Strategies in Writing (for the medical literature) What this presentation is not about: How to have good ideas How to find good questions How to obtain good data that address the ideas/questions How to enjoy a rich and fulfilling life... Its about how to most easily put together the best possible presentation of your ideas, questions, data and findings. And the process can improve your Disclaimer Don't ask me about: parts of speech, past participles, or split infinitives. I have no idea what these words mean. Pop Quiz How do you start writing? a. make a cup of coffee b. make two cups of coffee c. straighten up your desk d. see if the basement doesn’t need cleaning... I wonder if anything good is on TV?|¶ Strategies in Writing #1 - Write smart make use of efficient frameworks Get feedback ABSTRACT Context: Motivate the reader Why should the I care about your findings and conclusions? Objective: Simple, directly related to finding Methods: Must explain how result below was obtained, not other analyses in the paper. Results: Primary finding What is the one piece of data you want people to walk away with? Conclusion: Must be supported by result above ABSTRACT Context: Most professional US professional medical medical societies societies and and the national the national health health sysms systems of all other of all industrialed other industrialized nations now nations recognize now recognize that most women that most need women not need not undergo Pap underghkjhko Papsmear smearscreening screeningannually. annually.There Therearearenonodata, data,however, however, kk regarding the frequency the frequency at which women at which actually womenundergo actuallyscreening undergo screening in the Unjlkjljited in the United States. States. Objective: To consider describe the determine thefrequency amount prevalence of of cervical cancer of cervical cancer screening cancer cancer screening screening of screening theofcervix the in in thein the cervix United the United in States. the States. United States. Methods: We obtained Women aged the1998 18 and older Behavioral living in Risk households Factor Surveillance with telephones System of (86,715 respondents). the Centers for OurDisease main outcome Control measures and Prevention were: time (CDC)which since lastisPap a cross sectional smear; thesurvey estimated of a number random of sample American of American women women. receivingSample Pap smear Frame at various Women aged screening intervals. 18 andWe older obtained living the1998 in households Behavioral with telephones Risk Factor(86,715 Surveillance respondents). System of the Centers Our main theoutcome frequency measures of cervic were: for Disease time since Control last Pap andsmear; Prevention the estimated number (CDC)which is a cross of American sectionalwomen surveyreceiving of a random Papsample smear at of various American screening women. intervals.Frame Sample what you are really doing is figuring out the basic structure (as well as the basic point) of the paper Results: The vast Based onmajority these data, (YY%) we estimate of American that 45women millionreport American having had at least one women undergo Pap smear Pap smear in their screening lifetime.annually Among and women onlywho 6 million have not are had screened a hysterectomy using a 3-yearand interval. who have The vast beenmajority screened(YY%) at leastofonce, American ZZ% report womenhaving reporthad a Pap smear having had atwithin least one the past Pap smear three years, in their XX% lifetime. within Among the past women two years who and have 73%had not within a hysterectomy the past year. andBased who have on these beendata, screened we estimate at leastthat once, 45ZZ% million report American having hadwomen a Pap smear undergo within Pap the smear pastscreening three years, annually XX% and within onlythe 6 million past twoare screened years andusing 73% within a 3-yeartheinterval. past year. women