CURRICULUM VITAE
Xiao-Hua Andrew Zhou, Ph.D.
March 10, 2013
1. Biographical Information
1705 N.E. Pacific Street, Box 357232
Seattle, WA 98195-7232
E-mail: [email protected]
2. Education
Undergraduate:
Graduate:
Postdoctoral:
Sichuan University, B.Sc. (Mathematics)
University of Calgary, M.Sc. (Statistics)
Ohio State University, Ph.D. (Biostatistics)
Harvard University, Postdoctoral fellow (Biostatistics)
1984
1987
1991
1991-93
3. Licensure
Not applicable
4. Professional Positions
Academic & Hospital Appointments
1984 - 1985
Lecturer, Department of Mathematics, Sichuan University, China
1993 - 1997
Assistant Professor of Medicine, Division of Biostatistics, Indiana University School of
Medicine, Indianapolis IN
1997 - 2002
Associate Professor, Division of Biostatistics, Indiana University School of Medicine,
Indianapolis IN
2002 - 2003
Affiliate Associate Professor, Department of Biostatistics, School of Public Health and
Community Medicine, University of Washington, Seattle, WA
2002 -
Director and Research Career Scientist, Biostatistics Unit, Northwest Health Services
Research & Development Center of Excellence VA Puget Sound Health Care System
2003 - 2005
Research Professor, Department of Biostatistics, School of Public Health and
Community Medicine, University of Washington, Seattle, WA
2004 - 2005
Adjunct Research Professor, Department of Psychiatry and Behavior Sciences, School
of Medicine, University of Washington, Seattle, WA
2005 -
Professor, Department of Biostatistics, School of Public Health, University of
Washington, Seattle, WA
2006 -
Senior Biostatistician, National Alzheimer’s Coordinating Center, University of
Washington, Seattle, WA
2005 -
Adjunct Professor, Department of Psychiatry and Behavior Sciences, School of
Medicine, University of Washington, Seattle, WA
2009 -
2005 -
2009-
Adjunct Professor, Beijing International Center for Mathematical Research (BiCMR),
School of Mathematical Sciences, Peking University, Beijing, China
Adjunct Professor, Department of Mathematics, Chinese Academy of Science, Beijing,
China
Adjunct Professor, School of Statistics, Renmin University of China, Beijing, China
Visiting Appointments
2/2000 – 4/2000 Visiting Fellow, Centre for Mathematics and Its Applications, the Australian National
University, Canberra, Australia
9/2000 – 12/2000 Visiting Faculty, Department of Biostatistics, Harvard School of Public Health, Boston,
MA
5. Honors, Awards, Scholarships
1987
1997
1998
2001
2004
2007
2008
2008
Ohio State University Fellowship
Elected Fellow, Royal Statistical Society
Elected Member, the International Statistical Institute
Mitchell Prize, The International Society for Bayesian Analysis and Section on
Bayesian Statistical Sciences of American Statistical Association (With K. Hirano, G.
Imbens, and D. B. Rubin.)
Elected Fellow, the American Statistical Association
Research Career Scientist Award, U.S. Federal Government
Department of Veterans Affairs
Distinguished Overseas Young Scientist Award, National Natural Science Foundation
of China， National Natural Science Foundation of China
Advisory Committee Service Award, U.S. Federal Government Food and Drug
Administration
6. Professional Activities, outside of University of Washington
Membership in Professional Societies
American Statistical Association
International Biometric Society
Institute of Mathematical Statistics
Editorial Services
1999-2005
20052001-2007
2005- 2010
2006- 2009
Editorial Board Member, Statistics in Medicine
Associate Editor, Statistics in Medicine
Associate Editor, Biometrics
Co-Editor, Health Services and Outcomes Research Methodology
Associate Editor, Statistica Sinica
Professional Service – National and International
1996 - 1998
Member, Traveling Course Committee, Council of Chapters, American Statistical
Association
1998 - 2000
Chair, Traveling Course Committee, Council of Chapters, American Statistical
Association
2000
Program Chair–Elect, Section on Statistics in Epidemiology, American Statistical
Association
2001
Program Chair, Section on Statistics in Epidemiology, American Statistical Association
2001
Member, Program Committee for ENAR, International Biometrical Society
2001
Member, Program Committee for ICSA 2001 Applied Statistics Symposium,
International Chinese Statistical Association
2003
Chair–Elect, Section on Statistics in Epidemiology, American Statistical Association
2004
Chair, Section on Statistics in Epidemiology, American Statistical Association
2005-
Founding President, VA Statisticians’ Association (VASA) – U.S. Federal Government
Department of Veterans Affairs
2010
2011
2013
2012-2016
Chair-Elect, Section on Health Policy Statistics,
American Statistical Association
Chair,
Section on Health Policy Statistics,
American Statistical Association
Chair-Elect, Mental Health Statistics Section,
American Statistical Association
Vice President, World Federation of Chinese Medicine Societies Clinical Evaluation
Committee
Vice President, World Federation of Chinese Medicine Societies Postmarketing
Chinese Medicine Specialty Committee
President, International Biometric Society (IBS) – China Region.
2013-2017
2013-
Professional Service - State and Regional
1994
Vice-President, American Statistical Association Central Indiana Chapter
1995
President, American Statistical Association Central Indiana Chapter
National Study Section and Advisory Committee Activities
1994
Member, Agency for Health Care Policy and Research (AHCPR) Dissertation Grant
Panel
1994 - 1996
Member, Data Monitoring Board for Cooperative Study in Health Services, "Multi-Site
Study of Computer Generated Reminders to Enhance Adherence to Standards of
Ambulatory Care," Department of Veterans Affairs
1995
An external reviewer for a grant, dissemination study section of AHCPR
1999 - 2001
Member, Special Emphasis Panel, National Cancer Institute
2001 - 2002
Member, Special Emphasis Panel, National Institute of Mental Health
2002
Ad Hoc Member, Social Sciences, Nursing, Epidemiology and Methods-5 Study
Section [SNEM-5], NIH
2003 - 2007
Regular Member, Biostatistical Methods and Research Design Study Section (BMRD),
NIH
2010- Present
Member, Institutional Clinical and Translational Science Award (CTSA) Review
Committee, NIH National Centers for Research Resources
2004 -2008
Regular Member, Advisory Committee in Center for Devices and Radiological Health,
U.S. Food and Drug Administration (FDA)
2008 -2011
Consultant, Advisory Committee in Center for Devices and Radiological Health, U.S.
Food and Drug Administration (FDA)
2011 -Present
Regular Member, Advisory Committee in Center for Devices and Radiological Health,
U.S. Food and Drug Administration (FDA)
2008- Present
Consultant, Oncologic Drugs Advisory Committee in Center for Drug Evaluation and
Research, U.S. Food and Drug Administration (FDA)
2008- Present
Consultant, Hematology and Pathology Committee in Center for Devices and
Radiological Health, U.S. Food and Drug Administration (FDA)
2004 - 2006
Ad Hoc Member, HSR&D Scientific Merit Review Board for Special Populations, U.S.
Federal Government Department of Veterans Affairs
2006 - 2010
Regular Member, HSR&D Scientific Merit Review Board for Special Populations, U.S.
Federal Government Department of Veterans Affairs
Member, Board of Scientific Counselors (BSC), Division of Epidemiology, Statistics,
and Prevention, National Institute of Child Health and Human Development,
National Institute of Health.
2008
Manuscript Reviewer For
American Journal of Epidemiology
Annals of Internal Medicine
Biometrical Journal
Biometrics
Diabetes Care
Health Services and Outcomes Research Methodology
Journal of Agricultural, Biological and Environmental Statistics
Journal of American Statistical Association
Journal of Statistical Planning and Inference
Medical Care
Medical Decision Making
PharmacoEconomics
Statistics in Medicine
7. Bibliography
a) Refereed research articles
Statistical Methodology ( *Mentored Student Publication, **Senior Author)
1992
1. Zhou XH, Blumenthal S. Two-stage reliability tests for new series systems. J Stat Plan Infer 1992;
33:345-366.
1993
2. Zhou XH. Maximum likelihood estimators of sensitivity and specificity corrected for verification
bias. Commun Stat 1993; 22(11): 3177-3198.
1994
3. Zhou XH. Effect of verification bias on positive and negative predicted values. Stat Med 1994;
3:1737-1745.
1995
4. Zhou XH. Testing an underlying assumption on a ROC curve based on rating data. Med Decis
Making 1995; 3:276-282.
1996
5. Zhou XH. Empirical Bayes combination of estimated areas under the ROC curves using estimating
equations. Med Decis Making 1996; 16:24-28.
6. Zhou XH. A nonparametric maximum likelihood estimator for the receiver operating characteristic
curve area in the presence of verification bias. Biometrics 1996; 52:299-306.
7. Zhou XH, Gastonis CA. A simple method for comparing correlated ROC curves using incomplete
data. Stat Med 1996; 15:1687-1693.
8. Zhou XH, Katz BP, Holleman E, Melfi CA, Dittus R. An empirical Bayes method for studying
variation in knee replacement rates. Stat Med 1996; 15:1875-1884.
1997
9. Zhou XH, Melfi CA, Hui SL. Methods for comparison of Cost Data. Ann Intern Med 1997;
127(8): 752-756.
