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CURRICULUM VITAE
Education:
1965-1968
1969
1974
1985
Major in Philosophy, Immaculate Conception College, Troy, NY
B.A. (Biology), Salem State College, Salem, MA
M.A. (Physiology), University of Texas Medical Branch, Galveston, TX
Ph.D. (Psychology), Northeastern University, Boston, MA
Dissertation (Dr. Helen Mahut, major advisor): "Behavioral, anatomical, and
neurochemical deficits following a bout of thiamine deficiency in the rat."
Academic and Administrative Appointments:
2010 – Pres
2005 – 2010
2003 - 2005
2003 - Pres
2000 - 2003
1995 - 2004
1993 - 1994
1991 - 2003
1991 - 2003
1988 - 1990
1987 - 1992
1986 - 1988
1985 - 1986
1981 - 1985
Executive Committee Member, The ODU China Center
(http://al.odu.edu/chinacenter/executive.shtml)
Vice Provost for Graduate Studies and Research, Old Dominion University,
Norfolk, VA
Dean of Graduate Studies and Assoc. Vice President for Research, Old Dominion
University, Norfolk, VA
Professor, Dept. of Psychology, Old Dominion University, Norfolk, VA
Associate Dean for Research and Graduate Studies, College of Sciences, SDSU,
San Diego, CA
Research Neuroscientist, Dept. Neurosciences, UCSD Sch. Med., San Diego, CA
Assoc. Research Neuroscientist, Dept. Neurosciences, UCSD Sch. Med,
San Diego, CA
Graduate Group, SDSU/UCSD Joint Doctoral Program in Clinical Psychology
Professor, Dept. of Psychology, SDSU, San Diego, CA
Associate Professor, Dept. of Psychology, SDSU, San Diego, CA
Asst. Research Neuroscientist, Dept. Neurosciences, UCSD Sch. Med., San Diego
Instructor in Psychiatry, Harvard Medical School, Boston
Research Fellow in Psychiatry, Harvard Medical School, Boston
Associate in Neuropathology (Biochemistry), Harvard Medical School, Boston
Professional Activities and Elected Positions
2009 – Pres
American Association for the Advancement of Science (AAAS)-Chinese
Association of Science & Technology (CAST) Steering Committee on Ethics in
Science. ( http://www.aaas.org/news/releases/2010/0630cast_statement.shtml)
2008 – Pres
National Advisory Panel on Research Integrity – Co-Founder and Organizer
(http://research-ethics.net/introduction/NAPRI/)
2010 - Pres
Member, Special Review Panel, Research on Research Integrity Grants,
NIH/NIEHS
2008 - 2010
Board of Directors, Council of Graduate Schools
2009 – 2010
Past President, Conference of Southern Graduate Schools
2008 - 2009
President, Conference of Southern Graduate Schools
2007 - 2009
Vice President and President-elect, Conference of Southern Graduate Schools
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2005 – 2010
2007 - 2008
2009
2009 – 2011
2007
2006
2005
1994 - 2010
1992 - 1994
1986 - 1988
Executive Board, member, Conference of Southern Graduate Schools
Council of Graduate Schools, Review Team, NSF RCR programs
Consultant on RCR Programs to Appalachian State University
Commission on Graduates of Foreign Nursing Schools (CGFNS)-International:
ICHP Speech Language Pathology/Audiology Professional Standards
Committee
NY Board of Reagents, Chair, Evaluation Team, proposed Doctoral Nursing
Program, Molloy College, Rockville Center, NY
Council of Graduate Schools, Consultant to Appalachian State University, NC
Council of Graduate Schools, Consultant to Wilkes University Graduate
Programs, Wilkes-Barre, PA
Editorial Board, Metabolic Brain Disease
Ad hoc member, NLS 2 Study Section, NINCDS
External reviewer, VA Merit Review
Hospital/Medical Center Appointments:
1987 - 2001
Health Care Scientist, GS/13, V.A. Med. Ctr., San Diego, CA
1986 - 1987
Member, Research & Development Committee, V.A. Med. Ctr.,
Brockton/W.Roxbury, MA
1985 - 1988
Health Care Scientist, GS/13, V.A. Med. Ctr., Brockton, MA
1984 - 1985
Health Care Scientist, GS12. V.A. Med. Ctr., Providence, RI
1981 - 1985
Assistant in Biochemistry, Harvard/McLean Hosp., Belmont, MA
1977 - 1981
Consultant Neurochemist, Harvard/McLean Hosp., Belmont, MA
1972 - 1977
Research Biologist GS/9, V.A. Med. Ctr., Brockton, MA
Certificates, Professional
2006
1993
1992
Management and Leadership in Education (MLE) – The Harvard Institutes for
Higher Education, June, 2006
Clinical Hypnotherapy Certificate - Clinical and Transpersonal Hypnosis Institute,
Solana Beach, CA
EMDR Basic Certificate
Membership in Scientific Societies:
2009 – Pres
Association for Practical and Professional Ethics
1995 - 1998
American Society of Neurochemistry
1993 - Pres
International Society for Biomedical Research on Alcoholism
1993 - Pres
Research Society on Alcoholism
1989 -1993
Western Psychological Association
1988 -1993
American Psychological Society
1986 - Pres
Phi Kappa Phi
1984 - Pres
American Association for the Advancement of Science
1982 - Pres
European Brain and Behavior Society
1982 - Pres
British Brain Research Association
1982 - Pres
Society for Neuroscience
1979 - 1981
National Committee for Clinical Laboratory Standards
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Awards and Honors:
2001 - Psi Chi SDSU Chapter Outstanding Professor Award
2001 - Outstanding Faculty Award, SDSU
2000 - Phi Beta Kappa Univ. Lecturer,
1992 - Honorary Member, National Golden Key Honor Society
1990 - V.A. Superior Performance Award
1989 - V.A. Outstanding Performance Award
1986 - V.A. Special Achievement Award
1986 - Phi Kappa Phi, 1986
1982 - AHA Outstanding Program Volunteer Award
1980 - V.A. Commendation
1978 - V.A. Commendation
1969 - Golden Key Society Award
Extramural Projects
Recent Funding Proposals:
“Meeting of the National Advisory Panel on Research Integrity”
P.J. Langlais & M. Kalichman, Co-Organizers
Conference and Travel Award Proposal submitted to Office of Research Integrity
Total Costs: $14,500; Conference to be held August 28, 2012, Georgetown Univ.
“Collaborative Research: UBM-Institutional: Tidewater Math Biology Research Experience
(TiMBRE)”
H. Gaff, P.I.; P.J. Langlais, Co-Investigator
NSF – Interdisciplinary Undergraduate Training in Biology & Math
NSF Proposal # 1129176
Total Direct & Indirect Costs: $729,873; Funding Period: 01/01/12 to 12/31/16
“Improving Engineering Ethics Education: A Multidisciplinary and Multicultural Approach”
P. Pazos-Lago, P.I.: P. Langlais, Co-PI
NSF Proposal # 1135320; EESE program
Total Direct & Indirect Costs: $299,343; Funding Period: 01/01/12 to 12/31/14
Integrating Ethics Education: Capacity-Building Workshops for Science and Engineering Faculty”
M. Kalichman, P.I.; DK Plemmons, Co-P.I.; P.Langlais, Collaborator
NSF Proposal # 1135358; EESE program
Total Direct & Indirect Costs: $298,649
Submitted, not funded:
“Mutlidisciplinary Modeling and Simulation Programs”
P.J. Langlais, P.I.
NSF IGERT
Preliminary Proposal No. 0935685
“Virginia Alliance for Graduate Education & Professoriate”
P.J. Langlais, co-PI
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NSF AGEP proposal,
Total Direct Costs: $373,611; Funding Period: 01/09-12/13
“Are Injustices, Mentoring and RCR Training Predictors of Research Misbehaviors?
P.J. Langlais, P.I.
NIH application ID 1 R21 RR025301-01
Total Direct Costs: $200,000; Funding Period: 07/08-06/09
Funded – Past 15 years:
1.
“ODU Oral Pre-School Program”
P.J. Langlais, P.I.
Virginia Department of Education
Total Budget: $229,800
2. “Training and Assessment Program – Ethics, Professional Standards & Responsible Conduct”
P.J. Langlais, P.I.
CGS/NSF award, RCR Project, Funding period 01/01-12/31/07
Total Direct Costs: $15,000
3. “Graduate Education for the Responsible Conduct of Research – Avenues and Approaches”
P.J. Langlais, P.I.
CGS/ORI funding as part of the RCR Project, Funding period 10/04-09/05
Total Direct Costs: $15,000
4. “Histamine, IL-1 & Nitric Oxide in Wernicke Lesions”
P.J. Langlais, P.I.
NINDS #NS33157 – 05-07, funding period 12/10/99-03/02/04
Total Direct Costs: $422,255
5. “Developing and Enhancing Professional Master of Science Degrees at SDSU”
P.J. Langlais, P.I.
Alfred P. Sloan Foundation – #00004146, funding period 01/01/02-08/31/03
Total Costs: $34,500
6. "Neural and Cognitive Bases of Diencephalic Amnesia."
P. J. Langlais, P.I.
V.A. Merit Review #021347538-001; funding period: 10/01/98 - 09/31/01
Total Direct Costs: $380,600
7. “Histamine-Glutamate Interaction in Wernicke Lesions.”