are being screened are beingfor screened Conclusion: The majority of American cytotechnologists cervical for cervical cancer cancer too too frequently. frequently. Lengthening Lengthening the the screening screening interval interval would would not not only reduce the proportion number of pelvic of pelvic exams, exams, butbut would would alsoalso reduce reduce follow-up follow-up testing for abnormal testing for abnormal smears smears and theand volume the volume of specimens of specimens that cytotechnologists that cytotechnologists are required are required to read. to read. Get feedback It is a lot easier to get good feedback on 1 page than on an entire paper ABSTRACT Context: Most professional US professional medical medical societies societies and and the national the national health health sysms systems of all other of all industrialed other industrialized nations now nations recognize now recognize that most women that most need women not need not undergo Pap underghkjhko Papsmear smearscreening screeningannually. annually.There Therearearenonodata, data,however, however, kk regarding the frequency the frequency at which women at which actually womenundergo actuallyscreening undergo screening in the Unjlkjljited in the United States. States. Objective: To describe determinethe consider thefrequency amount prevalence of of cervical cancer of cervical cancer screening cancer cancer screening screening of screening theofcervix the in in thein the cervix the United United in States. the States. United States. Methods: We obtained Women aged the1998 18 and older Behavioral living in Risk households Factor Surveillance with telephones System of (86,715 respondents). the Centers for OurDisease main outcome Control measures and Prevention were: time (CDC)which since lastisPap a cross sectional smear; thesurvey estimated of a number random of sample American of American women women. receivingSample Pap smear Frame at various Women aged screening intervals. 18 andWe older obtained living the1998 in households Behavioral with telephones Risk Factor(86,715 Surveillance respondents). System of the Centers Our main theoutcome frequency measures of cervic were: for Disease time since Control last Pap andsmear; Prevention the estimated number (CDC)which is a cross of American sectionalwomen surveyreceiving of a random Papsample smear at of various American screening women. intervals.Frame Sample Results: The vast Based onmajority these data, (YY%) we estimate of American that 45women millionreport American having had at least one women undergo Pap smear Pap smear in their screening lifetime.annually Among and women onlywho 6 million have not are had screened a hysterectomy using a 3-yearand interval. who have The vast beenmajority screened(YY%) at leastofonce, American ZZ% report womenhaving reporthad a Pap smear having had atwithin least one the past Pap smear three years, in their XX% lifetime. within Among the past women two years who and have 73%had not within a hysterectomy the past year. andBased who have on these beendata, screened we estimate at leastthat once, 45ZZ% million report American having hadwomen a Pap smear undergo within Pap the smear pastscreening three years, annually XX% and within onlythe 6 million past twoare screened years andusing 73% within a 3-yeartheinterval. past year. women are being screened are beingfor screened Conclusion: The majority of American cytotechnologists cervical for cervical cancer cancer too too frequently. frequently. Lengthening Lengthening the the screening screening interval interval would would not not only reduce the proportion number of pelvic of pelvic exams, exams, butbut would would alsoalso reduce reduce follow-up follow-up testing for abnormal testing for abnormal smears smears and theand volume the volume of specimens of specimens that cytotechnologists that cytotechnologists are required are required to read. to read. Special