"Growth and Innovation opportunities and the
key players within BIO-IT in Europe"
An overview of opportunities for Bioinformatics knowledge and skills to
be exported into other industries and who in Europe is already
considering these areas.
Introduction of international consultants to work on innovative Bio-IT
projects with Finnish companies.
Today's presentation

Cait Murray,

CEO of Strategic Scientific Consulting

Life Sciences consulting company based in Scotland with
expertise in Informatics and Computational Chemistry
software business.



Formerly employee of Accelrys.
Worked with TEKES on the survey of Bioinformatics crosspollination to other industries in 2012.
Worked successfully with Finnish companies and organisations
for past 15 years.
The World of Bio-IT
Data
Applications
Data
Knowledge
Skills
Applications of Bioinformatics
Not just Human Health any more!


Cost of analysis and storage are reducing
If it is, or was, capable of respiration it has a
genome

8.7 million eukaryotic species on our planet

give or take 1.3 million. (counted Aug 2011)

Bacteria guesstimates 10 million to a billion

300,000 recognised species of plants
How much don't we know?


How many species have been sequenced?

Gold (genomes online database) had 4325
complete and 20131 incomplete, 30th Mar 2013

Barcode of Life, University of Guelph’s
database, currently includes 240,000 species.
Issues with quality of historic data
available.
Growing Acknowledgement

Bio-IT World


Also European event, now in its 5th year.
Health Informatics and Bioinformatics


April 9-11, 2013, World Trade Centre, Boston
5th international event, 27-29th Sept Ankara
Plant and Genome XXI Jan 12-16 Sand Diego

Dedicated workshop : Strategies For Leveraging
Bioinformatics and Genomic Data to Advance Food
Security
Tests for Food Safety

Must have product of the year


Traditionally tests work on immunological
premises therefore require to know what is
being sought

Looking for harmful items – mainly common bacteria

Cheap
New challenge

Identify what is there and what should not be
there at trace amounts

Sensitive testing, reliable reference database
Hot off the Press
Not just Europeans

“Oceana, the world’s largest marine
conservation organization, surveyed
seafood products being sold in American
stores and restaurants, and found a third
of over 1,200 samples were not as
advertised, and almost half of the 674
retail outlets screened were selling mislabeled fish.”

Snapper was found to be Tilapia;

Atlantic Cod was White Hake;

White tuna was Escolar. (National Post, 13
th
Mar 2013)
Is it what it says it is?

Also applies to Food Authenticity

EU regional “Geographical indications”

Food Industry IP

Lapin puikula, ‘karjalanpiirakka’ and ‘sahti’

Localised information, DNA, sometimes breed
specific
Saanko esitellä?

FERA
(Food and Environment Research Agency,
York, UK)


Nestle


Richard Thwaites
Patrick Descombes
Campden BRI, Gloucestershire, UK

John Dooley
Food Security


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US Feed the Future

The US government's global hunger and food
security initiative

Gates' Foundation research interests.
European Directive to reduce by half the
number of people suffering from hunger by
2015
Increasing policy in this area

Protection for Africa

Protection for Europe
Plant Science


Projects to collect genomic data on all living
things

Finland leads the way on Pine genome

Barcode of Life – Guelph Uni, Canada
Rijk Zwaan collaboration with Eagle
Genomics

accelerate plant trait prediction such as disease
resistance, taste, yield, and other factors.

Chris Rawlings of Rothampsted Inst

Manuel Peitsch of SBI
Other Ag research innovators


Parco Tecnologico Padano - Lodi cluster
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Incubator facility at the University of Milan and one
of europes leading Ag-Bio research centres.

Looking at Goats especially for sustainable food in
Africa
India http://nabg.iasri.res.in/


Allergans – safety of GM crops.
Monsanto and Atlas Venture Press Release 14

th
April 2011
strategic investments in a number of technology focus areas
within agriculture, including genomics, informatics and
biology.
Environment


CLC bio, a bioinformatics sequence analysis
software provider, announced that Sapphire Energy
(a leader in algae-based Green Crude oil
production) has installed a custom made
bioinformatics solution from CLC bio in their
research center in San Diego. Dec 16, 2011
Linked In group

Bioinformatics and computational analysis of
microbes for biofuel production

163 members
Market



US spend on Advanced Biofuels R&D
predicted to be $0.7 billion by 2016
(BioEconomic Research Associates report Feb
2009 “Economic Impact Advanced Biofuels)
Novozymes Has 10% of the $1 billion global
bioagriculture market
EU spent €3.2billion in 2007 and €3billion in
2008 for biofuel research and development
(R&D) but focus in changing away from crop
based solutions
Potential from Bacteria


DSM working actively to solve the
problems created by competitive demand
of land for food and land for fuel

Bacterial/algae production of biofuel

Hans Roubos - Principal Scientist
Bioinformatics & Modeling
Team at Brown Uni looking at Microbiome
of panda intestinal tract looking for clues
of how to break down tougher cellulose
structures
Market Opportunity
Europe Population
740 million
Finland Population
5.4 million
Bioinformatics markets
“ Bioinformatics is the application of information
technology to the life sciences to increase the
understanding of biological and chemical processes.
It is the study of the methods for storing, retrieving
and analyzing biological data, a wealth of which is
growing rapidly and thus feeding demand for more
bioinformatics. Fields that benefit from the output of
bioinformatics are many, including especially
agricultural biotechnology, pharmaceutical research
and development, and medical and clinical
diagnostics.”

Global Market size 2012
$2.3 Billion

Predicted Market size 2018
Billion
$9.1
How to make predictions a reality?

