REGIS J. O’KEEFE, MD, PhD
Curriculum Vitae
Personal
Office address: Washington University School of Medicine
660 South Euclid, Campus Box 8233
St. Louis, MO 63110
Phone:
314-747-8414
Fax:
314-747-2599
Email:
[email protected]
Home address: 4545 Forest Park Avenue, Apt B209, St. Louis, MO 63108
Born:
August 4, 1959, Pittsburgh, PA
Married:
July 23, 1983, Carol Lee Gabardine
Children:
Patrick Regis, born June 26, 1990
Daniel Eugene, born April 2, 1992
Kaylin Marie, born October 18, 1994
Abigail Lee, born December 16, 1997
Education and Training
Baldwin High School, Pittsburgh, PA 1973 – 1977
Highest Honors
Class President
Student Council President
Yale University, 1977 – 1981, B.A.
Phi Beta Kappa
Magna Cum Laude
Distinction in Major (Philosophy and Religious Studies)
Varsity basketball letter, 197 – 81, Captain 1980 – 81
Freshman Counselor, 1980 – 81
Harvard Medical School, 1981-1985, M.D.
Admissions Committee, 1982 – 83
Cardiovascular Research, Massachusetts General Hospital, 6/83 to 8/83 and 1/85 to 5/85
University of Rochester, School of Medicine and Dentistry, 2000, Ph.D.
Biochemistry and Biophysics
New England Deaconess Hospital, Harvard Medical School, 1985 – 86
Surgical Internship
University of Rochester School of Medicine and Dentistry, Instructor and Fellow in
Research, Orthopaedic Research Laboratories, 6/86 to 6/88 Endocrinology Training
Grant, 1986 – 1988
Resident in Orthopaedics, The University of Rochester Medical Center, Rochester, NY,
7/88 - 6/92
Fellowship in Orthopaedic Oncology, Massachusetts General Hospital, 7/92 – 6/93
Academic Appointments
Instructor, Orthopaedics, University of Rochester School of Medicine and Dentistry,
Rochester, NY, 7/93 – 3/94
Assistant Professor, Orthopaedics and Oncology, University of Rochester School of
Medicine and Dentistry, Rochester, NY, 4/94 – 04/97
Associate Professor, Orthopaedics and Oncology, University of Rochester School of
Medicine and Dentistry, Rochester, NY, 4/97 – 6/00
Professor, Orthopaedics, University of Rochester School of Medicine and Dentistry,
Rochester, NY, 6/00 – 09/14
Director, Center for Musculoskeletal Research, University of Rochester School of
Medicine and Dentistry, Rochester, NY, 7/05 – 11/11
Chair, Department of Orthopaedics and Rehabilitation, University of Rochester School of
Medicine and Dentistry, Rochester, NY, 3/07 – 09/14
Marjorie Strong Wehle Professor in Orthopaedics, University of Rochester School of
Medicine and Dentistry, Rochester, NY, 03/07 – 09/14
Professor, Department of Pathology and Laboratory Medicine, University of Rochester
School of Dentistry, Rochester, NY, 07/09 – 09/14
Professor, Department of Biochemistry and Biophysics, University of Rochester School
of Dentistry, Rochester, NY, 07/10 – 09/14
Associate Dean for Clinical Affairs - Department of Dean's Office, University of
Rochester School of Medicine and Dentistry, Rochester, NY, 07/11 – 09/14
Professor and Chair, Department of Orthopaedic Surgery, Washington University School
of Medicine, St. Louis, MO, 10/1/14 - present
2
Society Memberships
American Academy of Orthopaedic Surgeons
American Association for the Advancement of Science
American Board of Orthopaedic Surgeons, Inc.
American Orthopaedic Association
American Society of Bone and Mineral Research
Association of American Physicians
Association of Osteobiology
Interurban Orthopaedic Society
Monroe Medical Society
Musculoskeletal Tumor Society
New York Academy of Science
New York State Medical Society
Orthopaedic Research Society
Committees
University of Rochester
University of Rochester Research Core Facility Review Committee, 4/2003 – 6/2006
University of Rochester Executive Medical Scientist Training Program (“MSTP”)
Program Committee, Chairman, 5/2003 – 2014
University of Rochester Incentives Committee, 2003 – 2005
University of Rochester Scientific Publishing Committee, 2005 – 2014
University of Rochester Medical School Advisory Council (MEDSAC) Committee, 2005
– 2014
University of Rochester Medical School Advisory Council (MEDSAC) Steering
Committee, 2005 – 2008
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University of Rochester Medical Center Research CEO Research Advisory Group,
2005 – 2014
University of Rochester Medical Center Retention Policy Committee, 2006 – 2008
University of Rochester Medical Faculty Group Executive Committee, 2006 – 2014
University of Rochester Medical Center Clinical CEO Advisory Group, 2007 – 2014
University of Rochester Medical Center Lymphoma Specialized Programs of Research
Excellence (SPORE) Advisory Board, 2007 – 2014
University of Rochester Medical Center CEO Strategic Group, 2011 – 2014
Washington University:
Executive Faculty, 2014 – present
Executive Faculty Administration and Finance Committee, 2014 – present
Faculty Practice Plan Board of Directors, 2014 - present
Governance Committee, 2014 – present
Research Affairs Committee, 2014 – present
Siteman Cancer Center, 2014 - present
Barnes-Jewish Hospital
Medical Executive Committee
Peri-Operative Steering Committee
Search committees
Chair of the Hematology/Oncology Division Director Search Committee, University of
Rochester Medical Center, 2007
Chair of the Anesthesiology Department Chair Search Committee, University of
Rochester Medical Center, 2010 – 2011
University of Rochester Scientist Development Committee, 2010 – 2014
American Academy of Orthopedic Surgeons
Basic Science Subcommittee
Member
1996 – 2002
Council on Research and Scientific Affairs
Member
1999 – 2001
Academic Affairs Project Team
Member
2001
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Council on Academic Affairs
Member
2001 – 2006
Clinician-Scientist Program Committee
Chair
2001 – 2006
United States Bone and Joint Decade Project Team
Chair
2003 – 2007
Orthopaedic Basic Science Text, 3rd Edition
Co-Chair
2005 – 2007
Molecular Biology and Therapeutics in
Musculoskeletal Oncology Symposium
Co-Chair
2007 – 2008
AAOS Annual Meeting Task Force
Member
2008
Orthopaedic Research Society
Program Committee, Orthopaedic Research Society Meeting, New Orleans, LA, Adjunct
Reviewer, 1998
Program Committee, Orthopaedic Research Society Meeting Anaheim, CA, Adjunct
Reviewer, 1999
Program Committee, Orthopaedic Research Society Meeting Orlando, FL, Full Member,
2000
Treasurer, 2004 – 2007
Mentoring Committee, 2005 – present
Program Committee, 2007 – 2010
Executive Committee, 2007 – present
President-elect, 2008
President, February 2009 – March 2010
Immediate Past President, March 2010 – January 2011
American Orthopaedic Association
Resident’s Conference Committee, 1999
Member, 1999 – present
Executive Committee, 1999 – 2001
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Membership Committee, 1999 – 2001
Finance Committee, 1999 – 2001
Board of Directors, 1999 – 2001
Publication Committee, 2000 – 2003
Critical Issues Committee, 2002 – 2004
ABC Traveling Fellowship Committee, 2003 – 2006
Emerging Leaders Program Guide, 2004 – 2006
Critical Issues Committee, 2009 – 2012; Committee Chair 2012-present
American Board of Orthopaedic Surgery
Director, 2008 – present
Chair, Written Examination Committee, 2009 – present
Orthopaedic Research Education Foundation
Board of Trustees, 2003 – 2011
Chair, Grant Writing Workshop, 2006 – 2010
Executive Committee, 2007 – 2011
Secretary, 2007 – 2011
Awards
AOA Resident Traveling Research Award, “Differential expression of transforming
growth factor-ß receptors and biological effects in maturationally distinct subpopulations
of growth plate chondrocytes.” 1988
Kappa Delta Award, Orthopaedic Research and Education Foundation, 1995
The Dane and Mary Louise Miller Endowed Research Grant, Orthopaedic Research and
Educational Foundation, 1997
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Dean’s Endowed Chair, Associate Professor of Orthopaedics, University of Rochester
School of Medicine, 1998
American Orthopaedic Association ABC Traveling Fellowship, 1999
Dean’s Endowed Chair, Professor of Orthopaedics and Oncology, University of
Rochester School of Medicine, 2000
Fifth Annual Dr. Marvin J. Hoffman Award in the Area of Faculty Mentoring to Medical
Students, Awarded at the Annual Hoffman Awards Ceremony, April 25, 2003
Best Doctors in America for Cancerous Tumor Surgery, 2009
Orthopaedic Research Society and the Orthopaedic Research and Education Foundation
2013 Distinguished Investigator Award. Received on March 16, 2014
Research Support
Career Development Award, Orthopaedic Research and Education Foundation, “Protooncogene expression and the regulation of chondrocyte metabolism.” Principal
Investigator, 7/93 – 6/95
Wilmot Cancer Research Fellowship, James P. Wilmot Foundation, University of
Rochester, 7/93 – 6/96
Orthopaedic Research and Educational Foundation, “Identification and characterization
of an operant anti-inflammatory mechanism for the control of wear debris osteolysis.”
7/97 – 7/99
Wear Debris Osteolysis: New Strategies for Prevention, NIH R29 AR44220, Principal
Investigator, 9/97 – 8/02
Autocrine and Ionic Regulation of Chondrocyte Phenotype, NIH AR40325, CoInvestigator, (R. Rosier, Principal Investigator) 9/97 – 08/02
Growth Factors and Epiphyseal Chondrocyte Maturation. NIH RO1 AR38945, Principal
Investigator, 5/98 – 4/07
Prostaglandin Signaling in Wear Debris-induced Osteolysis, Principal Investigator,
National Institute of Arthritis and Musculoskeletal and Skin Disease, R01 AR46545, 7/00
– 6/10
Gene therapy for Prosthetic Loosening, NIH R01 AR46545, Principal Investigator, 9/00 –
8/04
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Acetabular Bone Loss Following Prosthetic Hip Arthroplasty, RO1 AR48149 CoPrincipal Investigator 4/02 – 3/05
Cellular and Molecular Effects of Lead on Chondrogenesis and Cartilage Differentiation,
P01 ES11854, 8/02 – 8/06. Principal Investigator, Project 2 in Lead Toxicity in the
Skeleton and its Role in Osteoporosis. Program Project, J.E. Puzas, PI, 8/02 – 8/06
Prostaglandin Signaling in Wear Debris–Induced Osteolysis, NIH R01 AR46545,
Principal Investigator, 07/00 – 06/11
Training in Orthopaedic Research, NIH T32 AR053459, Principal Investigator, 05/06 –
04/11
The use of genetic models to define the role of beta-catenin in post-natal growth,
National Institute of Arthritis and Musculoskeletal and Skin Disease, R01 AR 05371,
Principal Investigator, 9/07 – 8/12
Cyclooxygenases and Bone Repair, NIH RO1 AR48681, Principal Investigator RO1
7/09 – 6/14
Translating Molecular Signal Pathways to Orthopaedic Trauma Care, Dr. Randy Rosier,
Program Director, NIH P50, AR054041, Principal Investigator of Project 2, 8/06 – 7/11
The Mechanism through which TGF-beta Maintains Chondrocytes in Proliferating Stage
Principal Investigator: Di Chen; Role: Co-Investigator, NIH National Institute of
Arthritis and Musculoskeletal and Skin Disease, R01 AR054465, 2/07 – 1/11
Molecular Biology and Therapeutics in Musculoskeletal Oncology (MBTMO) Research,
NIH R13 CA135939, Awarded with Priority Score 150, Principal investigator, 9/08
Allografts and Gene Therapy in Flexor Tendon Tissue Engineering, National Institute of
Arthritis and Musculoskeletal and Skin Disease, Co-Investigator, R01AR056696, 7/09 –
6/14
Improving Orthopaedic Outcomes through a National TJR Registry, NIH, CO-PI, Prime
Award No. 5-P50-HS0189-10-02 (Subaward No. 6127964/RFS2011171), 4/10 – 03/14
Notch Signaling in Cartilage Development, NIH, Co-Investigator, R01AR057022, 7/10 –
06/15
Development of siRNA Technology to Prevent Scar Formation in Tendon Repair,
Department of Defense, Principal Investigator, W81XWH–10-1-0841, 10/10 – 09/13
The University of Rochester Core Center for Musculoskeletal Biology and Medicine,
NIH National Institute of Arthritis and Musculoskeletal and Skin Disease, Advisory
Committee Member, P30AR061307-01, 08/11 – 06/16
8
DKK1-Ab Regulation of the Stem Cell Responses to Skeletal Injury, AMGEN, Principal
Investigator, 12/12 – 11/15
Promoting MSC-mediated Musculoskeletal tissue regeneration using sustained, localized
SIRNA delivery, NYSTEM, Co-Investigator, 3/13 – 02/15
Translating Molecular Signal Pathways to Orthopaedic Trauma Care, Program Director
and PI of Project 1; NIH P50, AR054041, 09/12 – 08/17
National Research Review Committees
National Institutes of Health Review Panels
Study Section Member, National Institutes of Health RFA-HD-93-011 “Biomaterials to
restore function in people with physical disabilities.” NIH, December 1 – 3, 1993
Orthopaedic Study Section, National Institutes of Health, Ad Hoc Reviewer, February
21 – 23, 1999
Orthopaedic Study Section, National Institutes of Health, Ad Hoc Reviewer, June 26 –
27, 2000
Orthopaedic Study Section, National Institutes of Health, Permanent Member, October
2000 – 2003
Orthopaedic Study Section, National Institutes of Health, Chair, October 2003 – 2004
NIH GCRC Grant Reviewer, General Clinical Research Center Grant Review, Duke
University, Durham, NC, September, 16 – 17, 2003
NIH Skeletal Biology and Skeletal Regeneration Study Section, Chair, 2004 – 2005
NIH Electronic Review, Chair, ZRG1 MOSS-A (02) Skeletal Biology Structure and
Disease Special Emphasis Panel, November 2005
NIH Electronic Review, Chair, ZRG1 MOSS-A (02) Musculoskeletal Hard Tissue
Special Emphasis Panel, April 2006
National Institutes of Arthritis and Musculoskeletal and Skin Diseases (“NIAMS”),
Musculoskeletal Injury and Trauma Roundtable, Advisory Panel, January 22, 2007
NIH Skeletal Biology Structure & Regeneration Study Section, Center for Scientific
Review, Washington, DC, June 4, 2007
9
Proteus Syndrome Skeletal Biology (PSSB) Workshop, (Co-Organizer), National
Institutes of Health, Bethesda, Maryland, September 26 – 28, 2007
National Institutes of Arthritis and Musculoskeletal and Skin Diseases, National Institutes
of Health Review R03 Grants, July 2008
NIAMS Roundtable on Enhancing Clinical Trials in Orthopaedics and Osteoarthritis,
Bethesda, MD, December 14, 2009
NIAMS Advisory Council (National Institute of Arthritis and Musculoskeletal and Skin
Diseases NIH, DHHS), Bethesda, MD, February 2010 – February 2012
NIH Council Service
National Institutes of Health Council of Councils (CoC) Advisory Committee November 1, 2010 – 2013
National Institutes of Health (NIH) National Arthritis and Musculoskeletal and Skin
Disease Advisory Council - March 30, 2010 – 2013
NIAMS Advisory Council Working Group on Clinical Trials - June 15, 2010 – 2013
Howard Hughes Medical Institute Review Panels
HHMI Research Training Fellowships Review Committee Information, Washington, DC,
February 18, 2010
HHMI Research Training Fellowships Review Committee Information, Washington, DC,
February 17, 2011
Howard Hughes Medical Institute Research Training Fellowships Review Committee,
January 2010 – February 2012
NASA Review Panels
American Institute of Biological Sciences, NASA Life and Biomedical Sciences Division
Peer Review Committee, July 1994
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American Institute of Biological Sciences, NASA Bone Health and Military Medical
Readiness, Committee on genetics and stress fracture, Washington, DC, November 1997
Shriners Hospitals Research Panels
Shriners Hospitals for Children Research Advisory Board, Member, 2006 – present.
United States Military Review Panels
United States Army Review Panel, Chair, July 2006
Orthopaedic Trauma Research Program (OTRP) US Army Institute of Surgical Research,
Panel Chair, San Antonio, Houston, Texas, September 2007
Other Review Panels
Musculoskeletal Transplant Foundation Scientific Grant Award Committee, October
1996, October 1997, and October 1998
Reviewer, Whitaker Foundation Grants, April 1998
Bristol Meyers Squibb Zimmer Annual Distinguished Award in Orthopaedic Research
Selection Committee, Vail, CO, January 2001
The Bone and Joint Decade, Scientific Grant Award Committee, April 2006
Reviewer, Pilot/Feasibility Study, Dermatology and Immunobiology, Yale University,
January 2007
US Bone & Joint Decade Scientific Committee, Review and Select Awardees for the 2nd
BJD Award and Scholarships, March 2008
Merck & Co., Osteoporosis Orthopaedic Expert Input Forum, New Brunswick, New
Jersey, June 26 – 27, 2008
DoD Peer Reviewed Orthopaedic Research Program Stakeholders Meeting, Washington,
DC, March 26 – 27, 2009
All Hands Armed Forces Institute of Regenerative Medicine (AFIRM), St. Petersburg,
FL, January 12 – 15, 2010
University of Iowa, Consultant to the Carver College of Medicine for the Department of
Orthopaedic Surgery and Rehabilitation, Cedar Rapids, IA, July 15, 2010
11
All Hands Armed Forces Institute of Regenerative Medicine (AFIRM), Washington, DC,
December 9-10, 2010
BIDMC Orthopedic Surgery Review, Department of Orthopedic Surgery, Beth Israel
Deaconess Medical Center, Boston, MA, March 16 – 17, 2011
Hospital for Special Surgery (“HSS”) Scientific Advisory Board External Review,
New York, NY, April 11, 2011
Research Lobbying Activities
American Academy of Orthopaedic Surgeons, Research Lobby Day Participant, February
11 – 13, 2004
American Academy of Orthopaedic Surgeons, Research Lobby Day Participant, March
16 – 18, 2005
American Academy of Orthopaedic Surgeons, Research Lobby Day Participant, March
2007
Board Memberships
American Board of Orthopaedic Surgery, Question Writing Task Force, 2001 – present
Aircast Foundation, Scientific Board, 2002- 2006; Chair, 2005 – 2006
Orthopaedic Research and Education Foundation, Executive Committee 2003 – 2011,
Secretary, 2007 – 2011
Orthopaedic Research Society, Board of Directors 2003 – 2011, President 2010 – 2011,
Treasurer 2004 – 2007; Program Committee Member, 2007 – 2010
United States Bone and Joint Decade, President 2003 – 2005, Chair 2003 – 2007, Board
member, 2005 – present
Aircast Foundation, Extremity War Trauma Research Foundation Board of Directors,
2008 – 2009
Hospital for Special Surgery Scientific Advisory Board, 2006
American Board of Orthopaedic Surgery, Chair, Written Examinations Committee,
Committee Member of Research Committee, Oral Examinations Committee and
Maintenance of Certification Committee, February 2008 – present
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Thesis Committees
Daniel Jang, The University of New South Wales, Sydney Australia, “Studies on nitric
oxide in cartilage metabolism and septic arthritis.” Thesis Examiner, 1999
Christopher Grimsrud, University of Rochester School of Medicine, “Bone
morphogenetic proteins and chondrocyte maturation.” Ph.D. Research Advisor, 1995 –
1999
Andreia Ionescu, University of Rochester School of Medicine, “The role of CREB and cFos in PTHrP signaling in chondrocytes.” Ph.D. Research Advisor, 1998 – 2003
Andrew Gordon, University of Rochester School of Medicine, “The role of NFkB in
tumor metastasis.” Ph.D. Research Committee, 1998 – 2003
Dongwei Zhang, University of Rochester School of Medicine, “BMP receptors in skeletal
development and repair.” Ph.D. Research Advisor, 1999 – 2003
Lea Gunnell, University of Rochester School of Medicine, “ATF-2 in skeletal
development.” Ph.D. Research Advisor, 2002 – present
David Reynolds, University of Rochester School of Medicine, “Analysis of grafted bone
strength and structure and the effects of targeted gene therapy.” Ph.D. Research Advisor,
2002 – 2009
Xiaochao Wei, University of Rochester School of Medicine, “The role of the synovial
fibroblast in periprosthetic loosening.” Ph.D. Research Advisor, 2002 – present
Yu Zhang, University of Rochester School of Medicine, Department of Pathology,
“Growth factors and cell cycle regulation in endochondral ossification.” Ph.D. Research
Advisor, 2003 – 2008
Christine Clark, University of Rochester School of Medicine, “Cyclooxygenases and the
regulation of chondrocyte maturation.” Ph.D. Research Advisor, 2003 – 2008
Mo Chen, University of Rochester School of Medicine and Department of Genetics, "BCatenin Signaling in Postnatal Cartilage Development.” Ph.D. Research Advisor, 2004 –
2007
Alayna Loiselle, University of Rochester School of Medicine, Department of Pathology,
“Molecular events of tendon repair in an in vivo murine intra-synovial tendon healing
model.” Ph.D. Research Advisor, 2004 – 2009
13
Debbie Dao, University of Rochester School of Medicine, Department of Pathology,
“The role of axin 2 and beta-catenin on skeletal development and cartilage metabolism.”