topic: Abstract numbers 1. Be clear about the comparison “The risk of prostate cancer in men with a higher BMI was lower than that in men with a lower BMI BMI, but only if they were younger (RR = 0.52)” 2. Be clear about denominators So the reader doesn’t struggle with the question “% of what?” 3. Provide data on the magnitude of the effect, not just ratios. “ 2.4% of men who were current smokers developed prostate cancer compared to 1.2% of those never smoked (RR 2.0, 95% CI 1.4-2.8)” Efficient framework for the rest of the text Introduction Methods Results Discussion Efficient framework for the rest of the text Introduction Methods Results Discussion ¶ Question 1. What’s the current situation? 2. What's the the problem (or gap)? 3. How will this study help? Efficient framework for the rest of the text Introduction Methods Results Discussion • make sure there is a method for every result • use subheads to force structure Overview Setting Exclusions Exposure/Intervention Outcome Secondary Outcomes Analysis Special topic: Labels- names for things (or ideas) that appear repeatedly in text. Assertion: a specific thing (or idea) should always have the same name. control usual care The routine careprovf of phoek soboh flod increased expenditure returnindex intervalhas bodforden implications for grondening mawqork. revisit interval Boferman etal findgrom of visit interval exceddernon elevated resource use is potermanford per norm. High intensity patientbodterformes questionnaire koster mauk be questionnaire sdlamon and forwoz interim bedforn. 6-month questionnaire non-randomized trials observational studies before-after studies Clear ≠ Dull Make sure labels are consistent across abstract, text, tables and figures. Efficient framework for the rest of the text Introduction Methods Results Discussion • short and to the point • driven by your figures and tables Efficient framework for the rest of the text Introduction Methods Results Three Questions Discussion 1. What’s the central finding? 2. Could it be wrong? 3. What does it mean? Strategies in Writing #1 - Write smart make use of efficient frameworks Get feedback #2 - Write less focus on high-visibility components Get feedback Pop Quiz How do you read? a. in bed, for about half hour before I go to sleep b. in bed, for about 5 minutes before I go to sleep c. in bed, naked d. I don't read, I look at the pictures instead... Think like your target audience; write for them, not for yourself. Write less - focus on high-visibility components Focus on what readers look at: Abstract and Title the first (and often, the only) part of your paper that will be read. Figures and Tables probably the second most examined part of a paper. Write less - focus on high-visibility components Figures: The most efficient way to quickly communicate a “feel” for your findings Tables: The most efficient way to provide the relevant details Communicate your major finding(s) using figures Figure Basics 1. Simple axes 2. Simple keys 100 Maryland Indiana Rate per 100,000 90 80 75 70 60 50 40 30 25 20 10 0 Lung Colon Breast Prostate Melanoma Column graphs for categories Figure Basics 1. Simple axes 2. Simple keys (or none at all) Incidence 100 Rate per 100,000 Early-stage incidence 75 50 25 Late-stage incidence Mortality 0 198619871988198919901991 1986 199119921993199419951996 199619971998199920002001 2001 Year Line graphs for continuous data Figure Basics 1. Simple axes 2. Simple keys (or none at all) Figure 1: Melanoma incidence and mortality in the population age 65 and older for 9 SEER areas (1986-2001). Early-stage refers to in-situ and local disease; late-stage refers to regional and distant disease. 