Well-defined Functional Polymers
for Biomedical Applications
Biodegradable Polymers
Poly(2-oxazoline)s
Linear Polyethyleneimines
Poly(N-isopropylacrylamide)s
Poly(ethylene glycol)s
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Well-defined Functional Polymers for Biomedical Applications
Aldrich® Polymer Center of Excellence
2
Aldrich® Polymer Center of Excellence with expertise in the
research and development of polymers and monomers develops
innovative functionalized polymers and block copolymers for
biomedical applictions. We can serve you from research through
development to commercial-scale materials manufacture.
Polymers for Biomedical Applications include:
• Polymers for Dental or Ophthalmic Applications
• Polymers with Tailored Biomedical Degradation
• Well-defined Block Copolymers via RAFT Technology
• Functional Polymers, Crosslinkers and Monomers for
Drug Delivery
To inquire about our custom capbilities, contact us at
[email protected].
For more information on our polymer products, visit
aldrich.com/poly
aldrich.com
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Well-defined Biodegradable Polymers
For wound management, orthopedic devices, dental, cardiovascular and intestinal
applications, tissue engineering and controlled drug delivery system
Name
Poly(L-lactide), PLLA
Structure
Poly(D,L-lactide), PDLLA
Degradation time
> 3 years
Mn
5,000
10,000
20,000
PDI
< 1.2
< 1.2
< 1.2
Cat. No.
764590
765112
764698
< 6 months
6,000
10,000
20,000
< 1.2
< 1.2
< 1.2
764612
764620
767344
End-functionalized Well-defined Poly(L-lactide)s
Structure
Functional End Group [R]
alkyne
Mn
5,000
PDI
< 1.2
Cat. No.
774154
2,000
5,000
2,000
< 1.2
< 1.2
< 1.2
774871
774146
776378
methacrylate
2,500
5,500
< 1.2
≤ 1.2
771473
766577
acrylate
2,500
5,500
< 1.2
< 1.2
775991
775983
azide
amine
Well-defined Functional Polymers for Biomedical Applications
Well-defined Polylactides
Maleimide and thiol functionalized PLLAs coming available soon!
Well-defined Biodegradable Block Copolymers
AB Diblock Copolymers
PEG-PDLLA
PEG-PLGA
PEG Mn
2,000
2,000
B Block Mn
2,000
4,000
15,000
10,000
55,000
PDI
≤ 1.4
< 1.4
≤ 1.6
< 1.6
< 1.2
Degradation time
2-4 weeks
1-4 weeks
1-4 weeks
1-4 weeks
1-4 weeks
Cat. No.
764779
764825
764760
765139
764752
PEG Mn
900
10,000
1,000
B Block Mn
1,500
1,000
1,500
PDI
< 1.2
< 1.2
≤ 1.2
Degradation time
< 12 months
< 12 months
1-2 weeks
Cat. No.
659630
659649
764787
1,000
1,100
≤ 1.2
2-3 weeks
764817
5,000
6000
< 1.2
1-2 months
764833
5,000
BAB Triblock Copolymers
PLA-PEG-PLA
PLGA-PEG-PLGA
(lactide:glycolide=1:3)
PLGA-PEG-PLGA
(lactide:glycolide=3:1)
PLCL-PEG-PLCL
For a complete list of our biodegradable polymers including RESOMER®, visit
aldrich.com/biopoly
3
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Well-defined Poly(2-oxazoline)s
Well-defined Functional Polymers for Biomedical Applications
Hydrophilic water soluble PEG alternatives
Well-defined Poly(2-ethyl-2-oxazoline)s
Structure
Mn
2,000
5,000
10,000
PDI
< 1.4
≤ 1.2
< 1.3
Cat. No.
741884
740713
741906
Mn
2,000
5,000
10,000
PDI
< 1.2
< 1.2
< 1.2
Cat. No.