Ph.D. Research Advisor, 2006 – 2011
Ming Kung, University of Rochester School of Medicine, Department of Environmental
Medicine, “Mechanisms through which cigarette smoke regulates bone formation.”
Thesis co-Advisor (with Michael Zuscik, Ph.D.), 2006 – present
Minjie Zhang, University of Rochester School of Medicine, Department of Biomedical
Genetics, “The role of the various EP receptors in stem cell differentiation and bone
repair.” Thesis Advisor, 2007 – 2011
Yang Gao, University of Rochester School of Medicine, Department of Biomedical
Genetics, Thesis Committee Member, 2007 – present
ShanShan Shi, University of Rochester School of Medicine, Department of Pathology,
“Tendon healing and scar formation: Modulation of TGF-beta signaling” June 2009 –
present
Marina Feigenson, University of Rochester School of Medicine, Department of
Biochemistry, “The role of Prostaglandin E Receptor 1 in bone homeostasis and fracture
repair.” Thesis Advisor, 2010 – present.
Yongchun Zhang, University of Rochester School of Medicine, Department of
Biochemistry, “Investigating the roles of Bmp-2/Smad and Ihh signaling in Beta-cateninmediated endochondral bone formation.” Thesis Advisor, 2011 – present.
Post Doctoral Trainees
Theodore H. Blaine, MD: “The role of cAMP/CREB signaling in macrophage activation
secondary to particulate debris.” 07/94 – 07/95
Paul Pollice, MD: The role of IL-10 as a natural inhibitor of peri-prosthetic osteolysis.”
07/95 – 07/96
Susan Bukata, MD: Hydroxyapatite particles induce monocyte production of TNF-alpha
and bone resorption in vitro and in vivo.” 07/96 – 07/98
Allen P. Lu, MD: “The role of NFkB in the macrophage response to particulate debris.”
07/98 – 07/99
Xeufeng Li, MD, “The regulation of chondrocyte maturation by BMP’s and interaction
with other growth factors.” 06/98 – 02/03
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Cristin Ferguson, MD, “The regulation of chondrocyte maturation through SMAD
signaling.” 04/99 – 07/00
Alexander Soloviev, PhD, “Mechanisms of activation of NFkB by debris particles and
regulation of TNF-alpha in macrophages.” 08/99 – 06/01
Jill-Marie Gelinas, MD, “The role of IL-6 in periprosthetic osteolysis.” 08/01 – 09/02
Michael Darowish, MD, “The role of IL-6 in wear debris mediates osteolysis.” 06/04 –
06/05
Tian-fang Li, MD, “Smad3 regulation of chondrocyte maturation.” 06/02 – 6/06
Yufeng Dong, MD, “Wnt expression and signaling in endochondral bone formation.”
09/02 – 09/07
Jennifer Jonason, PhD, “Mechanisms involved in VEGF regulation by beta-cateinin.”
9/07 – present
Calvin Hu, MD, Post doctoral fellow, “The development of a non-union model in murine
fracture healing.” 07/08 – 6/09
Sarah Offley, MD, Post doctoral fellow, “The development of a non-union model in
murine fracture healing.” 07/09 – 06/10
Kiminori Yukata, PhD, “Intracellular signals regulating stem cell population recruitment
and expansion in fracture young and aged bone repair.” 06/09 – 05/11
Zaneb Yaseen, MD, “The development of a non-union model in murine fracture healing.”
07/10 – 06/11
Medical Student Trainee
James Hsu, B.A., “Effect of IL-10 on macrophage responses to wear particles” 06/97 –
06/98
Dhruv Pateder, B.S., “Regulation of PTHrP expression by chondrocytes, role of TGFbeta and Smad-mediated signaling.” 6/99 – 6/00
Emily Carmody, B.S., “IL-10 mediated gene therapy prevents wear debris induced bone
resorption. 6/00 – 6/01
Ra’Kerry Rahman, B.S., “IL-6 regulation by debris particles and a role in periprosthetic
osteolysis.” 6/02 – 6/03
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Ankur Chawla, B.S. “Distraction osteogenesis in the setting of chronic inflammation.”
8/03 – 8/04 (Awarded a Howard Hughes Medical Student Fellowship)
Amish Naik, B.S. "A comprehensive study of fracture healing in aged versus young
mice."
8/04 – 8/05 (Awarded a Howard Hughes Medical Student Fellowship)
Emmanuel Menga, “Smad-3 deficiency and fracture healing.” 6/06 – 8/06
Taylor Buckley, “The effect of lead on in vivo chondrogenesis in a murine model.” 7/06
– 6/07
Stephen George, “The effect of androgens and environmental exposure to the phthalates
on bone repair.” 6/06 – 8/07
Evan Katzel, “The role of Smad3 on tendon repair and adhesion formation.” 7/07 – 7/08
Sirish Kondabolu, “Modulation of tendon scar formation with siRNA against TGF-beta
signaling targets.” 07/10 – 07/11
Matthew Brown, “Fracture Healing and Obesity.” 07/11 – 07/12
Student/Fellowship Grant Awards
Paul Pollice, M.D. Orthopaedic Research and Educational Foundation, Resident
Fellowship, 1995 – 1996
Susan Bukata, M.D., Orthopaedic Research and Educational Foundation, Resident
Fellowship, 6/96 – 6/98
Ra’Kerry Rahman, B.S., Bristol-Myer Squibb, National Medical Academic Medicine
Fellowship, 6/02 – 6/03
Ankur Chawla, B.S., Howard Hughes Medical Student Fellowship, 8/03 – 8/04
Erik R. Lovria, Medical Student Summer Orthopaedic Research and Educational
Foundation Fellowship, 6/04 – 8/04
Michael Darowish, M.D., Orthopaedic Research and Educational Foundation Fellowship,
6/04 – 8/05
Amish Naik, B.S., Howard Hughes Medical Student Fellowship, 8/05 – 8/06
Stephen George, Howard Hughes Medical Student Fellowship, 8/06 – 8/07
Evan Katzel, Clinical Translation Science Award, University of Rochester, 7/07 – 7/08
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Sirish Kondabolu, Clinical Translation Science Award, University of Rochester, 07/10 –
07/11
Matthew Brown, Clinical Translation Science Award, University of Rochester, 07/11 –
07/12
Graduate School Teaching
Pathology 493: Pathways of Human Disease (Graduate School Course). “Skeletal
Development and Repair: The Role of Mesenchymal Stem Cells.” March 25, 2003
CMM Faculty Research Presentations: “Growth Plate Chondrocyte Differentiation and
Maturation; Biochemical Mechanisms of Prosthetic Implant Loosening; Mechanisms of
Tumor Mediated Bone Loss.” October 7, 2003
Pathology 493: Pathways of Human Disease “Skeletal Development and Repair: “The
Role of Stem Cells.” January 29, 2004
Pathology 593: Molecular Basis of Disease “The Role of Stem Cells in Musculoskeletal
Repair.” September 20, 2005
CMM Faculty Research Presentations: “Cell signaling in musculoskeletal tissues.”
September 14, 2006
Pathology 493: Pathways of Human Disease (Graduate School Course). “Cell Signaling
and Regulations of Growth and Development.” September 14, 2006
Medical School Teaching
Bench to Bedside: (Third year medical students) Journal Club Review: “The Treatment
of Osteoporosis.” March 25, 2003
Ortho Double Helix Curriculum: (First year medical students). Lower Extremity
Module II
Process of Discovery Lecture, “Genetic Advances in the Understanding of Osteoporosis,
Past Present and Future.” February 5, 2004
Process of Discovery (Required 4th year medical school course.) “Respondent of Student
Abstracts and Selector of Awards.” February 26, 2004
Process of Discovery Lecture, “Non-Modifiable Factors Influencing the Skeleton, and
What Does the Future Hold for Osteoporosis.” February 3, 2005
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Process of Discovery Lecture, “Understanding the Cellular and Molecular Signals
Required for Allograft Revitalization and Remodeling.” February 27, 2006
Scientific Reasoning in Medicine Course, “Models to Understand Bone Repair: Toward
Improving Patient Care.” May 5, 2006
Process of Discovery Lecture, “Understanding and Improving Fracture Healing with
Aging.” February 21, 2007
Problem Based Learning Module, 2nd year medical students, “Upper Extremity
Disorders.” April 4, 2007
Process of Discovery Lecture, “Understanding and Improving Fracture Healing with
Aging.” February 21, 2008
Upstate New York Musculoskeletal Basic Science Course, “Growth Plate Physiology.”
April 3, 2008
Process of Discovery Lecture, “Understanding and Improving Fracture Healing with
Aging.” February 20, 2009
Phelps Colloquium Series Lecture "Your aging bones - Growing older is getting better:
Stem cells, hormones, and novel therapies." February 3, 2010
Process of Discovery Lecture, “Understanding and Improving Fracture Healing with
Aging.” February 11, 2010
Surgery Interest Group Lecture, “Work Orthopaedic Tumor Surgeon.” February 7, 2011
Process of Discovery Lecture, “Translating Scientific Discovery into Better Bone
Healing", February 10, 2011
Second Friday Social Seminar Lecture Series, “Improving Orthopaedic Care Through
Translational and Clinical Research: Opportunities and Challenges.” February 11, 2011
Process of Discovery Lecture, “Translating Scientific Discovery into Better Bone
Healing”, February 16, 2012
Process of Discovery Lecture, “Translating Scientific Discovery into Better Bone
Healing”, February 18, 2013
Course Faculty
“Women’s Health: Special Imaging and Intervention.” Wyndham Aruba Beach Resort,
Aruba, July 31 – August 4, 2001
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“Emerging Technologies in Spine Surgery.” Sagamore Resort, Bolton Landing, NY,
June 20 – 23, 2002
“Your Winning Playbook for Healthy Joints.” Men’s Health Day, University of
Rochester, Rochester, NY, September 12, 2008
Editorial Service
Biochimica et Biophysica ACTA
Biomaterials
Bone
Calcified Tissue International
Cells, Tissues, and Organs
Clinical Cancer Research
Clinical Orthopaedics and Related Research
Development
Developmental Dynamics
Endocrinology
Experimental Cell Research
Gene
Journal of Biological Chemistry
Journal of Bone and Joint Surgery
Journal of Bone and Mineral Research
Journal of Cellular Biochemistry
Journal of Cellular Physiology
Journal of Clinical Investigation
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Journal of Histochemistry and Cytochemistry
Journal of Orthopaedic Research
Journal of Orthopaedic Trauma
Molecular and Cellular Biology
Molecular Therapy
Nature Medicine
Osteoarthritis and Cartilage
Plos One
Pediatric Research
Spine
Tissue Engineering
Toxicology and Applied Pharmacology
Editorial Boards
Journal of Bone and Joint Surgery, Basic Science, 2001 – 2006
Journal of Bone and Mineral Research, 2002 – present
Associate Editor - Journal of Bone and Mineral Research, 2008 – 2012
Associate Editor – Bone, 2013 – present
Books/Journals Edited
Current Opinions in Orthopaedics, Metabolic Bone Disease and Basic Science Edition
Editor, 2000
Orthopaedic Knowledge Update 7, Basic Science Section Editor, 2001
20
Current Opinions in Orthopaedics, Metabolic Bone Disease and Basic Science Edition
Editor, 2001
Orthopaedic Basic Science, Foundations of Clinical Practice, Third Edition, eds. Thomas
A. Einhorn, MD, Regis J. O'Keefe, MD, PhD, and Joseph A. Buckwalter, AAOS
Publications, 2007
Orthopaedic Basic Science, Foundations of Clinical Practice, Fourth Edition, eds. Regis
J. O’Keefe, MD, PhD, Joshua J. Jacobs, MD, Constance R. Chu, MD, and Thomas A.
Einhorn, MD. AAOS Publications, 2012
Publications
1.
O'Keefe, RJ, Domalik-Wawrzynski, L, Guerrero, JL Rosow, CE, Lowenstein, E, and
Powell, WJ: Locally and neurally mediated effects of sufentanil on canine skeletal
muscle vascular resistance. Journal of. Pharmacology and Experimental Therapeutics
242:699-706, 1987
2.
O'Keefe, RJ, Puzas, JE, Brand, JS, and Rosier, RN: Effects of transforming growth
factor-ß on matrix synthesis by chick growth plate chondrocytes. Endocrinology
122:2953-2961, 1988
3.
O'Keefe, RJ, Puzas, JE, Brand, JS, and Rosier, RN: Effect of transforming growth
factor-ß on DNA synthesis by growth plate chondrocytes: Modulation by factors present
in serum. Calcified Tissue International 43:352-358, 1988
4.
Rosier, RN, O'Keefe, RJ, Crabb, I.D., and Puzas, JE: Transforming growth factor beta:
An autocrine regulator of chondrocytes. Connective Tissue Research 20:295-301, 1989
5.
O'Keefe, RJ, Crabb, ID, Puzas, JE, and Rosier, RN.: Countercurrent centrifugal
elutriation: A high-resolution method for the separation of growth plate chondrocytes.
Journal of Bone and Joint Surgery 71A: 607-620, 1989
6.
O'Keefe, RJ, Rosier, RN, and Puzas, JE: Differential expression of biological effects in
maturationally distinct subpopulations of growth plate chondrocytes. Connective Tissue
Research 24:53-66, 1990
7.
Crabb, ID, O'Keefe, RJ, Puzas, JE, and Rosier, RN: Synergistic effect of transforming
growth factor-ß and fibroblast growth factor on DNA synthesis in chick growth plate
chondrocytes. Journal of Bone and Mineral Research 5:1105-1112, 1990
8.
O'Keefe RJ; Jones JA; Hurwitz SR. "Bilateral sacroiliac joint fracture-dislocation
requiring late coccygectomy: a case report." The Journal of Trauma 1992;33(5):793-4.
1992
21
9.
Crabb, ID, O'Keefe, RJ, Puzas, JE, and Rosier, RN: Differential effects of parathyroid
hormone on chick growth plate and articular chondrocytes. Calcified Tissue International
50:61-66, 1992
10.
O'Keefe, RJ, Crabb, ID, Puzas, JE, and Rosier, RN: Influence of prostaglandins on
DNA and matrix synthesis in growth plate chondrocytes. Journal of Bone and Mineral
Research 7:397-404, 1992
11.
O'Keefe, RJ, Crabb, ID, Puzas, JE, and Rosier, RN: Effects of transforming growth
factor-beta 1 and fibroblast growth factor on DNA synthesis in growth plate chondrocytes
are enhanced by insulin-like growth factor-I. Journal of Orthopaedic Research 12 (3):
299-310, 1994
12.
O'Keefe, RJ, Puzas, JE, Loveys, LS, Hicks, DG, and Rosier, RN: Analysis of type II
and type X collagen synthesis in cultured growth plate chondrocytes by in situ
hybridization. Journal of Bone and Mineral Research 9:1713-1722, 1994
13.
Scully, SP, Temple, HT, O'Keefe, RJ, and Gebhardt, MC: Case report 830:
Aneurysmal bone cyst. Skeletal Radiology 23 (2): 157-60, 1994
14.
Puzas, JE, Hicks, DG, Reynolds, SD, and O'Keefe, RJ: Regulation of osteoclastic
activity in infection. Methods in Enzymology 236:47-58, 1994
15.
Scully, SP, Mott, MP, Temple, HT, O'Keefe, RJ, O'Donnell, RJ, and Mankin, HJ: Late
recurrence of giant-cell tumor of bone: A report of four cases. Journal of Bone and Joint
Surgery 76 (8): 1231-1233, 1994
16.
Temple, HT, Scully, SP, O'Keefe, RJ, Rosenthal, DI, and Mankin, HJ: Clinical
presentation of alveolar soft-part sarcoma. Clinical Orthopaedics and related research
300:213-218, 1994
17.
Scully SP; Temple HT; O'Keefe RJ; Scarborough MT; Mankin HJ; Gebhardt MC.
"Role of surgical resection in pelvic Ewing's sarcoma." Journal of clinical oncology:
official journal of the American Society of Clinical Oncology. 13(9):2336-41. 1995
18.
Hicks DG; Gokan T; O'Keefe RJ; Totterman SM; Fultz PJ; Judkins AR; Meyers SP;
Rubens DJ; Sickel JZ; Rosier RN. "Primary lymphoma of bone. Correlation of magnetic
resonance imaging features with cytokine production by tumor cells." Cancer 75(4):97380. 1995
19.
Rosier, RN, Teot, LA, Hicks, DG, Schwartz, C, O'Keefe, RJ, and Puzas, JE: Multiple
drug resistance in osteosarcoma. The Iowa Orthopaedic Journal 15:66-73, 1995
20.
O'Keefe, RJ, O'Connell, JX, Temple, HT, Scully, SP, Kattapuram, SV, Springfield, DS,
Rosenberg, AE, and Mankin, HJ: Calcific myonecrosis: A late sequela to compartment
syndrome of the leg. Clinical Orthopaedics and related research 318:205-213, 1995
22
21.
O'Keefe, RJ, O'Donnell, RJ, Temple, HT, Scully, SP, and Mankin, HJ: Giant cell tumor
of bone affecting the foot and ankle. Foot and Ankle 16:617-623, 1995
22.
Hughes, SS, Hicks, DG, O'Keefe, RJ, Hurwitz, SR, Crabb, ID, Krasinskas, AM, Loveys,
L, Puzas, JE, and Rosier, RN: Shared phenotypic expression of osteoblasts and
chondrocytes in fracture callus. Journal of Bone and Mineral Research 10 (4): 533-544,
1995
23.
Blaine, TA, Rosier, RN, Puzas, JE, Looney, RJ, Reynolds, PR, Reynolds, SD, and
O'Keefe, RJ: Increased levels of tumor necrosis factor-2 and interleukin-6 protein and
messenger RNA in human peripheral blood monocytes due to titanium particles. Journal
of Bone and Joint Surgery 78A (8):1181-1192, 1996
24.
Teot, LA, O'Keefe, RJ, Rosier, RN, O'Connell, J, Fox, EJ, Puzas, JE, and Hicks, DG:
Extraosseous primary and recurrent giant cell tumors: Transforming growth factor-beta-1
and beta-2 expression may explain metaplastic bone formation. Human Pathology
27:625-632, 1996
25.
Reynolds, SD, Johnston, C., Leboy, PS, O'Keefe, RJ, Puzas, JE, Rosier, RN, and
Reynolds, PR: Identification and characterization of a unique chondrocyte gene involved
in transition to hypertrophy. Experimental Cell Research 226:197-207, 1996
26.
Scully, SP, Temple, HT, O'Keefe, RJ, Mankin, HJ, and Gebhardt, M: The surgical
treatment of patients with osteosarcoma who sustain a pathologic fracture. Clinical
Orthopaedics and related research 324:227-232, 1996
27.
Delsignore, JL, Dvoretsky, PM, Hicks, DG, O'Keefe, RJ and Rosier, RN: Mastocytosis
presenting as a skeletal disorder. The Iowa Orthopaedic journal 16:126-134, 1996
28.
Reynolds, PR, Reynolds, SD, O'Keefe, RJ, Puzas, JE, and Rosier, RN: Alternative
splicing of a chondrocyte-specific gene. Annals of the New York Academy Of Sciences
785:321-324, 1996
29.
Hicks, DG, O'Keefe RJ, Reynolds, KJ, Cory-Slechta, DA, Puzas, JE, and Rosier, RN:
Effects of lead on growth plate chondrocyte phenotype. Toxicology and. Applied
Pharmacology 140:164-172, 1996
30.
Hicks, DG, Judkins, AR, Sickel, JZ, Rosier, RN, Puzas, JE, and O'Keefe, RJ. Granular
histiocytosis of pelvic lymph nodes following total hip arthroplasty. Journal of Bone and
Joint Surgery 78A:482-496, 1996
31.