3. Legend in text Incidence 100 Rate per 100,000 Early-stage incidence 75 50 25 Late-stage incidence Mortality 0 1986 1991 1996 Year Line graphs for continuous data 2001 Special settings: As a vehicle to communicate individual data points Rate of follow-up mammography and biopsy for 186 radiologists (in the 8 months following screening mammography). Special settings: As a vehicle to communicate individual data points Site Mean 25 Staff Physician (all internists ) Mean Revisit Interval (weeks) Other Provider 20 15 10 5 0 Site 1 Site 2 Site 3 Mean revisit intervals for the 30 providers enrolling patients in the VA Cooperative Study of Telephone Care.. Special settings: As a vehicle to communicate sample selection Sample Frame HIV+, CD4 ≤ 200 male veterans (n=123) Exclusions djflssjjf (n=51) djflkjdfljflk (n=12) bvcmxz sd (n=4) Eligible patients (n=42) Did not consent (n=20) Final sample (n=22) And it doesn’t have to be a randomized trial Control (n=11) Intervention (n=11) Special settings: As a vehicle to communicate sample selection NHANES Target Population Non-institutionalized, civilian Americans Random sample of men 40 and older (n=1,601) Not eligible for PSA test* 114 History of prostate cancer Prostate biopsy (past month) Rectal exam (past week) Current prostate infection/inflammation Cystoscopy (past month) 63 8 26 20 8 Missing data 179 Any of eligibility criteria missing** PSA missing 139 40 Eligible for PSA test (n=1,487) Eligible with complete data (n=1,308) * 11 people answered yes to more than 1 criteria ** Generally men who did not attend the physician examination where the 5 eligibility items were collected Special settings: As a vehicle to communicate methods Overview of the task presented to a woman completing the survey and our measures of her ability to accurately apply risk reduction information Get feedback A good figure (and legend) should be understandable on its own Table Basics Exhibit 4 Characteristics of sample * Demogra phi cs Mean age (range ) Row headers n=203* 1. organize into logical groups 52 yea rs (30-91) 2. make groups visually distinct Age distribut ion 30-39 40-49 50-64 65+ Female • subheads • indents • spacing 25% 20% 26% 29% 65% Educa tion Less than high schoo l High schoo l gradu ate Some colle ge Coll ege gradua te Some gradua te school or degree 15% 25% 14% 25% 22% Total hous ehold inco me <$25,000 $25,000 - $49,999 $50,000 - $99,999 >$100,000 37% 19% 26% 18% Medication use Do you take any medicine to...** preven t heart attack or stroke treat any arthritis /joint pain 36% 34% Attention to drug ads Paid attention to any adve rtisements for prescription d rugs in past 3 mon ths 50% Table Basics Exhibit 4 Characteristics of sample * n=203* Demogra phi cs Mean age (range ) 52 yea rs (30-91) Age distribut ion 30-39 40-49 50-64 65+ 25% 20% 26% 29% Female 65% Educa tion Less than high schoo l High schoo l gradu ate Some colle ge Coll ege gradua te Some gradua te school or degree 15% 25% 14% 25% 22% Total hous ehold inco me <$25,000 $25,000 - $49,999 $50,000 - $99,999 >$100,000 Give exact survey question 37% whenever possible 19% Medication use Do you take any medicine to...** preven t heart attack or stroke treat any arthritis /joint pain Attention to drug ads Paid attention to any adve rtisements for prescription d rugs in past 3 mon ths 26% 18% 36% 34% 50% Table Basics Disease-specific mortality All-cause mo rtality Row headers (per 10,000 p erson -years) (per 10,000 p erson -years) 1. organize Screeni intonglogical groups Screeni ng Screened Cont rol benefit Screened Cont rol benefit 2.(a) make(b ) groups distinct (b-a ) visually (c) (d ) (d-c) Mammograph y • subheads 6.5 1.4 3.8 1.2 • indents 3.0 0.0 • spacing 2.4 1.1 HIP (17) 5.1 Swed is hT wo-coun ty (18) 2.6 Malm o (19) 3.0 Go thenbu rg (20) 1.3 Edinburgh (21) 2.9 3.5 Canad ia nN BS S1 (22) 1.4 Canadian NBS S2 (23) Incons istency 73.7 75.4 1.7 - 120 .4 120 .3 -0 .1 Direction 95.4 96.7 1.3 Direction 29.6 30.1 0.6 - 0.6 102 .9 123 .2 20.3 Mag ni tude 0.8 -0 .5 7.4 7.3 -0 .1 - 3.4 3.5 0.1 28.6 27.0 -1 .7 Direction Minne sota (24) 5.4 6.6 1.2 183 .6 183 .6 0.0 Direction No ttingha m (25) 6.0 7.0 1.0 211 .0 210 .0 -1 .0 Direction Funen (26) 6.5 8.2 