10. Zhou XH, Gao S, Hui SL. Methods for comparing the means of two independent log-normal
samples. Biometrics 1997; 53:1129-1135.
11. Zhou XH, Gao S. Confidence intervals for the lognormal mean. Stat Med 1997; 16: 783-790.
12. Gao S, Zhou XH*. An empirical comparison of two semi-parametric approaches for modeling
multivariate failure time data. Stat Med 1997; 16:2049-2062.
13. Hui SL, Gao S, Zhou XH, Johnston Jr CC, Lu Y, Gluer CC, Grampp S, Genant H. Optimal
universal standardization of multiple measurements: Application to dual-energy X-ray
absorptiometry. J Bone Miner Res 1997; 12:1463-1470.
1998
14. Zhou XH. Estimation of the lognormal mean. Stat Med 1998; 17: 2251-2264.
15. Zhou XH, Higgs R. COMPROC and CHECKNORM: Computer programs for comparing
accuracies of diagnostic tests using roc curves in the presence of verification. Comput Meth Prog
Bio 1998; 57:179-186.
16. Zhou XH. Estimating the mean value of occupational exposures. Am Ind Hyg Assoc J 1998;
59:785-788.
18. Zhou XH, Rodenberg CA. Estimating an ROC curve in the presence of non-ignorable verification
bias. Commun Stat 1998; 27(3): 635-637.
19. Zhou XH. Comparing accuracies of two screening tests in a two-phase study for dementia. J Roy
Stat Soc C – App 1998; 47:135-147.
20. Zhou XH. Comparing correlated areas under the ROC curves of two diagnostic tests In the presence
of verification bias. Biometrics 1998:54, 453-470.
21. Zhou XH. Correcting for verification bias in studies of a diagnostic test’s accuracy. Stat Methods
Med Res 1998; 7:337-53.
22. Hui SL, Zhou XH. Evaluation of diagnostic tests without gold standards. Stat Methods Med Res
1998; 7:354-70.
1999
23. Zhou XH, Brizendine EJ, Pritz MB. Methods for combining rates from several studies. Stat Med
1999; 18:557-566.
24. Zhou XH, Castellucio P, Hui SL, Rodenberg CA. Comparing two prevalence rates in a two-phase
design study. Stat Med 1999; 18:1171-1182.
25. Zhou XH, Tu W. Comparison of several independent population means when their samples contain
non-zero log-normal and possibly zero observations. Biometrics 1999; 55(2): 645-651.
26. Zhou XH, Perkins AJ, Hui SL. Comparisons of software packages for generalized linear multilevel
models. Am Stat 1999; 53(3): 282-90.
27. Tu W, Zhou XH*. A Wald test comparing medical costs based on log-normal distributions with zero
value costs. Stat Med 1999; 18:2749-2762.
2000
28. Zhou XH, Higgs RE. Assessing the relative accuracies of two screening tests in the presence of
verification bias. Stat Med 2000; 19:1697-1705.
29. Zhou XH*, Gao S. One-sided confidence intervals for means of positively skewed distributions.
American Stat 2000; 54:100-104.
30. Zhou XH*, Tu W. Confidence intervals for the mean of diagnostic test charge data containing zeros.
Biometrics 2000; 56:1118-1125.
31. Zhou XH*, Tu W. Interval estimation for the ratio in means of log-normally distributed medical
costs with zero values. Comput Stat Data An 2000; 35(2): 201-210.
32. Hirano K, Imbens GW, Rubin DB, Zhou XH. Assessing the effect of an influenza vaccine in an
encouragement design. Biostatistics 2000; 1:69-88.
33. Rodenberg CA, Zhou XH*. ROC curve estimation when covariates affect the verification process.
Biometrics 2000; 56: 1256-62.
34. Tu W, Zhou XH*. Pairwise comparisons of the means of skewed data. J Stat Plan Inf 2000; 88(1):
59-74.
35. Perkins SM, Tu W, Underhill MG, Zhou XH, Murray MD. The use of propensity scores in
pharmacoepidemiologic research. Pharmacoepidem Dr S 2000; 9(1): 93-101.
2001
36. Zhou XH, Li C, Gao S, Tierney WM. Methods for testing equality of means of health care costs in a
paired design study. Stat Med 2001; 20:1703-1720.
37. Zhou XH, Eckert G, Tierney WM. Multiple imputation in public health research. Stat Med 2001;
20:1541-1549.
38. Zhou XH, Stroupe KT, Tierney WM. Regression analysis of health care charges with
heteroscedasticity. J Roy Stat Soc C – App 2001; 50(3): 303-312.
2002
39. Zhang DD, Zhou XH, Freeman DH, Freeman JL. A non-parametric method for the comparisons of
partial areas under ROC curves and its application to large health care data sets. Stat Med 2002; 21:
701-715.
40. Zhou XH and Harezlak J. Comparison of kernel smoothing method for ROC curves. Stat Med
2002; 21: 2045 - 2055.
41. Zhou XH. Inferences about population means of health care costs. Stat Methods Med Res 2002; 11:
327-339.
42. Frangakis CE, Rubin DB, Zhou XH.
Clustered encouragement designs with individual
noncompliance: Bayesian inference with randomization, and application to advance directive forms.
Biostatistics (with Discussion) 2002: 3: 147-164.
43. Frangakis CE, Rubin DB, Zhou XH. Rejoinder to discussions on clustered encouragement designs
with individual noncompliance: Bayesian inference with randomization, and application to advance
directive forms. Biostatistics 2002; 3: 173-177.
44. Obuchowski N, Zhou XH. Prospective studies of diagnostic test accuracy when disease prevalence
is low. Biostatistics 2002; 3: 477-492.
45. Tu W, Zhou XH*. A bootstrap confidence interval procedure for the treatment effect using
propensity score subclassification. Health Services and Outcomes Research Methodology 2002;
3:135-147.
2003
46. Hall P, Zhou XH. Nonparametric estimation of component distributions in a multivariate mixture.
Ann Stat 2003; 31: 201-224.
47. Zhou XH, Castellucio P. Nonparametric analysis for the ROC areas of two diagnostic tests in the
presence of nonignorable verification bias. J Stat Plan Inf 2003; 115: 193-213.
48. Zhou XH and Ramsey S. Assessing the equality of means of health care costs. Expert review of
Pharmacoeconomics and Outcomes Research 2003; 3, 561-567.
2004
49. Peng L, Zhou XH**. Local linear smoothing of receiver operating characteristic (ROC) curves. J
Stat Plan Inf 2004; 118: 129-143.
50. Zhou XH, Qin GS, Tsao M. New intervals for the difference between two binomial proportions. J
Stat Plan Inf 2004; 123: 97-115.
51. Zhou XH, Castellucio P. Adjusting for non-ignorable verification bias in clinical studies for
Alzheimer's disease. Stat Med 2004; 23: 221-230.
52. Lui KJ. and Zhou XH. Testing non-inferiority (and equivalence) between two diagnostic procedures
in paired-sample ordinal data. Stat Med 2004; 28:545-549.
53. Lui KJ., Zhou XH., and Lin CD. Testing Equality between Two Diagnostic Procedures in PairedSample Ordinal Data. Biometrical J 2004; 46: 642-652.
54. Ren H., Zhou XH., and Liang H. A Flexible Method for Estimating ROC Curve. J Appl Stat 2004;
31: 773-784
55. Jiang H and Zhou XH**. Bootstrap confidence intervals for medical costs with censored
observations. Stat Med 2004; 18: 3365-3376.
2005
56. Wang L and Zhou XH. A Fully nonparametric diagnostic test for homogeneity of variance. The
Canadian Journal of Statistics 2005; 33: 545-558
57. Zhou XH*, Qin S. Improved confidence intervals for the sensitivity at a fixed level of specificity of a
continuous-scale diagnostic test. Stat Med 2005; 24:465-477.
58. Zhou XH*, Qin GS. A new confidence interval for the difference between two binomial proportions
of paired data. J Stat Plan Inf 2005; 128:527-542.
59. Zhou XH* and Dihn P. Nonparametric confidence intervals for one and two-sample problems.
Biostatistics 2005; 6:187-200.
60. Song X. and Zhou XH**. A marginal model approach for analysis of multi-reader multi-test
receiver operating characteristic (ROC) data. Biostatistics 2005; 6: 303-312.
61. Zhou XH**, Castelluccio P, and Zhou C. Nonparametric estimation of ROC curves in the absence
of the gold standard. Biometrics 2005; 61: 600-609.
2006
62. Welsh A and Zhou XH**. Estimating the retransformed mean in a heteroscedastic two-part model
Journal of Statistical Planning and Inferences 2006; 136(3): 860-881.
63. Zhou XH** and Liang H. Semi-parametric single-index two-part regression models for health care
costs with zero values. Comput Stat Data An 2006;50(5): 1378-1390.
64. Wang L and Zhou XH**. A Fully Nonparametric Diagnostic Test For Homogeneity of Variance."
Canadian Journal of Statistics 2005; 33 (4): 545-558.
65. Qin G, Hsu YS, and Zhou XH**. New confidence intervals for the difference between two
sensitivities at a fixed level of specificity. Stat Med 2006; 25: 3487-3502.