P.J. Langlais, P.I.
NINDS #NS33157; funding period: 08/01/95 - 06/30/99
Total Direct Costs: $663,9051.
8. "Neural and Cognitive Bases of Diencephalic Amnesia."
P. J. Langlais, P.I.
V.A. Merit Review #021347538-001; funding period: 10/01/94 - 09/31/98
Total Direct Costs: $341,265
9. “Chronic ETOH: Patho-Behavioral Lesions & Thiamine Status.”
P.J. Langlais, P.I.
NIAAA #AA10473; funding period: 08/01/95 - 07/71/98
Total Direct Costs: $420,825
10. "Excitotoxic Basis of Brain Damage in Thiamine Deficiency."
P. J. Langlais, P.I.
NINDS #NS29481-01; funding period: 04/01/91 - 03/31/95
Total Direct Costs: $481,402
11. "Neurochemical and Pharmacologic Aspects of Human Amnesia."
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P.J. Langlais, P.I.
V.A. Merit Review #021347538-001; funding period: 4/01/87 -3/31/90
Total Direct Costs: $497,555
12. "Neurochem Neurochemical Analyzer"
P. J. Langlais, P.I
NIH, #S10 RR04754-01; funding period: 5/1/89-4/30/90
Total Direct Costs: $107,000
Graduate Students Supervised:
1.
Alex Troster, Ph.D., SDSU/UCSD doctoral program in clinical psychology,
advisor and member dissertation committee, 1987-1991
2.
H. A. 'Buz' Jinnah, Ph.D., UCSD doctoral program in neurosciences,
advisor and member dissertation committee, 1987-1992.
3.
Joan Van Luyn, M.A., SDSU masters program in experimental psychology,
chair of thesis committee, 1988-1989.
4.
Tanis Ferman, M.A., SDSU masters program in pre-clinical psychology,
chair of thesis committee, 1989-1991.
5.
Steven Henderson, M.A., SDSU masters program in experimental psychology,
chair of thesis committee, 1989-1991.
6.
Dave Weiler, M.A., SDSU masters program in pre-clinical psychology,
member of thesis committee, 1989-1991.
7.
Jelena Radovanov, M.A., SDSU masters program in pre-clinical psychology,
chair of thesis committee, 1990-1991.
8.
Steve Henderson, Ph.D., SDSU/UCSD doctoral program in clinical psychology,
primary advisor and chair of dissertation & guidance committee, supervisor 2nd yr.
Project 1991 to 1995.
9.
Vince Filoteo, Ph.D., SDSU/UCSD doctoral program in clinical psychology,
member of guidance committee, 1990 to 1994.
10. Melissa Jenkins, Ph.D., SDSU/UCSD doctoral program in clinical psychology,
chair of dissertation committee, member guidance committee & supervisor 2nd yr
research, 1992 to 1994.
11. Deborah Cahn, Ph.D., SDSU/UCSD doctoral program in clinical psychology,
member of dissertation & guidance committee, 1993 to 1995.
12. Lauren Kwon, Ph.D., SDSU/UCSD doctoral program in clinical psychology,
member of guidance & dissertation committees, 1993 to 1996.
13. George McFetridge, M.A., SDSU, masters program in experimental psychology,
chair of thesis committee, 1993-1994.
14. Leah Ranney, M.A., SDSU, masters program in experimental psychology,
chair of thesis committee, 1993-1994.
15. Greg Weilersbacher, M.A., SDSU, masters program in experimental psychology,
chair of thesis committee, 1993- 1998.
16. Rhonda Lovec, M.A., SDSU, masters program in experimental psychology,
chair of thesis committee, 1994- 1995.
17. Rose Mastracci, M.A., SDSU, masters program in Public Health,
chair of thesis committee, 1995- 1998.
18. Yoshiko Kurata, M.A., SDSU, masters program in Psychology,
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chair of thesis committee, 1995- 1997.
Tanya Schwartz, Ph.D., SDSU/UCSD doctoral program in clinical psychology,
member of dissertation & guidance committee, 1995 to 1997.
Julie Rippeth, Ph.D., SDSU/UCSD doctoral program in clinical psychology,
member of dissertation committee, 1995 to 1997.
Lauren Norton, Ph.D., SDSU/UCSD doctoral program in clinical psychology,
member of dissertation committee, 1996 to 1998.
Micheal Diehr, Ph.D., SDSU/UCSD doctoral program in clinical psychology,
member of dissertation committee, 1996 to 1998.
Joanne Hamilton, SDSU/UCSD doctoral program in clinical psychology,
member of dissertation committee, 1996 to 1999.
Melissa Terry-Ferguson, M.A., SDSU, masters program in experimental psychology,
chair of thesis committee, 1997- 1998.
Tina Bernard, SDSU, masters program in experimental psychology,
chair of thesis committee, 1997- 1999.
Sarah Gatonska, M.A., masters program in experimental psychology,
chair of thesis committee, 1998- 1999.
Angela Eastvold, M.A., masters program in experimental psychology,
member of thesis committee, 1998- 1999.
Heidi Harston, Ph.D., SDSU/UCSD doctoral program in clinical psychology,
member of dissertation committee, 1997-1999.
Cindy Downs, masters program in Chemistry, chair of thesis committee,
2000-2003.
Kelly Lange, SDSU/UCSD doctoral program in clinical psychology,
member of dissertation committee, 2000-2005.
Brook Norwich, masters program in experimental psychology,
Chair of thesis committee, 2001-2004.
Susan Levenstein, masters program in experimental psychology,
Chair of thesis committee, 2001-2004
Theresa Demadura, SDSU/UCSD doctoral program in clinical psychology,
member of dissertation committee, 2001-2003.
Heather Brown, Old Dominion Univ., doctoral program in Instructional Design
& Technology, member of dissertation committee. 2007-2009.
Blake Bent, Old Dominion Univ., Doctoral program in Applied Experimental Psychology,
Student Advisor and thesis chair.
Postdoctoral Fellows:
1. Shu Xing Zhang, Ph.D. in Cell Biology (1989, Univ. of Peking), worked on
NMDA/glutamate excitotoxicity project funded by NINDS, 5/91 to 5/95.
2. Lisa Savage, Ph.D.in Experimental Psychology (1992, Univ. of Minn.), worked on neural
and cognitive substrates of learning and memory deficits supported by VA Merit
Review, from 8/92 to 7/94.
3. Rosanne Ciccia, Ph.D. in Anatomical Sciences (1996, SUNY Buffalo), worked on
pathological and behavioral consequences of chronic ethanol and thiamine deficiency,
supported by NIAAA #AA10473 and VA Merit Program Award to PJL, 10/96 to 5/01.
4. Carter McRee, Ph.D. in Pharmacology (1993, Univ. Virginia Commonwealth), worked on
role of histamine and glutamate in thiamine deficiency-induced pathological lesions,
supported by NINDS #NSS33157, from 12/96 to 7/00.
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Recent Invited Articles, Presentations, Workshops and Editorial/Opinion Articles
Cultural Differences – Common Principles, Invited article to appear in Office of Research
Integrity (ORI) Newsletter, December 2011 issue.
Beyond Compliance – Creating an Institutional Culture of Ethics & Integrity, Invited
Presentation given at the “Ethics and Compliance Issues in Business and
Academia” Symposium, Univ. of Alabama, Huntsville, Nov. 9, 2010.
Ways to Enhance Science Ethics & Integrity in Academic Institutions, Invited talk given at the
Forum on Scientific Ethics, 12th Annual Meeting of the China Association for Science
and Technology, Oct. 31, 2010, Fuzhou, China
Coordinating Efforts at Home: Strategies at Old Dominion University, in Global Perspectives
on Graduate International Education: Proceedings of the 2009 Strategic Leaders Global
Summit on Graduate Education, 2010 Council of Graduate Schools.
Research Integrity and Professional Standards – The Call for Social Accountability and
Responsibility. Keynote Address given at Research Induction Ceremony, Univ. of
Arkansas for Medical Sciences, Sept. 27, 2010, Little Rock, AK
International Responsible Conduct of Research Education – 2nd World Conference on Research
Integrity – post conference workshop, July 24, 2010, Singapore
Challenges and Solutions to Establishing an Institutional Culture of Research Integrity - Invited
talk given at the 2nd World Conference on Research Integrity, July 23, 2010, Singapore
Assessing and Strengthening the Ethical Climate of University Campuses - Session VIII, Invited
Presentation given at 19th Annual Meeting of the Association for Practical and
Professional Ethics, March 6, 2010, Cincinnati, OH.
Surviving with Significant Budget Cuts – Progress Check – Plenary III, invited speaker, 39th
Annual Meeting of the Conference of Southern Graduate Schools, Feb 27, 2010,
Savannah, GA.
Science and Engineering Ethics Education: Recipes for Success – Invited presentation given at
the 2010 Annual Meeting of the American Association for the Advancement of Science
(AAAS), February, 19, 2010, San Diego, CA.
National Panel Recommends New Direction in Research Ethics & Integrity Education, P.J.
Langlais & M. Kalichman, ORI Newsletter, Vol. 17, No. 2., pg 9, 2009.