Rosier, RN, O'Keefe, RJ, Teot, LA, Fox, EJ, Nester, TA, Schnell, J, Puzas, JE,
Reynolds, PR, and Hicks, DG. P-glycoprotein expression in cartilaginous tumors.
Journal of Surgery and Oncology 65:95-105, 1997
23
32.
O'Keefe, RJ, Teot, LA, Singh, D, Puzas, JE, Rosier, RN, and Hicks, DG: Osteoclasts
constitutively express regulators of bone resorption. An immunohistochemical and in-situ
hybridization study. Laboratory Investigation 76:457-465, 1997
33.
O'Keefe, RJ, Loveys, LS, Hicks, DG, Reynolds, PR, Crabb, ID, Puzas, JE, and Rosier,
RN. Differential regulation of type-II and type-X collagen synthesis by parathyroid
hormone-related protein in chick growth plate chondrocytes. Journal of Orthopaedic
Research 15 (2):162-74, 1997
34.
Hicks, DG, Stroyer, BF, Teot, L.A, and O'Keefe, RJ: In-situ hybridization in skeletal
tissues utilizing non-radioactive probes. Journal of Histotechnology 20:215-224, 1997
35.
Blaine, TA, Pollice, PF, Rosier, RN, Reynolds, PR, Puzas, JE, and O'Keefe, RJ:
Modulation of the production of cytokines in titanium stimulated human peripheral blood
monocytes by pharmacological agents: The role of cAMP mediated signaling
mechanisms. Journal of Bone and Joint Surgery 79A (10):1519-28, 1997
36.
Rosier RN; O'Keefe RJ. "Autocrine regulation of articular cartilage." Instructional
course lectures. 47:469-75. 1998
37.
Grimsrud, C, Rosier, RN, Puzas, JE, Reynolds. PR, Reynolds, SD, Hicks, DG, and
O'Keefe, RJ: BMP-7 in growth plate chondrocytes: Regulation by retinoic acid is
dependent upon the stage of chondrocyte maturation. Journal of Orthopaedic Research
16:247-255, 1998
38.
Romano, PR, Wang, J, O’Keefe, RJ, Puzas, JE, Rosier, RN, and Reynolds, PR:
HiPER1, a phosphatase of the endoplasmic reticulum with a role in chondrocyte
maturation. Journal of Cell Science 111:803-813, 1998
39.
Rapoport, AP, Constine, LS, Packman, CH, Rosier, RN, O’Keefe, RJ, Hicks, DG,
Rubin, SJ, and Rowe, JM: Treatment of multifocal lymphoma of bone with intensified
promace-cytabom chemotherapy and involved field radiotherapy. American Journal of
Hematology 58:1-7, 1998
40.
Guerra, CE, Betts, RF, O’Keefe, RJ, and Shilling, JW: Mycobacterium bovis
osteomyelitis involving a hip arthroplasty after intravesicular Bacille Calmette-Guerin for
bladder cancer. Clinical Infectious Diseases 27:639-640, 1998
41.
O’Keefe, RJ, Rosier, RN, Teot, LA, Stewart, J.M.M, and Hicks, DG: Cytokine and
matrix metalloproteinase expression in pigmented villonodular synovitis may mediate
bone and cartilage destruction. The Iowa Orthopaedic Journal 18:26-34, 1998
42.
Pollice, PF, Hsu, J, Hicks, DG, Bukata, S, Rosier, RN, Reynolds, PR, Puzas, JE, and
O’Keefe, RJ: IL-10 inhibits cytokine synthesis in monocytes stimulated by titanium
particles: evidence of an anti-inflammatory regulatory pathway. Journal of Orthopaedic
Research 16:697-704, 1998
24
43.
Serletti, JM, Carras, AJ, O’Keefe, RJ, and Rosier, RN: Functional outcome after softtissue reconstruction for limb salvage after sarcoma surgery. Plastic and Reconstructive
Surgery 102(5): 1576-1583, 1998
44.
Reynolds, SD, Zuscik, MJ, Gunter, TE, O’Keefe, RJ, Puzas, JE, Rosier, RN, and
Reynolds, PR: Parathyroid hormone and parathyroid hormone-related peptide effects on
growth plate chondrocytes: an overview. Cells and Materials 7 (4): 289-300, 1998
45.
Rosier, RN, O’Keefe, RJ, and Hicks, DG: The potential role of transforming growth
factor beta in fracture healing. Clinical Orthopaedics and related research 355S:S294S300, 1998
46.
Grimsrud, C, Romano, PM, Rosier, RN, Puzas, JE, Reynolds,.PR, and O'Keefe, RJ:
BMP-6 is an autocrine stimulator of chondrocyte differentiation. Journal of Bone and
Mineral Research 14:475-482, 1999
47.
Chi, H, Tiller, GE, Dasouki, MJ, Romano, PR, Wang, J, O’Keefe, RJ, Puzas, JE,
Rosier, R.N., and Reynolds, P.R.: Multiple inositol polyphosphate phosphatase: Evolution
as a distinct group within the histidine phosphatase family and chromosomal localization of
the human and mouse genes to 10q23 and 19. Genomics, 56:324-336, 1999
48.
Vena, VE, Hsu, J., Rosier, RN, and O’Keefe, RJ. Pelvic reconstruction for severe
periacetabular metastatic disease. Clinical Orthopaedics and related research 362:171-180,
1999
49.
Temple, HT, Scully, SP, O'Keefe, RJ, Katapurum, S, and Mankin, HJ: Clinical outcome
of 38 patients with juxtacortical osteosarcoma. Clinical Orthopaedics and related
research 373:208-17, 2000
50.
Schwarz, EM, Lu, AP, Goater, JJ, Benz, EB, Kollias, G, Rosier, RN, Puzas, JE, and
O’Keefe, RJ: Tumor necrosis factor-alpha/nuclear transcription factor-kappa ß signaling in
periprosthetic osteolysis. Journal of Orthopaedic. Research 18 (3):472-80, 2000
51.
Goater, JJ, Müller, R, Kollias, G, Firestein, GS, Sanz, I, O’Keefe, RJ, and Schwarz,
EM: Empirical advantages of adeno-associated viral vectors for in vivo gene therapy for
arthritis. The Journal of Rheumatology 27 (4):983-9, 2000
52.
Schwarz, EM, Benz, EB, Lu, AP, Goater, Mollano, AV, Rosier, RN, Puzas, JE, and
O’Keefe, RJ: A quantitative small animal surrogate to evaluate drug efficacy in
preventing wear debris-induced osteolysis. The Journal of Orthopaedic Research 18:84955, 2000
53.
Schwarz, E.M., Looney, R.J. and O’Keefe, RJ: Anti- TNFα therapy as a clinical
intervention for periprosthetic osteolysis. Arthritis Research 2 (3):165-68, 2000
25
54.
Pateder, DB, Rosier, RN, Schwarz, EM, Reynolds, PR, Puzas, JE, D’Souza, M, and
O’Keefe, RJ: PTHrP expression in chondrocytes, regulation by TGF-ß and interactions
between epiphyseal and growth plate chondrocytes. Experimental Cell Research 256
(2):555-62, 2000
55.
Reynolds, SD, Zhang, D, Puzas, JE, O'Keefe, RJ, Rosier, RN, and Reynolds, PR:
Cloning of the chick BMP1/Tolloid cDNA and expression in skeletal tissues. Gene 248
(1-2):233-43, 2000
56.
Ferguson, CM, Schwarz, EM, Reynolds, PR, Puzas, JE, Rosier, RN, and O’Keefe, RJ:
Smad2 and 3 mediate TGF-ß1-induced inhibition of chondrocyte maturation.
Endocrinology 141:4728-35, 2000
57.
Rosier, RN, and O'Keefe, RJ: Hyaluronic acid therapy. Instructional Course Lectures
49:495-502, 2000
58.
Li, P, Sanz, I, O'Keefe, RJ, and Schwarz, EM: NF-kappa ß regulates VCAM-1
expression on fibroblast-like synoviocytes. The Journal of Immunology 164 (11):5990-7,
2000
59.
O’Keefe, RJ, Schwarz, EM, and Boyce, BF: Bone metastases: An update on
mechanisms of bone resorption and therapeutic strategies. Current Opinion in
Orthopaedics 11 (5):353-359, 2000
60.
Schwarz, EM, and O’Keefe, RJ: Breakthrough in bone: The molecular mechanism of
osteoclast/osteoblast coupling revealed. Current Opinion in Orthopaedics 11 (5):329335, 2000
61.
Chi, H, Yang, X, Kingsley, PD, O’Keefe, RJ, Puzas, JE, Rosier, RN, Shears, SB, and
Reynolds, PR: Targeted deletion of Minpp1 provides new insight into the activity of
multiple inositol polyphosphate phosphatase in vivo. Molecular and Cellular Biology 20
(17):6496-6507, 2000
62.
Andela, VB, Schwarz, EM, Puzas, JE, O’Keefe, RJ, and Rosier, RN: Tumor metastasis
and the reciprocal regulation of prometastatic and antimetastatic factors by nuclear factor
к ß. Cancer Research 60:6557-62, 2000
63.
Grimsrud, CD, Romano, PR, D’Souza, M, Reynolds, PR, Puzas, JE, Rosier, RN, and
O’Keefe, RJ: BMP signaling stimulates chondrocyte maturation and expression of
Indian Hedgehog. The Journal of Orthopaedic Research 19 (1):18-25, 2001
64.
Pollice, PF, Rosier, RN, Puzas, JE, Schwarz, EM, and O’Keefe, RJ: Oral pentoxifylline
inhibits the release of tumor necrosis factor alpha from human peripheral blood
monocytes: A potential treatment for aseptic loosening. The Journal of Bone and Joint
Surgery 83:1057-1061, 2001
26
65.
Ionescu, AM, Schwarz, EM, Vinson, C, Puzas JE, Rosier, RN, Reynolds, PR, and
O’Keefe, RJ: PTHrP modulates chondrocyte differentiation through AP-1 and CREB
signaling. The Journal of Biological Chemistry 276 (15):11639-47, 2001
66.
Childs, LM, Goater, JJ, O’Keefe, RJ, and Schwarz, EM: Efficacy of etanercept for wear
debris-induced osteolysis. The Journal of Bone and Mineral Research 16:338-47, 2001
67.
Zhang, X, Morham, SG, Langenbaach, R, Young, DA, Xing, L, Boyce, BF, Puzas, JE,
Rosier, RN, O’Keefe, RJ, and Schwarz, EM: Evidence for a direct role of
cyclooxygenase 2 in implant wear debris-induced osteolysis. The Journal of Bone and
Mineral Research 16 (4):660-670, 2001
68.
Pateder, DB, Ferguson, CM, Schwarz, E.M, Rosier, RN, Reynolds, PR, Puzas, JE, and
O’Keefe, RJ: PTHrP expression in chick sternal chondrocytes is regulated by TGF-ß
through Smad-mediated signaling. Journal of Cellular Physiology 188 (3):343-51, 2001
69.
Childs, LM, Goater, JJ, O’Keefe, RJ, and Schwarz, EM: The effect of anti-tumor
necrosis factor-α (TNFα) gene therapy on wear debris-induced osteolysis. The Journal of
Bone and Joint Surgery 83:1789-97, 2001
70.
Pateder, DB, Eliseev, RA, O'Keefe, RJ, Schwarz, EM, Okunieff, P, Constine, LS, Puzas,
JE, and Rosier, RN: The role of autocrine growth factors in radiation damage to the
epiphyseal growth plate. Radiation Research. 155 (6):847-57, 2001
71.
Zhang, X, Zhang, Y, Schwarz, EM, and O’Keefe, RJ: Cyclooxygenase and bone repair.
Current Opinion in Orthopaedics 12:397-402, 2001
72.
Huang, W, O’Keefe, RJ, and Schwarz, EM: Gene polymorphisms and musculoskeletal
disease. Current Opinion in Orthopaedics 12:416-23, 2001
73.
Konttinen YT; Mandelin J; Li TF; Salo J; Lassus J; Liljeström M; Hukkanen M; Takagi
M; Virtanen I; Santavirta S.; O'Keefe RJ. "Acidic cysteine endoproteinase cathepsin K
in the degeneration of the superficial articular hyaline cartilage in osteoarthritis." Arthritis
and rheumatism. 46(4):953-60. 2002
74.
Paavonen K; Mandelin J; Partanen T; Jussila L; Li TF; Ristimaki A; Alitalo K; Konttinen
YT. O'Keefe RJ "Vascular endothelial growth factors C and D and their VEGFR-2 and 3
receptors in blood and lymphatic vessels in healthy and arthritic synovium." The Journal
of rheumatology 29(1):39-45. 2002
75.
Mungo DV; Zhang X; O'Keefe RJ; Rosier RN; Puzas JE; Schwarz EM. "COX-1 and
COX-2 expression in osteoid osteomas." Journal of orthopaedic research: official
publication of The Orthopaedic Research Society 20(1):159-62, 2002
76.
Looney, RJ, Boyd, A., Totterman, S, Seo, GS, Tamez-Pena, J, Campbell, D, Novotny, L.,
Olcott, C., Martell, J, Hayes, FA, O'Keefe, RJ, and Schwarz, EM: Volumetric
27
Computerized Tomography as a measurement of periprosthetic acetabular osteolysis and
its correlation with wear. Arthritis Research 4 (1):59-63, 2002
77.
Carmody, EE, Schwarz, EM, Puzas, JE, Rosier, RN, and O’Keefe, RJ: IL-10 gene
therapy inhibits inflammation, osteoclastogenesis, and bone resorption in response to
titanium particles. Arthritis Research 46 (5):1298-1308, 2002
78.
Pateder, DB, Gish, MW, O’Keefe, RJ, Hicks, DG, Teot, L.A, and Rosier, RN:
Parathyroid hormone related peptide expression in cartilaginous tumors correlates with
malignancy. Clinical Orthopaedics and related research 403:198-204, 2002
79.
Goater, JJ, O’Keefe, RJ, and Schwarz, EM. Efficacy of ex vivo OPG gene therapy in
preventing wear debris induced osteolysis. The Journal of Orthopaedic Research 20
(2):169-73, 2002
80.
Puzas, JE, O’Keefe, RJ, and Lieberman, J: The orthopaedic genome: What does the
future hold and what are we ready to deal with it. The Journal of Bone and Joint Surgery
84-A (1):133-41, 2002
81.
Soloviev, A, Schwarz EM, Rosier RN, Reynolds PR, Puzas JE, and O’Keefe, RJ. The
role of p105 protein in NFk ß activation in ANA-1 murine macrophages following
stimulation with titanium particles. The Journal of Orthopaedic Research 20 (4):714-22,
2002
82.
Zuscik, MJ, O’Keefe, RJ, Gunter, TE, Puzas, JE, Schwarz, EM, and Rosier, RN:
Parathyroid hormone – related peptide regulation of chondrocyte maturation requires
protein kinase A. The Journal of Orthopaedic Research 20 (5):1079-90, 2002
83.
Zuscik, MJ, Pateder, DB, Puzas, JE, Schwarz, EM, Rosier, RN, and O'Keefe, RJ. Lead
alters parathyroid hormone-related peptide and transforming growth factor-beta1 effects
and AP-1 and NF-kappa ß signaling in chondrocytes. The Journal of Orthopaedic
Research 20 (4):811-18, 2002
84.
Andela, VB, Sheu, TJ, Puzas, EJ, Schwarz, EM, O'Keefe, RJ, and Rosier, RN:
Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of
NFkappaß. Biochemical and Biophysical Research Communications 297:237-41, 2002
85.
Good, CR, O’Keefe, RJ, Puzas, JE, Schwarz, EM, and Rosier, RN: An
immunohistochemical study of receptor activator of nuclear factor Kappa ß ligand
(RANK-L) in human osteolytic bone tumors. The Journal of Surgery and Oncology 79
(3):174-9, 2002
86.
Pateder, DB, Sheu, TJ, O'Keefe, RJ, Puzas, JE, Schwarz, EM, Constine, LS, Okunieff,
P, and Rosier, RN: Role of pentoxifylline in preventing radiation damage to epiphyseal
growth plate chondrocytes. Radiation Research 157(1):62-8, 2002
28
87.
Zhang, X, Schwarz, EM, Young, DA, Xing, L, Boyce, BF, Puzas, JE, Rosier, RN, and
O’Keefe, RJ: Cyclooxygenase-2 regulates mesenchymal cell differentiation into the
osteoblast lineage and is critically involved in bone repair. The Journal of Clinical
Investigation 109 (11):1405-1415, 2002
88.
Zuscik, MJ, D'Souza, M, Gunter, K.K, Gunter, TE, O'Keefe, RJ, Schwarz, EM, Puzas,
JE, and Rosier, RN: Growth plate chondrocyte maturation is regulated by basal
intracellular calcium. Experimental Cell Research 276:310-9, 2002
89.
Sheu, TJ, Schwarz, EM, O'Keefe, RJ, Rosier, RN, and Puzas, JE: Use of a phage
display technique to identify potential osteoblast binding sites within osteoclast lacunae.
The Journal of Bone and Mineral Research 17 (5):915-22, 2002
90.
Andela, VB, Rosenblatt, JD, Schwarz, EM, Puzas, JE, O'Keefe, RJ, and Rosier, RN:
Synergism of aminobisphosphonates and farnesyl transferase inhibitors on tumor
metastasis. Clinical Orthopaedics and related research 397:228-39, 2002
91.
Zhang, D, Ferguson, CM, O'Keefe RJ, Puzas, JE, Rosier, RN, and Reynolds, PR: A role
for the BMP antagonist chordin in endochondral ossification. The Journal of Bone and
Mineral Research 17 (2):293-300, 2002
92.
Childs, LM, Paschalis, EP, Xing, L, Dougall, WC, Anderson, D, Boskey, AL, Puzas, JE,
Rosier, RN, O'Keefe, RJ, Boyce, BF, and Schwarz, EM: In vivo RANK signaling
blockade using the receptor activator of NF-kappa ß: Fc effectively prevents and
ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting
osteogenesis. The Journal of Bone Mineral Research 17(2):192-9, 2002
93.
O’Keefe, RJ: Determination of responsiveness in biological systems is dependent on
highly sensitive quantitative measures. Annals of the New York Academy of Sciences
961:206, 2002
94.
Guilak, F., Kapur, R, Sefton, MV, Vandenburgh, H, Koretsky, AP, Kriete, A, and
O'Keefe, RJ: Functional assessment of engineered tissues and elements of tissue design:
breakout session summary. Annals of the New York Academy of Sciences 961:207-09,
2002
95.
Ulrich-Vinther, M, Maloney, M D, Goater, JJ, Soballe, K, Goldring, MB, O'Keefe, RJ,
and Schwarz, EM: Light-activated gene transduction enhances adeno-associated virus
vector-mediated gene expression in human articular chondrocytes. Arthritis
Rheumatology 46 (8):2095-104, 2002
96.
Ulrich-Vinther, M, Carmody, EE, Goater, JJ, Soballe, K, O'Keefe, RJ, and Schwarz,
EM: Recombinant adeno-associated virus-mediated osteoprotegerin gene therapy
inhibits wear debris-induced osteolysis. The Journal of Bone and Joint Surgery 84A
(8):1405-12, 2002
29
97.
Ballock RT; O'Keefe RJ. "Physiology and pathophysiology of the growth plate." Birth
defects research. Part C, Embryo today : reviews. 69(2):123-43. 2003
98.
Huang W; Drissi MH; O'Keefe RJ; Schwarz EM. "A rapid multiparameter approach to
study factors that regulate osteoclastogenesis: demonstration of the combinatorial
dominant effects of TNF-alpha and TGF-ss in RANKL-mediated osteoclastogenesis."
Calcified tissue international. 73(6):584-93. 2003
99.
Huang, W, O'Keefe, RJ, and Schwarz, EM: Exposure to receptor-activator of NFkappa
ß ligand renders pre-osteoclasts resistant to IFN-gamma by inducing terminal
differentiation. Arthritis Research and Therapy 5 (1):R49-59, 2003
100.
Li, X, Ionescu, AM, Schwarz, EM, Zhang, X, Drissi, H, Puzas, JE, Rosier, RN, Zuscik,
MJ, and O'Keefe, RJ: Smad6 is induced by BMP-2 and modulates chondrocyte
differentiation. The Journal of Orthopaedic Research 21 (5):908-13, 2003
101.
Li, X, Schwarz, EM, Zuscik, MJ, Rosier, RN, Ionescu, A.M, Puzas, JE, Drissi, H, Sheu,
TJ, and O'Keefe, RJ: Retinoic acid stimulates chondrocyte differentiation and enhances
bone morphogenetic protein effects through induction of Smad1 and Smad5.