66. Chen YH and Zhou XH*. Interval estimates for the ratio and difference of two lognormal means. Stat
Med 2006, 25: 4099-4113.
67. Qin G and Zhou XH*. Empirical likelihood inference for the area under the ROC curve. Biometrics
2006, 62: 613-622.
68. Harel O and Zhou XH*. Multiple imputation for correcting verification bias. Stat Med 2006; 25:
3769-3786.
69. Dinh P and Zhou XH*. Nonparametric statistical methods for cost-effectiveness analyses.
Biometrics 2006; 62: 576-588.
70. Zhou XH*, Qin G, Lin H, and Li G. Inferences in censored cost regression models with empirical
likelihood. Statistica Sinica 2006, 16: 1213-1232.
71. Zhou XH*, Qin G, and Maciejewski ML. Estimating the VA health care cost using a semi-parametric
heteroscedastic two-part model. Health Serv Outcomes Res Method 2006, 6: 69-80.
72. Zhou XH* and Li SM. ITT analysis of randomized encouragement design studies with missing
data. Statistics in Medicine 2006; 25: 2737-2761.
2007
73. Mercaldo N, Lau KF, and Zhou XH*. Confidence intervals for predictive values with an emphasis to
case control studies. Statistics in Medicine 2007; 26(10): 2170-2183.
74. Harel O and Zhou XH*. Multiple imputation: Review of theory, implementation, and software.
Statistics in Medicine, 2007, 26(16): 3057-3077.
75. Harel O and Zhou XH*. Multiple imputation for the comparison of two screening tests in twophase Alzheimer studies. Statistics in Medicine, 2007, 26(11): 2370-2388.
76. Song X, Ma S, Huang J, and Zhou XH. A semiparametric approach for the nonparametric
transformation survival model with multiple covariates. Biostatistics, 2007, 8(2): 197-211.
77. Koepsell T.D., Chi YY, Zhou XH, Lee WW, Ramos EM, and Kull WA. An alternative method for
estimating efficacy of the AN1792 vaccine for Alzheimer’s disease. Neurology 2007; 69: 1868-1872.
78. Wang L and Zhou XH*. Assessing the adequacy of variance function in heteroscedastic regression
models. Biometrics 2007; 63: 1218-1225.
79. Zhou XH*, Li SM, and Gatsonis CA. Wilcoxon-based group sequential designs for comparisons of
areas under two correlated ROC curves. Statistics in Medicine 2007; 27: 213-223.
2008
80. Zhou XH*, Li, CM, and Yang Z. Improving interval estimation of binomial proportions. Phil.
Trans. R. Soc. A. 2008, 366: 2405-2418.
81. Zhou XH* and Cheng H. A computer program for estimating the re-transformed mean in
heteroscedastic two-part transformation models. Comput Meth Prog Bio. 2008, 90: 210-216.
82. Song X. and Zhou XH*. A semiparametric approach for the covariate specific ROC curve with
survival outcomes. Statistica Sinica 2008, 8: 947-965.
83. Chi YY and Zhou XH*. Receiver operating characteristic surfaces in the presence of verification
bias . Journal of Royal Statistical Society Series C (JRSS C) 2008; 57 : 1-23.
84. Tang L., Emerson S., Zhou XH*. Nonparametric and semiparametric group sequential methods for
comparing accuracy of diagnostic tests. Biometrics 2008； 64: 1137-1145.
85. Zhou XH* and Lin, H. Semi-parametric maximum likelihood estimates for ROC curves of
continuous-scale tests. Statistics in Medicine 2008; 27: 5271-5290.
86. Chi, YY and Zhou XH*. The need for reorientation toward cost-effective prediction. Statistics in
Medicine 2008; 27: 182-184.
2009
87. Taylor L and Zhou XH*. Multiple imputation methods for treatment noncompliance and missing
Data. Biometrics 2009； 65：88-95.
88. Zhou XH*, Lin H, and Eric Johnson. Nonparametric heteroscedastic transformation regression
models for skewed data with an application to health care costs. Journal of Royal Statistical Society
Series B (JRSS B) 2009; 70: 1029-1047
89. Taylor L and Zhou XH*. Relaxing latent ignorability in the ITT analysis of randomized studies
with missing data and noncompliance. Statistica Sinica 2009; 19: 749-764. .
90. Tang L and Zhou XH*. Semiparametric inferential procedures for comparing multivariate ROC
curves with interaction terms. Statistica Sinica 2009; 19: 1203-1221.
91. Zhou XH*, Hu N., Hu G., and Root M. Synthesis analysis of regression models with a continuous
outcome Statistics in Medicine 2009; 28: 1620-1635.
92. Chen H, Geng Z, and Zhou XH*. Identifiability and estimation of causal effects in randomized
trials with noncompliance and completely nonignorable missing data (with discussion). Biometrics
2009; 65： 675-691.
93. Hsieh H. N., Su H.Y., and Zhou XH*. Interval estimation for the difference in paired areas under
the ROC curves in the absence of a gold standard test. Statistics in Medicine 2009; 28: 3108-3123.
94. Lin H and Zhou XH*. A Semi-parametric two-part mixed-effects heteroscedastic transformation
model for correlated right-skewed semi-continuous data. Biostatistics 2009; 10(4): 640-658.
95. Li J and Zhou XH*. Nonparametric and semiparametric estimation of the three way receiver
operating characteristic surface. Journal of Statistical Planning and Inferences 2009; 139(12):
4133-4142
2010
97. H. Wang and Zhou XH*. Quantile regression for estimating conditional means of health care costs .
Biometrika 2010; 97: 147-158.
98. H. Z. Lin, D. P. Liu, and Zhou XH*. A correlated random-effects model for normal longitudinal
data with nonignorable missingness. Statistics in Medicine 2010; 29:236-247.
99. Liu DP and Zhou XH*. Adjusting for non-ignorable verification bias in estimation of ROC curve and
its area with likelihood-based approach. Biometrics 2010; 66: 1119-1128
100. Young K, Laird A., and Zhou XH*. The efficiency of clinical trial designs for predictive biomarker
validation. Clinical Trials 2010; 7 (5): 557-566.
2011
101. Taylor, L. and Zhou XH*. Methods for clustered encouragement design studies with noncompliance
and missing data. Biostatistics; 12: 313-326
102. Lin H, Zhou L, Peng H. and Zhou XH*. Selection and combination of biomarkers using the
optimal ROC curve for disease classification and prediction. Canadian Journal of Statistics 39(2):
324-343.
103. Liu DP and Zhou XH*. Nonparametric estimation of the covariate-specific ROC curve in presence
of ignorable verification bias. Biometrics 2011; 67: 906-916.
104. Wang ZY, Zhou XH*, and M. Wang. Evaluation of diagnostic accuracy in detecting ordered
symptom statuses without a gold standard. Biostatistics 2011: 12: 567-581.
105. Hubbard R. and Zhou XH. A comparison of non-homogeneous Markov regression models with
application to Alzheimer's disease progression. Journal of Applied Statistics 2011; 38: 2313-2326.
106. Chen BJ and Zhou XH*. Doubly robust estimates for longitudinal data analysis with missing
response and missing covariates. Biometrics 2011; 67: 830-842
107. Ding P, Geng Z, Yan W, and Zhou XH*. Identifiability and Estimation of Causal Effects by
Principal Stratification with Outcomes Truncated by Death. Journal of the American Statistical
Association 2011; 106: 1578-1591.
108. Song X and Zhou XH*. Evaluating Markers for Treatment Selection Based on Survival Time.
Statistics in Medicine 2011; 30: 2251-2264.
109. Chen BJ and Zhou XH* Non-homogeneous Markov process models with incomplete observations:
application to a dementia disease study. Biometrical Journal 2011; 3: 444-463.
110. Tang, L., Ming, T. and Zhou, XH. A Sequential Conditional Probability Ratio Test Procedure for
Comparing Diagnostic Accuracy. Journal of Applied Statistics 2011; 38: 1623–1632.
2012
111. Rajan KB and Zhou XH*. Regression Method for the Area Under the Curve for Ordinal Outcomes.
Biometrical Journal 2012; 54: 143-156.
112. Zhou XH*, Chen B., Xie YM, Tian F., Liu H., and Liang X. Variable selection using the optimal
ROC curve: An application to a Traditional Chinese Medicine study on osteoporosis disease.
Statistics in Medicine 2012; 31: 628-635.
113. Zhou XH*, Cai B.J. , Li S. L., Y.M. Xie YM, Pei Y., Tian F., Fan N, Li J. P. Determining risk
factors of osteoporosis, based on traditional Chinese medicine symptoms and western medicine risk
factors. Statistics in Medicine 2012; 31: 643-652.
114. Shuai P, Zhou XH*, Lao L, and Li X. Issues of design and statistical analysis in controlled
clinical acupuncture trials: An analysis of English-language reports from Western journals. Statistics
in Medicine 2012; 31: 606-618
115. Feng P, Fan MY, Zhou XH*, Zou QM, and Li XS. Generalized propensity score in making causal
inference for experimental data with multiple treatments Statistics in Medicine 2012; 31: 681-697.
116. Wang ZY and Zhou XH*. Random effects models for assessing diagnostic accuracy of traditional
Chinese doctors in absence of a gold standard. Statistics in Medicine 2012; 31: 661-671.