U.S.-China Workshop on Ethics Education in Science – Chair of Session on Informal Education,
Workshop sponsored by AAAS and China Association of Science and Technology
(CAST), April 27-29, 2009, San Diego, CA
Broadening Participation in Graduate Education –Council of Graduate Schools Report, member
of Advisory Committee that prepared report issued April, 23, 2009
Enhancing Research Integrity through Effective Mentoring-Impact on Next Generation of
Researchers and Academics – Presentation given at Ann Mtg of the Society of Research
Administrators, International, Northeast Section, April 7, 2009, Baltimore, MD
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Responsible Conduct of Research – The Institutional Perspective – Presentation given at the
Winter Chapter of the Soc. Of Research Administrators, Jan. 9, 2009, VCU, Richmond,
VA
Creative Recruitment Strategies for Master’s Degree Programs – Presentation given at the 48th
Ann Mtg Council of Graduate Schools, Dec 3-6, 2008, Washington, DC
Budget and Staff Management Strategies – Workshop presented at the Council of Graduate
Schools Summer Workshop, Jul 12-16, 2008, Vail, CO
Responsible Conduct of Research – The Institutional Perspective – Plenary lecture given at Ann
Mtg National Council of University Research Administrators (NCURA), Nov 2-5, 2008,
National Harbor, MD
Research Integrity – The Institutional Perspective: International Comparisons and Contrasts Presentation given at the 2008 Ann. Mtg Society of Research Administrators
International, Oct 17-21, 2008, Seattle, WA
An Institutional Model for the Administration and Support of Multidisciplinary M&S Graduate
Programs – Presentation given at the 2008 Spring Simulation Multiconference, Apr 1417, 2008, Ottawa, Canada
Designing Institutional and Across-the-Curriculum RCR EIT Programs – Chair and presenter,
First Biennial RCR EIT Conference, Apr 17-19, 2008, Washington Univ., St. Louis, MO
How Do We Increase the Diversity and Cultural Richness of Our Programs and Graduates –
facilitator and commentator, 37th Ann Mtg, Conference of Southern Graduate Schools,
Feb 22-25, 2008, Austin, TX
Building and Administering Interdisciplinary Programs and Certificates within Existing
Departmental Based Graduate Degrees – Presentation and workshop given at the 37th
Ann Mtg, Conference of Southern Graduate Schools, Feb 22-25, 2008, Austin, TX
Research Integrity: The Institutional Perspective – An educational session presented as part of a
Human Protections Certificate Program conducted at the Society of Research
Administrators (SRA) International annual meeting, Oct 13-17, 2007, Nashville, TN
Institutional and Societal Issues – Educating for Responsible Research – Chair, ESF-ORI First
World Conference on Research Integrity: Fostering Responsible Research, Calouste
Gulbenkian Foundation, September 16-19, 2007, Lisbon, Portugal
The Role of Graduate Schools - Presentation given at “Research Ethics Education: Beyond
RCR Training” an International Workshop, April 12-14, 2007, UNC
A Case Study: Ethics, Professional Standards and the Role of the Graduate Dean – Interactive
workshop conducted at at the 35th Annual Meeting, Conference of Southern Graduate
Schools, Feb. 23-26, 2007, Chatanooga, TN
Ethics for the Next Generation, Lecture sponsored by the Institute for Ethics and Public Affairs,
Old Dominion University, April 18, 2006
Responsible Conduct of Research – Ethics in Scientific Research, Lecture given to the College
of Science, Old Dominion University, March 14, 2006
Where is the Moral Outrage among Americans? Editorial, The Virginian Pilot, February 28,
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2006
Integrity of Research/Scholarly Activities and Professional Standards: Cause for Concern?
Plenary Talk given at the 35th Annual Meeting of the Conference of Southern Graduate
Schools, Feb 24-26, 2006.
Ethics and Professional Standards – A Plenary talk given at the 35th Annual Meeting,
Conference of Southern Graduate Schools, Feb. 23-26, 2007, Chatanooga, TN
Ethics for the Next Generation, Plenary Talk given at the 16th Annual Teaching Renewal
Conference, University of Missouri-Columbia, Feb 23, 2006.
Ethics for the Next Generation, published in The Chronicle of Higher Education, Jan. 13, 2006.
Ethics and RCR – A Workshop co-chaired with Thomas Yorio, 45th Annual CGS Meeting,
December 7, 2005
Articles in Peer Reviewed Journals
1.
Gabay S, Langlais PJ, Huang PC. (1972). Evidence for the involvement of dopaminergic
mechanisms in the ECC Syndrome. The Pharmacologist 16:308.
2.
Blankenship JE, Langlais PJ, Kittredge JS. (1975). Identification of a cholinomimetic compound
in the digestive gland of Aplysia californica. Comp Biochem Physiol. 51C:129-137.
3.
Langlais PJ, Huang PC, Gabay S. (1975). The involvement of monoaminergic mechanisms in a
chemically induced hyperkinetic syndrome in the rat. Psychopharmacol Bull. 11:38-39.
4.
Langlais PJ, Huang PC, Gabay S. (1975) Regional neurochemical studies on the effect of ', 'iminodiproprionitrile (IDPN) in the rat. J. Neurosci Res. 1:419-435.
5.
Langlais PJ, Huang PC, Gabay S. (1977) Effects of neuropharmacologic agents on a chemically
induced hyperkinetic animal model. Int J Neurol. 12:97-119.
6.
Langlais PJ, Gabay S. (1977) Quipazine exacerbation of a hyperkinetic syndrome: Involvement
of brain dopamine and serotonin. J Neurosci Res. 3:135-141.
7.
Langlais PJ, McEntee WJ, Bird ED. (1980). Rapid liquid-chromatographic measurement of 3methoxy-4-hydroxyphenylglycol and other monoamine metabolites in human cerebrospinal
fluid. Clin Chem. 26:786-788.
8.
Langlais PJ. (1981). Sensitivity, specificity and predictive value: Keys to improving diagnostic
accuracy. Diagnostic Dialog. 3:16-18.
9.
McEntee WJ, Mair RG, Zatorre RJ, Langlais PJ. (1981). Response to clonidine in Korsakoff's
disease: Significance and implications for future research. Psychopharmacol Bull. 17:123124.
10. McEntee WJ, Mair RG, Langlais PJ. (1981). Clonidine in Korsakoff's disease: Pathophysiologic
and therapeutic aspects. Prog Clin Biol Res. 71:211-223.
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11. Langlais PJ, Bird ED, McEntee WJ. (1982). Stability of monoamine metabolites in human
cerebrospinal fluid. Ann Neurol. 12:48-51.
12. Walsh FX, Stevens TJ, Langlais PJ, Bird ED. (1982). Dopamine and homovanillic acid
concentrations in striatal and limbic regions of human brain. Ann Neurol. 12:52-55.
13. Walsh FX, Langlais PJ, Bird ED. (1982). Liquid-chromatographic identification of
acetaminophen in cerebrospinal fluid with electrochemical detection. Clin Chem. 28:382-383.
14. Langlais PJ, Walsh FX, Stevens TJ, Bird ED. (1983) Decreased catecholamine content caused by
slicing of frozen human post mortem brain with an electric blade. Neurosci Lett. 41:99-103.
15. McEntee WJ, Mair RG, Langlais PJ. (1984) Neurochemical pathology in Korsakoff's psychosis.
Implications for other cognitive disorders. Neurology 34:648-652.
16. Beal MF, Bird ED, Langlais PJ, Martin JB. (1984). Somatostatin is increased in the nucleus
accumbens in Huntington's disease. Neurology 34:663-666.
17. Direnfeld LK, Albert ML, Volicer L, Langlais PJ, Marquis J, Kaplan E. (1984) Parkinson's
disease: The possible relationship of laterality to dementia and neurochemical findings. Arch
Neurol. 41:934-941.
18. Langlais PJ, Rothschild AJ, Schatzberg AF, Cole JO, Bird ED. (1984). Dexamethasone elevates
dopamine in human plasma and rat brain. Psychopharmacol Bull. 20:365-370.
19. Matson WR, Langlais PJ, Volicer L, Gamache PH, Bird E, Mark KA. (1984). n-Electrode threedimensional liquid chromatography with electrochemical detection for determination of
neurotransmitters. Clin Chem. 30:1477-1488.
20. Rothschild AJ, Langlais PJ, Schatzberg AF, Walsh FX, Cole JO, Bird ED. (1984).
Dexamethasone increases plasma free dopamine in man. J Psychiat Res. 18:217-223.
21. Langlais PJ, Walsh FX, Bird ED, Levy HL. (1985). Cerebrospinal fluid neurotransmitter
metabolites in neurologically normal infants and children. Pediatrics 75:580-586.
22. Volicer L, Direnfeld L, Freedman M, Albert M, Langlais PJ, Bird ED. (1985). Serotonin and 5hydroxyindoleacetic acid in CSF: Difference in Parkinson's disease and dementia of Alzheimer
type. Arch Neurol. 42:127-129.
23. Jankovic J, Kirkpatrick JB, Blomquist KA, Langlais PJ, Bird ED. (1985). Late-onset
Hallervorden-Spatz disease presenting as familial parkinsonism. Neurology 35:227-234.