1.7 221 .0 224 .0 3.0 - Czecho s lovak ian t rial (27) 33.6 24.7 -9 .0 179 .2 153 .9 -25 .4 Mag ni tude Mayo Lung Pro je ct (28) 43.9 39.5 -4 .4 324 .8 318 .5 -6 .3 - Fecal O ccul t B lood Ch es t X-ray Table Basics Disease-specific mortality (per 10,000 p erson -years) Screened (a) Mammograph y Cont rol (b ) Screeni ng benefit (b-a ) HIP(17) Column headers 5.1 6.5 1.4 Swed is hT wo-coun ty (18) 2.6 Malm o (19) 3.0 Go thenbu rg (20) 1.3 Edinburgh (21) 2.9 Canadian NBS S1 (22) 1.4 Canadian NBS S2 (23) 3.4 Fecal O ccul t B lood 3.8 1.2 All-cause mo rtality (per 10,000 p erson -years) Screeni ng benefit (d-c) Screened (c) Cont rol (d ) 73.7 75.4 1.7 - 120 .4 120 .3 -0 .1 Direction 1. organize into logical groups 3.0 0.0 95.4 96.7 1.3 and 2.4make 1.1 groups visually distinct0.6 29.6 30.1 3.5 0.6 102 .9 123 .2 20.3 • subheads 0.8 -0 .5 7.4 7.3 -0 .1 3.5 0.1 28.6 27.0 -1 .7 • spacing 2. make algebra explicit 6.6 1.2 183 .6 183 .6 0.0 Incons istency Direction Mag ni tude Direction Minne sota (24) 5.4 Direction No ttingha m (25) 6.0 7.0 1.0 211 .0 210 .0 -1 .0 Direction Funen (26) 6.5 8.2 1.7 221 .0 224 .0 3.0 - Czecho s lovak ian t rial (27) 33.6 24.7 -9 .0 179 .2 153 .9 -25 .4 Mag ni tude Mayo Lung Pro je ct (28) 43.9 39.5 -4 .4 324 .8 318 .5 -6 .3 - Ch es t X-ray Table Basics Exhibit 4 Characteristicsof sample * n=203* Demographics Mean age (range) Age distribution 30-39 40-49 50-64 65+ 52 years (30-91) 25.4% 20.1% 26.9% 29.3% Female Male Education Less than high school High school graduate Some college College graduate Some graduate school or degree 15.5% 25.8% 14.7% 25.2% 22.3% Total household income <$25,000 $25,000 - $49,999 $50,000 - $99,999 >$100,000 37.2% 19.9% 26.7% 18.5% Medication use Do you take any medicine to...** prevent heart attack or stroke treat any arthritis/joint pain 36.4% 34.5% Table body 1. right align data (i.e. on decimal point) 2. avoid excessive precision Attention to drug ads Paid attention to any advertisements for prescription drugs in past 3 months 65.2% 34.8% 50.1% Table Basics Exhibit 4 Characteristicsof sample * n=203* Demographics Mean age (range) 52 years (30-91) Age distribution 30-39 40-49 50-64 65+ 25% 20% 26% 29% Female Male Education Less than high school High school graduate Some college College graduate Some graduate school or degree 15% 25% 14% 25% 22% Total household income <$25,000 $25,000 - $49,999 $50,000 - $99,999 >$100,000 37% 19% 26% 18% Medication use Do you take any medicine to...** prevent heart attack or stroke treat any arthritis/joint pain 36% 34% Table body 1. right align data (i.e. on decimal point) 2. avoid excessive precision 3. remove redundant data Attention to drug ads Paid attention to any advertisements for prescription drugs in past 3 months 65% 35% 50% Table Basics Disease-specific mortality (per 10,000 p erson -years) Screened (a) Cont rol (b ) Screeni ng benefit (b-a ) …consider helping the reader with a All-cause mo rtality (per 10,000 p erson -years) summary column Screened (c) Cont rol (d ) Screeni ng benefit (d-c) Incons istency Mammograph y HIP(17) 5.1 Swed is hT wo-coun ty (18) 2.6 Malm o (19) 3.0 When1.4the table73.7body 75.4 3.8 1.2 120 .4 120 .3 is complex… 3.0 0.0 95.4 96.7 Go thenbu rg (20) 1.3 2.4 1.1 29.6 Edinburgh (21) 2.9 3.5 0.6 Canadian NBS S1 (22) 1.4 0.8 Canadian NBS S2 (23) 3.4 Minne sota (24) 6.5 1.7 - -0 .1 Direction 1.3 Direction 30.1 0.6 - 102 .9 123 .2 20.3 Mag ni tude -0 .5 7.4 7.3 -0 .1 - 3.5 0.1 28.6 27.0 -1 .7 Direction 5.4 6.6 1.2 183 .6 183 .6 0.0 Direction No ttingha m (25) 6.0 7.0 1.0 211 .0 210 .0 -1 .0 Direction Funen (26) 6.5 8.2 1.7 221 .0 224 .0 3.0 - Czecho s lovak ian t rial (27) 33.6 24.7 -9 .0 179 .2 153 .9 -25 .4 Mag ni tude Mayo Lung Pro je ct (28) 43.9 39.5 -4 .4 324 .8 318 .5 -6 .3 - Fecal O ccul t B lood Ch es t X-ray Special settings: As a vehicle to present prior work Special settings: As a vehicle to highlight major points or suggested actions Table 2: Guidance for