117. Zhou XH* and Ma Y. BATE curve in assessment of clinical utility of predictive biomarkers.
Science China Mathematics 2012; 55: 1529-1552.
118. LI JL, Zhou XH*, and Fine JP. A regression approach to ROC surface, with applications to
Alzheimer's disease. Science China Mathematics 2012; 55: 1583-1595.
119. Song X, Zhou XH, and Ma S. Nonparametric receiver operating characteristic-based evaluation for
survival outcomes. Statistics in Medicine 2012; 2660-26675.
120. Tang L and Zhou XH*. A semiparametric separation curve approach for comparing correlated ROC
data from multiple markers. J Comput Graph Stat. 2012; 21:662-676.
121. Lin H and Zhou XH*, and Li G. . A direct semiparametric receiver operating characteristic
curve regression with unknown link and baseline functions. Statistical Sinica. 2012; 22:
1427-1456.
122. Skaron A, Li K, and Zhou XH*. Statistical Methods for MRMC ROC Studies. Academic Radiology;
19(12): 1499-1507.
123.
Chen, BJ and Zhou, XH*. A Latent-Variable Marginal Method for Multi-Level Incomplete
Binary Data. Statistics in Medicine; 31 (26): 3211–3222.
124.
Tang L, Liu A., Schisterman E. F. , and Zhou XH. Homogeneity tests of Clustered Diagnostic
Markers with Applications to the BioCycle Study. Statistics in Medicine ; 31 (28): 3638–3648.
2013
125. Tang L and Zhou XH*. A general framework of marker validation designs with optimal allocation.
Statistics in Medicine 2013; 32 (4): 620–630.
126. Liu D.P. and Zhou X. H., ROC Analysis in Biomarker Combination with Covariate Adjustment.
Acad Radiol. 2013; 20(7): 874–882
127. Liu D and Zhou XH*. Covariate adjustment in estimating the area under ROC curve with partially
missing gold standard. Biometrics 2013; 69: 91-100.
128. Chen, BJ and Zhou, XH*. Generalized Partially Linear Models for Incomplete Longitudinal Data In
the Presence of Population-Level Information. Biometrics 2013; 69(2):386-95.
129.
Chen BJ and Zhou XH*. A Correlated Random Effects Model for Non-homogeneous Markov
Processes with Nonignorable Missingness. Journal of Multivariate Analysis 2013; 117: 1–13.
130.
Sachs M and Zhou XH*. Partial summary measures of the predictiveness curve. Biometrical
Journal 2013 ;55(4):589-602
131.
Duan XG and Zhou XH* Composite quantile regression for the receiver operating characteristic
curve. Biometrika 2013; 100: 889-900.
132.
Li X, Zhou XH, and Tian L. Interval Estimation for the Mean of Lognormal Data with Excess
Zeros. Statistics and Probability Letters 2013; 83:2447–2453.
133.
Sherwood B, Wang L, and Zhou XH**. Weighted Quantile Regression for Analyzing Health
Care Cost Data with Missing Covariates. Statistics in Medicine 2014; 32: 4967–4979
2014
134.
Bin Peng, Dianwen Zhu, Xiaowei Yang, Ling Liu, Wenquan Huang, Zhou XH & Dong Yi. An
extended association rule mining strategy for gene relationship discovery from microarray data.
Journal of Statistical Computation and Simulation 2014; 84: 384-396.
135.
Lai P, Wang Q. and Zhou XH*. Variables Selection and Semiparametric Efficient Estimation for
the heteroscedastic partially linear single-index model. Computational Statistics and Data Analysis
2014; 70: 241–256
In Press
136.
Zhou XH*, Sheng E, Chen H., Hu G., Duncan A. A new synthesis analysis method for
developing a multivariate logistic regression prediction model. Statistics in Medicine (in press).
137.
Chen BJ, Zhou XH*, and Chan G. Pseudo-empirical likelihood-based method using calibration
for longitudinal data with drop out. JRSS C (in press)
138.
Lin H., Ling Zhou L, and Zhou XH*. Semiparametric regression analysis of longitudinal skewed
data. Scandinavian Journal of Statistics.
(in press).
Submitted
139. Ding XB, Zhou XH*, and Wang Q. Constrained least square estimator of the transformation
function for a partially linear single-index transformation model (submitted).
140. Ding XB and Zhou XH*. Nonparametric transformation regression with unknown variance
function for highly skewed data (submitted).
141. Liu W., Zhang B., and Zhou XH**. Joint Modeling of Transitional Patterns of Alzheimer's Disease
(submitted).
Medical Science
In Press
142.
Tao Zhang, Xiaoyan Wu, Chaofu Ke, Mingzhu Yin, Zhenzi Li, Lijun Fan,Wang Zhang, Haiyu
Zhang, Falin Zhao, Xiaohua Zhou, Ge Lou, and Kang Li. Identification of potential biomarkers for
ovarian cancer by urinary metabolomic profiling. Journal of Proteome Research.
143.
Lijun Fan, Wang Zhang, Mingzhu Yin, Tao Zhang, Xiaoyan Wu, Haiyu Zhang, Meng Sun,
Zhenzi Li, Yan Hou, Zhou XH, Ge Lou, Kang Li. Identification of metabolic biomarkers to diagnose
epithelial ovarian cancer using a UPLC/QTOF/MS platform. Acta oncologica
144.
Bizu Gelaye, Michlle A. Williams, Seblewengel Lemma , Negussie Deyessa, Yonas Bahretibeb,
Teshome Shibre, Dawit Wondimagegn, AsnakeLemenhe, Jesse R.Fann, Ann Vander Stoep, XiaoHua Andrew Zhou.. Diagnostic Validity of the Composite International Diagnostic Interview (CIDI)
Depression Module in an East African Population. International Journal of Psychiatry and Medicine
145.
Bizu Gelaye, Michlle A. Williams, Seblewengel Lemma , Negussie Deyessa, Yonas Bahretibeb,
Teshome Shibre, Dawit Wondimagegn, AsnakeLemenhe, Jesse R.Fann, Ann Vander Stoep, XiaoHua Andrew Zhou.. Diagnostic Validity of the Composite International Diagnostic Interview (CIDI)
Depression Module in an East African Population. International Journal of Psychiatry and Medicine
146.
Zhang B, Zhi W, and Zhou XH* Joint Modeling of Transitional Patterns of Alzheimer's Disease.
PLOS ONE (in press).
2013
147.
Bizu Gelaye, Michlle A. Williams, Seblewengel Lemma , Negussie Deyessa, Yonas Bahretibeb,
Teshome Shibre, Dawit Wondimagegn, AsnakeLemenhe, Jesse R.Fann, Ann Vander Stoep, XiaoHua Andrew Zhou. Validity of the patient health questionnaire-9 for depression screening and
diagnosis in East Africa. Psychiatry Research.
2012
148.
Tao Zhang, Xiaoyan Wu, Mingzhu Yin, Lijun Fan, Haiyu Zhang, Falin Zhao, Wang Zhang,
Chaofu Ke, Guangming Zhang, Yan Hou, Zhou XH, Ge Lou, Kang Li. Discrimination between
malignant and benign ovarian tumors by plasma metabolomic profiling using ultra performance liquid
chromatography/mass spectrometry. Clinica Chimica Acta 413 (2012) 861–868.
2010
149. Hernandez S, McClendon MJ, Zhou XH, Sachs M, Lerner AJ. Pharmacological Treatment
of Alzheimer's Disease: Effect of Race and Demographic Variables. J Alzheimers Dis.
2010; 19: 665-672.
150. Zhao X, Zhao Q, Chu B, Yang Y, Li F, Zhou XH, Cai J, Cai Z, and Yuan C. Prevalence
of Compositional Features in Subclinical Carotid Atherosclerosis Determined by Highresolution Magnetic Resonance Imaging in Chinese Patients with Coronary Artery Disease.
Stroke. 2010; 41: 1157-1162
2009
151. Luk, A. J., Levin, G. P., Moore, E. E., Zhou, X.-H., Kestenbaum, B. R., & Choi, H. K.
(2009). Allopurinol and mortality in hyperuricaemic patients. Rheumatology. 48 (7), 804806.
152. Hedrick S. C., Guihan, M., Sullivan, J. H., Zhou, X.H., Manheim, L. M.,Forsberg, C. W.,
Mambourg, F. J. Assisted living pilot program: health outcomes. Journal of Aging and
Health 2009; vol 21: pp190-207.
153. Chapko, M. K., Manheim, L. M., Guihan, M., Sullivan, J. H., Zhou, X.H., Wang L.,
Mambourg, F. J., Hedrick, S. C. Assisted Living Pilot Program: Utilization and Cost
Finding. Journal of Aging and Health 2009; Vol. 21; pp 208-225.
154. Estes A., Munson, J., Koehler, E., Zhou, X. H., and Abbott, R. D. Parenting stress and
psychological functioning among mothers of preschool children with autism and
developmental delay Autism. Autism 2009; Vol 13: pp 375-387.
2008
155. Koepsell TD, Kurland BF, Zhou XH, Harel O, and Kukull, WA. Education, cognitive
function, and severity of neuropathology in Alzhemier’s disease. Neurology 2008 May 6;
70: 1732-1739
156. Xi LF, Kiviat NB, Galloway DA, Zhou XH, Ho J, Koutsky LA. Effect of cervical
cytologic status on the association between human papillomavirus type 16 DNA load and the
risk of cervical intraepithelial neoplasia grade 3. The Journal Of Infectious Diseases 2008
Aug 1; Vol. 198 (3), pp. 324-31.