24. Zubenko GS, Volicer L, Direnfeld LK, Freeman M, Langlais PJ, Nixon RA. (1985).
Cerebrospinal fluid levels of angiotensin-converting enzyme in Alzheimer's disease, Parkinson's
disease and progressive supranuclear palsy. Brain Res. 328:215-221.
25. Schatzberg AF, Rothschild AJ, Langlais PJ, Bird ED, Cole JO. (1985). A
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corticosteroid/dopamine hypothesis for psychotic depression and related states.
J Psychiatr Res. 19:57-64.
26. Volicer L, Langlais PJ, Matson WR, Mark KA, Gamache PH. (1985). Serotoninergic system in
dementia of Alzheimer type: Abnormal forms of 5-hydroxytryptophan and serotonin in
cerebrospinal fluid. Arch Neurol. 42:1158-1161.
27. Mair RG, Anderson CD, Langlais PJ, McEntee WJ. (1985). Thiamine deficiency depletes
cortical norepinephrine and impairs learning processes in the rat. Brain Res. 360:273-284.
28. Rothschild AJ, Langlais PJ, Schatzberg AF, Miller MM, Salomon MS, Lerbinger JE, Cole JO,
Bird ED. (1985). The effects of a single dose of dexamethasone on monoamine and metabolite
levels in rat brain. Life Sci. 36:2491-2501.
29. Volicer L, Direnfeld LK, Langlais PJ, Freedman M, Bird ED, Albert ML. (1985). Catecholamine
metabolites and cyclic nucleotides in cerbrospinal fluid in dementia of Alzheimer type. J
Gerontology. 40:708-713.
30. Direnfeld LK, Volicer L, Langlais PJ, Marquis J, Albert ML. (1985). Laterality and symptom
association in Parkinson's disease. Arch. Neurol. 42:1132-1133.
31. Anderson, CD, Mair RG, Langlais PJ, McEntee WJ. (1986). Learning impairments after 6OHDA treatment: A comparison with the effects of thiamine deficiency. Behav. Brain Res.
21:21-27.
32. Zubencko GS, Marquis JK, Volicer L, Direnfeld LK, Langlais PJ, Nixon, RA. (1986).
Cerebrospinal fluid levels of angiotensin-converting enzyme, acetylcholinesterase and dopamine
metabolites in dementia associated with Alzheimers's disease and Parkinsons's disease. A
correlative study. Biol. Psychiat. 21:1365-1381.
33. Mair RG, Langlais PJ, Beal MF, Mazurek M, Martin J, McEntee WJ. (1986). Reduced
concentrations of arginine vasopressin (AVP) and MHPG in lumbar CSF of patients with
Korsakoff's psychosis. Life Sci. 38:2301-2306.
34. Mair RG, Doty R, Kelly KM, Wilson C, Langlais PJ, McEntee WJ, Vollmecke TA. (1986).
Multimodal sensory discrimination deficits in Korsakoff amnesics. Neuropsychologia.
24:831-839.
35. McEntee WJ, Mair RG, Langlais PJ. (1987). Neurochemical specificity of learning: Dopamine
and motor learning. Yale J. Biol. & Med. 60:187-193.
36. Rothschild AJ, Schatzberg AJ, Langlais PJ, Lerbinger JE, Miller MM, Cole JO. (1987).
Psychotic and nonpsychotic depression. I. Comparison of plasma catecholamines and cortisol
measures. Psychiat Res. 20:143-153.
37. Schatzberg AJ, Rothschild AJ, Langlais PJ, Lerbinger JE, Schildkraut JJ, Cole JO. (1987).
Psychotic and nonpsychotic depression. II. Relationships among platelet MAO activity, plasma
catecholamines, cortisol, and specific symptoms. Psychiat Res. 20:155-164.
12
38. Irons M, Levy HL, O'Flynn ME, Stack CV, Langlais PJ, Butler IJ, Milstein S, Kaufman S.
(1987). Folinic acid therapy in the treatment of dihydropteridine reductase deficiency. J.
Pediatrics. 110:61-67.
39. Langlais PJ, Mair RG, Anderson CD, McEntee WJ. (1987). Monoamines and metabolites in
cortex and subcortical structures: Normal regional distribution and the effects of thiamine
deficiency in the rat. Brain Research. 421:140-149.
40. Mair RG, Anderson CD, Langlais PJ, McEntee WJ. (1988). Behavioral impairments, brain
lesions and monoaminergic activity in the rat following recovery from a bout of thiamine
deficiency. Behav Brain Res. 27:233-239.
41. Langlais PJ, Mair RG, Whalen P, McCourt W, McEntee WJ. (1988). Memory effect of DLthreo-3,4-dihydroxyphenylserine (DOPS) in human Korsakoff's disease. Psychopharmacology
95:250-254.
42. Langlais PJ, Mair RG, Anderson CD, McEntee WJ. (1988). Long-lasting changes in regional
brain amino acids and monoamines in recovered pyrithiamine treated rats. Neurochem Research
13:1199-1206.
43. Wolf JA, Fisher LJ, Xu L, Jinnah HA, Langlais PJ, Iuvone PM, O'Malley KL, Rosenberg MB,
Shimohama S, Freidmann T, Gage FH. (1989). Grafting fibroblasts genetically modified to
produce L-DOPA in a rat model of Parkinsons's disease. Proc Nat'l Acad. Sci. 86:9011-9014.
44. Langlais, PJ, Mair RG. (1990). Protective effects of the glutamate antagonist MK-801 on
pyrithiamine-induced lesions and amino acids changes in rat brain. J Neuroscience 10:16641674.
45. Mair RG, Otto TA, Knoth RL, Rabchenuk SA, Langlais PJ. (1991). An analysis of aversively
reinforced learning in rats recovered from pyrithiamine-induced thiamine deficiency. Behav
Neurosci 105:351-359.
46. Mair RG, Knoth RL, Rabchenuk SA, Langlais PJ. (1991). Impairment of olfactory, auditory, and
spatial serial reversal learning in rats recovered from pyrithiamine induced thiamine deficiency.
Behav Neurosci 105:360-374.
47. Connor DJ, Langlais PJ, Thal L. (1991). Behavioral impairments after lesions of the nucleus
basalis by ibotenic acid and quisqualic acid. Brain Res, 555:84-90..
48. Langlais PJ, Wardlow ML, Yamamoto H. (1991). Changes in CSF neurotransmitters in patients
with Infantile Spasms. Pediatric Neurology, 7:440-445.
49. Connor DJ, Dietz S, Langlais PJ, Thal, LJ. (1992). Behavioral effects of concurrent lesions of the
nucleus basalis magnocellularis and the dorsal noradrenergic bundle. Experimental Neurology,
116:69-75.
13
50. Langlais PJ, Mandel RF, Mair RG. (1992). Diencephalic lesions, learning impairments, and
intact retrograde memory following acute thiamine deficiency in the rat. Behavioral Brain
Research,48:177-185.
51. Connor, DJ, Thal, LJ, Mandel, RJ, Langlais, PJ, Masliah, E. (1992). Independent effects of age
and NBM lesion: Maze learning, cortical neurochemistry and morphometry. Behavioral
Neuroscience, 106:776-788.
52. Jinnah, HA, Langlais, PJ, Friedman, T. (1992). Behavioral and biochemical response to
amphetamine in a genetic mouse model of Lesch-Nyhan Syndrome. J. Pharmacol. &
Experimental Therapeutics 263:596-607.
53. Langlais PJ, Connor, DJ, Thal, LJ. (1993). Comparison of the effects of single and combined
neurotoxic lesions of the nucleus basalis magnocellularis and dorsal noradrenergic bundle on
learning, reference and working memory in the rat. Behavioral Brain Research 54:81-90.
54. Langlais, PJ, Thal, L, Hansen, L, Galasko, D, Alford, M, Masliah,E. (1993). Neurotransmitters
in basal ganglia and cortex of Alzheimer's Disease with and without Lewy Bodies.
Neurology 43:1927-1934.
55. Langlais, PJ, Zhang, SH. (1993). Extracellular glutamate is increased in thalamus during
thiamine deficiency-induced lesions and is blocked by MK-801. J. Neurochem. 61:2175-2182.
56. Connor, DJ, Langdon, D, Langlais, PJ, Thal, LJ. (1993). Effects of NBm lesion on T-maze
performance and thalamic biochemistry. Neurobiology of Aging 14:535-537.
57. O'Connor DT, Cervenka, J.H., Stone, R.A., Parmer, R.J., Franco-Bourland, R.E., Madrazo, I.,
Langlais, P.J. (1993). Chromagranin A immunoreactivity in human cerebrospinal fluid:
Properties, relationship to noradrenergic neuronal activity, and variation in neurologic disease.
Neuroscience 56:999-1007.
58 . O'Connor DT, Cervenka RT, Frigon RP, Stone RA, Levine GL, Parmer RJ, Franco-Bourland
RE, Langlais PJ, Biaggioni I. (1994). Dopamine-beta-hydroxylase immunoreactivity in human
cerebrospinal fluid: Properties, relationship to central noradrenergic activity, and variation in
neurologic disease. Clinical Science 86:149-158.