774197
774189
774170
Poly(2-ethyl-2-oxazoline) mono
amine terminated
2,000
5,000
10,000
< 1.2
< 1.2
< 1.2
773360
773379
773387
Poly(2-ethyl-2-oxazoline)
α-propionic acid & ω-hydroxy
terminated
5,000
< 1.2
774235
Mn
2,200
5,000
10,000
PDI
< 1.2
< 1.2
< 1.2
Cat. No.
764892
764647
764965
Mn
2,500
5,000
10,000
PDI
< 1.2
< 1.2
< 1.2
Cat. No.
764604
764582
765090
End-group Functionalized Poly(2-oxazoline)s
Name
Poly(2-methyl-2-oxazoline)
mono amine terminated
Structure
*Azide and alkyne functionalized poly(2-ethyl-2-oxazoline)s coming available soon!
Linear Polyethyleneimines (PEI)
Non-viral transfection agent for gene delivery
Linear PEI in the HCl salt form
Structure
Linear PEI in the free amine form
Structure
4
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New Innovative Polymeric Advanced Materials (NIPAMs)
Stimuli-responsive smart polymers for micro- and nanofluidics, tissue engineering, drug
delivery, and purification of proteins and DNA
Structure
Molecular Weight
Mn 10,000 - 15,000
Mw 19,000 - 30,000
*
Cat. No.
724459
535311
741620
* Linear hydrogel, viscosity 40,000-50,000 cPs (5 % in H2O, 25 °C)
End-Functionalized PNIPAM
Structure
End Group Functionality (R )
Maleimide
N-hydroxylsuccinimide (NHS) ester
Carboxylic acid
Amine
Triethoxysilane
Mn
2,000
5,000
2,000
2,000
5,000
7,000
2,500
5,500
2,000-3,000
Cat. No.
731048
728632
725668
724815
724807
724866
724823
724831
760978
Well-defined Functional Polymers for Biomedical Applications
Poly(N-isopropylacrylamide) (PNIPAM), LCST = 32 °C
Temperature & pH Sensitive PNIPAM Copolymers
Copolymer
Poly(NIPAM-co-BA) – BA 12 mol %
Poly(NIPAM-co-BA) – BA 5 mol %
Poly(NIPAM-co-MAA-co-ODA)* – MAA 5 mol %, ODA 1 mol %
Poly(NIPAM-co-MAA)* – MAA 5 mol %
Poly(NIPAM-co-MAA)* – MAA 10 mol %
Poly(NIPAM-co-MAA)* – MAA 10 mol %
Poly(NIPAM-co-AA)* – AA 15 mol %
Poly(NIPAM-co-AAm) – AAm 15 mol %
Poly(NIPAM-co-AAm) – AAm 10 mol %
Mn
30,000
30,000
30,000-60,000
30,000-50,000
60,000
8,000-10,000
**
20,000-25,000
20,000
LCST
14-16 °C
25 °C
22-32 °C
29-32 °C
29-32 °C
29-32 °C
32-36 °C
30-34 °C
34-38 °C
Cat. No.
762881
762857
724475
724467
724858
750166
741930
738735
738727
BA: butylacrylate, MAA: methacrylic acid, ODA: octadecyl acrylate, AA: acrylic acid, AAm: acrylamide
*pH sensitive
** Linear hydrogel, viscosity 7,500-12,500 cPs (5 wt. % in H2O, 25 °C)
For a complete list of our hydrophilic polymers, visit
aldrich.com/hydrophilic
5
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Functionalized Poly(Ethylene Glycol)s
Well-defined Functional Polymers for Biomedical Applications
PEG conjugations for drug/gene delivery, PEG hydrogels for cell encapsulation, drug delivery,
wound covering and surface modification
Functional PEG
Heterobifunctional PEGs
Azide-PEG-NH2
Azide-PEG-OH
Biotin-PEG-Maleimide
Biotin-PEG-NHS ester
Biotin-PEG-NH2
Maleimide-PEG-NHS ester
Cyclooctyne-PEG-Biotin
Cyclooctyne-PEG-Maleimide
Cyclooctyne-PEG-COOH
Cyclooctyne-PEG-NH2
Cyclooctyne-PEG-OH
HOOC-PEG-SH
HOOC-PEG-NH2
Homobifunctional PEGs
Acetylene-PEG-Acetylene
Azide-PEG-Azide
HS-PEG-SH
Acrylamide-PEG-Acrylamide
Methacrylate-PEG-Methacrylate
Acrylate-PEG-Acrylate
2-bromoisobutyrate-PEG-2-bromoisobutyrate
(ATRP macroinitiator)
DDMAT-PEG-DDMAT (RAFT macroCTA)
Epoxy-PEG-Epoxy
Tos-PEG-Tos
6
PEG Mn
Cat. No.
