PD36
The probability of distribution Alfa-gal associated allergy in Ukraine
Svitlana Zubchenko
Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
Background: Annually number of reports about anaphylaxis caused by food products increases. The
development of IgE-mediated reactions to food that is well tolerated in the past, now, sometimes is a true
diagnostic and therapeutic challenge for the patient and the doctor. An example of such allergies is delayed
allergy to red meat that is associated with the formation of IgE antibody to the oligosaccharide galactosealfa-1,3-galactose (Alfa-gal). During evolution human body formulated the immunological tolerance to Alfagal production through IgG. Factor launch IgE-mediated process are tick bites, which linked the spread of
geographical features of this type of food allergy (FA). Proved that serious manifestations of anaphylaxis
occur in conditions of consumption of fatty meat or large quantities of meat. Determined that Alfa-gal
epitope transmitted through the milk that gives grounds to say about later reaction to this product. It is
believed that the alternative cause of sensitization to Alfa-gal infection are different types of parasites.
Aim: The aim of our study was to determine the probability of distribution associated Alfa-gal allergy
among Ukrainian patients.
Results: We conducted a comparative assessment of different components of the ticks saliva, on which was
identified allergic reactions to Alfa-gal in the USA (Amblyomma americanum), Australia (Ixodes holocyclus)
and Europe (Ixodes ricinus). The same ingredients not found in these types of ticks, but each of them has a
specific immunotropic action. In particular, I. ricinus, prevalence of which in Ukraine in recent years
increased by 14-18% containing biological substances that intensified alternative pathway of complement
activation, Th2-response, inhibited proliferation of B lymphocytes.
Conclusion: Ukraine has a high probability of spreading Alfa-gal associated FA. The arguments are the
same: rising prevalence of I. ricinus, Ukrainian traditional consumption of fatty foods and dairy products,
high prevalence of parasitic invasions. There is a necessity of component diagnostics Alfa-gal, which today
is not performed. In this case the only way to diagnose is carefully collected history.
POSTER DISCUSSION SESSION 2:
Management of food allergy • Diagnosis and treatment • Epidemiology • Therapeutic options