59. Jinnah, HA, Wojcik, BE, Hunt, M., Narang, N, Lee, KY, Goldstein, JK, Wamsley, JK,
Langlais PJ, Friedman, T. (1994). Dopamine deficiency in a genetic mouse model of LeschNyhan Disease. J. Neuroscience 14:1164-1175.
60. Shults CW, Matthews RT, Altar CA, Langlais PJ. (1994). A single intramesencephalic injection
of brain-derived neurotrophic factor induces persistent rotational asymmetry in rats. Exp.
Neurol. 125:183-194.
61. Langlais, PJ, Zhang, SX, Weilersbacher G, Hough LB, Barke, KE. (1994). Histamine-mediated
neuronal death in a rat model of Wernicke's encephalopathy. J. Neurosci. Res 38: 565-574.
14
62. Langlais, PJ. (1995). Pathogenesis and selectivity of diencephalic lesions in a rat model of
thiamine deficiency-induced Wernicke's Encephalopathy. Metabolic Brain Disease 10:31-44.
63. Langlais, PJ, Savage L. (1995). Thiamine deficiency in rats produces cognitive and memory
deficits on spatial tasks that correlate with tissue loss in diencephalon, cortex and white matter.
Behavioral Brain Res 68:75-89.
64
Zhang SX, Weilersbacher GS, Henderson SW, Corso T, Olney JW, Langlais PJ. (1995).
Excitotoxic cytopathology, progression, and reversibility of thiamine deficiency-induced
diencephalic lesions. J. Neuropathol Exp Neurol 54:255-267.
65. Langlais PJ. (1995) Alcohol-related thiamine deficiency: Impact on cognitive and memory
functioning. Alcohol Health Research World 19:113-121.
66. Savage LM, Langlais PJ. (1995). Differential outcomes attentuate memory impairments on
matching-to-position following pyrithiamine-induced thiamine deficiency in rats. Psychobiology
23:153-160.
67. Langlais PJ, Zhang SX, Savage LM.(1996) Neuropathology of thiamine deficiency: An update
on the comparative analysis of human disorders and experimental models. Metab Brain Dis
11:19-37.
68. Langlais PJ, Anderson G, Guo SC, Bondy SD. (1997). Increased cerebral free radical production
during thiamine deficiency. Metab Brain Dis 12:137-144.
69. Langlais PJ, Zhang SX (1997). Cortical and subcortical white matter damage without Wernicke's
encephalopathy after recovery from thiamine deficiency in the rat. Alcohol Clin Exp Res
21:434-443.
70. Savage LM, Sweet AJ, Castillo R, Langlais PJ. (1997). The effects of lesions to thalamic lateral
internal medullary lamina and posterior nuclei on learning, memory, and habituation in the rat.
Behav Brain Res 82:133-147.
71. Jenkins, MA, Langlais, PJ, Delis, D., Cohen, R. (1998). Learning and Memory in Post-Rape
Posttraumatic Stress Disorder. Am. J. Psychiat . 155:278-279.
72. Savage LM, Castillo R, Langlais PJ. (1998). Effects of lesions of thalamic intralaminar nuclei
and internal medullary lamina on spatial memory and object discrimination. Behav. Neurosci.
112:1339-1352.
73. Langlais PJ, Hall T. (1998). Thiamine deficiency-induced disruptions in the diurnal rhythm and
regulation of body temperature in the rat. Metab Brain Dis 13:225-239.
74. Chen LH, Zhao Y, Ciccia R, Langlais PJ. (1999). Effects of long-term alcohol feeding and
thiamin deficiency on antioxidant defense systems in the liver and spleen of rats. Biochem. Arch.
15:103-116.
15
75. Ferguson M, Dalve-Endres A, McRee RC, Langlais PJ (1999). Increased mast cell degranulation
within thalamus in early pre-lesion stages of an experimental model of Wernicke’s
encephalopathy. J. Neuropath. Exp. Neurol. 58:773-783.
76. McRee CR, Terry-Ferguson M, Langlais PJ, Chen Y, Nalwalk JW, Hough L. (2000). Increased
histamine release and granulocyte proliferation in a rat model of Wernicke’s encephalopathy.
Brain Res. 858:227-236.
77. Jenkins MA, Langlais PJ, Delis D., Cohen R. (2000). Attentional Deficits in Post-Rape
Posttraumatic Stress Disorder. The Clinical Neuropsychologist 14;7-12.
78. Ciccia R, Langlais PJ (2000). An examination of the synergistic interaction of ethanol and
thiamine deficiency in the development of neurological signs and long-term cognitive and
memory impairments. Alcohol Clin Exp Res. 24:622-634.
79. Chen L.H., Thielen V., Ciccia, R., Langlais, P.J. (2002). Effects of chronic ethanol consumption
and thiamin deficiency on antioxidant defenses in heart and skeletal muscle of rats. Nutrition
Research 22:835-845.
80. Langlais P.J., McRee R.C., Nalwalk J.A., Hough L.B. (2002). Depletion of brain histamine
protects against thiamine deficiency-induced thalamic lesions in the rat. Metab Brain Dis.
17:199-210.
81. Chen L.H., Thielen V, Ciccia R.M., Langlais P.J. (2003) Effects of chronic ethanol feeding and
thiamin deficiency on antioxidant defenses in kidney and lung of rats. Alcohol Research 8:107111.
82. Langlais P.J., Godinez M., Garrett R., Powell H. Ultrastructural analysis of the nature and course
of glio-vascular changes within thalamus of a rat model of Wernicke’s encephalopathy. Brain
Pathology (submitted).
83. Adinoff BH, Ciccia R, Langlais PJ. Absence of adrenocortical hypertrophy in rats following
thirty-two weeks of alcohol administration. Alcohol Clin Exp Res (submitted).
84. Langlais PJ, Ciccia R, Biane J, Penland A, Bangasser D. Attention deficits following thalamic
damage induced by experimental thiamine deficiency in the rat. Behav Brain Res (submitted,
revisions requested)
Books & Invited Chapters
1.
McEntee WJ, Mair RG, Langlais PJ. (1981). Clonidine in Korsakoff's disease:
Pathophysiological and therapeutic implications. In: Lal J, Fielding S, eds.
Psychopharmacology of Clonidine. New York: Allen Liss, pp. 211-223.
2.
McEntee WJ, Mair RG, Langlais PJ. (1983). Cerebrospinal fluid monoamine metabolites in
Korsakoff's disease: Relationship to memory impairment and drug response. In: Wood JH, ed.
Neurobiology of CSF. Vol. 2 New York: Plenum Publishing Corp. pp. 163-171.
16
3.
Langlais PJ, Matson WR, Bird ED. (1986). An Automated HPLC, series coulometric
electrochemical detection method for the simultaneous analysis of monoamines and metabolites
in crude tissue extracts or CSF. In: Joseph MH, Fillenz M, MacDonald IA, Marsden CA, eds.
Monitoring Neurotransmitter Release During Behavior. Chichester, England: Ellis Horword, pp.
224-232.
4.
Svendsen CN, Langlais PJ, Benes FM, Bird ED. (1986). Monoamine levels in the left and right
amygdaloid complex of schizophrenic postmortem brain. In: Shagass C, et al., eds. Biological
Psychiatry 1985, Amsterdam: Elsevier, pp. 1115-1117.
5.
Langlais, PJ. (1992). Role of diencephalic lesions and thiamine deficiency in Korsakoff's
amnesia: Insights from animal models. In: Larry R. Squire and Nelson Butters, eds.,
Neuropsychology of Memory., New York: The Guilford Press, pp. 440-450.
6.
Langlais PJ. (1997). Neurotransmitter disturbances in Alzheimer’s disease with and without
Lewy Body Disease. In: Parves H, Naoi M, Ackworth I and Matson W, eds., Coulometric
Electrode Array Detectors for HPLC. Vol. 6 in The Progress of HPLC Series, VSP press,
Netherlands. pp 259- 272.
7.
Langlais PJ. (1998). Three Dimensional HPLC-EC Analyses of Regional Brain Neurotransmitter
Disturbances in Alzheimer's Disease With and Without Lewy Bodies. In: Qureshi AG, Parvez
H, Caudy P, & Parvez S, eds. Neurochemical Markers of Degenerative Nervous Diseases &
Drug Addiction. Vol. 7. in The Progress in HPLC-HPCE: VSP press, the Netherlands, pp.817830.
8.
Langlais PJ. (1999). Thiamine Deficiency-Induced Damage in the Nervous System: A Review.
In: Bondy SC, ed. Chemicals and Neurodegenerative Disease. Prominent Press, Scottsdale AZ
pp. 189-229.
9.
Langlais PJ (2001). Role of Histamine and Mast Cells in Metabolic Encephalopathy. In:
Watanabe T, Timmerman H, and Yanai K, eds. Histamine Research in the New Millenium,
Elsevier Science, Amsterdam, pp. 281-286.
10. Langlais PJ, Ulmer L. (2010). Teaching Handbook, Center for Learning Technologies & Office
of Graduate Studies, Old Dominion University.
11. Langlais PJ (2011). Establishing an institutional culture of research integrity: key challenges &
successful solutions. In: Promoting Research Integrity on a Global Basis, World Scientific
Publishing, Imperial College Press.
Published Abstracts
1.
Langlais PJ, Blankenship JE. Cholinomimetic compound extracted from digestive gland of
Aplysia. Fed Proc Am Soc Exp Biol. 31:822, 1972.