Endocrinology 144 (6):2514-23, 2003
102.
Ionescu, AM, Schwarz, EM, Zuscik, MJ, Drissi, H, MJ, Puzas, JE, Rosier, RN, and
O'Keefe, RJ: ATF-2 cooperates with Smad3 to mediate TGF-beta effects on
chondrocyte maturation. Experimental Cell Research 288 (1):198-207, 2003
103.
Flick, L, Weaver, JM., Ulrich-Vinther, M, Abuzzahab, F, Zhang, X, Dougall, WC,
Anderson, D, O'Keefe, RJ, and Schwarz, EM: Effects of receptor activator of NFkappa
ß (RANK) signaling blockade on fracture healing. The Journal of Orthopaedic Research
21 (4):676-84, 2003
104.
Andela, VB, Gingold, BI, Souza, MD, O'Keefe, RJ, Puzas, EJ, Schwarz, EM, and
Rosier, RN: Clinical relevance of increased retinoid and cAMP transcriptional programs
in tumor cells rendered non-malignant by dominant negative inhibition of NFkappa ß.
Cancer Letters 194 (1):37-43, 2003
105.
Ballock, RT., and O'Keefe, RJ: The biology of the growth plate. The Journal of Bone
and Joint Surgery 85A (4):715-26, 2003
106.
Sheu, TJ, Schwarz, EM, Martinez, DA, O'Keefe, RJ, Rosier, RN, Zuscik, MJ, and Puzas,
JE: A phage display technique identifies a novel regulator of cell differentiation. The
Journal of Biological Chemistry 278 (1):438-43, 2003
107.
Andela, VB, Gordon, AH, Zotalis, G, Rosier, RN, Goater, JJ, Lewis, G.D, Schwarz, EM,
Puzas, JE, and O’Keefe, RJ: NFKappa ß: A pivotal transcription factor in prostate
cancer metastasis to bone. Clinical Orthopaedics and related research 415:S75-85, 2003
30
108.
Andela, VB, Pirri M, Schwarz, EM, Puzas, JE, O’Keefe, RJ, Rosenblatt, JD, and Rosier,
RN: The mevalonate synthesis pathway as a therapeutic target in cancer. Clinical
Orthopaedics and related research 415 S:S59-66, 2003
109.
O’Keefe, RJ, and Guise, TA: Molecular mechanisms of bone metastasis and therapeutic
implications. Clinical Orthopaedics and related research 415 S:S100-04, 2003
110.
Zhang, D, Schwarz, EM, Rosier, RN, Zuscik, MJ, Puzas, JE, and O’Keefe, RJ: ALK2
functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during
skeletal development. The Journal of Bone and Mineral Research 18 (9):1 593-604, 2003
111.
Ulrich-Vinther, M, Maloney, M.D, Schwarz, EM, Rosier, R, and O'Keefe, RJ: Articular
cartilage biology. The Journal of the American Academy of Orthopaedic Surgeons 11
(6):421-430, 2003
112.
Bukata, SV, Gelinas, J, Wei, X, Rosier, RN, Puzas, JE, Zhang, X, Schwarz, EM, Song,
XR, Griswold, DE, and O'Keefe, RJ: PGE2 and IL-6 production by fibroblasts in
response to titanium wear debris particles is mediated through a Cox-2 dependent
pathway. The Journal of Orthopaedic Research 22 (1):6-12, 2003
113.
Drissi, M.H., Li, X., Sheu, T.J., Zuscik, M.J., Schwarz, E.M., Puzas, J.E., Rosier, R.N.,
and O'Keefe, RJ: Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2
signaling through interaction with Smad1 on the collagen X promoter in chondrocytes.
The Journal of Cellular Biochemistry. 90 (6):1287-98, 2003
114.
Schwarz, EM, Campbell, D, Totterman, S, Boyd, A, O'Keefe, RJ, and Looney, RJ: Use
of volumetric computerized tomography as a primary outcome measure to evaluate drug
efficacy in the prevention of peri-prosthetic osteolysis: A 1-year clinical pilot of
etanercept vs. placebo. The Journal of Orthopaedic Research 21 (6):1049-55, 2003
115.
Puzas, JE, O’Keefe, RJ, Schwarz, EM, and Zhang, X: Pharmacologic modulators of
fracture healing: The role of cyclooxygenase inhibition. Journal of Musculoskeletal
Neuronal Interactions 3 (4):308-312, 2003
116.
Ito, H, Goater, JJ, Tiyapatanaputi, P, Rubery, PT, O'Keefe, RJ, and Schwarz, EM:
Light-activated gene transduction of recombinant adeno-associated virus in human
mesenchymal stem cells. Gene Therapy. 11 (1):34-41, 2004
117.
Li, P, Schwarz, EM, O’Keefe, RJ, Ma, L, Looney, RJ, Ritchlin, CT, Boyce, BF, and
Xing, L: Systemic tumor necrosis factor α mediates an increase in peripheral
CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice.
Arthritis and Rheumatology 50 (1):265-276, 2004
118.
Ionescu, AM, Drissi H, Schwarz, E.M, Kato, M, J. Puzas, JE, McCance, DJ, Rosier,
31
RN, Zuscik, MJ, and O’Keefe, RJ: CREB cooperates with BMP-stimulated Smad
signaling to enhance transcription of the Smad6 promoter. Journal of Cellular
Physiology 198 (3):428-440, 2004
119.
Li, P, Schwarz, EM, O’Keefe, RJ, Ma, L, Boyce, BF, and Xing, L: RANK signaling is
not required for TNF alpha-mediated increase in CD11bhi osteoclast precursors but is
essential for mature osteoclast formation in TNF alpha-mediated inflammatory arthritis.
The Journal of Bone and Mineral Research 19 (2):207-213, 2004
120.
Bukata, SV, Gelinas, J, Wei, X, Rosier, RN, Puzas, JE, Zhang, X, Schwarz, EM, Song,
XR, Griswold, DE, and O’Keefe, RJ: PGE2 and IL-6 production by fibroblasts in
response to titanium wear debris particles is mediated through a Cox-2 dependent
pathway. The Journal of Orthopaedic Research 22:2-12, 2004
121.
Zuscik, MJ, Baden, JF, Wu, Q, Sheu, TJ, Schwarz, E.M, Drissi, H, O’Keefe, RJ, Puzas,
JE, and Rosier, RN: 5-azacytidine alters TGF-beta and BMP signaling and induces
maturation in articular chondrocytes. Journal of Cellular Biochemistry 92 (2):316-31,
2004
122.
Zhang, X, Ziran, N, Goater, JJ, Schwarz, E.M, Puzas, JE, Rosier, RN, Zuscik, MJ, Drissi,
H, and O’Keefe, RJ: Primary murine limb bud mesenchymal cells in long-term culture
complete chondrocyte differentiation: TGF-beta delays hypertrophy and PBGE2 inhibits
terminal differentiation. Bone 34: 909-817, 2004
123.
Ferguson, CM, Schwarz, EM, Puzas, JE, Zuscik, MJ, Drissi, MH, and O’Keefe, RJ:
Transforming growth factor – beta1 induced alteration of skeletal morphogenesis in vivo.
The Journal of Orthopaedic Research 22 (4):687-96, 2004
124.
Ritchlin, CT, Schwarz, EM, O’Keefe, RJ, and Looney, RJ.: RANK, RANKL and OPG
in inflammatory arthritis and periprosthetic osteolysis. Journal of Musculoskeletal
Neuronal Interactions, 4 (3):276-284, 2004
125.
Ulrich-Vinther, M, Duch, MR, Soballe, K, O’Keefe, RJ, Schwarz, EM, and Pedersen,
FS: In vivo gene delivery to articular chondrocytes mediated by an adeno-associated virus
vector. The Journal of Orthopaedic Research 22 (4):726-34, 2004
126.
Schwarz, EM, O’Keefe, RJ, and Looney, RJ: Bone implant interface, osteolysis and
potential therapies. Journal of Musculoskeletal Neuronal Interactions 4 (4):390-392,
2004
127.
Li, TF, Dong, Y, Ionescu, AM, Rosier, RN, Zuscik, MJ, Schwarz, EM, O’Keefe, RJ, and
Drissi, H: Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression
through the PKA signaling pathway. Experimental Cell Research 299: 128-136, 2004
32
128.
Li, TF, Zuscik, MJ, Ionescu, AM, Zhang, X, Rosier, RN, Schwarz, EM, Drissi, H, and
O’Keefe, RJ: PGE2 inhibits chondrocyte differentiation through PKA and PKC
signaling. Experimental Cell Research 300 (1):159-169, 2004
129.
Tiyapatanaputi, P, Rubery, PT, Carmouche, J, Schwarz, EM, O’Keefe, RJ, and Zhang,X.
A novel murine segmental femoral graft model: Journal of Orthopaedic Research 22
(6):1254-1260, 2004
130.
Guldberg, RE, Oest, M, Lin, ASP, Ito, H, Chao, S, Gromov, K, Goater, JJ, Koefoed, M,
Schwarz, EM, O’Keefe, RJ, and Zhang, X: Functional integration of tissue- engineered
bone constructs. Journal of Musculoskeletal and Neuronal Interactions 4 (4):399-400,
2004
131.
O’Keefe, RJ, and Rubery, PT: Point of View. Spine 30 (1):31-32, 2005
132.
Li, T, O’Keefe, RJ, and Chen, D: TGF- Beta signaling in chondrocytes. Frontiers in
Bioscience 10: 681-688, 2005
133.
Blaine, TA, Kim, YS, Voloshin, I, Chen, D., Murakami, K, Chang, SS, Winchester, R,
Lee, F.Y., O’Keefe, RJ, and Bigliani, L.U.: The molecular pathophysiology of
subacromial bursitis in rotator cuff disease. Journal of Shoulder and Elbow Surgery 14
(1S):84S-89S, 2005
134.
Ito, H, Koefoed, M, Tiyapatanaputi, P, Gromov, K, Goater, JJ, Carmouche, J, Zhang, X,
Rubery, PT, Rabinowitz, J, Samulski, RJ, Nakamura, T, Soballe, K, O’Keefe, RJ, Boyce,
BF, and Schwarz, EM: Remodeling of cortical bone allografts mediated by adherent
rAAV-RANKL and VEGF gene therapy. Nature Medicine 11 (3):291-297, 2005
135.
Clark, CA, Zuscik, MJ, Zhang, X, Ziran, NM, Drissi, H, Schwarz, EM, and O’Keefe, RJ:
Differential regulation of EP receptor isoforms during condrogenesis and chondrocyte
maturation. Biochemical and Biophysical Research Communications 328: 764-776, 2005
136.
Gordon, AH, O’Keefe, RJ, Schwarz, EM, Rosier, RN, and Puzas, JE: Nuclear factorkappaB-dependent mechanisms in breast cancer cells regulate tumor burden and
osteolysis in bone. Cancer Research 65 (6):3209-17, 2005
137.
Soloviev, A, Schwarz, EM, Darowish, M and O’Keefe, RJ: Sphingomyelinase mediates
macrophage activation by titanium particles independent of phagocytosis: A role for free
radicals, NFkappaB, and TNFalpha. The Journal of Orthopaedic Research 23 (6):125865, 2005
138.
Dong, Y, Drissi, H, Chen, M, Chen, D. Zuscik, MJ, Schwarz, EM, and O’Keefe, RJ:
Wnt-mediated regulation of chondrocyte maturation: Modulation by TGF-beta. Journal
of Cellular Biochemistry 95:1057-68, 2005
33
139.
Drissi, H, Zuscik, M, Rosier, R, and O’Keefe, RJ: Transcriptional regulation of
chondrocyte maturation: Potential involvement of transcription factors in OA
pathogenesis. Molecular Aspects of Medicine 26:169-179, 2005
140.
Carmouche, JJ, Puzas, JE, Zhang, X, Tiyapatanaputi, P, Cory-Slechta, DA, Gelein, R,
Zuscik, M, Rosier, RN, Boyce, BF, O’Keefe, RJ, and Schwarz, EM: Lead exposure
inhibits fracture healing and is associated with increased chondrogenesis, delay in
cartilage mineralization, and a decrease in osteoprogenitor frequency. Environmental
Health Perspectives 113 (6):749-755, 2005
141.
Wei, X, Zhang, X, Zuscik, MJ, Drissi, MH, Schwarz, EM, and O’Keefe, RJ: Fibroblasts
express RANKL and support osteoclastogenesis in a COX-2 dependent manner after
stimulation with titanium particles. The Journal of Bone and Mineral Research 20
(7):1136-48, 2005
142.
Koefoed, M., Ito, H, Gromov, K, Awad, HA, Rubery, PT, Ulrich-Vinther, M, Soballe, K,
Guldberg, RE, Lin, AS, O’Keefe, RJ, and Schwarz, EM: Biological effects of rAAVcaAlk2 coating on structural allograft healing. Molecular Therapy 12(2):212-8, 2005
143.
Wang, Y, Belflower, RM, Dong, YF, Schwarz, EM, O’Keefe, RJ, and Drissi, H:
Runx1/AML1/Cbfa2 mediates onset of mesenchymal cell differentiation toward
chondrogenesis. The Journal of Bone and Mineral Research 20 (9):1624-36, 2005
144.
Voloshin,I, Gelinas J, Maloney MD, O'Keefe, RJ, Bigliani LU, and Blaine TA:
Proinflammatory cytokines and metalloproteases are expressed in the subacromial bursa
in patients with rotator cuff disease. The Journal of Arthroscopic and Related Surgery 21
(9):1076-1076, 2005
145.
Eliseev, RA, Zuscik, MJ, Schwarz, EM, O'Keefe, RJ, Drissi, H, and Rosier, RN:
Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: A role
for c-Jun N-terminal kinase. Journal of Cellular Biochemistry 96-6:1262-73, 2005
146.
Boyce, BF, Li, P, Yao, Z, Zhang, Q, Badell, IR, Schwarz, EM, O'Keefe, RJ, and Xing,
L: TNF-alpha and pathologic bone resorption. The Keio Journal of Medicine 54 (3):12731, 2005
147.
Zhang, X, Xie, C, Lin, AS, Ito, H, Awad, H, Lieberman, JR, Rubery, PT, Schwarz, EM,
O'Keefe, RJ, and Guldberg, RE: Periosteal progenitor cell fate in segmental cortical
bone graft transplantations: implications for functional tissue engineering. The Journal of
Bone and Mineral Research 20 (12):2124-37, 2005
148.
Andela, VB, Schwarz, EM, O'Keefe, RJ, Puzas, EJ, Rosenblatt, JD, and Rosier, RN: A
genome-wide expression profile and system-level integration of nuclear factor kappa B
regulated genes reveals fundamental metabolic adaptations during cell growth and
survival. FEBS Letters 579 (30):6814-6820, 2005
34
149.
Zhang, X, Naik, A, Xie, C, Reynolds, D, Palmer, J, Lin, A, Awad, H, Guldberg, R,
Schwarz, EM, and O'Keefe, RJ: Periosteal stem cells are essential for bone
revitalization and repair. Journal of Musculoskeletal Neuronal Interactions 5 (4):360-2,
2005
150.
O'Keefe, RJ: Summary - cell therapies for orthopedic applications. Journal of
Musculoskeletal Neuronal Interactions 5 (4):367-8, 2005
151.
Smith, N, Dong, Y, Lian, JB, Pratap, J, Kingsley, PD, VanWijnen, AJ, Stein, JL,
Schwarz, EM, O'Keefe, RJ, Stein, GS, Drissi, MH: Overlapping Expression of Runx1
(Cbfa2) and Runx2 (Cbfa1) Transcription Factors Supports Cooperative Induction of
Skeletal Development. Journal of Cellular Physiology 203:133-143, 2005
152.
Xie,C.; Reynolds,D.; Awad,H.; Rubery,P. T.; Pelled,G.; Gazit,D.; Guldberg,R. E.;
Schwarz,E. M.; O'Keefe,R. J.; Zhang,X.;. "Structural Bone Allograft Combined with
Genetically Engineered Mesenchymal Stem Cells As a Novel Platform for Bone Tissue
Engineering". Tissue Engineering 2006
153.
Shen, R, Chen, M, Wang, YJ, Kaneki, H, Xing, L, O'Keefe, RJ, and Chen, D: Smad6
interacts with Runx2 and mediates Smad ubiquitin regulator factor1-induced Runx2
degradation. The Journal of Biological Chemistry 281 (6):3569-76, 2006
154.
O’Keefe, RJ, Tiyapatanaputi, P, Xie, C, Fang Li, T, Clark, C, Zuscik, MJ, Chen, D,
Drissi, H., Schwarz, EM, and Zhang, X: COX-2 has a critical role during incorporation
of structural bone allografts. Annals of the New York Academy of Sciences 1068:53242, 2006
155.
Looney, RJ, Schwarz, EM, Boyd, A, and O'Keefe, RJ: Periprosthetic osteolysis: an
immunologist's update. Current Opinion in Rheumatology 18 (1):80-87, 2006
156.
Li, TF, Darowish, M, Zuscik, MJ, Chen, D, Schwarz, EM, Rosier, RN, Drissi, H, and
O'Keefe, RJ: Smad3-deficient chondrocytes have enhanced BMP signaling and
accelerated differentiation. The Journal of Bone and Mineral Research 21:4-16, 2006
157.
Eliseev, RA, Schwarz, EM, Zuscik, MJ, O'Keefe, RJ, Drissi, H, and Rosier, RN:
Smad7mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB.
Experimental Cell Research 312:40-50, 2006
158.
Maloney, MD, Goater, JJ, Parsons, R., Ito, H., O’Keefe, RJ, Rubbery, PT, Drissi, MH,
and Schwarz, EM: Safety and efficacy of ultraviolet-A light-activated gene transduction
for gene therapy of articular cartilage defects. The Journal of Bone and Joint Surgery
88:753-761, 2006
159.
Shen, R, Wang, W, Drissi, H, Liu, F, O’Keefe, RJ, and Chen, D: Cyclin D1-cdk4 induce
Runx2 ubiquitination and degradation. The Journal of Biological Chemistry 281
(24):16,347-53, 2006
35
160.
Dong, Y, Soung, DY, Schwarz, EM, O’Keefe, RJ, and Drissi, H: Wnt induction of
chondrocyte hypertrophy through the Runx2 transcription factor. Journal of Cellular
Physiology 208:77-86, 2006
161.
Nishio,Y, Dong,Y, Paris, M, O’Keefe, RJ, Schwarz, EM and Drissi, MH: Runx2mediated Regulation of the Zinc Finger Osterix/Sp7. Gene 372: 62-70, 2006
162.
Li, TF, Chen, D, Wu, Q, Sheu, T, Schwarz, EM, Drissi, H, Zuscik, MJ. and O’Keefe, RJ:
TGF-catenin signaling in
chondrocytes. The Journal of Biological Chemistry 281 (30):21,296-304, 2006
163.
Schwarz, EM, Looney, RJ, Drissi, MH, O’Keefe, RJ, Boyce, BF, Xing, L. and Ritchlin,
CT: Autoimmunity and bone. Annals of the New York Academy of Sciences 1068:275283, 2006
164.
Robertson, G, Xie, C, Chen, D, Awad, H, Schwarz, EM, O’Keefe, RJ, Guldberg, R.E.
and Zhang, X. Alteration of femoral bone morphology and density in COX-2-/- mice.
Bone 39:767-72, 2006
165.
Baumhauer, JF, O’Keefe, RJ, Schon, LC and Pinzur, MS: Cytokine-induced osteoclastic
bone resorption in Charcot Arthropathy: An immunohistochemical study. Foot and
Ankle International 10:797-800, 2006
166.
O’Keefe, RJ, Leach, JK, McDevitt, CA: On the horizon from the ORS. Journal of
American Academy of Orthopaedic Surgery 14 (10):629-31, 2006
167.
Xie, C, Reynolds, D, Awad, H, Rubery, PT, Pelled, G., Gazit, D., Guldberg, RE,
Schwarz, E.M., O’Keefe, RJ, Zhang, X. Structural bone allograft combined with
genetically engineered mesenchymal stem cells as a novel platform for bone tissue
engineering. Tissue Engineering 13 (3):435-45, 2007
168.
Chen M, Lichtler AC, Sheu TJ, Xie C, Zhang X, O’Keefe RJ, Chen, D. Generation of a
transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression
of Cre recombinase. Genesis 45:44-50, 2007
169.