Take Bioinformatics further within
traditional areas



More accurate, comprehensive, easier to use
information and knowledge acquisition for specific
disease areas.
Personalised Medicine as a B-2-C (deCODE
Genetics)
Push the boundaries into new areas

Predictive Toxicology & new areas of the Drug
Discovery process
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Handling of larger datasets

Acquisition of new datasets
Healthy Pets and more Healthy Meat

Animal Health companies dominated by

Merck Animal Health (Intervet / Schering-Plough)
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Zoetis (Pfizer Inc.)
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Merial, Inc.
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Bayer HealthCare Animal Health Division

80% market covered by top 10 companies

Predicted to be US$42.9 billion by 2018

Bioinformatics identified as a business
strategy in recent market report
(Reportlinker, Nov 2012)
Animal Health

Royal Veterinary College, London

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
Bevan McWilliam – Innovation manager

Victoria Offord
Zhangrui Cheng

Adam Witney
Richard Tyler
ARK Genomics, Roslin Inst

(birth place of PPL Therapeutics & Dolly the Sheep)

Mick Watson, Director of Bioinformatics
Pure Research

Vincent Laudet, Dir functional Genomics Inst, Lyon
Human Health/Pharma Research
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David Pisano,
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Prof Barbara Demeneix
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Paris National Museum of Natural History molecular
physiology and endocrinology also www.watchfrog.fr
Michel Souchet, Harmonic Pharma, France

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Spain's Centre Nacional de Investigaciones Oncologicas
Preclinical Compound Profiling, Drug Repositioning &
Natural Compound Valorization
Cedric Merlot, drugdesigntech, Geneva

Predictive Toxicology and Biocorpora
Medical Imaging
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Opportunities for

Analysis of data & Handling of digital files
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Integration of knowledge into Clinical Trials data and R&D
Pure research

Peter Van der Spek Erasmus

Neuroscience with Bioinformatics and Medical Imaging.
Big Data and Medical Imaging Informatics for
Oncology

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Omer Casher - Imaqa
Research Services & Training

Roger Gunn - Imanova
BioBanks/Personalised Medicine

DeCODE genetics

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London Genetics International
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Iceland, masters of innovation in this area.
Elizabeth Foot VP Personalised Medicines & Nutrition
Ariana Pharma
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Mohammad Afshar
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Rancho Biosciences

Tissue Solutions
ICT - Big Data

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Opportunities in 4 areas

Data as a Service (DaaS),

Software as a Service (SaaS),

Platform as a Service (PaaS),

Infrastructure as a Service (IaaS),
Hot Topic

Seattle-based Spiral Genetics has raised $3
million for its service that helps researchers in
academia and industry more quickly analyze raw
sequence data. 12th Mar 2013.
ICT - Cloud
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Mainly happening in US.

Distributed Bio, San Francisco based Cloud
Bioinformatics

Amazon Web Service - Life Sciences
Collaboration between researchers and
complex data, including 1000 Genomes
project (a public/private project)
BioIT world Cloud Summit Sept 11-13, San
Francisco

Many more commercial speakers than the
cloud stream in Bio-IT Europe, Vienna (1)
And Elsewhere

Some European efforts


Eagle seeks £1m for new cloud technology
(Sept 2012)
Some Global

The CompBio Experiment – global
participation

The open experiment started last July with
160 organizations and 25 teams, helping
industry end-users explore access and use of
remote computing resources available from
computing centres and from the cloud.
Support Services

Underpinning the Applications are experts in
niche areas

Data Supply eg NGS Sequencing,
Instrumentation
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Information handling eg Database management

Consultancies

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outsourcers of science or skill provision
Training

Not academic qualification, but industrial
focus
Sequence Service Providers

Growing need for new data, Growing need for
better data

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
Several in Finland, Many more across Europe

Genterprise, Germany

DTU Multi-Assay Core (DMAC), Denmark

PersMed, Czech Republic
Almost a commodity, average prices <€1K
Illumina world leaders on technology

Scott Kahn, CIO Illumina
Infrastructure and Support

ERBI – European Project ELIXIR


John Overington ERBI
Training – for the job not academic degree

Pedro Ferandes

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Bioinformatics Training Coordinator at
Instituto Gulbenkian de Ciência
Chair, Education and Training Committee at
EMBnet
Consultancies


Building on increase tendency for out-sourcing
there are growing opportunities in providing
science/technology of Bioinformatics through
consultancies

Almac Group, Integromics, Virtosia

Eagle Genomics : Richard Holland – CBO
Also a breed of service to take software to the
market.

Massimo de Francesco - Eccelis

Eccelis assists companies with innovative scientific
software products to expand into the Europe
Market Opportunity is not all one way

At Bio-IT Europe in Vienna in 2012

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Usual faces of
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Software providers

High Performance Computing power
A few predictable new comers
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Data content

Data Protection

CRO

Software Developer
New skills, new technologies for Bio-IT

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Linguamatics
Natural language
processing (NLP)-based
text mining

Virtalis

Virtual Reality,

Haptic Cow,

3d Visualisation

Tetrabytes of
on-the-fly
calculations

Steve Carpenter
It's all about the money!
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Product Development

Expertise in understanding customer needs

Expertise in understanding technology
Commercial success

Right product, right place, right price

Right promotion, right placement

Get the Marketing and Sales right

Get the funding to do it correctly

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Management Events

Miruna Cosma

Vilma Westerlund
TEKES


Teppo Tuomikoski
Ja kiitos mielenkiinnostanne