450
530
350
200
400
3,400
5,400
3,400
5,000
2,000
3,400
5,000
4,000
200
200
200
100
200
1,000
2,000
3,400
5,000
1,000
2,000
3,400
5,000
10,000
76318
77787
76172
727423
689440
757713
757748
757799
757802
757756
757764
757772
757853
760749
760676
759902
745073
761982
757810
757829
757837
757845
757861
757888
757896
757918
757705
2,000
2,000
5,000
10,000
350
230
3,500
10,000
20,000
1,000
6,000
10,000
20,000
700
1,000
2,200
4,300
5,600
2,000
6,000
600
1,300
3,500
10,000
20,000
699810
689696
689580
767530
734616
736678
725676
725684
725692
729086
701963
729094
767549
767573
740888
741019
740896
741728
731811
731803
733652
719080
701750
705047
733415
aldrich.com
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Functional PEG
Monofunctional mPEGs
mPEG-Acetylene
mPEG-Azide
mPEG-SH
mPEG-Methacrylate
mPEG-Acrylate
mPEG-2-bromoisobutyrate (ATRP macroinitiator)
mPEG-DDMAT (RAFT macroCTA)
mPEG-4-cyano-4-pentanoate dodecyl trithiocarbonate (RAFT macroCTA)
mPEG-Tos
mPEG-OH
Cat. No.
2,000
200
400
600
1,000
2,000
5,000
10,000
20,000
750
2,000
10,000
1,000
2,000
5,000
1,500
4,000
2,000
5,000
1,200
2,000
5,000
1,100
1,400
900
2,000
5,000
10,000
20,000
699802
712590
767557
712604
733407
689807
689475
726168
726176
712558
731765
712469
729108
729140
729159
730319
730327
730270
730289
739456
750069
736333
740705
752487
729116
729124
729132
732621
732613
Well-defined Functional Polymers for Biomedical Applications
mPEG-Maleimide
PEG Mn
Bis-MPA* Dendron Functionalized PEGs
Dendritic materials based on Bis-MPA* are biodegradable and do not display immunogenic properties.
Generation
1
No. of Surface group
4
Surface Group
acetylene
hydroxyl
2
8
acetylene
hydroxyl
3
16
acetylene
hydroxyl
4
32
hydroxyl
PEG Mn
6,000
20,000
6,000
20,000
6,000
20,000
6,000
20,000
6,000
20,000
6,000
20,000
6,000
20,000
Cat. No.
760900
760935
752401
752398
760919
760943
760862
760889
760927
760951
752371
752363
760870
760897
*Bis-MPA: 2,2-Bis(hydroxyl-methyl)propionic acid
For a complete list of available PEG materials, visit
aldrich.com/PEG
7
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Select Polymer Products Now Feature
Characterization by MALDI-TOF Mass Spectroscopy
Poly(ethylene glycol) 2-aminoethyl ether biotin
Batch No. MKBK1768V
Cat. No.
Mn
Mw
PDI
757756
2230
2250
1.01
Enabling Science to
Improve the Quality of Life
Order/Customer Service: sigma-aldrich.com/order
Technical Service: sigma-aldrich.com/techservice
Development/Custom Manufacturing Inquiries
[email protected]
Safety-related Information: sigma-aldrich.com/safetycenter
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