Wang Q, Wei X, Zhu T, Zhang M, Shen R, Xing L, O'Keefe RJ, Chen D. Bone
morphogenetic protein 2 activates Smad6 gene transcription through bone-specific
transcription factor Runx2. The Journal of Biological Chemistry 282 (14):10742-8, 2007
170.
Awad HA, Zhang X, Reynolds DG, Guldberg RE, O'Keefe RJ, Schwarz EM. Recent
Advances in Gene Delivery for Structural Bone Allografts: A Review. Tissue
Engineering 13 (8): 1973-85, 2007
171.
Reynolds DG, Hock C, Shaikh S, Jacobson J, Zhang X, Rubery PT, Beck CA, O'Keefe
RJ, Lerner AL, Schwarz EM, Awad HA. Micro-computed tomography prediction of
36
biomechanical strength in murine structural bone grafts. Journal of Biomechanics 40
(14):3178-86, 2007
172.
Soung do Y, Dong Y, Wang Y, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H.
Runx3/AML2/Cbfa3 Regulates Early and Late Chondrocyte Differentiation. The Journal
of Bone and Mineral Research 22 (8):1260-70, 2007
173.
Zuscik MJ, Ma L, Buckley T, Puzas JE, Drissi H, Schwarz EM, O'Keefe RJ. Lead
induces chondrogenesis and alters transforming growth factor-beta and bone
morphogenetic protein signaling in mesenchymal cell populations. Environmental Health
Perspectives 115 (9):1276-82, 2007
174.
Dao DY, Yang X, Chen D, Zuscik M, O'Keefe RJ. Axin1 and Axin2 are regulated by
TGF- and mediate cross-talk between TGF- and Wnt signaling pathways. Annals of the
New York Academy of Sciences 15:82-99, 2007
175.
Dong YF, Soung do Y, Chang Y, Enomoto-Iwamoto M, Paris M, O'Keefe RJ, Schwarz
EM, Drissi H. Transforming growth factor-beta and Wnt signals regulate chondrocyte
differentiation through Twist1 in a stage-specific manner. Molecular Endocrinology 21
(11):2805-20, 2007
176.
Zhu M; Chen M; Lichtler AC; O'Keefe RJ; Chen D. "Tamoxifen-inducible Crerecombination in articular chondrocytes of adult Col2a1-CreER(T2) transgenic mice."
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 16(1):129-30, 2008
177.
Li D, Gromov K, Soballe K, Puzas JE, O'Keefe RJ, Awad H, Drissi H, Schwarz EM.
Quantitative mouse model of implant-associated osteomyelitis and the kinetics of
microbial growth, osteolysis, and humoral immunity. The Journal of Orthopaedic
Research 26 (1): 96-106, 2008
178.
Usui M, Xing L, Drissi H, Zuscik M, O'Keefe RJ, Chen D, Boyce BF Murine and
Chicken Chondrocytes Regulate Osteoclastogenesis by Producing RANKL in Response
to BMP2. The Journal of Bone and Mineral Research 23 (3): 314-325, 2008
179.
Wu Q, Chen D, Zuscik MJ, O'Keefe RJ, Rosier RN. Overexpression of Smurf2
Stimulates Endochondral Ossification Through Upregulation of beta-Catenin. The
Journal of Bone and Mineral Research 26 (5):704-712, 2008
180.
Kaback LA, Soung DY, Naik A, Smith N, Schwarz EM, O'Keefe RJ, Drissi H.
Osterix/Sp7 regulates mesenchymal stem cell mediated endochondral ossification.
Journal of Cellular Physiology. 214 (1):173-82, 2008
181.
Wu Q, Wang M, Zuscik MJ, Chen D, O'Keefe RJ, Rosier RN.-Regulation of embryonic
endochondral ossification by Smurf2. The Journal of Orthopaedic Research 26 (5): 704712, 2008
37
182.
Basile P, Dadali T, Jacobson J, Hasslund S, Ulrich-Vinther M, Søballe K, Nishio Y,
Drissi MH, Langstein HN, Mitten DJ, O'Keefe RJ, Schwarz EM, Awad HA. Freezedried Tendon Allografts as Tissue-engineering Scaffolds for Gdf5 Gene Delivery.
Molecular Therapy 16 (3): 466-473, 2008
183.
Hasslund S, Jacobson JA, Dadali T, Basile P, Ulrich-Vinther M, Schwarz EM, O'Keefe
RJ, Mitten DJ, Awad HA. Adhesions in a murine flexor tendon graft model: Autograft
versus allograft reconstruction. The Journal of Orthopaedic Research 26 (6): 824-33,
2008
184.
Eliseev RA, Dong YF, Sampson E, Zuscik MJ, Schwarz EM, O'Keefe RJ, Rosier RN,
Drissi MH. -Runx2-mediated activation of the Bax gene increases osteosarcoma cell
sensitivity to apoptosis. Oncogene 27: 3605-14, 2008
185.
Xie C, Xue M, Wang Q, Schwarz EM, O'Keefe RJ, Zhang X. Tamoxifen- inducible
CreER-mediated gene targeting in periosteum via bone-graft transplantation. The Journal
of Bone and Joint Surgery 90 Suppl 1:9-13, 2008
186.
Zuscik MJ, Hilton MJ, Zhang X, Chen D, O'Keefe RJ. Regulation of chondrogenesis
and chondrocyte differentiation by stress. The Journal of Clinical Investigation 118: 42938, 2008
187.
Chen M, Zhu M, Awad H, Li TF; Sheu TJ, Boyce BF, Chen D, O'Keefe RJ. Inhibition
of (beta)-catenin signaling causes defects in postnatal cartilage development. Journal of
Cell Science 21; (Pt 9):1455-65, 2008
188.
Xie C, Ming X, Wang Q, Schwarz EM, Guldberg RE, O’Keefe RJ, Zhang X. COX-2
from the injury milieu is critical for the initiation of periosteal progenitor cell mediated
bone healing. Bone 43 (6): 1075-83, 2008
189.
Tsutsumi R, Hock C, Bechtold CD, Proulx ST, Bukata SV, Ito H, Awad H, Nakamura T,
O'Keefe RJ, Schwarz, EM. Differential effects of biologic versus bisphosphonate
inhibition of wear debris-induced osteolysis assessed by longitudinal micro-CT. The
Journal of Orthopaedic Research 26 (10):1340-6, 2008
190.
Kaback, LA, Soung DY, Naik A, Geneau G, Schwarz EM, Rosier RN, O’Keefe, RJ,
Drissi, H. Teriparatide (1-34 human PTH) regulation of osterix during fracture repair.
Journal of Cellular Biochemistry 1:105: (1):219-26, 2008
191.
Zhang X, Awad, HA, O’Keefe, RJ, Guldberg, RE, Schwarz, EM. A perspective:
engineering periosteum for structural bone graft healing. Clinical Orthopaedics and
Related Research 466: 1777-87, 2008
192.
Bostrom M, O'Keefe RJ. What experimental approaches (eg, in vivo, in vitro, tissue
retrieval) are effective in investigating the biologic effects of particles? The Journal of
the American Academy of Orthopaedic Surgeons 16 Suppl 1:S63-67, 2008
38
193.
Wu Q, Kim KO, Sampson ER, ChenD, Awad H, O’Brien T, Puzas JE, Drissi H, Schwarz
EM, O’Keefe RJ, Zuscik, MJ, Rosier RN. Induction of an osteoarthritis-like phenotype
and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice. Arthritis and
Rheumatism 58 (10): 3132-44, 2008
194.
Wu, W; Huang, JH; Sampson, ER; Kim, KO; Zuscik, MJ; O'Keefe, RJ; Chen, D; Rosier,
RN. "Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in
chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular
cartilage". Experimental Cell Research 315(14): 2386-98, 2009
195.
Clark CA, Li RF, Kim KO, Drissi H, Zuscik MJ, Zhang X, O’Keefe RJ. Prostaglandin
E2 inhibits BMP signaling and delays chondrocyte maturation. The Journal of
Orthopaedic Research 27(6):785-92, 2009
196.
Loiselle AE, Bragdon GA, Jacobson JA, Hasslund S, Cortes ZE, Schwarz EM, Mitten
DJ, Awad HA, O’Keefe RJ. Remodeling of murine intravnovial tendon adhesions
following injury; MMP and neotendon gene expression. The Journal of Orthopaedic
Research 27(6):833-40, 2009
197.
Zhu M, Tang D, Wu Q, Hao S, Chen M, Xie C, Rosier RN, O'Keefe RJ, Zuscik MJ,
Chen D. Activation of beta-Catenin Signaling in Articular Chondrocytes Leads to
Osteoarthritis-Like Phenotype in Adult beta-Catenin Conditional Activation Mice. The
Journal of Bone and Mineral Research 24(1):12-21, 2009
198.
Crane DP, Gromov K, Li D, Soballe K, Wahnes C, Buchner H, Hilton MJ, O’Keefe RJ,
Murray CK, Schwarz EM. Efficacy of colistin-impregnated beads to prevent multidrugresistent A. baumannii implant-associated osteomyelitis. The Journal of Orthopaedic
Research (8):1008-15, 2009
199.
Naik AA, Xie C, Zuscik MJ, Kingsley P, Schwarz EM, Awad H, Guldberg, R, Drissi H,
Puzas JE, Boyce B, Zhang X, O’Keefe RJ. Reduced COX-2 expression in aged mice is
associated with impaired fractured healing. The Journal of Bone and Mineral Research
24 (2): 251-64, 2009
200.
Reynolds DG, Shaikh S, Papuga MO, Lerner AL, O’Keefe RJ, Schwarz EM, Awad HA.
muCT-based measurement of cortical bone graft-to-host union. The Journal of Bone and
Mineral Research 24 (5): 899-907, 2009
201.
Taylor DK, Meganck JA, Terkhorn S, Rajani R, Naik A, O’Keefe RJ, Goldstein SA,
Hankenson KD. Thrombospondin-2 influences the proportion of cartilage and bone
during fracture healing. The Journal of Bone and Mineral Research 24 (6): 1043-54, 2009
202.
Tsutsumi R, Xie, C, Wei X, Zhang X, Flick LM, Schwarz EM, O’Keefe RJ. PGE2
signaling through the EP4 Receptor on fibroblasts upregulates RANKL and stimulates
osteolysis. The Journal of Bone and Mineral Research 24 (10): 1753-62, 2009
39
203.
Darowish M. Rahman R. Li P, Bukata SV, Gelinas J, Huang W, Flick LM, Schwarz EM,
O’Keefe RJ. Reduction of particle-induced osteolysis by interleukin-6 involves antiinflammatory effect and inhibition of early osteoclast precursor differentiation. Bone.
45(4):661-8, 2009
204.
Xie C, Liang B, Xue M, Lin AS, Loiselle A, Schwarz EM, Guldberg RE, O’Keefe RJ,
Zhang X. Rescue of impaired fracture healing in COX-2-/- mice via activation of
prostaglandin E2 receptor subtype 4. The American Journal of Pathology 175 (2): 77285, 2009
205.
Wei X, Zhang X, Flick LM, Drissi H, Schwarz EM, O’Keefe RJ. Titanium particles
stimulate COX-2 expression in synolvial fibroblasts through an oxidative stress- induced,
calpain-dependent, NF-Kappa B pathway. American Journal of Physiology 297
(2):C310-20, 2009
206.
Frisch BJ, Porter RL, Gigliotti BJ, Olm-Shipman AJ, Weber JM, O'Keefe RJ, Jordan
CT, Calvi LM. In vivo prostaglandin E2 treatment alters the bone marrow
microenvironment and preferentially expands short-term hematopoietic stem cells. Blood
114-19:4054-63, 2009
207.
Yan Y, Tang D, Chen M, Huang J, Xie R, Jonason JH, Tan X, Hou W, Reynolds D, Hsu
W, Harris SE, Puzas JE, Awad H, O'Keefe RJ, Boyce BF, Chen D. Axin2 controls bone
remodeling through the beta-catenin-BMP signaling pathway in adult mice. Journal of
Cell Science 122-Pt 19:3566-78, 2009
208.
Guise, TA, O'Keefe, RJ, Randall, RL, Terek, RM.: Molecular biology and therapeutics
in musculoskeletal oncology. The Journal of Bone and Joint Surgery 91:724-32, 2009
209.
Shane E, Burr D, Ebeling PR, Abrahamsen B, Adler RA, Brown TD, Cheung AM,
Cosman F, Curtis JR, Dell R, Dempster D, Einhorn TA, Genant HK, Geusens P,
Klaushofer K, Koval K, Lane JM, McKiernan F, McKinney R, Ng A, Nieves J, O'Keefe
R, Papapoulos S, Sen HT, van der Meulen MC, Weinstein RS, Whyte M; American
Society for Bone and Mineral Research. "Atypical subtrochanteric and diaphyseal
femoral fractures: report of a task force of the American Society for Bone and Mineral
Research." Journal of Bone and Mineral Research. 2010; 25(11): 2267-94
210.
Li D, Gromov K, Proulx ST, Xie C, Li J, Crane DP, Soballe K, O'Keefe RJ, Awad HA,
Xing L, Schwarz EM. Effects of anti-resorptive agents on osteomyelitis: Novel insights
on osteonecrosis of the jaw (ONJ) pathogenesis. Annals of the New York Academy of
Sciences 1192(1):84-95, 2010
211.
Gunnell, LM, Jonason, JH, Loiselle, AE, Kohn, A, Schwarz, EM, Hilton, M J. O'Keefe,
RJ. TAK1 regulates cartilage and joint Development via the MAPK and BMP Signaling
pathways. The Journal of Bone and Mineral Research 25 (8): 1784-97, 2010
40
212.
Dao DY, Yang X, Flick LM, Chen D, Hilton MJ, O’Keefe RJ. Axin2 regulates
chondrocyte maturation and axial skeletal development. The Journal of Orthopaedic
Research 28(1):89-95, 2010
213.
Dong Y, Jesse AM, Kohn A, Gunnell LM, Honjo T, Zuscik MJ, O'Keefe RJ, Hilton MJ.
RBPj(kappa)-dependent Notch signaling regulates mesenchymal progenitor cell
proliferation and differentiation during skeletal development. Development 137
(9):1461-71, 2010
214.
Yanoso-Scholl L, Jacobson JA, Bradica G, Lerner AL, O'Keefe RJ, Schwarz EM,
Zuscik MJ, Awad HA. Evaluation of dense polylactic acid/beta-tricalcium phosphate
scaffolds for bone tissue engineering. Journal of Biomedical Materials Research 2010
215.
Li TF, Gao L, Sheu RJ, Sampson ER, Flick LM, Konttinnen YR, Chen D. Schwarz EM,
Zuscik MJ, Jonason JH, O’Keefe RJ. Aberrant hypertrophy in Smad3-deficient murine
chondrocytes is rescued by restoring transforming growth factor beta-activated kinase
1/activating transcription factor 2 signaling: a potential clinical implication for
osteoarthritis Arthritis and Rheumatism 62 (8):2359-69, 2010
216.
Wu Q, Zhu M, Rosier RN, Zuscik MJ, O’Keefe RJ, Chen D. Beta-catenin, cartilage, and
osteoarthritis. Annals of the New York Academy of Sciences Mar;1192:344-50, 2010
217.
Katzel EB, Koltz PF, Tierney R, Williams JP, Awad HA, O’Keefe RJ, Langstein HN. A
novel animal model for studying silicone gel-related capsular contracture. Plastic
Reconstructive Surgery, 126(5):1483-91, 2010
218.
Bukata SV, Kates, SL, O’Keefe, RJ. Short-term and Long-term Orthopaedic Issues in
Patients with Fagility Fractures. Clinical Orthopaedics and Related Research Jan 29
2011
219.
Jacobson JA, Yanoso-Scholl L, Reynolds DG, Dadali T, Bradica G, Bukata S, Puzas EJ,
Zuscik MJ, Rosier R, O'Keefe RJ, Schwarz EM, Awad HA. "Teriparatide therapy and
beta-tricalcium phosphate enhance scaffold reconstruction of mouse femoral defects."
Tissue Engineering: Part A. 17(3-4): 389-98, February 2011
220.
Zhang M, Ho HC, Sheu TJ, Breyer MD, Flick LM, Jonason JH, Awad HA, Schwarz EM,
O’Keefe RJ. EP1-/- mice have enhanced osteoblast differentiation and accelerated
fracture repair. Journal of Bone and Mineral Research 26:792-802, 2011
221.
Sampson ER, Beck CA, Ketz J, Canary KL, Hilton MJ, Awad H, Schwarz EM, Chen D,
O'Keefe RJ, Rosier RN, Zuscik MJ. Establishment of an index with increased
sensitivity for assessing murine arthritis. Journal of Orthopaedic Research Mar 3 2011
222.
Reynolds DG, Takahata M, Lerner AL, O'Keefe RJ, Schwarz EM, Awad HA.
"Teriparatide therapy enhances devitalized femoral allograft osseointegration and
biomechanics in a murine model." Bone; 48(3): 562-70, March 2011
41
223.
Sampson ER, Amin V, Schwarz, EM, O’Keefe, RJ, Rosier, RN. The histone deacetylase
inhibitor vorinostate selectively sensitizes fibrosarcoma cells to chemotherapy. Journal of
Orthopaedic Research. 29 (4): 623-32, April 2011
224.
Zhang M, Ho HC, Sheu TJ, Breyer MD, Flick LM, Jonason JH, Awad HA, Schwarz EM,
O'Keefe RJ. "EP1(-/-) mice have enhanced osteoblast differentiation and accelerated
fracture repair." The Journal of Bone and Mineral Research; 26(4): 792-802, April 2011
225.
Kung, MH, Yukata, K, O’Keefe RJ, Zuscik, MJ. Aryl Hydrocarbon Receptor-Mediated
impairment of chondrogenesis and fracture healing by cigarette smoke and benzo(a)
pyrene. Journal of Cell Physiology, May 12 2011
226.
Katzel EB, Wolenski M, Loiselle AE, Basile P, Flick LM, Langstein HN, Hilton MJ,
Awad HA, Hammert WC, O'Keefe RJ. "Impact of Smad3 loss of function on scarring
and adhesion formation during tendon healing." The Journal of Orthopaedic Research.
29(5): 684-93, May 2011
227.
Takahata M, Awad, HA, O’Keefe, RJ, Bukata SV, Schwarz, EM. Endogeneous tissue
engineering: PTH therapy for skeletal repair. Cell and Tissue Research, May 31 2011
228.
Sampson ER, Martin BA, Morris AE, Xie C, Schwarz EM, O’Keefe RJ, Rosier, RN. The
orally bioavailable met inhibitor PF-2341066 inhibits osteosarcoma growth and
osteolysis/marix production in a xenograft model. The Journal of Bone and Mineral
Research, June 26 2011
229.
Katzel EB, Koltz, PF, Tierney R, Williams JP, Awad HA, O’Keefe RJ, Langstein HN.
The impact of Smad3 loss of function on TGF-B Signaling and Radiation-Induced
Capsular Contracture. Plastic and Reconstructive Surgery. 27 (6); 2263-9, June 2011
230.
Dhakal S, Chen J, McCance S, Rosier R, O'Keefe R, Constine LS. "Bone density
changes after radiation for extremity sarcomas: exploring the etiology of pathologic
fractures." International Journal of Radiation Oncology, Biology, Physics; 80(4): 115863, July 2011
231.
Hu CT, Offley SC, Yaseen Z, O'keefe RJ, Humphrey CA. "Murine model of
oligotrophic tibial nonunion." Journal of Orthopaedic Trauma. 25(8): 500-5, August
2011
42
232.
Yacizi C, Takahata M, Reynolds DG, Xie C, Samulski RJ, Samulski J, Beecham EJ,
Gertzman AA, Spilker M, Zhang X, O’Keefe RJ, Awad HA, Schwarz EM. Selfcomplementary AAV2.5-BMP2-coated Femoral Allografts Mediated Superior Bone
Healing Versus Live Autografts in Mice With Equivalent Biomechanics to Unfractured
Femur. Molecular Therapy 19 (8): 1416-25. August 2011
233.
Bukata SV, Kates SL, O'Keefe RJ. "Short-term and long-term orthopaedic issues in
patients with fragility fractures." Clinical Orthopaedics and Related Research. 469(8):
2225-36. August 2011
234.
Sampson ER, Hilton MJ, Tian Y, Chen D, Schwarz EM, Mooney RA, Bukata SV,
O'Keefe RJ, Awad H, Puzas JE, Rosier RN, Zuscik MJ. "Teriparatide as a
chondroregenerative therapy for injury-induced osteoarthritis." Science Translational
Medicine. 2011; 101(3). September 2011
235.