17
2.
Langlais PJ, Huang PC, Gabay S. Effect of 3,3'-iminodipropionitrile on levels of biogenic
amines in discrete areas of rat brain. Abst 29th Ann Convention Soc Biol Psychiat. 9: 27, 1974.
3.
Langlais PJ, Huang PC, Gabay S. The involvement of monoaminergic mechanisms in a
chemically-induced hyperkinetic syndrome in the rat. Proc 13th Ann Mtg Am College
Neuropsychopharmacol. 1974.
4.
Gabay S, Langlais PJ, Huang PC. A possible model for human extrapyramidal disorders-some biochemical and pharmacological determinants. Proc. 1st World Cong Biol Psychiat.,
Buenos Aires, 1974.
5.
Gabay S, Langlais PJ, Huang PC. Effects of neuropharmacologic agents on a chemicallyinduced hyperkinetic animal model. Proc. 7th International Symp Fulton Soc. on "Basal
Ganglia", New York, 1975.
6.
Langlais PJ, Bird ED, McEntee WJ. Stability of monoamine metabolites in human cerebrospinal
fluid. Proc 8th Mtg International Soc Neurochem. pg. 439, 1981.
7.
McEntee WJ, Mair RG, Langlais PJ. MHPG is always while HVA and 5-HIAA are often
diminished in the CSF of patients with Korsakoff's psychosis. Neurology 32:A229, 1982.
8.
Langlais PJ, Walsh FX, Bird ED, McEntee WJ, Mair RG. Liquid
chromatography/electrochemistry in the measurement of human CSF MHPG, HVA and 5-HIAA:
Methods and applications to clinical research investigations. LCEC Symposium, Abstract No.
41, 1982.
9.
Langlais PJ, Walsh FX, Stevens TJ, Bird ED. Estimation of dopamine turnover in striatal, limbic
and frontal cortical areas of human brain. Soc. Neurosci. Abstr. 8:234, 1982.
10. Bird ED, Benes FM, Langlais PJ, Walsh FX, Stevens TJ. Catecholamines and their metabolites
in specific areas of frontal cortex in postmortem schizophrenic brain. Int J Psychophysiol.
1:109- 110, 1983.
11. Rothschild AJ, Schatzberg AF, Langlais PJ, Bird E, Cole JO. Dexamethasone
increases plasma dopamine. New Research Abstracts, Am Psychiat Assoc Ann Mtg, New York,
Abstract No NR26, 1983..
12. Bird ED, Langlais PJ, Stevens TJ, Walsh FX. Dopamine and serotonin turnover in postmortem
human brain. J Neurochem, 41:33B, 1983.
13. McEntee WJ, Mair RG, Langlais PJ. Catecholamine deficiency in Korsakoff's psychosis. 5th
CA Symposium, Goteborg, Abstract No. 328, 1983.
14. Volicer L, Direnfeld LK, Langlais PJ, Freedman M, Bird Ed, Albert ML. Changes of
monoamine metabolism in senile dementia of Alzheimer type (SDAT). Soc. Neurosci Abstr. 9:
305.4, 1983.
18
15. Finkelstein S, Campbell A, Bird E, Moya K, Langlais PJ, Baldessarini R. Reciprocal changes in
subcortical dopamine metabolism following focal cortical lesions in animal and human brain.
Neurology 34 (Suppl 1):230, 1984.
16. Matson WR, Gamache PH, Volicer L, Bird E, Langlais PJ. N-electrode 3 dimensional LCEC
for neurotransmitter analysis. Sixteenth Ann Symp, Am Assoc Clin Chem, Knoxville, 1984.
17. Rothschild AJ, Schatzberg AF, Langlais PJ, Cole JO, Bird ED. Dexamethasone elevates
dopamine in human plasma and rat brain. Proc 22nd Mtg Am College Neuropsychopharmacol.,
San Juan, 1983.
18. Jankovic J, Kirkpatrick JB, Langlais PJ, Bird ED. Late onset Hallervorden-Spatz disease
presenting as Parkinsonism: Clinical, biochemical, and neuropathologic study. Neurology
34 (Suppl 1): 271, 1984.
19. Bird ED, Langlais PJ, Benes FM. Dopamine and homovanillic acid in postmortem schizophrenic
brain. Clinical Neuropharmacology 7(Suppl 1):910-911, 1984.
20. Langlais PJ, Bird ED, Matson WR. An Automated HPLC, three cell electrochemical method for
the simultaneous assay of monoamines and metabolites in crude brain extracts. Clin Chem.
30:1046, 1984.
21. Volicer L, Direnfeld LK, Langlais PJ, Marquis J, Freedman M, Bird ED, Albert AL. Cyclic
nucleotides in cerebrospinal fluid in patients with Alzheimer's (DAT) and Parkinson's (PD)
diseases. Neurology 35(Suppl 1):145, 1984.
22. Rothschild AJ, Schatzberg AF, Langlais PJ, Cole JO, Bird ED. Effects of dexamethasone on
monoamine and metabolite levels in rat brain and human plasma. 14th Ann CINP Mtg.,
Florence, 1984.
23. Volicer L, Langlais PJ, Matson WR, Mark KA, Gamache PH. Abnormal form of 5hydroxytryptophan and serotonin in cerebrospinal fluid (CSF) of Alzheimer patients. Soc.
Neurosci Abstr. 10: 1984.
24. Rothschild AJ, Langlais PJ, Schatzberg AF, Cole JO, Bird ED. Dexamethasone elevates
dopamine in rats and humans. Ann Mtg. APA, Los Angeles, 1984.
25. Anderson CD, Mair RG, McEntee WJ, Langlais PJ, Brown WA. Decreased cortical
norepinephrine in an animal model of Korsakoff's psychosis. Proc 23rd Mtg Am Coll
Neuropsychopharmacol., San Juan, 1984.
20. Rothschild AJ, Schatzberg AF, Langlais PJ, Miller M, Cole JO. Plasma cortisol and dopamine
levels in psychotic and non-psychotic depressed patients. Proc 23rd Mtg Am Coll
Neuropsychopharmacol., San Juan, 1984.
26. Svendsen CN, Langlais PJ, Benes FM, Bird ED. Amygdaloid catecholamine levels in
schizophrenic and control postmortem brain. IV World Congress of Biol Psychiat, Philadelphia,
1985.
19
27. Irons M, Langlais PJ, Levy H. Folinic acid (FA) therapy in dihydropteridine reductase deficiency
(DHPRD). Pediatr Res 19:249A, 1985.
28. Rothschild AF, Schatzberg AF, Langlais PJ, Lerbinger JE, Cole JO. Corticosteroid/dopamine
interactions in rats, normal controls, and psychotic depression. Proc 24th Mtg Am Coll
Neuropsychopharmacol., Maui, 1985.
29. Langlais PJ, Mair RG, Anderson CD, McEntee WJ. Thalamic lesions and regional brain
monoaminergic alterations following an acute bout of thiamine deficiency in the rat. Soc.
Neurosci Abstr.12:751, 1986.
30. Mair RG, Anderson CD, Langlais PJ, McEntee WJ. Evidence for spatial memory deficits in the
rat following recovery from a bout of thiamine deficiency. Soc. Neurosci. Abstr.12:745, 1986.
31. Langlais PJ, Mair RG, Anderson CD, McEntee WJ. Reduced GABA & glutamate and increased
serotonin activity in midbrain-thalamus of rats following recovery from acute thiamine
deficiency. Soc. Neurosci. Abstr. 13:217, 1987.
32. Knoth RL, Otto TA, Goodness TP, Mair RG, Langlais PJ. Thiamine deficiency in the rat
produces bilaterally symmetrical lesions of medial thalamus and impairs acquisition of
aversively conditioned behavior. Soc. Neurosci. Abstr. 13:1127, 1987.
33. Langlais PJ, Korson MS, Levy HL. Cerebrospinal fluid (CSF) monoamine (MA) metabolite
profile in inborn errors of metabolism. Amer. Soc. Human Genetics, San Diego, 1987.
34. Levy HL, Korson MS, Langlais PJ. Cerebrospinal fluid (CSF) monoamine (MA) metabolites in
newborn and early-treated off diet PKU. Amer. Soc. Human Genetics, San Diego, 1987.
35. Mair RG, Slade C, Langlais PJ. Monoaminergic activity in olfactory bulb and
cerebellum during olfactory and motor learning tasks. 9th Ann. Chemical Senses Mtg.,
Sarasota, 1987.
36. Langlais PJ, Mair RG, McEntee WJ. Acute thiamine deficiency in the rat: Brain lesions, amino
acid changes and MK-801 pretreatment. Soc. Neurosci. Abstr. 14: 774, 1988.
37. Mair RG, Flint DB, Inhoff A, Langlais PJ. Voluntary control of attention is impaired in
Korsakoff's syndrome. Soc. Neurosci. Abstr. 14: 1044, 1988.
38. Knoth RL, Mair RG, Rabchenuk SA, Langlais PJ. Impairment of spatial, olfactory, and
auditory serial reversal learning in an animal model of human diencephalic amnesia. Soc.
Neurosci. Abstr. 14: 1230, 1988.