157. Munson J, Daswon G, Sterling L, Beauchaine T, Zhou XH, Koehler E, Lord C, Rogers S,
Sigman M, Estes A, and Abbott R. Evidence for latent classes of IQ in young children with
autism spectrum disorder. American Journal on Mental Retardation 2008 Nov; Vol 113, pp.
439-452.
2007
158. Koepsell TD, Chi YY, Zhou XH, Lee WW, Ramos EM, Kukull WA. An alternative
method for estimating efficacy of the AN1792 vaccine for Alzheimer disease. Neurology
2007 69(19):1868-72
159. Hedrick, S, Chapko, M., Manheim, L., Sullivan, J., Thomas, M., Barry, S., and Zhou, A.
Characteristics of residents and providers in the assisted living pilot program. Geronotologist
2007; 47:365-377.
2005
160. . Tierney WM, Overhage JM, Murray MD, Harris LE, Zhou XH, Eckert GJ, Smith FE,
Nienaber N, McDonald CJ, and Wolinsky FD. Can computer-generated evidence-based care
suggestions enhance evidence-based management of asthma and chronic obstructive
pulmonary disease? A randomized, controlled trial. Health Serv Res. 2005;40:477-98.
161. McFall M, Saxon AT, Thompson CE, Yoshimoto D, Malte C, Strats-Trster K, Kanter E,
Zhou XH, Dougherty CM, Steele B. Improving the rates of quitting smoking for Veterans
with posttraumatic stress disorder. Am J Psychiatry. 2005;162:1311-9.
162. Duncan GE, Li SM, and Zhou XH. Age and kidney function are the primary correlates of
fasting plasma total homocysteine levels in non-diabetic and diabetic adults. Results from the
1999-2002 National Health and Nutrition Examination Survey. Nutr Metab; 26;2:13.
163. Katon , WJ, Schoenbaum M, Fan MY, Callahan CM, Williams J, Hunkeler F, Harpole L,
Zhou XH, Langston C, and Unutzer J. Cost-effectiveness of improving primary care
treatment of late-life depression. Arch Gen Psychiatry. 2005 Dec;62(12):1313-20.
164. Duncan GE, Li SM, and Zhou XH. Cardiovascular fitness among US adults: NHANES
1999-2000 and 2001-2002. Medicine and Science in Sports and Exercise. 2005; 37(8): 13248.
2004
165. Subramanian U., Fihn SD, Weinberger W., Plue L, Smith, F.E., Udris E., McDonell
M,Eckert G. J., Temkit M., Zhou X.H., Yeung A.,Chen L., and Tierney MD. A controlled
trial of including symptom data in computer-based care suggestions for managing chronic
heart failure. American Journal of Medicine 2004; 116: 375-384.
166. Murray MD, Harris LE, Overhage, Zhou XH, Eckert GJ, Smith FE, Buchanan NN,
Wolinsky FD, McDonald CJ, Tierney WM . Failure of Computerized Treatment Suggestions
to Improve the Health Outcomes of Outpatients with Uncomplicated Hypertension: Results
of a Randomized Controlled Trial. Pharmacotherapy 2004: 324-337.
167. Tierney WM, Brunt M, Dave S, Kesterson J, Zhou XH, L’Italien G, Lapuerta P.
Quantifying risk of adverse clinical events with one set of vital signs among primary care
patients with hypertension. Annals of Family Medicine 2: 209-217 .
168. Duncan GE, Li SM, and Zhou XH. Prevalence and trends of a metabolic syndrome
phenotype among u.s. Adolescents, 1999-2000. Diabetes Care. 2004;27:2438-43.
169. Burman M. L., Buchbinder M., Kivlahan D., Broglio K., Zhou XH, Merrill, J. O.,
McDonell, Fihn S. D., and Bradley K. Alcohol-related advice for Veterans Affairs primary
care patients: Who gets it? Who gives it? J Stud Alcohol. 2004 ;65:621-30.
170. Bradley KA, Kivlahan DR, Zhou XH, Sporleder JL, Epler AJ, McCormick K, Merrill
JO, McDonell MB, and Fihn SD. Using alcohol screening results and treatment history to
assess the severity of at-risk drinking in Veterans Affairs primary care patients. Alcohol Clin
Exp Res. 2004;28:448-55.
2003
171. Swindle RW, Helmy A, Rao J, Adams L, Zhou XH, Eckert G, Weinberger M. (2003)
Integrating clinical nurse specialists into primary care: A randomized controlled trial for
patients with depression. International Journal of Psychiatry in Medicine 33, 17-37.
172.
Hedrick SC, Sales AEB, Sullivan J, Gray S, Tornatore J,Michael Curtis M, Zhou XH
(2003). Resident outcomes of Medicaid funded community residential care. Gerontologist
43: 473-482.
173. Tierney WM, Overhage JM, Murray MD, Harris LE, Zhou XH, Eckert GJ, Smith FE,
Nienaber N, McDonald CJ, and Wolinsky FD (2003). Effects of Computerized Guidelines
for Managing Heart Disease in Primary Care: A Randomized, Controlled Trial. Journal of
General Internal Medicine 18(12):967-976.
2001
174. Tierney WM, Dexter PR, Gramelspacher GP, Perkins AJ, Zhou XH, and Wolinsky FD
(2001): The effect of discussions about advance directives on patients' satisfaction with
primary care. Journal of General Internal Medicine;16:32-40.
175. Swindle, R, Harris L, Kroenke, K, Tu, W, Zhou, X.H. (2001). Can mental health
treatment be effectively delivered in primary care? A primer for employee benefit design,
decision makers and an outcome research example. In I. Farquhar, K. Summers, and A.
Sorkin (Eds.) Research in human capital and development (14, 343-375). The Netherlands:
Elsevier Science Ltd.
176. Kroenke K, West S, Swindle R, Gilsenan A, Eckert G, Dolor R, Stang P, Zhou XH, Hays
R, Weinberger M (2001). Similar effectiveness of paroxetine, fluoxetine, and sertraline in
primary care: a randomized trial. JAMA, Vol. 286, 2947-2955.
2000
177. Tierney WM, Harris LE, Gaskins DL, Zhou XH, Eckert GL, Bates AS, Wolinsky FD.
Restricting Medicaid payments for transportation: effects on inner-city patients' health care.
American Journal of the Medical Sciences 2000;319:326-333.
1999
178. Katz BP, Zhou XH, Gao S, Heck DA, Freund DA. Revision rates following staged and
simultaneous bilateral knee replacement. JCOM 1999;6(8):30-34.
179. Swindle R, Harris L, Tu W, Zhou XH. A primary care model of depression screening,
physician intervention and outcomes monitoring feedback: intervention process, three month
symptoms and service utilization. International Journal in Psychiatry in Medicine
1999;28(4): 403-404.
180. Smith DM, Zhou XH, Weinbeger M, Smith F, McDonald R. Mail reminders for areawide influenza vaccination: A randomized control trial. J Am Geriatrics Soc 1999;47:1-5
181. Murray M, Loos B, Tu W, Eckert G, Nienaber N, Zhou XH, Tierney WM. Work
patterns of ambulatory care pharmacists with access to electronic guideline-based treatment
suggestions. Am J Health-Systems Pharm 1999;56(3):225-232.
1998
182. Dexter PR, Wolinsky FD, Gramelspacher GP, Zhou XH, Nienaber N, Eckert G,
Waisburd M, Tierney WM. Effectiveness of computer-generated reminders to increase
discussions about advance directives and completion of advance directive forms. Ann Intern
Med 1998;128:102-110.
183. Barkmeier J, Trerotola SO, Wiebke E, Sherman S, Harris VJ, Snidow J, Johnson MS,
Rogers W, Zhou XH. Percutanenus radiologic, surgical endoscopic, and percutaneous
endoscopic gastrostomy/gastrojejunostomy; Comparative study and cost analysis.
Cardiovascular and International Radiology. Cardiovasc Intervent Radiol 1998;21:324-328.
184. McMahan DA, Smith DM, Carey MA, Zhou XH. The risk of major hemorrhage for
outpatients treated with warfarin. J Gen Intern Med 1998;13:311-316.
185. Murray M, Loos B, Tu W, Eckert G, Zhou XH, Tierney WM. Effect on pharmacist
work patterns of computer-based prescribing. J Am Med Inform Assoc 1998;5:546-553.
1997
186. Ferguson JA, Tierney WM, Westmoreland GR, Mamlin LA, Segar DS, Eckert GJ, Zhou
XH, Martin DK, Weinberger M. Examination of racial differences in management of
cardiovascular disease. J Am Coll Cardiol 1997; 30:1707-1713.
187. Tierney WM, Murray MD, Zhou XH. Using computer-based medical records to predict
mortality risk for inner-city patients with reactive airways disease. J Am Med Informatics
Assoc 1997;4:313-321.
188. Gramelspacher GP, Zhou XH, Hanna MP, Tierney WM. Preferences of physicians and
their patients for end-of-care. J Gen Intern Med 1997;12:346-351.