Takahata M, Schwarz EM, Chen T, O'Keefe RJ, Awad HA. "Delayed short course
treatment with teriparatide (PTH(1-34) ) improves femoral allograft healing by enhancing
intramembranous bone formation at the graft-host junction." Journal of Bone and Mineral
Research 27 (1) 26-37. January 2012
236.
Shu B, Zhang M, Xie R, Wang M, Jin H, Hou W, Tang D, Harris SE, Mishina Y,
O'Keefe RJ, Hilton MJ, Wang Y, Chen D. "BMP2, but not BMP4, is crucial for
chondrocyte proliferation and maturation during endochondral bone development."
Journal of Cell Science; 124: 3428-40. October 2011
237.
O'Keefe RJ, Mao J. "Bone tissue engineering and regeneration: from discovery to the
clinic--an overview." Tissue Engineering Part B 17(6): 389-92. December 2011
238.
Xie C, Schwarz EM, Sampson ER, Dhillon RS, Li D, O'Keefe RJ, Tyler W. "Unique
angiogenic and vasculogenic properties of renal cell carcinoma in a xenograft model of
bone metastasis are associated with high levels of vegf-a and decreased ang-1
expression." Journal of Orthopaedic Research. 30(2): 325-33. February 2012
239.
Kohn A, Dong Y, Mirando AJ, Jesse AM, Honjo T, Zuscik MJ, O'Keefe RJ, Hilton MJ.
"Cartilage-specific RBPj?-dependent and -independent Notch signals regulate cartilage
and bone development." Development. 139(6): 1198-212. March 2012
240.
Kung MH, Yukata K, O'Keefe RJ, Zuscik MJ. "Aryl hydrocarbon receptor-mediated
impairment of chondrogenesis and fracture healing by cigarette smoke and
benzo(a)pyrene." Journal of Cellular Physiology. 227(3): 1062-70. March 2012
241.
Zuch D, Giang AH, Shapovalov Y, Schwarz E, Rosier R, O'Keefe RJ, Eliseev RA.
"Targeting radioresistant osteosarcoma cells with parthenolide." Journal of Cellular
Biochemistry. 113(4): 1282-91. April 2012
242.
Kim KO, Sampson ER, Maynard RD, O'Keefe RJ, Chen D, Drissi H, Rosier RN, Hilton
MJ, Zuscik MJ. "Ski inhibits TGF-B/phospho-Smad3 signaling and accelerates
43
hypertrophic differentiation in chondrocytes." Journal of Cellular Biochemistry. 113(6):
2156-66. June 2012
243.
Loiselle AE, Frisch BJ, Wolenski M, Jacobson JA, Calvi LM, Schwarz EM, Awad HA,
O'Keefe RJ. "Bone marrow-derived matrix metalloproteinase-9 is associated with
fibrous adhesion formation after murine flexor tendon injury". PLoS One. 2012; 7(7).
July 2012
244.
Dao DY, Jonason JH, Zhang Y, Hsu W, Chen D, Hilton MJ, O'Keefe RJ. "Cartilagespecific ß-CATENIN signaling regulates chondrocyte maturation, generation of
ossification centers, and perichondrial bone formation during skeletal development."
Journal of Bone and Mineral Research 27:1680-1694, August 2012
245.
Wang M, Tang D, Shu B, Wang B, Jin H, Hao S, Dresser KA, Shen J, Im HJ, Sampson
ER, Rubery PT, Zuscik MJ, Schwarz EM, O'Keefe RJ, Wang Y, Chen D. "Conditional
activation of B-catenin signaling leads to severe defects in intervertebral disc tissue."
Arthritis and Rheumatism. August 2012
246.
Farhat YM, Al-Maliki AA, Chen T, Juneja SC, Schwarz EM, O'Keefe RJ, Awad HA.
"Gene expression analysis of the pleiotropic effects of TGF-?1 in an in vitro model of
flexor tendon healing." PLoS One. December 2012
247.
Ma Y, Ren Y, Han EQ, Li H, Chen D, Jacobs JJ, Gitelis S, O'Keefe RJ, Konttinen YT,
Yin G, Li TF. “Inhibition of the Wnt-β-catenin and Notch signaling pathways sensitizes
osteosarcoma cells to chemotherapy.” Biochem Biophys Res Communication. February
2013
248.
Dhillon RS, Xie C, Tyler W, Calvi LM, Awad HA, Zuscik MJ, O'Keefe RJ, Schwarz
EM. "PTH-enhanced structural allograft healing is associated with decreased
angiopoietin-2-mediated arteriogenesis, mast cell accumulation, and fibrosis." Journal of
Bone and Mineral Research. 28(3): 586-97 March 2013
249.
Juneja SC, Schwarz EM, O'Keefe RJ, Awad HA. "Cellular and molecular factors in
flexor tendon repair and adhesions: a histological and gene expression analysis."
Connective Tissue Research. 54(3): 218-26. April 2013
250.
Shah K, Majeed Z, Jonason J, O'Keefe RJ. "The role of muscle in bone repair: the cells,
signals, and tissue responses to injury." Current Osteoporosis Reports. 11(2): 130-5. June
2013
251.
Bonewald LF, Kiel DP, Clemens TL, Esser K, Orwoll ES, O'Keefe RJ, Fielding RA.
"Forum on bone and skeletal muscle interactions: summary of the proceedings of an
ASBMR workshop." Journal of Bone and Mineral Research. 28(9): 1857-65. September
2013
44
252.
Mirando AJ, Liu Z, Moore T, Lang A, Kohn A, Osinski AM, O'Keefe RJ, Mooney RA,
Zuscik MJ, Hilton MJ. "RBP-J?-Dependent Notch Signaling Is Required for Murine
Articular Cartilage and Joint Maintenance." Arthritis Rheumatology. 65(10): 2623-33.
October 2013
253.
Giang AH, Raymond T, Brookes P, de Mesy Bentley K, Schwarz E, O'Keefe R, Eliseev
R. "Mitochondrial dysfunction and permeability transition in osteosarcoma cells showing
the Warburg effect." The Journal of Biological Chemistry. 288(46): 33303-11.
November 2013
254.
Gao L, Sheu TJ, Dong Y, Hoak DM, Zuscik MJ, Schwarz EM, Hilton MJ, O'Keefe RJ,
Jonason JH. "TAK1 regulates SOX9 expression in chondrocytes and is essential for
postnatal development of the growth plate and articular cartilages." Journal of Cell
Science. 126: 5704-13. December 2013
255.
Shen J, Li J, Wang B, Jin H, Wang M, Zhang Y, Yang Y, Im HJ, O'Keefe R, Chen D.
"Deletion of the transforming growth factor ? receptor type II gene in articular
chondrocytes leads to a progressive osteoarthritis-like phenotype in mice." Arthritis and
Rheumatism. 65(12): 3107-19. December 2013
256.
Shane E, Burr D, Abrahamsen B, Adler RA, Brown TD, Cheung AM, Cosman F, Curtis
JR, Dell R, Dempster DW, Ebeling PR, Einhorn TA, Genant HK, Geusens P, Klaushofer
K, Lane JM, McKiernan F, McKinney R, Ng A, Nieves J, O'Keefe RJ, Papapoulos S,
Howe TS, van der Meulen MC, Weinstein RS, Whyte MP. "Atypical subtrochanteric and
diaphyseal femoral fractures: Second report of a task force of the American Society for
Bone and Mineral Research." Journal of Bone and Mineral Research 29 (1) 1-23. January
2014
257.
Hasslund S, O'Keefe RJ, Awad HA. “A mouse model of flexor tendon repair” Methods
of Molecular Biology. 1130:73-88. 2014
258.
Jonason JH, O'Keefe RJ. “Isolation and culture of neonatal mouse calvarial osteoblasts”
Methods Molecular Biology. 1130:295-305. 2014
259.
Li TF, Yukata K, Yin G, Sheu T, Maruyama T, Jonason JH, Hsu W, Zhang X, Xiao G,
Konttinen YT, Chen D, O’Keefe RJ. “BMP-2 induces ATF4 phosphorylation in
chondrocytes through a COX-2/PGE2 dependent signaling pathway”. Osteoarthritis
Cartilage 22(3): 481-9. March 2014
260.
Yukata K, Xie C, Li TF, Takahata M, Hoak D, Kondabolu S, Zhang X, Awad HA,
Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ. “Aging periosteal progenitor cells
have reduced regenerative responsiveness to bone injury and to the anabolic actions of
PTH 1-34 treatment”. Bone. 62:79-89. May 2014
261.
Tyler W, Bukata S, O'Keefe RJ. “Atypical femur fractures”. Clinics in Geriatric
Medicine. 30(2):349-59. May 2014
45
262.
Brown ML, Yukata K, Farnsworth CW, Chen DG, Awad H, Hilton MJ, O'Keefe RJ,
Xing L, Mooney RA, Zuscik MJ. “Delayed fracture healing and increased callus
adiposity in a C57BL/6J murine model of obesity-associated type 2 diabetes mellitus”.
PLoS One.;9(6). June 2014
263.
Farhat YM, Al-Maliki AA, Easa A, O'Keefe RJ, Schwarz EM, Awad HA. “TGF-beta1
Suppresses Plasmin and MMP Activity in Flexor Tendon Cells via PAI-1: Implications
for Scarless Flexor Tendon Repair”. Journal of Cellular Physiology. June 2014
264.
Huang C, Xue M, Chen H, Jiao J, Herschman HR, O'Keefe RJ, Zhang X. “The
spatiotemporal role of COX-2 in osteogenic and chondrogenic differentiation of
periosteum-derived mesenchymal progenitors in fracture repair”. PLoS One. 2;9(7). July
2014
265.
Mann T, Baumhauer JF, O'Keefe RJ, Harrast J, Hurwitz SR, Voloshin I. “High
Incidence of Hemiarthroplasty for Shoulder Osteoarthritis Among Recently Graduated
Orthopaedic Surgeons”. Clinical Orthopaedics and Related Research 472(11):3510.
November 2014
266.
Hadjiargyrou M, O’Keefe RJ. “The Convergence of Fracture Repair and Stem Cells:
Interplay of Genes, Aging, Environmental Factors and Disease”. Journal of Bone and
Mineral Research 29(11):2307. November 2014
267.
DiGiovanni BE, Southgate RD, Mooney CJ, Chu JY, Lambert DR, O’Keefe RJ.
“Factors Impacting Musculoskeletal Knowledge and Clinical Confidence in Graduating
Medical Students”. Journal of Bone and Joint Surgery 96A:21:e185. November 2014
268.
Jonason JH, Hoak D, O’Keefe RJ. “Primary Murine Growth Plate and Articular
Chondrocyte Isolation and Cell Culture”. Methods in Molecular Biology 1226:11.
January 2015
269.
Dong Y, Long T, Wang C, Mirando AJ, Chen J, O’Keefe RJ, Hilton MJ. “NOTCHMediated Maintenance and Expansion of Human Bone Marrow Stromal/Stem Cells: A
Technology Designed for Orthopedic Regenerative Medicine”. Stem Cells Translational
Medicine (in press). November 2014.
270.
Lee DJ, Southgate RD, Farhat YM, Loiselle AE, Hammert WC, Awad HA, O’Keefe RJ.
“Parathyroid hormone 1-34 enhances extracellular matrix deposition and organization
during flexor tendon repair”. Journal of Orthopaedic Research 33:17. January 2015
271.
Buckwalter JA, Tolo VT, O’Keefe RJ. “How Do You Know It Is True? Integrity in
Research and Publications”. Journal of Bone and Joint Surgery (in press).
46
272.
Zhang M, Feigenson, M, Sheu, T-J, Awad, HA, Schwarz EM, Jonason JH, Loisell AE,
O’Keefe RJ. “Loss of the PGE2 Receptor EP1 Enhances Bone Acquisition, Which
Protects Against Age and Ovariectomy-induced Impairments in Bone Strength”. Bone
72:92-100. January 2015.
On-Line Publications
1.
Grimsrud, C.D., Baumhauer, J.F., Teot, L., and O’Keefe, R.J.: Lytic lesion of the talus.
AAOS Orthopaedic Short Stories, posted October 1999
Abstracts Provided Upon Request
Book Chapters
1.
Rosier, R.N., Gelb, D.E., Landeserg, R.L., Crabb, I.D., O'Keefe, R.J., and Puzas, J.E.:
“Transforming growth factor beta synthesis in endochondral ossification, in calcium
regulation and bone metabolism.” Basic and Clinical Aspects, editors: Cohn, D.V.,
Glorieux, F.H., and Martin, T.J. Vol. 10:291-297, Elsevier, Amsterdam, 1990
2.
Puzas, J.E., O'Keefe, R.J., and Hicks, D.G.: “Mechanisms of bone resorption in
osteomyelitis.” Methods in Enzymology, 1994
3.
Temple, H.T., O'Keefe, R.J., and Scully, S.P.: “Benign and malignant tumors of the
foot.” Orthopedic Knowledge Update of the Foot 1, American Academy of Orthopedic
Surgeons, Rosemont, IL, 1994
4.
Rosier, R.N., and O’Keefe, R.J.: “Autocrine regulation of articular cartilage.”
Instructional Course Lectures, Vol. 47, editor: W.D. Cannon, Jr., American Academy of
Orthopaedic Surgeons, Rosemont, IL.1998
5.
Rosier, R.N, O’Keefe, R.J., Reynolds, P.R., Hicks, D.G., and Puzas, J.E.: “Expression
and function of TGF-ß and PTHrP in the growth plate.” Skeletal Growth and
Development, editors: Buckwalter, J.A., Ehrlich, M.G., Sandell, L.J., and Trippel, S.B.:
pp. 285-299, American Academy of Orthopaedic Surgeons, Rosemont, IL, 1998
6.
O’Keefe, R.J., Grimsrud, C., D’Souza, M., Hicks, D.G., Puzas, J.E., Reynolds, P.R., and
Rosier, R.N.: “Bone morphogenetic proteins commit growth plate chondrocytes to
maturation.” Skeletal Growth and Development, editors: Buckwalter, J.A., Ehrlich,
M.G., Sandell, L.J., and Trippel, S.B.: pp. 319-332, American Academy of Orthopaedic
Surgeons, Rosemont, IL, 1998
47
7.
Reynolds, P.R., Romano, P.R., Hongbo, C., Wang, J., Reynolds, S.D., Johnston, C.J.,
Leboy, P.S., Tiller, G.E., Dasouki, M.J., O’Keefe, R.J., Puzas, J.E., and Rosier, R.N.:
“Identification and characterization of a novel phosphatase with a role in the growth plate
chondrocyte maturation.” Skeletal Growth and Development, editors: Buckwalter, J.A.,
Ehrlich, M.G., Sandell, L.J., and Trippel, S.B.: pp. 359-369, American Academy of
Orthopaedic Surgeons, Rosemont, IL, 1998
8.
Rosier, R.N. and O’Keefe, R.J.: “Molecular mechanisms of metastasis.” Management
of Metastatic Disease to the Musculoskeletal System, editors: Heiner, J.P, Kinsella, T.,
and Zdeblick, T.A.: Quality Medical Publishing, Inc. St. Louis, MO. (In press), 1998
9.
O'Keefe, R.J. and Terek, R.M.: “Musculoskeletal oncology.” Orthopedic Knowledge
Update 6, editor: Beaty, J.H.: American Academy of Orthopedic Surgeons, Rosemont,
IL, 1998
10.
Rosier, R.N., O’Keefe, R.J., and Reynolds, P.R.: “Molecular and cellular biology in
orthopaedics.” Orthopaedic Basic Science: Biology and Biomechanics of the
Musculoskeletal System, 2nd edition, editors: Buckwalter, J.A., Einhorn, T.A., and
Simon, S.R.: pp. 19-76. American Academy of Orthopaedic Surgeons, Rosemont, IL,
2000
11.
O'Keefe, R.J., Totterman, S., Schwarz, E.M., Looney, J.M., Seo, G.S., Tamez-Pena, J.,
Boyd, A. Bukata, S., Monu, J. and Parker, K.: “Assessment of the performance of
engineered tissues in humans requires the development of highly sensitive and
quantitative noninvasive outcome measures.” Function Tissue Engineering, editors:
Guilak, F., Butler, D.L., Goldstein, S.A., and Mooney, D.J.: Springer-Verlag New York,
Inc., 2003
12.
Ionescu A.M., Drissi, M.H., and O'Keefe, R.J.: “Regulation of chondrocyte
differentiation.” The Skeleton, editors: Massaro, M.J. and Rogers, J.M.: pp. 43-53.
Humana Press, Totowa, NJ, 2004
13.
Puzas, J.E., Campbell, J., O’Keefe, R.J., and Rosier, R.N.: “Lead toxicity in the skeleton
and Its role in osteoporosis.” Nutrition and Bone Health, editors: Holick, M.F. and
Dawson-Hughes, B.: pp. 363-376. Humana Press, Totowa, NJ, 2004
14.
Ballock, R.T. and O’Keefe, R.J.: “Growth and development of the skeleton.”
Orthopaedic Basic Science, 3rd Edition, editors: Einhorn, T.A., Buckwater, JA., and
O’Keefe, R.J., 2005
15.
Bukata, S.V. and O’Keefe, R.J.: “Orthopaedic complications of osteoporosis.” Primer
on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 6th Edition,
founding editor Favus, M.J.: pp. 313-318. American Society for Bone and Mineral
Research, Washington, DC, 2006
48
16.
Awad, H.A., O’Keefe, R.J., Lee, C.H., Mao, J.J: “Bone Tissue Engineering: Clinical
Challenges and Emergent Advances in Orthopaedic and Craniofacial Surgery.”
Principles of Tissue Engineering. LANZA, Chapter 83. 2013
Book Reviews
1. O’Keefe, R.J.: “Osteoporosis in Men. The Effects of Gender on Skeletal Health.” Eric
S. Orwoll, editor. San Diego: Academic Press; 1999. Review in J. Bone Joint Surg.
83A: 319, 2001
Oral Presentations
“The characterization of growth plate chondrocytes separated by countercurrent
centrifugal elutriation.” AOA Traveling Fellows Conference, Rochester, NY, October 9,
1987
“The response of epiphyseal chondrocytes to transforming growth factor-beta is
influenced by serum factors.” 34th Annual Meeting of the Orthopaedic Research
Society, Atlanta GA, February 2, 1988
“Synergistic effects of IGF-I with TGF-ß and FGF are specific for DNA synthesis in
growth plate chondrocytes.” 35th Annual Meeting of the Orthopaedic Research Society,
Las Vegas, Nevada February 7, 1989
“The influence of prostaglandins on DNA and matrix synthesis by growth plate
chondrocytes.” 35th Annual Meeting of the Orthopaedic Research Society, Las Vegas,
NV, February 8, 1989
“Differential expression of transforming growth factor-beta receptors and biological
effects in chondrocytes.” 36th meeting of the Orthopaedic Research Society, New
Orleans, LA, February 6, 1990
“Analysis of type II and type X collagen synthesis in cultured chondrocytes by in-situ
hybridization.” 37th meeting of the Orthopaedic Research Society, Washington, DC,
February 17, 1992
“TGF-ß secretion is regulated by inflammatory cytokines in both growth plate and
articular chondrocytes.” 41st Meeting of the Orthopaedic Research Society, Orlando, FL,
February 13-16, 1995
49
“The pathophysiology and treatment of metastatic bone disease.” Pathologic Bone Loss
Symposium at the 44th Annual meeting of the Orthopaedic Research Society, New
Orleans, LA, March 17, 1998
“Cells in pigmented villonodular synovitis secrete cytokines known to mediate
osteoclastic bone resorption and cartilage degradation.” American Academy of
Orthopaedic Surgeons Annual Meeting, New Orleans, LA, March 20, 1998
“Infection and bone healing.” American Academy of Orthopaedic Surgeons 65th annual
meeting, New Orleans, LA, March 21, 1998
“Limb salvage in foot and ankle sarcoma.” Musculoskeletal Tumor Society, Washington,
DC, May 8, 1998
“Molecular approaches to an understanding of periprosthetic osteolysis.” Interurban
Orthopaedic Association Meeting, Baltimore, MD, October 2, 1998
“Bone morphogenetic protein signaling regulates chondrocyte maturation and Indian
hedgehog expression.” 2nd Joint Meeting of The American Society for Bone and
Mineral Research and The International Bone and Mineral Society, San Francisco, CA,
December 2, 1998
“Coordinate interaction of tissues, cells, and growth factors during skeletal growth and
development.” Skeletal Development and Regeneration Workshop at the 45th Annual
Meeting of the Orthopaedic Research Society, Anaheim, CA, February 1, 1999
“Molecular changes and soft tissue sarcoma.” Musculoskeletal Tumor Society Specialty
Day, 68th Annual Meeting of the American Academy of Orthopaedic Surgeons, San
Francisco, CA, March 3, 2001
“Intracellar signals regulate chondrocyte differentiation in the growth plate.” AAOS/NIH
Workshop Biology in Orthopaedics, Scottsdale, AZ, September 8, 2001
“Intracellular signaling and chondrocyte differentiation.” National Institute of Health
(NIAMS), Bethesda, MD, December 6, 2001
“Signaling mechanisms utilized by TGF-β to regulate the rate of chondrocyte
differentiation.” TGF-β Signaling Symposium at the 48th Annual meeting of the
Orthopaedic Research Society, Dallas, TX, February 10, 2002
“The cellular and molecular basis of gene therapy.” Gene Therapy in Orthopaedic
Surgery at the 69th Annual Meeting of the American Academy of Orthopaedic Surgeons,
Dallas, TX, February 14, 2002
“US Bone and Joint Decade team report.” AAOS Board of Directors Meeting, AAOS
Annual Meeting, San Francisco, CA, March 8, 2004
50
“Update on US Bone and Joint Decade.” Orthopaedic Research Society Annual Business
Meeting, Council of Musculoskeletal Specialty Societies, San Francisco, CA, March 10,
2004
“Effects of Cox-2 inhibitors on fracture healing.” AAOS Annual Meeting, AAOS Adult
Reconstruction Hip and Knee Symposium: The Role of Pharmacological Agents in
Fracture Healing and Implant Fixation, San Francisco, CA, March 10, 2004
“Overview of the AAOS Clinician Scientist Program and career path timeline.” Clinician
Scientist Development Program, 117th Annual Meeting American Orthopaedic
Association, Boston, MA, June 22, 2004
“NFk ß and retinoid receptors regulate pro-and anti-metastatic gene expression”.