39. Langlais PJ, Mandel RJ, Mair RG. Thiamine deficiency-induced thalamic lesions in rats:
Learning but not memory deficits. Proc. 1st Ann. Convention. APS, Alexandria, VA.,
June 8-10, 1989.
20
40. Connor DJ, Thal LJ, Langlais PJ. Effect of ibotenate and quisqualate lesions of the nBM on
water maze performance. Soc. Neurosci. Abstr. 15:80, 1989.
41. Knoth RL, Mair RG, Rabchenuk SA, Langlais PJ. Impairment on a pretrained spatial nonmatchto-sample task in an animal model of human diencephalic amnesia. Soc. Neurosci. Abstr.15:
304, 1989.
42. Mair RG, Ferguson AE, Knoth RL, Langlais PJ. Widespread cortical denervation in rats
following recovery from thiamine deficiency. Soc. Neurosci. Abstr. 15:1104, 1989.
43. Fisher LJ, Jinnah HA, Rosenberg MB, Langlais PJ, Friedmann T, Gage FH. L-DOPA
producing fibroblasts grafted in a rat model of Parkinson's disease. Soc. Neurosci. Abstr. 15:
1358, 1989.
44. Warner M, Speigel W, Henderson S, Langlais PJ. Effects of different delay conditions on
nonmatching-to-sample performance. WPA Annual Convention, Los Angeles,April 26-29,
1989.
45. Langlais PJ, Van Luyn J. Learning deficit and neurotransmitter disturbances in a rat model of
diencephalic amnesia. 2nd Ann APS Convention, Dallas, June 7-10, 1990.
46. Fisher LJ, Jinnah HA, Langlais PJ, Higgins GA, Friedmann T, Gage FH.
Primary fibroblasts that produce L-DOPA: Long term survival and behavioral effects when
implanted in rats with 6-OHDA lesions. Soc. Neurosci Abstr. 16:23.4, 1990.
47. Henderson SW, Langlais PJ. Differences in spatial learning and memory abilities following
mediodorsal versus posterior thalamic lesions in rat. Soc. Neurosci. Abstr. 16:250.14, 1990.
48. Connor DJ, Langlais PJ, Thal LJ. Behavioral effects of combined cholinergic and noradrenergic
lesions. Soc. Neurosci. Abstr.16:511.19, 1990.
49. Yamamoto H, Langlais PJ, Wardlow ML. CSF analysis in patients with Infantile Spasms. Ann.
Mtg. American Epilepsy Society, San Diego, 1990.
50. Patel PM, Drummond JC, Langlais PJ, Grafe M, Cole DJ. Assessment of behavioral outcome
following incomplete forebrain ischemia by T-maze performance in rats. Ann. Mtg. American
Soc. of Anesthesiologists, New Orleans, 1990.
51. Ferman TJ, Langlais PJ. Nonspatial attentional shifting in the auditory modality. APA Annual
Convention, New York, 1991.
52. Langlais PJ, Connor DJ, Thal LJ. Effects of single and combined cholinergic and noradrenergic
lesions on delayed non-match to sample performance. 3rd IBRO World Congress of
Neuroscience, Montreal, Aug 4-9, 1991.
53. Langlais PJ, Thal LJ, Hansen L, Galasko D, Alford M, Masliah, E. Loss of basal ganglia
dopamine in the Lewy body variant of Alzheimer's disease. Soc. Neurosci. Abstr.17:691, 1991.
21
54. Connor DJ, Langlais PJ, Mandel RJ, Thal LJ. Effects of age and NBM lesion on maze learning
and cortical neurochemistry. Soc. Neurosci. Abstr.17:478, 1991.
55. Langlais PJ, Sheffield B, Nicholson K, Henderson S. Anterograde but not retrograde memory
deficits following medial thalamic lesions in rats. 4th Ann APS Convention, San Diego, June
20-22, 1992.
56. Radovanov J, Langlais PJ. Attentional deficits in Posttraumatic Stress Disorder among Vietnam
combat veterans. 4th Ann APS Convention, San Diego, June 20-22, 1992.1992.,
57. Langlais PJ, Henderson SW, Zhang, SX. Increased extracellular glutamate in thalamus of
acutely thiamine deficient rats. Soc. Neurosci. Abstr.18:1599, 1992.
58. Zhang SX, Langlais PJ. Pathologic changes in thalamus, hippocampus and cortex of rats
following thiamine deficiency induced seizures. Soc. Neurosci. Abstr.18:1599, 1992.
59. Shults CW, Matthews RT, Langlais PJ. A single intramesencephalic injection of BDNF induces
persistent rotational asymmetry in rats. Soc. Neurosci. Abstr.18:695, 1992.
60. Langlais PJ, Henderson SW, Zhang SX. Pattern and progression of thiamine deficiency-induced
diencephalic lesions in the rat. Soc. Neurosci. Abstr. 19:1887, 1993.
61. Zhang SX, Weilersbacher GS, Henderson SW, Hough LG, Langlais PJ. Evidence for
histamine-mediated thalamic lesions in acute thiamine deficient rats. Soc. Neurosci. Abstr.
19:1887, 1993.
62. Savage L, McFetridge G, Sheffield B, Gordon R, Langlais PJ. Effects of thiamine deficiency
induced diencephalic lesions on spontaneous activity, retrograde memory, and anterograde
learning and memory. Soc. Neurosci. Abstr. 19:365, 1993.
63. Henderson SH, Langlais PJ, Moser KM, Archibald C., Watt C, Mazzel W, Auger W, Fedullo P,
Winkler M, Jameison S. . Neuropsychologic sequellae following pulmonary
thromboendarectomy: A prospective study. 22nd Annual Meeting of the International
Neuropsychological Society, Cincinnati, OH, 1994.
64. Langlais PJ, Heald N, Ranney L, Deforneaux D, Weilersbacher G, Anderson C, Zhang S-X.
Effects of chronic alcohol consumption and thiamine deficiency in the rat. Alcoholism: Clin Exp
Res. 18:50A, 1994.
65. Langlais PJ, S.X. Zhang SX, Weilersbacher GS, Corso T, Olney JW. Excitotoxic-type
necrosis in thalamus precededs motor seizures in a rat model of Wernicke's
Encephalopathy. Soc. Neurosci Abstr. 20:1677, 1994.
66. Zhang SX, Weilersbacher BS, Langlais PJ. Progression and reversibility of brainstem lesions
produced by acute thiamine deficiency in rats. Soc. Neurosci Abstr. 20:415, 1994.
22
67. Savage LM, Sweet A, Bassett A, Langlais PJ. Retrograde and anterograde spatial
memory impairments following radio-frequency l;esions to the lateral internal medullary
lamina. Soc. Neurosci Abstr. 20:1212, 1994.
68. Olney JW, Farber NB, Corso, T, Labruyere J, Zhang SC, Langlais PJ. Hyperactivation of glutamate
pathways induces thalamic cytopathology resembling Wernicke-Korsakoff encephalopathy.
Soc. Neurosci Abstr. 20:1677, 1994.
69. Jenkins M, Langlais PJ, Delis D, Jernigan T, Matloff J, Paulsen J, Rosenbaum G
Attentional and memory dysfunction associated with Posttraumatic Stress Disorder among
rape survivors. 15th Ann. Mtg. National Academy of Neuropsychology, San
Francisco, CA., Nov 1-4, 1995.
70. Savage LM, Castillo R, Langlais PJ. Thiamine deficiency in 16 month old rats versus 3
month old rats: Behavioral and pathological differences. Soc. Neurosci. Abstr. 21:1940, 1995.
71. Langlais PJ, Zhang SX. Degeneration of cortical tracts following mild thiamine deficiency
in the rat. Soc. Neurosci. Abstr. 21:493, 1995.
72. Zhang SX, Langlais PJ. NMDA receptor mediated brainstem lesions produced by acute thiamine
deficiency in rats. Soc. Neurosci. Abstr. 21:1339, 1995.
73. Mastracci R, Zhang SX, Langlais PJ. Excitotoxic lesions of the rat mammillary body in a
thiamine deficiency model of Wernicke-Korsakoff syndrome. Ann. Mtg. Soc. of
Toxicology, Anaheim, CA., Mar. 10-14, 1996,
74. Hall T, Langlais PJ. Effects of thiamine deficiency on thermostasis and circadian rhythm.
WPA Annual Meeting, San Jose, CA, Apr 11-14, 1996.
75. Langlais PJ, Anderson G, Guo SX, Bondy SC. Measures of oxidative stress in a rat model of
Wernicke's encephalopathy. J. Neurochem. 66 (Suppl 1): S93, 1996.
76. Langlais PJ, Zhang SX. Cortical white matter damage without Wernicke's encephalopathy
following mild thiamine deficiency in rats. Alcoholism: Clin Exp Res 20:76A, 1996.
77. Langlais PJ, Eastvold A, Ciccia R, Hall T, Lopez N, Michaels LJ, Ward C, Bernard TM, Shields
TC, Terry M, Gatonska S. (1997). Cortical and limbic neuronal degeneration following chronic
ethanol exposure and multiple episodes of thiamine deficiency. Alcoholism: Clin Exp Res
22:89A, 1997.
78. Hall T, Langlais PJ. (1997). Thiamine deficiency-induced alterations in circadian rhythm,
thermoregulation and hypothalamic nuclei of rat. Alcoholism: Clin Exp Res
22:89A, 1997.