189. Park HM, Park YH, Zhou XH. Detection of thyroid remnant/metastasis without
stunning: an ongoing dilemma. Thyroid 1997;7:277-279.
190. Overhage JM, Tierney WM, Zhou XH, McDonald CJ. Decreasing mistakes in drug/test
monitoring using computer generated reminder: A randomized Controlled trial. JAMIA
1997;4:364-375.
1996
191. Trerotola SO, Johnson MS, Schauwecker DS, Davidson DD, Filo RS, Zhou XH, Eckert
GJ, Dreesen RG, Calson KA, Forney M. Pulmonary emboli from pulse-spray and mechanical
thrombolysis: evaluation with an animal dialysis-graft model. Radiology 1996; 200:169-176.
192. Kuhn-Fulton J, Trerotola S, Harris V, Snidow J, Johnson M, Carey M, Zhou XH,
Lumeng L. Transjugular intrahepatic portosystemic shunt procedure: Efficacy of 10-mm
versus 12 mm Wallstents. Radiology 1996; 199:658-664.
193. Broderick LS, Shemesh J, Wilensky RL, Zhou XH, Torres WE, Balk MA, Rogers WJ,
Conces DJ Jr, Kopecky KK. Measurement of coronary artery calcium with dual-slice helical
CT compared with coronary angiography: Evaluation of CT scoring methods, interobserver
variations and reproducibility. Am J Roentgenol 1996; 167:439-444.
194. Pritz MB, Zhou XH, Brizendine EJ. Hyperdynamic therapy for cerebral vasospasm: a
meta-analysis of 14 studies. J Neurovas Dis 1996; 1:6-8.
195. Tierney WM, Takesue BY, Vargo DL, Zhou XH. Using electronic medical records to
predict mortality in primary care patients with heart disease. J Gen Intern Med 1996; 11:8391.
196. Ferguson JA, Suelzer CJ, Eckert G, Zhou XH, Dittus RS. Risk factors for inpatient
delirium tremens development. J Gen Intern Med 1996; 11:410-414.
1995
197. Megibow AJ, Zhou XH, Rotterdam H, Francis IR, Zerhouni EA, Balfe DM, Weinreb JC,
Aisen A, Kuhlman J, Heiken JP, Gastonis C, McNeil BJ. Pancreatic adenocarcinoma: CT
versus MR imaging in the evaluation of respectability - report of the Radiology Diagnostic
Oncology Group. Radiology 1995; 195:327-332.
1994
198. Cavallo A, Zhou XH. LHRH test in the assessment of puberty in normal children.
Horm Res 1994; 41:10-15.
199. Tempany CM, Zhou XH, Zerhouni EA, Rifkin MD, Quint LA, Picoli C, Ellis J, McNeil
BJ. Staging of prostate cancer with MRI; the results of Radiology Diagnostic Oncology
Group project: Comparison of different techniques, including the endorectal coil. Radiology
1994; 192:47-54.
b) Other refereed scholarly publications
Not applicable
c) Books and book chapters
Medical Science
Swindle, R, Harris L, Kroenke, K, Tu, W, Zhou, X.H. (2001). Can mental health treatment be
effectively delivered in primary care? A primer for employee benefit design, decision makers
and an outcome research example. In I. Farquhar, K. Summers, and A. Sorkin (Eds.) Research
in human capital and development (14, 343-375). The Netherlands: Elsevier Science Ltd.
Statistical Methodology
Morris C, Norton E, Zhou XH. Parametric duration analysis of nursing home data. (Book
chapter) Case Studies in Biometry. Eds. Lange N, Billiard L, Brillinger D, Conquest L,
Greenhouse J, Ryan L. Nicholas Lange and Louise Ryan eds. John Wiley & Son, Inc. 1994;
231-248.
Textbooks
Zhou XH, Obuchowski NA and Obuchowski DM (2002). Statistical Methods in Diagnostic
Medicine. First Edition. Wiley & Sons, New York, USA
Zhou XH, Obuchowski NA and Obuchowski DM (2010). Statistical Methods in Diagnostic
Medicine. Second Edition. Wiley & Sons, New York, USA
d) Other non-refereed published scholarly publications
1.
Hall P, Zhou XH. Effects of smoothing on distribution approximations. In Probability,
Statistics,
and their Applications: Papers in Honor of Rabi
Bhattacharya. Editors, K. Athreya, M. Majumdar,
2.
M. Puri, and E. Waymire. Institute of Mathematical Statistics Lecture Notes-Monograph
Series 2003; Volume 41: 169-186. Institute of Mathematical Statistics, Beachwood, CA.
8. Patents and Other Intellectual Property
Not applicable
9. Funding History – Grants and Fellowships during past five years
As Principal Investigator on Grants for Statistical Methodology
1) U.S. Federal Government National Institute of Health (NIH) R29 (FIRST
award), Solution for Verification Bias in Diagnostic Tests, 09/30/94 –
09/29/99, Principal Investigator, $475,119.
2) U.S. Federal Government Agency for Health Care Policy and Research
(AHCPR) R03, Comparing Mean Costs Before and After a Policy Change,
09/01/97 – 03/01/99, Principal Investigator, $35,743.
3) U.S. Federal Government NIH R01, Methods for Analyzing Mental Care
Expenditures, 09/01/98 – 05/30/01, Principal Investigator, $286,770.
4) U.S. Federal Government NIH R01, Causal Analysis of Encouragement
Design Studies, 09/30/2002 – 09/30/2006, Principal Investigator, $661,500.
5) U.S. Federal Government NIH R01, Statistical Methods in Diagnostic
Medicine, 07/1/2005 – 06/30/2008, Principal Investigator, $540,000.
6) U.S. Federal Government Agency for Healthcare Research and Quality
(AHRQ) R01, Regression Analysis of Health Care Costs, 09/30/2002 –
09/30/2006, Principal Investigator, $476,000.
7) U.S. Federal Government NIH R03, Extension of Causal Inference - FIRCA,
12/01/2006 – 11/30/2010, Principal Investigator, $100,000.
8) U.S. Federal Government Department of Veterans Affairs, New Statistical
Methods for Analyzing Veterans’ Health Care Costs, 12/01/2004 – 06/30/2007,
Principal Investigator, $340,340.
9) U.S. Federal Government Department of Veterans Affairs, Causal
Inferences on Quality of Life with Deaths, 07/01/2007-12/30/2009, Principal
Investigator,$303,000
10) U.S. National Science Foundation, Empirical Likelihood Based Statistical
Methods for Diagnostic Systems, 07/15/2006 – 06/30/2010, Principal
Investigator, $70,000.
11) U.S. National Science Foundation, Novel Semiparametric Two-part Models:
New Theories and Applications, 07/1/2008 – 06/30/20112 Principal
Investigator, $105,000.
12) U.S. Federal Government Department of Veterans Affairs, Modeling of
Health Care Costs of Veterans with Chronic Diseases, 10/01/2008 –
06/30/2011, Principal Investigator, $501,364.
13) U.S. Federal Government Department of Veterans Affairs, Statistical
Designs for Marker Validation Studies in Treatment Selection, 2/01/2009 –
01/30/2011, Principal Investigator, $200,000.
14) U.S. Federal Government NIH Challenge Grants in Health Sciences
Research (RC1), Building Disease Prediction Models by Synthesis Analysis,
09/30/2009 – 08/29/2012, Principal Investigator, $224,242.
15) U.S. Federal Government Department of Veterans Affairs, A joint
evaluation of surgery-related outcomes and costs across VAMCs 01/30/2012 –
01/29/2015, Principal Investigator, $224,242.
As Principal Investigator on Grants for Training
16) U.S. Federal Government National Institute of Health (NIH) T32, Training
Program on Biostatistics in Mental Health, 07/01/2007 – 06/30/2017, Director,
$1,336,287.
As Statistician on Grants for Medical Sciences
1) U.S. Federal Government Agency for Health Care Policy and Research
(AHCPR), “Advance Directives, Proxies & Electronic Medical Records”,
4/1/1993-4/31/1997, (William M. Tierney, M.D., P.I.), Co-investigator, $703,709.
2) U.S. Federal Government AHCPR, "Computer-Based Prospective Drug
Utilization Review," 7/1/1993-12/31/1997, (William M. Tierney, M.D., P.I), Coinvestigator, $1,043,874.
3) U.S. Federal Government Department of Veterans Affairs, an Integrated Model of
Primary Care in Mental Health, 07/01/1997 – 06/30/2000, (Morris Weinberger,
Ph.D., P.I.), Co-Investigator, $583,634.
4) U.S. Federal Government Department of Veterans Affairs, Computerized
Guidelines Enhanced by Symptoms and History: Clinical Effects, 07/01/1997 –
06/30/2000, (William M. Tierney, M.D., P.I.), Co-Investigator, $621,941.
5) Eli Lilly & Company, Randomized clinical trial comparing selective serotonin
reuptake inhibitors in the treatment of depression in primary care Investigator
(Kurt Kroenke, PI), Co-Investigator, 07/01/1998 - 09/01/2000, $1,700,000.
6) U.S. Federal Government Department of Veterans Affairs, Evaluation of
Community Based Outpatient Clinic Costs Using DSS Data, 10/1/2001 –
09/30/2004, (Matthew L. Maciejewski, Ph.D., P.I.), Co-Investigator, $491,847.