reporting the result s of multi variate ana lyses wh ich assume a continuous relationsh ip between exposu re and ou tcome Step Purpose Expression of exposure 1. Provide crude rates for dis crete catego ries Comm unicate the rela tionship that is actuall y ob served in the data Categor ical 2. Provide fully adjusted rates for discrete catego ries Comm unicate observed relationsh ip adjusted for all relevan t confound ers Categor ical 3. Provide summary measure (e.g. slop e) or ill ustration (e.g. graph ) of con tinuous relationsh ip Comm unicate hypo thesized relationsh ip between exposu re and outcome Continuou s 4. Supe rimpo se continuous on ca tego rical results Comm unicate both catego rical and continuous rela tionships Both Special settings: As a vehicle to summarize the effect of a change on multiple outcomes Table 3: Expec ted change in 5 -yea r surv ival, mortalit y and incidenc e unde r various cond iti ons . Condi tion Expected change in: 5-year survival Mortality Incidence no change early treatment is effective early treatment is not effective no change* no change More effective treatment of existing disease More cases found ea rly and Incr ease in the true oc currenc e of dis ease (assumi ng no change in tumo r aggressiveness) Table/Figure combinations Base rates RRs and CIs Table/Figure combinations Base rates RRs and CIs Strategies in Writing #1 - Write smart make use of efficient frameworks Get feedback #2 - Write less focus on high-visibility components Get feedback #3 - Write again in response to feedback from others Get feedback Good papers are made, not born. They are the product of multiple revisions, revisions made in response to the criticisms of others. Write again - in response to feedback from others Get help: 1. General reviewer - whose primary job is to determine whether your writing can be understood. 2. Expert reviewer - whose primary job is to help prepare you for external review. A “content" expert to scrutinize specific technical or theoretical issues. A "hostile friend" who will look hard for flaws. Tactics to get useful help Author Tactics for eliciting feedback Tactics for receiving feedback Use these tactics 1. Have a conversation to get feedback for 1. Get an explicit commitment 2. Don't be defensive the “guts” of your paper:2. Clarify the review purpose 3. Focus on understanding problems 3. Simple courtesies ABSTRACT 4. Judge suggestions critically TABLES FIGURES Internal Reviewer • General • Expert Strategies in Writing #1 - Write smart make use of efficient frameworks Get feedback #2 - Write less focus on high-visibility components Get feedback #3 - Write again in response to feedback from others #4 - Write now don't wait until you think you're done Get feedback Write now It's easier to revise than write from scratch The earlier you start the easier it is to find time to allow yourself to step back, digest, and read your work with a fresh perspective Write now - don't wait until you think you're done Bite size task Introduction Methods Dummy Figures & Tables Abstract Helps: Clarify the motivation; helps you identify a context in which to place your work Avoid having to reconstruct subtle details of the analysis long after they occurred. Focus the analytic effort Organize the entire package Write now Even if it's a work of fiction Get feedback Strategies in Writing #1 - Write smart make use of efficient frameworks Get feedback #2 - Write less focus on high-visibility components Get feedback #3 - Write again in response to feedback from others #4 - Write now don't wait until you think you're done Get feedback Strategies in Writing #1 - Write smart make use of efficient frameworks Get feedback #2 - Write less focus on high-visibility components Get feedback #3 - Write again in response to feedback from others Get feedback #4 - Write now don't wait until you think you're done Get feedback
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