Molecular Biology and Pathology of Bone Working Group - Skeletal Metastasis: Tumor
Interactions w/the Bone Microenvironment, 26th Annual Meeting ASBMR, Seattle, WA,
October 4, 2004
“Smad3 deficient chondrocytes have accelerated differentiation and enhanced BMP
signaling: concurrent oral 25, BMPs and other growth factors II”, 26th Annual Meeting
ASBMR, Seattle, WA, October 5, 2004
“Bone and Joint Decade: Good moves for life.” National Association of Orthopaedic
Nurses, ORS/AAOS Annual Meeting, Washington, DC, February 19-25, 2005
“TGF-ß and PTHrP regulate the stimulatory effects of BMPs, Runx2 and ß -Catenin on
chondrocyte maturation.” Molecular Circuits Regulating Long Bone and Joint
Development, ORS/AAOS Annual Meeting, Washington, DC, February 19-25, 2005
“Allograft bone revitalization through gene delivery.” Gene Therapy and Tissue
Engineering in Orthopaedic Surgery, ORS/AAOS Annual Meeting, Washington, DC,
February 19-25, 2005
“COX-2 in cartilage and bone.” New York Academy of Sciences Meeting, New York,
NY, May 19, 2005
“The clinician scientist as an endangered species: A great time to start.”
AAOS/OREF/ORS Clinician Scientist Development Program, Huntington, CA, June 2022, 2005
“The Clinician Scientist Program and career path timeline.” AAOS/OREF/ORS
Clinician Scientist Development Program, Huntington, CA, June 20-22, 2005
“Infrastructure support for the basic scientist.” AAOS/OREF/ORS Clinician Scientist
Development Program, Huntington, CA, June 20-22, 2005
51
“Grant writing for the basic scientist.” AAOS/OREF/ORS Clinician Scientist
Development Program, Huntington, CA, June 20-22, 2005
“TGF-ß signaling in chondrocytes.” Parathyroid Hormone: A New Frontier in Bone
Health, ASBMR 27th Annual Meeting, Nashville, TN, September 23-27, 2005
“The RANK RANKL OPB Axis.” ASBMR 27th Annual Meeting, Nashville, TN,
September 23-27, 2005
“Revitalization of allograft bone by addition of cells and genes: Can we replace
autograft?” Orthopaedic Basic Science Conference, Minneapolis, MN, November 19,
2005
“Allograft bone revitalization through gene delivery.” Gene Therapy and Tissue
Engineering in Orthopaedic Surgery, ORS/AAOS Annual Meeting, Chicago, IL, March
18-24, 2006
“Bone and Joint Decade: Report.” AAOS Board of Directors Meeting, ORS/AAOS
Annual Meeting, Chicago, IL, March 18-24, 2006
“The challenge of basic science research training in orthopaedics.” Educational
Paradigms in Orthopaedic Research Workshop, ORS/AAOS Annual Meeting, Chicago,
IL, March 18-24, 2006
“Overview of the AAOS clinician scientist program and career path.”
AAOS/OREF/ORS Clinician Scientist Development Program, San Antonio, TX, June 1920, 2006
“Morphometric Analysis of Osteoarthritis in Murine Models.” The Xth Congress of the
International Society of Bone Morphometry, Philadelphia, PA, September 20, 2006
“Potentials for Pharmacological Treatment.” Visiting Professor, Alumni Association 88th
Annual Meeting, Hospital for Special Surgery, New York, NY, November 9, 2006
“Fracture Healing - Current Concepts and Research Directions.” Introductory Lecture at
Orthopaedic Research Society Session 37, Fracture Healing. Orthopaedic Research
Society Meeting, San Diego, CA, February 13, 2007
“Gene Therapy & Tissue Engineering in Orthopaedic Surgery”. AAOS Instructural
Course, San Diego, CA, February 14, 2007
“TGF-beta/Smad3 signaling modulate multiple signaling pathways during chondrocyte
differentiation”. Gordon Research Conference (Cartilage Biology & Pathology),Ventura
Beach Marriott, Ventura, CA. March 4-9, 2007
52
“Transcription Regulation of Cartilage”. The New York Academy of Sciences, 2nd
Conference on Skeletal Biology, New York Academy of Sciences, New York, NY. April
25-28, 2007
“Grant Writing 101”. AAOS Clinician Scientist Development Program, Asheville, NC,
June 10-12 2007
“A Personal Perspective: Balancing it All”. AAOS Clinician Scientist Development
Program, Asheville, NC, June 10-12 2007
“Wnt Signaling in Chondrocyte Differentiation.” AAOS/ORS/OREF Combined
Meetings, San Francisco, CA, March 2, 2008
“Delayed Bone Repair in Aged Animals is Associated with Altered Cellular and
Molecular Signals”. Workshop 5 - Orthopaedic Complications in Animal Models of
Aging - Orthopaedic Research Society Annual Meeting, Las Vegas, NV, February 23,
2009
“Molecular targets and potential therapies to improve fracture healing in aging.”
AIMM/ASBMR John Haddad Young Investigators Conference, Fracture healing lecture,
Snowmass, CO, April 4, 2009
“Translational research using animal models of human disease.” AIMM/ASBMR John
Haddad Young Investigators Conference, Meet the Professor lecture, Snowmass, CO,
April 5, 2009
“Gene Therapy & Tissue Engineering in Orthopaedic Surgery”. AAOS Instructural
Course, Las Vegas, CA, February 26, 2009
“Role of Non-Orthopaedic Providers in the Education of Orthopaedic Residents: Non
Orthopaedic Providers: Can Teaching be Integrated into Clinical Service?” AOA Annual
Meeting Hyatt Regency Coconut Point Resort, Bonita Springs, FL, June 11, 2009
“ICL 262 Biological Implants”, AAOS Instructural Course - New Orleans, LA, March
10, 2010
“What have been the most significant advances in musculoskeletal basic science in the
last decade? What breakthroughs do you see being made in the next decade?” BJD
World Network Conference, Lund, Sweden, September 10-11, 2010
“Cells and Molecular Signals Involved in Bone Repair: Insights Gained from Animal
Models,” In Vivo Working Group, Bone Fracture Repair: From Bench to Bedside,
ASBMR Annual Meeting, Toronto, Ontario, Canada, October 15, 2010
“Clinician Scientist/Scholar Timeline,” AAOS CSDP Webinar Module OneTranslational Research, CS Timeline and Work/Life Balance, November 2, 2010
53
“MAP Kinase Signaling and Chondrocyte Differentiation” 4th New York Skeletal
Biology and Medicine Conference, Mt. Sinai School of Medicine, New York, NY, April
30, 2011
Implementing Results of CER in Academic Medical Centers: Panel Discussion: Joshua
Jacobs, MD, James Wright, Regis O'Keefe, MD PhD and Michael Keith, MD
AAOS/ORS Comparative Effectiveness Research Symposium - Hyatt Regency on
Capitol Hill, Washington, DC, May 20, 2011
"Improving Orthopaedic Care Through Translational and Clinical Research:
Opportunities and Challenges", OREF-ORS Research Symposium, Naval Academy, San
Diego, CA, May 23, 2011
"Cellular and Molecular Targets to Enhance Fracture Healing and Bone Formation in
Aging" OREF-ORS Research Symposium, Naval Academy, San Diego, CA, May 24,
2011
"The Science of Mentoring and Scientific Development: Roles, Responsibilities, and
Rewards" OREF-ORS Research Symposium, Naval Academy, San Diego, CA, May 24,
2011
“Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI)”
Council of Councils, NIAMS Advisory Council Meeting, Bethesda, Maryland,
September 27, 2011
“Signals Regulating the Proliferation, Expansion, and Differentiation of Mesenchymal
Stem Cells in Skeletal Tissue Repair” International Symposium of Mesenchymal Stem
Cells, Chengdu, China, October 12, 2011
“Orthopaedic Departmental Leadership – Lessons Learned And What Can I Do To Lead
Effectively In My Workplace” SOMOS Annual Meeting, San Diego, CA, December 13,
2011
“From The Deckplates To The Military Treatment Center: How To Conduct Successful
Military/Civilian Research” SOMOS Annual Meeting, San Diego, CA, December 14,
2011
“Harassment and Headaches: Why Bother with Multicenter Trials”, 2012 AOA Annual
Meeting, Washington, DC, June 28, 2012
“Orthopaedic Applications and Repair: Gaps in Our Knowledge of the Role of Muscle on
Bone Repair” ASBMR Topical Meeting on Bone and Skeletal Muscle Interactions,
Kansas City, MO, July 18, 2012
54
“Pearls and Pitfalls: What I Have Learned from Wins and Losses” OTA/ORS Grant
Writing Workshop, Minneapolis, MN, October 3, 2012
“Atypical Femoral Fractures” ASBMR Annual Meeting, Minneapolis, MN, October 13.
2012
“Morphometric and Molecular Assessment of Bone Fracture Repair” XIIth Congress of
the International Society of Bone Morphometry, Minneapolis, MN, October 18, 2012
“Stem Cells and their Regulation in Bone Repair”, OREF/ORS Central Indiana Regional
Resident Research Symposium, Indiana University, Indianapolis, IN, April 5, 2013
“How Do You Know It Is True? Integrity In Research And Publications”, Symposium,
AOA Annual Meeting, Denver, CO, June 13, 2013
“Why Delegate: Developing an Effective Leadership Team”, AOA Annual Meeting,
Denver, CO, June 14, 2013
“How Do You Know It Is True? Integrity in Research and Publications, AAOS Annual
Meeting, New Orleans, LA, March 12, 2014
“Clinician Scientist (Scholar): Timeline Overview”, AAOS/OREF/ORS Clinician
Scholar Career Development Program, Rosemont, IL, September 26, 2014
“Progenitor Cells and Tissue Injury and Repair Processes”, Society of Military
Orthopaedic Surgeons Annual Meeting, Phoenix, AZ, December 18, 2104
Invited Lectures/Grand Rounds
“Reversal of digitoxic ventricular arrhythmia’s by the alpha adrenergic blocking agents
prazosin and trimazosin.” Cardiology Research Conference, Massachusetts General
Hospital, Boston MA, October 19, 1983
“The local and neutrally mediated effects of sufentanil on canine skeletal muscle vascular
resistance.” Cardiology Research Conference, Massachusetts General Hospital, Boston,
MA, May 29, 1985
“Effects of transforming growth factor-ß on growth plate and articular chondrocytes.”
Endocrinology Research Conference, University of Rochester, Rochester, NY, March 31,
1987
“Countercurrent centrifugal elutriation: a preliminary report on the separation of growth
chondrocytes.” University of Rochester Orthopaedic Alumni Conference, Rochester,
NY, June 11, 1987
55
“Growth factor effects in chondrocytes from different maturational stages separated by
countercurrent centrifugal elutriation.” Endocrinology Research Conference, University
of Rochester, Rochester, NY, April 5, 1988
“Correlation between TGF-ß receptor binding and biological effects in growth plate
chondrocytes.” University of Rochester Orthopaedic Alumni Conference, Rochester NY,
May 4, 1988
“The influence of prostaglandins on DNA and matrix synthesis by growth plate
chondrocytes.” Orthopaedic Resident's Night, New York Academy of Medicine, New
York, NY, May 8, 1989
“Synergistic effects of IGF-I with TGF-ß and FGF are specific for DNA synthesis in
growth plate chondrocytes.” University of Rochester, Orthopaedic Alumni Conference,
Rochester, NY, May 19, 1989
“A complex thumb M-P dislocation in a 4 year old: A case report and review of the
literature.” University of Rochester, Biannual Hand Symposium, Rochester, NY, May
1990
“Structure and function of the growth plate.” University of Rochester Surgical Grand
Rounds, Rochester, NY, November 23, 1991
“P-glycoprotein expression in benign and malignant cartilage tumors.” Meeting of the
North American Traveling Fellows, Rochester, NY, October 15, 1993
“Update on evolution and treatment of soft tissue sarcomas with emphasis on synovial
sarcoma.” Grand Rounds, University of Rochester, Rochester, NY, November 11, 1993
“Mechanism and role of P-glycoprotein in chemotherapeutic resistance in
musculoskeletal neoplasms.” Brown University, Department of Orthopedics Grand
Rounds, Providence, RI, December 15, 1993
“Biology of fracture repair.” Oral Surgery Grand Rounds, Genesee Hospital, Rochester,
NY, November 29, 1994
“Biological mechanisms of prosthetic implant loosening.” University of Rochester,
Department of Orthopaedics Grand Rounds, Rochester, NY, March 16, 1995
“Bone growth and development from conception to old age.” Keynote Speaker, National
Association of Orthopaedic Nurses Annual Meeting, Rochester, NY, March 25, 1995
“Cell signaling and regulation of cytokine synthesis in wear debris stimulated
monocytes.” Case Western Reserve University, Department of Orthopaedics, Grand
Rounds, Cleveland, OH, January 26, 1996
56
“Pharmacologic modification of the inflammatory response to wear debris particles.”
Case Western Reserve University, Cleveland, OH, Department of Orthopaedics Grand
Rounds, January 27, 1996
“Mechanism of bone loss in metastatic carcinomas and reconstruction of severe
acetabular bone deficits in metastatic disease.” University of Rochester, Department of
Orthopaedics Grand Rounds, Rochester, NY, May 11, 1996
“The role of in situ hybridization for examination of musculoskeletal tissues.”
Symposium Presenter, Society of In Vitro Biology Annual Meeting, San Francisco, CA,
June 24, 1996
“The cloning and expression of BMP-7 in chick growth plate chondrocytes.” Gordon
Research Conference, Proctor Academy, Andover, MA, July 29, 1996
“The potential of pharmacologic agents for the inhibition of periprosthetic bone loss and
loosening.” Visiting Lecturer, Novartis Pharmaceuticals, Summit, NJ, April 24, 1997
“Bone morphogenetic proteins commit growth plate chondrocytes to maturation.”
Invited Participant/Presenter NIH/AAOS Workshop on “Skeletal Morphogenesis in
Growth.” Howey-in- the-Hills, FL, May 3-6, 1997
“Bone loss in cancer and in association with joint prostheses.” Grand Rounds,
Department of Orthopaedics, University of Rochester, Rochester, NY April 10, 1998
“Periprosthetic loosening: Molecular mechanisms and therapeutic intervention.”
University of Bristol, U.K., April 19, 1999
“Molecular mechanisms of bone metastasis: A search for therapeutic intervention.”
University of Manchester, U.K., April 21, 1999
“Bone morphogenetic proteins are modulators of chondrocyte maturation.” University of
Nottingham, U.K., April 26, 1999
“BMP’s stimulate chondrocyte maturation.” Southampton University, U.K. May 5, 1999
“Reconstruction of severe periacetabular metastases restores ambulation and
independence.” Perth, Australia, May 9, 1999
“Periprosthetic loosening: Molecular mechanisms and therapeutic intervention.”
University of Adelaide, Australia, May 12, 1999
“Reconstruction of severe periacetabular metastases restores ambulation and
independence.” Adelaide, Australia, May 13, 1999
57
“Periprosthetic loosening: Molecular mechanisms and therapeutic intervention.”
University of Melbourne, Australia, May 15, 1999
“Mechanisms of periprosthetic loosening.” Christchurch, NZ, May 17, 1999
“Mechanisms of bone metastasis.” Auckland, NZ, May 22, 1999
“Biological mechanisms of prosthetic loosening and potential therapeutic strategies.”
Visiting Professor, Johns Hopkins Medical School, Department of Orthopaedics
Baltimore, MD, September 30, 1999
“Periprosthetic osteolysis: Signaling pathways and pharmacologic approaches.” 93rd
Annual Interurban Orthopaedics Society Meeting, In Symposium, Molecular Biological
Approaches to the Prediction and Prevention of Arthroplasty Loosening, Rochester, NY,
October 8, 1999
Visiting Professor for Resident Research Day, Hamot Medical Center, Erie, PA, May 2,
2000
Visiting Professor for Resident Research Day, University of Toronto, Toronto, Canada,
May 29, 2000
“Functional evaluation of tissue engineered products requires innovative, sensitive, and
quantitative methods.” Tissue Engineering Workshop, National Science Foundation,
Tampa, FL, September 15-18, 2000
“Skeletal growth and development.” University of Rochester, Pathology and Molecular
Medicine Seminar Series, April 18, 2001
“Regulation of chondrocyte differentiation in the growth plate.” University of Rochester,
Department of Biochemistry Seminar Series, April 25, 2001
“Signaling events involved in PTHrP expression and effects in the growth plate.” First
International Conference on the Growth Plate, San Antonio, Texas, June 17, 2001
Robert J. Kelly Visiting Professor, Mayo Clinic, Rochester Minnesota, November 29December 1, 2001
“Molecular and therapeutic approaches to periprosthetic bone loss.” Mayo Clinic,
Rochester, MN, November 30, 2001
“What motivates the clinician scientist.” Mayo Clinic, Rochester, MN, November 30,
2001
“Cyclooxygenases and bone repair.” Mayo Clinic, Rochester MN, December 1, 2001
58
“RANKL and NFk β regulation of bone destruction.” Association of Bone and Joint
Surgeons Workshop on Metastatic Bone Disease, Tampa, FL, November 8, 2002
“Cytokines, metalloproteases, and bone metastases.” Association of Bone and Joint
Surgeons Workshop on Metastatic Bone Disease, Tampa, FL, November 8, 2002
“Mevalonate pathway and control of metastases: bisphosphonates, farnesyl transferase
inhibitors and cytoskeletal regulation.” Association of Bone and Joint Surgeons
Workshop on Metastatic Bone Disease, Tampa, FL, November 8, 2002
“Breakout session I report: Molecular biology and treatment of bone metastases.”
Chairman, Association of Bone and Joint Surgeons Workshop on Metastatic Bone
Disease, Tampa, FL, November 9, 2002
“The molecular events underlining prosthetic loosening.” University of Wisconsin,
Madison, WI, December 18, 2002
“Transcriptional regulation of chondrocyte maturation.” Hospital for Special Surgery,
New York, NY, January 13, 2004
“Mechanisms regulating chondrocyte differentiation.” Pathology, Oncology and
Molecular Medicine Seminar Series, University of Rochester, Rochester, NY, March 29,
2004
“TGF-beta and BMP signaling in chondrocytes: mechanisms regulating chondrocyte
maturation and osteoarthritis.” Molecular and Cell Pathology Seminar, The University of
Alabama at Birmingham, Birmingham, AL, April 1, 2004
“The use of animal models to study human musculoskeletal diseases.” 42nd Murray S.