7) U.S. Federal Government Department of Veterans Affairs, Evaluation of Assisted
Living Pilot Program, 10/1/2001 – 09/30/2004, (Susan Hedrick, Ph.D., P.I.), CoInvestigator, $873,654.
8) U.S. Federal Government Department of Veterans Affairs, Effects of Outlier
Identification Strategy on Facility Profiling, 10/1/02 – 10/1/05, (Kevin Sloan,
M.D., P.I.), Co-Investigator, $745,029.
9) U.S. Federal Government National Institute of Health, University of Washington
Autism Research Center of Excellence, 10/1/04- 9/30/2006, (Geraldine Dawson,
Ph.D., P.I.), Co-investigator, $5,000,000.
10) U.S. Federal Government National Institute of Health, National Alzheimer’s
Disease Coordinating Center, 10/1/05- 9/30/2015, (Walter Kukull, Ph.D., P.I.),
Co-investigator, $15,000,000.
10. Public Health Practice Activities
Not applicable
11. Conferences and Symposiums
Invited Talks (2005-2013)
1) Oct 16-19, 2013. Design and Analysis of Postmarketing Studies2013 International
Conference on Postmarketing Surveillance of Chinese Medicines, Beijing, China
2) August 6, 2013. Causal Mediation Analysis in Comparative Effectiveness
Research. Joint Statistical Meetings 2013, Montreal, Canada
3) July 6, 2013. Generalized Partially Linear Models for Incomplete Longitudinal
Data In the Presence of Population-Level Information. Joint Conference of the
Fifth Annual International Symposium on the Evaluation of Clinical Trials and
the Fourth East Asia Regional Biometric Conference
4) June 30-July 4, 2013. Causal inference with propensity score in the presence of
missing outcome data. IMS-China International Conference on Statistics and
Probability 2013, Chengdu, China
5) June 6-8, 2013. Causal Inference in Broken Randomized Clinical Trials, Beyond
Intention-To-Treat Analysis Advanced Workshop on Clinical Trials of
Investigational New Drug. Beijing, China.
6) December 30, 2012. Statistical Inferences for the Analysis of Health Care Costs.
Workshop on Modern Statistical.
Shanghai University of Finance and
Economics, Shanghai, China
7) April 2. 2012. Semiparametric estimation of the covariate-specific ROC curve in
presence of ignorable and non-ignorable verification bias. Eastern North
American Region of the International Biometric Society (ENAR), Washington
DC
8) April 8, 2012. Designs and Sample Size Calculation for Postmarketing Studies.
First International Workshop on Safety Surveillance of Post-market of Chinese
Medicine, Beijing, China.
9) May 24, 2012.
Optimal treatment Selection. 2012 Atlantic Causal Inference
Conference. Baltimore, MD, USA.
10) June 26, 2012. Quantile Regression-Based Covariate-Specific ROC Curves.
International Workshop on the Frontier of Statistics. Yunan, China.
11) June 23, 2012. Causal Inference in Randomized Clinical Trial. Advanced
Seminar on Clinical Evaluation of New Drugs. Beijing, China.
12) July 7, 2012. Designs in Evaluation of Medical Devices. Second Joint
Biostatistics Symposium. Beijing, China.
13) Juy 8, 2012 Latent-Variable Marginal Method for Multi-Level Incomplete Binary
Data. Second Joint Biostatistics Symposium. Beijing, China.
14) July 31, 2012. Identifiability and Estimation of Causal Effects of a New
Treatment on Patient’s Outcomes Truncated by Deaths. Joint Statistical Meetings
(JSM). San Diego, CA.
15) Sept 27, 2012. Semiparametric estimation of the covariate-specific ROC curve.
University of New York at Buffalo, Buffalo, NY.
16) Dec 30, 2012 Prediction of Skewed Health Care Costs. the Frontier of Modern
Statistics Workshop. Shanghai, China.
17) August 2, 2011. Empirical Likelihood-Based Method Using Calibration for
Longitudinal Data with Drop-Out. Joint Statistical Meetings. San Diego, CA,
USA
18) July 7, 2011. Assessing Predictive Biomarkers in Selecting a Best Treatment
using BATE Curve. The 3rd IMS-China International Conference on Statistics
and Probability, Xian, China.
19) July 4, 2011. Estimating the accuracy of diagnostic tests in the presence of
verification bias. The Fourth Military Medical University, Xian, China
20) July 2, 2011. Disease Progression Models with an Application to Alzheimer's
Disease. The Fourth International Symposium on Clinical evaluation and
application. Beijing, China
21) June 8, 2011. Roles of Biostatistics in Advancement of Evidence-based and
Personalized Medicine. Harbin Medical University, Harbin, China.
22) June 20, 2011. Semiparametric estimation of the covariate-specific ROC curve.
Chinese Academy of Sciences. Beijing, China
23) March 21, 2011. A Procedure for Evaluating Predictive Accuracy of Biomarkers
for Selecting Optimal Treatment. Eastern North American Region of the
International Biometric Society (ENAR), Miami, Florida, USA.
24) Aug. 16, 2010. Clinical and statistical evaluation of diagnostic agents in
compliance with FDA guidelines). China Heart Congree & International Heart
Forum, Beijing, China.
25) July 18, 2010. Biostatistics in Public Health and Medicine. Department of
Mathematics and Physics, China University of Petroleum, Beijing, China.
26) July 7, 2010. Doubly Robust Estimation for Binary Longitudinal Data Analysis
with Missing Response and Missing Covariates. An International Conference in
Honor of P.L. Hsu’s 100th Birthday, Peking Universuty, China
27) July 10, 2010. Semi-parametric methods for correcting for verification bias under
both ignorable and non- ignorable verification. The fourth International Forum on
Statistics, Beijing, China.
28) July 18, 2010. Semi-parametric methods for correcting for verification bias under
both ignorable and non-ignorable verification.
First Joint Biostatistics
Symposium. Beijing, China.
29) July 3, 2010. BATE Curve in Assessed of Clinical Utility of Predictive
Biomarkers. Department of Biostatistics, the Second Military Medical University,
Shanghai, China.
30) July 1, 2010. An Introduction to Survival Analysis in Medical Research.
Department of Biostatistics, Chongqing Medical University.
31) March 23, 2010. A Procedure for Evaluating Predictive Accuracy of Biomarkers
for Selecting Optimal Treatment. Eastern North American Region of the
International Biometric Society (ENAR), New Orleans, USA.
32) August 3, 2009. Some New Models for Predicting Health Care Costs of
Individual Patients. Joint Statistical Meetings. Washington, D.C., USA
33) July 18, 2009. Analysis of correlated right-skewed semi-continuous data with a
semi-parametric two-part mixed-effects transformation model. International
Conference on Statistics and Management, Shanghai University of Finance and
Economics, Shanghai, China.
34) June 27, 2009. Evaluation of Diagnostic tests in TCM , a keynote speaker at
Third Annual International Symposium on the Evaluation of Clinical Trials
Methodologies, Renmin University, Beijing, China
35) April 29, 2009. Evaluating Markers for Treatment Selection Based on Survival
Time. Statistical Issues in Developing Targeted Therapies. University of
Pennsylvanis Annual Conference on Statistical Issues in Clinical Trials: From
Bench to Bedside to Community, Philadelphia, PA.
36) December 23, 2008. Evaluation of Prognostic Accuracy of Biomarkers, Peking
University, Peking, China.
37) December 1, 2008. Evaluation of Prognostic Accuracy of Biomarkers. Mayo
Clinic, Rochester, MN.
38) Nov 3, 2008. Development of biomarkers: from exploration to qualification of
clinical utility for therapeutics. FDA Center for Drug Evaluation and Research
Visiting Professor Lecture Series. Silver Spring, MD.
39) Oct 6, 2008. Non-parametric heroscedastic transformation regression models for
skewed data with an application to prediction of future health care costs. College
of Public Health, Ohio State University, Columbus, OH.
40) August 5, 2008. A semi-parametric two-part mixed-effects model for longitudinal
skewed semi-continuous data. Joint Statistical Meetings. Denver, TX, USA
41) July 7, 2008. Selection and combining biomarkers for disease prediction.
Chongqing University of Medical Sciences, Chongqing, China.
42) July 1, 2008. Identifiability and Estimation of Causal Effects in Randomized
Trials with Noncompliance and Completely Non-ignorable Missing Data. The
first international symposium on biopharmaceutical statistics. Shanghai, China
43) July 1, 2008. The Efficiency of Clinical Trial Designs for Predictive Biomarker
Validation. The first international symposium on biopharmaceutical statistics.
Shanghai, China.
44) July 4 , 2008. Selection and combination of biomarkers. Sichuan University,
Chengdu, China.
45) June 30, 2008. Non-parametric heroscedastic transformation regression models
for skewed data with an application to prediction of future health care costs.
Fudan University, Shanghai, China.
46) March 24, 2008. Causal Inferences in Randomized Clinical Trials for Multicomponent
Interventions.
Stanford
University,
Stanford,
CA
47) Jan 18, 2008. Statistcial and economic Prospectives on utilization, costs, and costeffectiveness. The 7th International Conference on Health Policy Statistics –
Striving for Consensus on Method. Philadelphia, Pennsylvania.
