, University of Michigan (Ann Arbor, MI)
Host: Deneen Willek
Invited Speaker, EMBO Beta Cell Differentiation & Regeneration
(Edinburgh, Scotland)
Keynote Speaker, SE Regional Society for Developmental Biology Annual
Meeting (Birmingham, AL) Host: Brad Yoder
Speaker, Progenitor to differentiated cell conversions”, BCBC Investigator
Retreat (Chantilly, VA)
Participant, “Understanding and Controlling Pancreatic development”
Workshop, University of Lund (Copenhagen, Denmark) Host: Henrik Semb
Invited Speaker, Medical School of Geneva (Geneva, Switzerland) Host: Pedro
L. Herrera
February 2009
March 2009
May 2009
June 2009
July 2009
January 2010
February 2010
March 2010
March 2010
June 2010
July 2010
August 2010
October 2010
November 2010
November 2010
Updated 7/13/17
Graduate Student Invited Speaker, “Progenitor regulation by transcription
factors in pancreas organogenesis”, University of Pennsylvania (Philadelphia,
PA) Host: Mitchell A. Lazar
Invited Speaker, “Progenitor behavior in pancreas organogenesis and mature
organ regeneration”, EPVL SV ISREC (Lausanne, Switzerland) Host: Anne
Grapin-Botton
Speaker, JDRF Niche Workshop, Session 1 – Differentiation of hESC to betacells: Where are we now? - “A critical overview of the field”, JDRF (New
York, NY)
Invited Speaker, CDB Symposium 2010 Frontiers in Organogenesis,
“Progenitor regulation by transcription factors in pancreas organogenesis”,
(Kobe, Japan)
Invited Speaker, ADA 70th Scientific Sessions, “Transdifferentiation within
endocrine cells”, (Orlando, FL)
Invited Speaker, UK NSCN Third Annual Scientific Conference, (Nottingham,
UK)
Invited Speaker and Discussion Participant, “Lessons from developmental
biology of the beta cell”, European Association for the Study of Diabetes
(Oxford, UK)
Invited Speaker, Joslin Diabetes Seminar, ““Commitment issues:
reprogramming in pancreatic endocrine cells driven by transcription factor
regulation”, (Boston, MA) Host: Susan Bonner-Weir
Invited Speaker, “Progenitors, lineage allocation and plasticity in pancreas
formation”, Institute of Medical Biology (Singapore) Host: Ray Dunn
Invited Speaker, “Left-right asymmetry: a process regulated by fast farranging movement of nodal and left ligands”, Temasek Life Sciences
Laboratory (Singapore) Host: Karuna Sampath
Page 31
Biographical Sketch - Christopher V.E. Wright D.Phil.
September 2011
September 2011
October 2011
Updated 7/13/17
Invited Speaker, “Pancreatic cell reprogramming – plasticity under duress”,
University of Minnesota Stem Cell Institute (Minneapolis, MN) Host: Jonathan
Slack
Invited Speaker, “Pancreatic cell reprogramming plasticity under duress”, UT
Southwestern (Dallas, TX) Host: Ondine Cleaver
Invited Speaker, “Transcriptional regulation of pancreas development”,
BetaCell Workshop 2011 (Copenhagen)
Page 32