79. Langlais PJ, Anderson G, Powell H, Dimlich R. (1997). Mast cell degranulation and edematous
changes in pre-necrotic stages of a rat model of Wernicke's encephalopathy. Brain Pathol.
7:1020. 1997.
80. Langlais PJ, Anderson G, Germeys I. (1997). Attentional and cognitive deficits following
recovery from thiamine deficiency in the rat. Soc. Neurosci. Abstr. 23:1840.
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81
McRee C, Langlais PJ, Terry M, Hough L, Nowak, K. (1997). Role of histamine release and
mast cells in the pathogenesis of Wernicke's encephalopathy. Soc. Neurosci. Abstr. 23:829.
82. Langlais PJ, Zhang SX. (1997). Cortical white matter damage without Wernicke’s
encephalopathy following thiamine deficiency. Brain Pathol. 7:1256.
83. McRee RC, Langlais PJ, Terry-Ferguson M, Nalwalk JB, Hough L. Histamine release during
thiamine deficiency in the rat. Paper presented at the 9th Annual Meeting Histamine
Neuroscience Research Group. Oct. 24, 1997, New Orleans, LA.
84. Kurata Y, Langlais PJ, Ciccia R, Hall T, Lopez N, Michaels LJ, Ward C, Bernard T, Terry M,
Gatonska S. (1998). Regionally selective reductions in synaptophysin binding following
chronic ethanol exposure in the rat. Alcohol Clin Exp Res. 22:64A.
85. Ciccia R, Langlais PJ, Hall T, Lopez N, Michaels LJ, Bernard T, Gatonska S, Burr JA. (1998).
Behavioral effects of chronic ethanol intake and thiamine deficiency in the rat. Alcohol Clin Exp
Res. 22:64A.
86. Langlais PJ, Ciccia R, Hall T, Lopez N, Michaels L, Bernard T, Gatonska S, Ward C, Terry M,
Eastvold A. (1998). Pathological effects of chronic ethanol intake and thiamine deficiency in the
rat. Alcohol Clin Exp Res. 22:89A.
87. Langlais PJ (1998). The role of thiamine deficiency in cortical atrophy and white matter damage
in alcoholics without Wernicke’s encephalopathy. Alcohol Clin Exp Res.22:137A.
88. Terry-Ferguson M, McRee RC, Langlais PJ. (1998). Relationship of mast cell proliferation and
macrophage activation to thiamine deficiency-induced focal lesions. Soc. Neurosci. Abstr.
24:1470
89. McRee RC, Terry-Ferguson M, Langlais PJ, Chen Y, Nalwalk JW, Hough L. (1998). Evidence
for increased histamine release and granulocyte proliferation in a rat model of Wernicke’s
encephalopathy. Soc. Neurosci. Abstr. 24:1472.
90. Langlais PJ, Godinez M, Powell HC, Garrett RS, Terry-Ferguson M, McRee RC (1999). Early
ultrastructural changes in blood vessels and mast cells in experimental Wernicke’s
encephalopathy. Alcohol Clin Exp Res 23:69A.
91. Thomas JD, Quinn V, O'Neill TM, Riley EP, Langlais PJ (2000). Alterations in motor activity
following pre- and neonatal thiamine deficiency. Alcohol Clin Exp Res 24:59A.
92. Ciccia R, Langlais PJ (2000). Anterior thalamic damage following chronic ethanol and/or
repeated bouts of dietary thiamine deficiency. Alcohol Clin Exp Res 24:66A.
93. Langlais PJ, Bannykh S, Bannykh RS, Garrett RS, Powell HC (2000). Thiamine deficiencyinduced damage to and loss of cortical and cerebellar myelinated fibers. Alcohol Clin Exp Res
24:222A.
94. Bangasser D, Ciccia R, Langlais PJ (2001). Deficits of attention and response selection in a rat
model of Wernicke’s encephalopathy. Presented at WPA annual meeting, Hawaii.
95. Langlais PJ, Ciccia R, Bangasser PJ, Penland A, Biane J (2001). Cognitive and attention deficits
in a rat model of Wernicke-Korsakoff Syndrome. Soc. Neurosci. Abstr. 27: 827.
24
96. Summers-Torres D, Kennedy JP, Franken L, Macian-Allen D, Ramirez JO, Abou JJ, Langlais PJ
(2002). Role of histamine in Wernicke’s encephalopathy. Paper presented at 72 Annual
Convention, Rocky Mountain Psychological Association, Utah (April 5-7).
97. Langlais PJ, Biane J, Penland A, Bangasser D, Ciccia R (2003). Disturbances of attention and
executive functions in a rat model of Wernicke’s encephalopathy. Invited lecture at 1st
International Symposium of Neurobehavioral Pharmacology, Sept. 13-15, Okayama, Japan.
Teaching Experience:
1970 - 1972 Research and Teaching Assistant, Department of Physiology, University of Texas
Medical Branch, Galveston, TX
Medical Physiology and Biophysics, (3 semesters)
1982 - 1985 Teaching Assistant, Department of Psychology, Northeastern University,
Boston, MA
Sensory Psych Fall '82; Intro Psych Winter & Spring '83
Abnormal Psych I Fall '82; Abnormal Psych II Spring '84
Abnormal Psych II & Found. Psych Spring '85
1986 - 1988 Part-Time Faculty, Department of Psychology, Stonehill College, N. Easton, MA
General Psych 101, Fall '86
General Psych 101, Spring '87
1988 - 1990 Assoc. Professor, Department of Psychology, SDSU
1991 - 2003 Professor, Department of Psychology, SDSU
Psych 260 - Intro Physio Psych,
Psych 600 - Seminar Research Orientation
Psych 760 - Graduate Seminar Physiological Psychol, Masters prgm.
Psych 860 - Physiological Fdns of Behavior, Clinical Psych Ph.D. prgm.
CogSci 294 – Neuropsychology Proseminar (UCSD JDP course)
CogSci 295 – Research Methods (UCSD JDP course)
Gen Studies 100 – University Seminar
2003 –
Professor, Dept of Psychology, Old Dominion University
DPT 785 – Clinical Neurophysiology
PSYC 873/673 – Biological Bases I: Physiological Psychology
PSYC 696 – Ethics, Professional Standards and Responsible Conduct
Recent University & Department Committees:
2010 – Pres
2003 - 2010
2008 – Pres
2003 – 2010
2003 – 2010
2003 – 2010
2004 – 2010
Member, Virginia State Science & Engineering Fair Committee
Chair, University Modeling & Simulation Steering Committee
Member, University Policy Review Committee
Chair, Graduate Administrators Committee
Member, Senate Committee C – Graduate Programs
Member, Provost Council
Chair, Graduate Financial Committee
Other Professional Administrative Positions:
25
1974 – 1977
1977 - 1981
1981 - 1985
1985 - 1987
1987 - 2001
1995 - 2003
Assoc. Director, Clinical Laboratories,
Lawrence Memorial Hospital, Medford, MA
Quality Control Supervisor, Clinical Laboratory
Service, V.A. Med. Ctr., Brockton, MA
Associate Director, Brain Tissue Resource Center,
McLean Hospital, Belmont, MA
Director, Behavioral Biology Section, Research Service,
V.A. Med. Ctr., Brockton, MA
Principal Investigator, VA Merit Review Program Grant;
V.A. Med Ctr., San Diego, CA
Director, P.I. Behavioral Neurobiology Section, Dept. of Psychology, SDSU
Community and Other Committee Assignments:
2009-2010 Member, Board of Directors, Coalition for Hearing, Education and Research (CHEAR)
2008 – Pres Member, Board of Directors, Wetlands Watch
1975 - 1977 Member, CPR-ECC Committee, S.E. Division, American Heart Association
1977 - 1978 Vice Chairman, CPR-ECC Committee, S.E. Division,AHA
1978 - 1980 Chairman, CPR-ECC Committee, S.E. Division, AHA.
1977 - 1980 Member, Program Planning Council, S.E. Division, AHA.
1980 - 1984 Chairman, Program Planning Council, S.E Division, AHA
1980 Member, Executive Committee, S.E. Division, AHA.
1980 - 1982 Member-At-Large, Board of Directors, S.E. Division, AHA.
1982 - 1984 Vice-Chairman, Board of Directors, S.E. Division, AHA.
1984 - 1985 Chairman, Board of Directors, S.E. Division, AHA.
1985 - 1987 Past Chairman, Board of Directors, S.E. Division, AHA.
1982 - 1983 Chairman, Hypertension Planning Committee, S.E. Division,AHA.
1977 - 1980 Member, CPR-ECC Ad Hoc Committee, Mass. Affiliate, AHA.
1979 - 1984 Member, Program Planning Council, Mass. Affiliate, AHA.
1981 - 1982 Member Task Force on Program Review, Mass. Affiliate, AHA.
1983 - 1984 Member Task Force on Extramural Program Review, Mass. Affiliate, AHA.
1988 - 1992 Member, School Board, St. Patrick's School Carlsbad, CA
2002- Pres Member, Board of Directors, The Woman’s Heart, San Diego, CA
2004- Pres Member, Executive Committee, The Wetlands Watch, Norfolk, VA