48) Oct 5, 2007. Direct semiparametric ROC regression models with unknown link
and baseline functions. National Institute of Health, Bethesda, MD.
49) Oct. 4, 2007.
Double-Semiparametric ROC Regression Analysis. Department
of Statistics, George Mason University, Fairfax, Virginia.
50) March 22, 2007. Non-parametric analysis of skewed data with heteroscedasticity.
Department of Biostatistics, University of Michigan.
51) March 21, 2007. Non-parametric group sequential designs in diagnostic
medicine.
Department of Biostatistics, Duke University, Durham, North
Carolina.
52) March 20, 2007. A new non-parametric method for predicting health care costs
with
Heteroscedasticity. Department of Biostatistics, University of North
Carolina at Chapel
Hills, Chapel Hills, North Carolina.
53) September 14, 2006. Nonparametric transformation regression models for
skewed data with heteroscedastic variance. Department of Statistics and Actural
Sciences, University of Waterloo, Canada
54) August 8, 2006. Double-semiparametric ROC regression analysis. 2006 Joint
Statistical Meetings. Seattle, USA.
55) July 9, 2006. New statistical methods in health economics. International
Conference on Design of Experiments and Its Applications. Tianjin, China.
56) July 7, 2006. New statistical methods in diagnostic medicine. International
Conference on Frontiers of Statistics -Biostatistics and Bioinformatics,
Changchun , China.
57) June 23, 2006. Verification bias in assessment of accuracy of clinical diagnosis:
importance and correction illustrated in a study of Zlzheimer’s disease. 2nd North
American Congress of Epidemiology 2006. Seattle, Washington, USA.
58) April 20, 2006. Nonparametric transformation models with heteroscedastic
variance. School of Statistics, University of Minnesota, Minneapolis, USA.
59) March 29, 2006. Optimal estimation of ROC curves of continuous-scale tests.
International Biometric Society Eastern Norther American Region, Tampa, FL.
60) Jan 27, 2006. Double semiparametric ROC regression models. Department of
Biostatistics and Appplied Mathematics, M.D. Anderson Cancer Center,
University of Texas, Houston.
61) August 7 2005. A Marginal model approach for analysis of multi-reader multitest receiver operating characteristic (ROC) data. Joint Statistical Meetings.
Minneapolis, Minnesota, USA.
62) Nov 28, 2005. Semi-parametric maximum likelihood estimation of ROC curves.
Department of Epidemiology and Biostatistics, University of California, San
Fransciso, San Fransciso, CA.
63) July 15, 2005. Statistical methods for analysis of missing data. School of Public
Health, Sichuan University, Chengdu, China.
64) July 5, 2005. Case-mix adjusted facility profiling in the VA health care system.
Guanghua School of Management, Beijing University, Beijing, China.
65) July 3, 2005. Statistical methods in diagnostic medicine. Zhengzhou University
School of Public Health, Zhengzhou, China.
66) June 28, 2005. Inferences in censored cost regression models with empirical
likelihood. Chinese Academy of Science, Beijing.
67) June 27, 2005. Estimating the causal effect of flu shot for influenza in an
encouragement design study. Department of Statistics and Probability, Beijing
University, Beijing.
68) June 22, 2005. Western North American Region of International Biometrical
Society, Fairbanks, Alaska.
Estimating the Retransformed Mean in a
heteroscedastic Two-Part Model.
69) May 27, 2005, Division of Biostatistics, Washington University, St. Louis,
Missouri. Two-part Regression Models for Skewed Health Care Costs.
70) March 21, 2005, Eastern North American Region of International Biometrical
Society, Austin, TX. Tips for handling good data with bad properties.
12. University Service
Indiana University (1993 - 2002)
1996 - 1997
Member, Statistics-Subcommittee, Committee on Medical Student
Curriculum, Indiana University School of Medicine
1997 - 2002
Member, Admission Committee, Department of Public Health, Indiana
University School of Medicine
University of Washington (2003 - present)
2003 - 2004
Member, Ad Hoc Faculty Informal Seminar, Department of Biostatistics,
University of Washington
2004- 2005
Member, Ad Hoc Student Informal Seminar, Department of Biostatistics,
University of Washington
2005 - 2006
Member, Admission Committee, Department of Biostatistics, University of
Washington
2005- 2006
Chair, Postdoctoral Fellow/Visitor Committee, Department of Biostatistics,
University of Washington
2006-
Chair, Alumni Relation Committee, Department of Biostatistics, University of
Washington
13. Graduate Students, Post-doc Fellows, and Visiting Scholars Mentored
a)
Former Graduated Students:
Name
Year
Degree
Current Position
Kristine Broglio
2001-2003
M.Sc.
Statistician, MD Anderson Cancer Center
Richard Wang
2001-2003
M.Sc.
Statistician, Fred Hutchinson Cancer Center
Yea-Hong Chen
2004-2006
M.Sc
Staff Research Associate
University of California, San Francisco
Christopher Forsberg 2005-2007
.M.Sc.
Statistician, VA Pudget Sound ERIC
Eric Johnson
2006-2008
M.Sc.
Statistician, Group Health Cooperative
Kim Young
2005-2007
M.Sc.
Annie Skaron
2008- 2010 M.Sc.
Krisztian Sebestyen
2007-2011
M.Sc.
Fred Hutchison Cancer Research Center
Cindy Rodenberg
1993-1996
Ph.D
Statistician, Procter and Gamble
Phil Dinh
2002 -2006
Ph.D.
Senior Mathematical Statistician, U.S. FDA
Leslie Taylor
2004-2008
Ph.D.
Mathematical Statistician
US Department of Veterans Affairs
Bharat Rajan
2005-2009
Ph.D
Assistant Professor, Rush University
Nan Hu
2005-2010
Ph.D
Assistant Professor, University of Utah.
Michael Sachs
2006-2011
Ph.D
Research Scientist, University of Washington
Danping Liu
2007-2012
Ph.D
Tenure-track Investigator, National Institute of
Health
b) Former Post-doctoral Fellows:
Name
Year
Degree
Richard Evans
1995-1996
post-doc Assistant Professor, Iowa State University
Sujuan Gao
1995-1997
post-doc
Professor, Indiana University
Wanzhu Tu
1997-1999
post-doc
Professor, Indiana University
Chunming Li
1998-2000
post-doc
Associate Director, Pfizer Global Pharmaceuticals
Gengsheng Qin
2000-2001
post-doc Associate Professor, Georgia State University
Ming-Yu Fan
2003-2005
post-doc
Washington
Current Position
Research Assistant Professor, University of
Chuan Zhou
2003-2005
post-doc
Research Associate Professor, University of
Ofer Harel
2003-2005
post-doc
Associate Professor, University of Connecticut
Huazhen Lin
2003-2005
post-doc
Professor, Sichuan University, China
Hongqi Xue
2004-2006
post-doc
Washington
Assistant Research Professor, University of
Rochester
Liansheng Tang 2005-2007
post-doc
Assistant Professor, George Mason University
Yueh-Yun Chi
2005-2007
post-doc
Assistant Professor, University of Florida
Rebecca Hubbart 2007-2008
post-doc
Assistant Scientific Investigator, Group Health
Cooperative, Seattle, WA
Hua Chen
2007-2009
post-doc Assistant Researcher, Institute of Applied Physics and
Computational Mathematics
Baojiang Chen
2008-2010
post-doc Assistant Professor, Department of Biostatistics,
University of Nebraska
Yunbei Ma
2009-2011
post-doc Assistant Professor, Southwest University of Finance
and Economics
c) Former Visiting Scholars :
Name
Hui Chen
Year
2005-2006
Current Position
Associate Professor, Tongji Medical College,
Huazhong University of Science and Technology, China
Lesan Wang
2007-2008
Associate Professor, School of Public Health
Central South University, China
Xiaotong Li
2007-2008 Associate Professor, Department of Mathematics and Physics
China University of Petroleum, China
Chuanhua Yu
2007-2008
Professor and Vice Dean, School of Public Health,
Wuhan University, China
Dong Yi
2011-2012
Professor and Chair, Department of Biostatistics
Third Military Medical University, China
Xueli Wang
2011-2012
Associate Professor, Department of Mathematics
Beijing University of Posts and Telecommunications
d) Current Graduate Students:
Name
Degree
School
Zheyu Wang
Ph.D student
Elisa Sheng
Ph.D student
d) Current Post-doctoral Fellows:
Name
Jie Zhou
Degree
Post-doc fellow
School
Academy of Mathematics and System Science,
Chinese Academy of Chinese Sciences
Xiaobo Ding
Post-doc fellow
Academy of Mathematics and System Science,
Chinese Academy of Sciences
14. Courses Taught
a) Indiana University (1993-2002)
G652 Biostatistics
Biostatistics for Physicians: A Short Course
b) University of Washington (2002-present)
578C Statistical Analysis of Missing Data (Winter, 2005)
578C Statistical Analysis of Missing Data in Epidemiology (Winter 2006)
578A Measurement, Design, and Analysis in Behavioral or Mental Health (Winter 2007)
578A Statistical Analysis of Missing Data (Spring 2008)
578A Measurement, Design, and Analysis in Behavioral or Mental Health (Spring 2009)