Danforth Oration, Brown University, Providence, RI, May 12, 2004
“TGF-ß and BMP signaling in chondrocytes: mechanisms regulating chondrocyte
maturation and osteoarthritis.” 42nd Murray S. Danforth Oration, Brown University,
Providence, RI, May12, 2004
“The development and use of animal models to understand human musculoskeletal
diseases.” Senior Resident’s Day, Dartmouth College, Dept. of Orthopaedic Surgery,
Hanover, NH, June 18, 2004
“Understanding the cellular and molecular signals required for allograft revitalization and
remodeling.” Gordon Research Conference - Signal Transduction By Engineered
Extracell Matrices, Lewiston, ME, June 30, 2004
“TGF-beta and BMP signaling in chondrocytes: Mechanisms regulating chondrocyte
maturation and osteoarthritis.” Endocrine Conference, Emory University, Atlanta, GA,
October 11, 2004
59
“Fracture repair.” Grand Rounds, Department of Orthopaedics, University of Rochester,
Rochester, NY, February 3, 2005
“Methods to revascularize allograft bone in settings of segmental bone loss.” Regenerate
2005 Meeting, Georgia Tech, Atlanta, GA, June 2-3, 2005
“Defining the signals necessary for structural allograft revitalization and remodeling:
Towards improving outcomes following bone resection.” Suzanne Berman Lectureship,
University of Chicago, Chicago, IL, June 14-15, 2005
“Cell therapies for orthopaedic applications.” Chairman, Sun Valley Workshop, Sun
Valley, ID, August 3, 2005
“Understanding the cellular and molecular signals required for allograft revitalization and
remodeling.” 21st Annual Arkansas Orthopaedic Forum, Little Rock, AR, October 20-21,
2005
“Revitalization of allograft bone by addition of cells and genes: Can we replace
autograft?” 35th Annual Ortho and Trauma Seminar, Minneapolis, MN, November 18,
2005
“Regeneration and remodeling of allograft bone.” Center for Craniofacial Regeneration
Seminar, University of Michigan, Flint, MI, March 29, 2006
“Understanding and improving fracture healing in aging.” Columbia University Grand
Round, New York, NY, April 12-13, 2006
“Models to investigate musculoskeletal diseases.” Celgene Cellular Therapeutics,
Summit, NJ, April 20, 2006
“The role of stem cell signals in bone repair.” Bioengineering Seminar Series, University
of NY at Stony Brook, Stony Brook, NY, May 3, 2006
“Understanding and improving fracture healing in aging.” Graduate Research Forum,
University of California at Irvine, Irvine CA, May 31-June 2, 2006
“Understanding the cellular and molecular signals required for allograft revitalization and
remodeling.” Graduate Research Forum, University of California at Irvine, Irvine CA,
May 31-June 2, 2006
“Smads mediate chondrocyte hypertrophy and bone growth.” International Workshop on
the Skeletal Growth Plate, Portland, OR, June 11-14, 2006
“Understanding and improving fracture healing in aging.” Graduation and Thesis Day
Seminar Series, Cleveland Clinic Foundation, Cleveland, OH, June 15-16, 2006
60
“Understanding the cellular and molecular signals required for allograft revitalization and
remodeling.” Graduation and Thesis Day Seminar Series, Cleveland Clinic Foundation,
Cleveland, OH, June 15-16, 2006
“Growth Factors and the Growth Plate.” 2006 Research Symposium on Developmental
Biology in Orthopaedics, Toronto, Canada, October 26, 2006
“Economic Conditions of Running an Orthopaedic Department and Research Effort.”
Visiting Professor, Alumni Association 88th Annual Meeting, Hospital for Special
Surgery, New York, NY, November 10, 2006
“Understanding and Improving Fracture Healing In Aging.” Grand Rounds lecturer,
Thomas McGowan Institute for Regenerative Medicine, University of Pittsburgh,
Pittsburgh, PA, November 29, 2006
“Cells and Signals Necessary for Bone Regeneration and Repair.” Visiting Professor,
Thomas McGowan Institute for Regenerative Medicine, University of Pittsburgh,
Pittsburgh , PA, November 30, 2006
“Smad3 regulates multiple intracellular signaling pathways during chondrocyte
maturation.” Grand Rounds speaker, Thomas Jefferson University, Philadelphia, PA,
December 18, 2006
“Understanding and improving fracture healing in aging.” Visiting Professor, Thomas
Jefferson University, Philadelphia, PA, December 18, 2006
“TGF-beta/Smad3 signaling modulate multiple signaling pathways during chondrocyte
differentiation.” Gordon Research Conference - Cartilage Biology & Pathology, Ventura,
CA, March 4-9, 2007
“Understanding and Improving Fracture Healing in Aging.” University of Iowa Sr.
Residents' Day Program speaker, Cedar Rapids, IA, June 7-9, 2007
“Understanding the Cellular and Molecular signals required for Allograft Revitatilization
and Remodeling.” University of Iowa Sr. Residents' Day Program speaker, Cedar Rapids,
IA, June 7-9, 2007
“Understanding and improving bone repair in the aging population: new therapies on the
horizon.” University of Washington Resident Research Days, Seattle, WA, June 27-30, 2007
“The Orthopaedic Clinician Scientist: What is the role and is it important.” University
Washington Resident Research Days, Seattle, WA, June 27-30, 2007
61
“Signaling Pathways Controlling Chondryocyte Maturation: Implications for the
Development and Treatment of Osteoarthritis.” REF Marshall J. Schiff, M.D. Memorial
Lectureship, American College Rheumatology, Boston, MA, November 8, 2007
“The challenges of allograft use for tumor surgery: strategies to improve allograft
incorporation and function.” Residents’ speaker, University of Pennsylvania,
Philadelphia, PA, January 9-10, 2008
“Fracture healing and aging: improved management through new therapies to improve
healing.” Grand Rounds speaker, University of Pennsylvania, Philadelphia, PA, January
9-10, 2008
“The pathogenesis of osteoarthritis: molecular targets for potential therapeutics.”
Laboratory presentation, University of Pennsylvania, Philadelphia, PA, January 9-10,
2008
“The challenges of allograft use for tumor surgery: strategies to improve allograft incorporation
and function.” The John Hopkins University-School of Medicine, Department of Orthopaedic
Surgery, 2nd Annual George B. Reid, Jr. Memorial Lecture, Baltimore, MD, March 13, 2008
“Fracture healing and aging: improved management through new therapies.” Visiting Professor
Keynote Address, Stanford Research Day, Palo Alto, CA, March 29, 2008
“Fracture healing and aging: Improved management through therapies to improve
healing.” Yale University, Center for Musculoskeletal Disorders, New Haven, CT, April
9, 2008
“Fracture healing in aging: Devising strategies to increase bone formation.” University
of Connecticut, New Haven, CT, April 10, 2008
“The challenges of allograft use for tumor surgery: Strategies to improve allograft
incorporation and function.” Grand Rounds, Yale School of Medicine, New Haven, CT,
April 11, 2008
“Fracture healing and aging: Improved management through therapies to improve
healing.” University of Minnesota, Minneapolis, MN, October 8, 2008.
“The Role of Stem Cells in Bone Repair and the Role of Altered Signals with Aging.” Bone
Disease Program of Texas Seminar Series, MD Cancer Center, Houston, Texas, October 21,
2008
“Cells and Signals Involved in Bone Regeneration.” Hilton Head Workshop, Keynote
Speaker, Regenerative Medicine: Advancing to Next Generation Therapies, Hilton Head,
SC, March 6, 2009
62
"Translational Research Using Animal Models of Human Disease.” Albert B. Ferguson
Jr., MD Visiting Professor, Ferguson Visiting Professor, Resident Research Day,
University of Pittsburgh, Pittsburgh, PA, May 19-20, 2009
“Translational Research Using Animal Models of Human Disease”- Bone & Joint Seminar and
“Methods to Improve Fracture Healing in Aging.” Orthopaedic Grand Rounds, University of
Wooster, University of Massachusetts, Memorial Medical Center, Wooster, MA, May 26, 2009
“Molecular Mechanisms of Reduced Bone Healing in Aging: Targets for Therapy.”
Plenary Lecture: Bone Biology Forum, Saturday, August 22, 2009, Tokyo, Japan
“Cells and Signals in fracture repair: strategies to improve healing with aging." and
“Signals and stem cell populations involved in tendon repair.” Hark Lecturer Orthopaedics Grand Rounds, University of Virginia, Charlottesville, VA, October 14,
2009
“Signals and stem cell populations involved in tendon repair.” Grand Rounds Lecturer,
Institute of Molecular Medicine and Genetics Medical College, Georgia, Augusta, GA,
October 29, 2009
“Signals and stem cell populations involved in tendon repair.” Zunyi Medical College,
Zunyi, Guizhou, China, November 16, 2009
“Molecular mechanisms of reduced bone healing in aging: Targets for therapy.” Eastern
Forum Meeting, Shanghai, China, November 21, 2009
“The tissue, cellular, and molecular responses involved in scarring and adhesion
formation during tendon repair" and "Molecular mechanisms of reduced bone healing in
aging: Targets for therapy." China Orthopaedics Association, Shanghai, China,
November 22, 2009
“Department of Orthopaedics and Rehabilitation Update: A Commitment to Excellence.”
University of Rochester, Rochester, NY, Department of Orthopaedics Grand Rounds,
January 21, 2010
“Cross Pollination Orthobiologics - What can we learn from our orthopaedic colleagues”
AOFAS Specialty Day - New Orleans, LA, March 13, 2010
“Mechanisms whereby PTH stimulates fracture healing in young and aged mice.” Annual Biologic Stain Commission Meeting, Renaissance at the Del Monte Lodge,
Pittsford, NY, June 4, 2010
“Endochondral Bone Formation During Fracture Healing Is Coordinated by Periosteal
Cell Signaling.” ASBMR Plenary Symposium III, Toronto, Ontario, Canada, October 18,
2010
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“Cellular and Molecular Targets to Enhance Fracture Healing and Bone Formation in
Aging.” 5th International Conference on Osteoporosis and Bone Research, Shenzhen,
China, October 30, 2010
"Improving Orthopaedic Care through Translational and Clinical Research:
Opportunities and Challenges" CTSI Seminar Series, University of Rochester Medical
Center, November 23, 2010
"Improving Orthopaedic Care Through Translational and Clinical Research:
Opportunities and Challenges." University of Rochester, Rochester, NY, Department of
Orthopaedics Grand Rounds, February 3, 2011
“Work Orthopaedic Tumor Surgeon” University of Rochester, Rochester, NY, Surgery
Interest Group (“SIG”), February 7, 2011
"Improving Orthopaedic Care Through Translational and Clinical Research:
Opportunities and Challenges", Second Friday Social Seminar Lecture Series, University
of Rochester Medical Center, Rochester, New York, February 11, 2011
“The Science of Mentoring and Scientific Development: Roles, Responsibilities, and
Rewards”, Vanderbilt University, Nashville Orthopaedic Society, Nashville, Tennessee,
April 6, 2011
“Improving Orthopaedic Care Through Translational and Clinical
Research: Opportunities and Challenges”, Vanderbilt University, Grand Rounds,
Nashville, Tennessee, April 7, 2011
“Cellular and Molecular Targets to Enhance Fracture Healing and Bone Formation in
Aging” Vanderbilt University, J. William Hillman Lecture, Nashville, Tennessee, April
8, 2011
“Improving Orthopaedic Care Through Translational and Clinical Research:
Opportunities and Challenges” Arthur Stein Lecture, Washington University, St. Louis,
MO, April 20, 2011
“Stem Cell Populations and Their Regulation in Bone Repair” 2011 Avioli
Musculoskeletal Seminar, Washington University, St. Louis, MO, April 21, 2011
Grand Rounds Lecture: "The Science of Mentoring and Scientific Development: Roles,
Responsibilities and Rewards”, UCLA, Los Angeles, CA, May 4, 2011
Grand Rounds Lecture: "Improving Orthopaedic Care Through Translational and Clinical
Research: Opportunities and Challenges”, UCLA, Los Angeles, CA, May 4, 2011
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"How Do We Preserve and Stimulate INNOVATION in an Environment of Active
Management, Standardization, Efficiency, and Cost Cutting?" Health Care Quality
Innovation Summit, Cleveland Clinic, Cleveland, OH, May 11, 2011 – May 13, 2011
“Department of Orthopaedics and Musculoskeletal Care: Strategies for the Future”,
University of Rochester, Rochester, NY, February 16, 2012
“Stem Cell Populations and Their Regulation in Bone Repair” Michigan State University,
Secchia Center, MI, March 7, 2012
“Improving Orthopaedic Care Through Translational and Clinical Research:
Opportunities and Challenges” Van Andel Research Institute, MI, March 7, 2012
“Chondrocyte Phenotype and Gene Expression and The Pathogenesis of Osteoarthritis”,
University of North Carolina, Thurston Arthritis Research Center, Chapel Hill, NC,
March 30, 2012
“The Role of Stem Cells and Their Regulation in Bone Repair” West Virginia University,
Morgantown, WV, May 11, 2012
“Challenges of Health Reform: Need for Innovation in Musculoskeletal Care” West
Virginia University, Morgantown, WV, May 11, 2012
“Use of Complementary Murine Models to Define the Cells, Molecular signals, and
Therapeutic Targets to Improve Fracture Healing” AMGEN, Thousand Oaks, CA,
May 31, 2012
“Improving Orthopaedic Care Through Translational and Clinical Research:
Opportunities and Challenges” Annual Mallory-Coleman Research Day, Ohio State
University, OH, June 8, 2012
“The Role of Stem Cells and Their Regulation in Bone Repair” University of Connecticut
Health Center, New England Musculoskeletal Institute, Farmington, CT, June 22, 2012
“Healthcare Reform: Changes in the Care Delivery Model”, University of Rochester,
Rochester, NY, February 7, 2013
“The Integration of TGF-beta and BMP Signaling in Cartilage Through MAP Kinase
Signaling”, Orthopaedic Hospital Research Center, University California Los Angeles,
CA, March 14, 2013
“Improving Orthopaedic Care Through Translational and Clinical Research:
Opportunities and Challenges” University of North Carolina, Chapel Hill, NC, May 17,
2013
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“U.S. Healthcare and the World: How Do We Compare and Do We Need Change?”
University of North Carolina, Chapel Hill, NC, May 17, 2013
“Stem Cell Populations and Signals That Regulate Bone Regeneration” Kobe Convention
Center, Kobe, Japan, June 1, 2013
“Stem Cell Populations and Signals That Regulate Bone Regeneration” Rush University,
Chicago, Illinois, June 20, 2013
“Bone Tumor – Clinical Progress” Southwest Hospital, Chongqing, China, August 12,
2013
“Bone Tumor – Clinical Progress” Zhejiang University, Hangzhou, China, August 15,
2013
“Musculoskeletal Medicine: Strategies for Future Success”, Yale University, New Haven,
CT, March 19, 2014
“Stem Cell Populations and Signals that Regulate Bone Regeneration”, University of
Alabama, Birmingham, AL, May 16, 2014
“The Clinician Scientist: Connecting Discovery with Advances in Clinical Care”
Wake Forest School of Medicine, Winston-Salem, NC, November 20, 2014
Moderator of Scientific Sessions
“Scientific Session #2.” 93rd Annual Interurban Orthopaedics Society Meeting,
Rochester, NY, October 9, 1999
“Basic Science 1.” 67th Annual Meeting of the American Academy of Orthopaedic
Surgeons, Orlando, FL, March 17, 2000
“Miscellaneous Fundamentals.” 68th Annual Meeting of the American Academy of
Orthopaedic Surgeons, San Francisco, CA, March 2, 2001
“Developmental Biology Session.” 2001 AAOS/NIH Workshop Biology in
Orthopaedics, Moderator, Scottsdale, AZ, September 7, 2001
“Basic Science II.” 69th Annual Meeting of the American Academy of Orthopaedic
Surgeons, Dallas, TX, February 14, 2002
“Breakout Session I: Molecular Biology and Treatment of Bone Metastases.”
Association of Bone and Joint Surgeons Workshop on Metastatic Bone Disease, Tampa,
FL, November 9, 2002
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“The Orthopaedic Clinician Scientist.” American Orthopaedic Association 2003
Meeting, Symposium Moderator, Charleston, SC, June 9, 2003
“Evaluation of Biophysical Regulation of Skeletal Cells and Tissues.” NIH/AAOS
Physical Regulation of Skeletal Repair Workshop, Session Moderator, Baltimore, MD,
September 5-7, 2003
“Fracture Healing Session 15.” 50th Annual Meeting of the Orthopaedic Research
Society, San Francisco, CA, March 7, 2004
“Influence of Sex Specificity and Gender on Musculoskeletal Health.” American
Academy of Orthopaedic Surgeons, Hunt Valley, MD, April 22-24, 2004
“Symposium 1: Successful Clinician Scientist Business Models.” American
Orthopaedic Association 117th Annual Meeting, Boston, MA, June 24, 2004
“Translation: Basic Science to Clinical Application.” Gordon Research Conference,
Musculoskeletal Biology and Bioengineering, Andover, NH, July 28, 2004
“Panel reactor (American Academy of Orthopaedic Surgeons).” ACR Annual Meeting,
San Antonio, TX, October 18, 2004
“Fracture healing.” ORS/AAOS Annual Meeting, Washington, DC, February 19-25,
2005
“Chondrocyte, Joint and Growth Plate Development land Pathology.” 2006 Research
Symposium on Developmental Biology in Orthopaedics, Toronto, Canada, October 26,
2006
“Fracture Healing”, Moderator, Orthopaedic Research Society Annual Meeting, San
Diego, CA, February 13, 2007
“Biological Questions in Implant Wear”, Moderator, AAOS/NIH Osteolysis and Implant
Wear: Biological, Biomedical Engineering and Surgical Principles, Austin, TX,
November 9-11, 2007
“Gene Therapy and Tissue Engineering in Orthopaedic Surgery”, Moderator with Steve
Goldstein, PhD and Johnny Huard, MD, AAOS Annual Meeting, San Francisco, CA,
March 6, 2008
“Running a Lab.” AAOS / ORS / OREF Clinician Scientist Development Program
(CSDP) Quebec City, Canada, June 1-3, 2008
“Paper session: Tumor.” Moderator, AOA/COA Combined Annual Meeting, Quebec
City, Canada, June 4-7, 2008
67
“Genomic Screening Techniques for Disease Susceptibility and New Treatments.”
Moderator, 2008 AAOS/ORS Molecular Biology and Therapeutics in Musculoskeletal
Oncology Research Symposium Therapeutics in Musculoskeletal Oncology, Research
Symposium, Hilton Salt Lake City Center, Salt Lake City, UT, September 25-27, 2008
“Gene Therapy and Tissue Engineering in Orthopaedic Surgery.” Moderator with Steve
Goldstein, PhD and Johnny Huard, MD, AAOS Annual Meeting, Las Vegas, NV,
February 23, 2009
“Bone Tissue Engineering and Regeneration: From Discovery to the Clinic” CoChair/Moderator with Dr. Jeremy Mao - 2010 TERMIS-NA Pre-Conference Workshop,
Lake Buena Vista, Florida, December 4, 2010
“How to gain independence from your mentor or advisor and develop your own niche”
Professional Advancement Series I, Developing and Managing your Collaborations and
Colleagues, 2011 Orthopaedic Research Society Annual Meeting, Long Beach, CA,
January 13, 2011
“A typical fractures: What are they? Does the epidemiologic evidence support defining
them as a separate entity?” Workshop 10, Atypical Subtrochanteric Femoral Shaft
Fractures: The What, the How, and Where Do We Go Now? 2011 Orthopaedic Research
Society Annual Meeting, Women’s Leadership Forum, Long Beach, CA, January 15,
2011
"Building Your Local Orthopaedic Research Program" Funding a Program: What
is the Role of Institutional, Departmental, and Extramural Support? AOA Symposium,
AOA Annual Meeting, Boston, MA, June 24, 2011
“Session 2 MSCs in Bone Formation” International Symposium of Mesenchymal Stem
Cells, Chengdu, China, October 11, 2011
“Basic Science Session II.” Moderator with LCDR Joseph R. Carney, MD, MC, USN.,
SOMOS Annual Meeting, San Diego, CA, December 13, 2011
“Tumor/Infection/Practice Management Scientific Session IV.” Moderator with
MAJ Joseph F. Alderete MD, MC. SOMOS Annual Meeting, San Diego, CA,
December 13, 2011
“Sixteenth Annual Resident Research Symposium.” West Virginia University,
Morgantown, WV, May 11, 2012
“40th Annual Mallory-Coleman Research Day” Ohio State University, Columbus, OH,
June 8, 2012
“Session 4, Defective Mechanotransduction and Repair”, ASBMR Topical Meeting on
Bone and Skeletal Muscle Interactions, Kansas City, MO, July 18, 2012
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