New generation BIOMIMETIC and customized IMPLANTS for
BONE ENGINEERING
COST Action – MP 1301 – http://www.cost-newgen.org
NEW GENERATION BIOMIMETIC
AND CUSTOMIZED IMPLANTS FOR
BONE ENGINEERING
Chair : Dr Francis Cambier
Brussels, 9th March 2015
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www.bcrc.be
[email protected]
Tél: 065/40 34 34
1
New generation BIOMIMETIC and customized IMPLANTS for
BONE ENGINEERING
What context ?
With a predicted ageing population and increasing expectations
regarding quality of life in old age, there is an ever increasing demand
for procedures such as total hip replacements, bone reconstructions,
and spinal fusions, resulting from conditions such as joint cartilage
degeneration and osteoporosis.
 Due to the gap between academic R&D and commercial production,
and between materials scientists and clinicians, medical application of
these new materials will never be possible unless companies and medics
are involved in the development.
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This COST Action, NEWGEN, aims at creating the seed for the European
research and industry collaboration, combining basic knowledge from
academic laboratories, R&D centers, medical units from hospitals, and a
significant number of companies
-
www.bcrc.be
[email protected]
Tél: 065/40 34 34
2
New generation BIOMIMETIC and customized IMPLANTS for
BONE ENGINEERING
Some figures
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One third of the population is more than 60 years old in 2010
600.000 hip replacements in Europe /year
150.000 invasive spinal fusions in Europe /year
More than 4.000.000 operations involving bone grafting or bone substitutes
performed around the world / year
Orthopedic biomaterials market : ~ $8 billions (grow rate 5%)
US: 42 %, Europe: 31 %
-
www.bcrc.be
[email protected]
Tél: 065/40 34 34
3
New generation BIOMIMETIC and customized IMPLANTS for
BONE ENGINEERING
The need of cooperation
Biomaterials
preparation
Design
Strong interactions between :
Medical assessment
Processing
R&D
Characterisations
Functionalization
In vitro / In vivo testings
Fabrication
Hospital
units
Producers
Surgical operation
-
www.bcrc.be
[email protected]
Tél: 065/40 34 34
4
New generation BIOMIMETIC and customized IMPLANTS for
BONE ENGINEERING
Lack of communications between R&D, Hospital units and Industry
 Unique opportunity to link European researchers to industries and end-users
-
www.bcrc.be
[email protected]
Tél: 065/40 34 34
5
New generation BIOMIMETIC and customized IMPLANTS for
BONE ENGINEERING
Objectives, benefits, impacts
– Establish a structured coordination, helping in the development of the
right products.
– R&D increasing performance
– Increase of competitiveness of European companies
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Concrete achievements
– Multi-partners projects, mainly on new bioactive and customized
bone implants, incorporating every aspect of the whole value chain
(including H2020 projects)
– Attraction of an Asian company to Europe
– Dissemination (1 collective book, papers, Web site)
-
www.bcrc.be
[email protected]
Tél: 065/40 34 34
6
New generation BIOMIMETIC and customized IMPLANTS for
BONE ENGINEERING
Consortium of partners
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– 29 COST countries + 3 non-COST countries (USA, Canada, Australia)
– 141 partners
30
25
kick off
20
160
140
kick off
15
after 18 months
10
120
after 18 months
5
100
0
80
Countries
60
IPC
40
20
0
– 50% of the consortium members are companies, surgeons/medical units and
research centers
-
www.bcrc.be
[email protected]
Tél: 065/40 34 34
7
New generation BIOMIMETIC and customized IMPLANTS for
BONE ENGINEERING
How it works
COST Office
Members
Core group
Management committee
• Chair/Vice-chair
• 4 WG Leaders
• At least 1 by COST country
• 1 by non-COST participant
• Chair, VC, WG leaders
• GH
• STSM, Dissemination, Web
WG 1
WG 2
WG 3
WG 4
• 1 WG Leader – 1 vice leader
• Transversal activities (web page feeding, events organisation, communication, STSMs…)
• Each WG will consist of partners from academic institutes, industries and medical units
-
www.bcrc.be
[email protected]
Tél: 065/40 34 34
8
New generation BIOMIMETIC and customized IMPLANTS for
BONE ENGINEERING
The tools
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Core group meetings
WG meetings
Scientific workshops
MC meetings (to approve the suggestions)
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STSM – selection is difficult: 1st quality, ECI , inclusiveness policy countries,
gender balance, etc.
Summer schools
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Dissemination – grants, book, papers, etc. http://www.cost-newgen.org
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-
www.bcrc.be
[email protected]
Tél: 065/40 34 34
9
New generation BIOMIMETIC and customized IMPLANTS for
BONE ENGINEERING
Is it easy ?

How to get the support of COST:
– Pre-proposal (4 pages, web) 30rd Sept 2012  2 experts eligible (10th Oct 2012)  ok for a full
proposal (end Nov 2012)
– Proposal (40 pages) end Jan 2013  experts
– Selection to present (orally)  DC Hearing in Brussels (40 people, mid March 2013)
– Decision of DC (9th April 2013)  administrative details to be completed
– Decision by Cost Office and CSO (end of May 2013)  beginning of signature of MoU by the
countries
– Kick Off Meeting  2nd Oct 2013 (starting date)
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The language:
– Everything is in the Vademecum (including a 2 pages lexicon)
– Examples : WG, STSM, LOS, ECI (was ESR), GH, MC, AO, SO, KOM, CNC, SC, EB, (CSO, DC ?), etc.
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The role of the grant holder:
– Follow the rules (Vademecum) while scientists do not understand (or are not willing to do that)
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A difficulty and advantage:
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loss of control of the players (members of MC) – but it is a part of the interest  opening to
new countries, etc.
-
www.bcrc.be
[email protected]
Tél: 065/40 34 34
10
New generation BIOMIMETIC and customized IMPLANTS for
BONE ENGINEERING
Conclusion:
A very nice experience
Thank you for your attention
-
www.bcrc.be
[email protected]
Tél: 065/40 34 34
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