Sensors 2017, 17, doi:10.3390/s17020287; 287
S1 of S1
Supplementary Materials: Diagnosis by
Volatile Organic Compounds in Exhaled Breath
from Lung Cancer Patients Using Support Vector
Machine Algorithm
Yuichi Sakumura, Yutaro Koyama, Hiroaki Tokutake, Toyoaki Hida, Kazuo Sato, Toshio Itoh,
Takafumi Akamatsu and Woosuck Shin
Butane
0.6
0.3
0.2
0.25
0.25
Probability
Probability
Probability
0.4
0.2
0.15
0.1
0.1
0.2
0.4
0.6
0.8
0
1
0
50
100
ppb)
C8H16
0.05
5
0.3
0.2
0
10
0
0.1
0.2
20
0.3
0.2
0.3
0.2
0
0.6
0.2
0.15
0.1
0.05
0
0.5
1
1.5
ppb)
2
2.5
0
0
2
4
ppb)
(g)
8
(i)
Unknown
0.5
0.25
6
ppb)
(h)
Nonanal
80
0.25
0.1
0.4
60
Toluene
0.3
Probability
0.4
0.2
40
(f)
0.4
Probability
Probability
0
ppb)
Methylcyclohexane
0.5
0.1
0.4
Probability
Probability
0
0.3
(e)
0.5
0.2
0.15
0.1
0.3
0.2
0.1
0.05
0
0.1
ppb)
(d)
0.3
0.2
0.15
0.05
ppb)
Xylene
6
0.25
0.1
0
4
C8H17OH
0.3
Probability
Probability
Probability
0.1
0.6
2
(c)
0.4
0
0
ppb)
Dichlorobenzene
0.5
0.15
0
0
150
(b)
0.2
0
0.1
ppb)
(a)
0.25
0.2
0.15
0.05
0.05
0
2-Propanol
0.3
0.3
0.5
0
Acetone
0.35
0
1
2
3
0
0
5
10
ppb)
(j)
15
ppb)
(k)
Figure S1. VOC concentration distributions from lung cancer (red, n = 107) and healthy (green,
n = 29) controls’ breath; (a) butane; (b) acetone; (c) 2-propanol; (d) C8H16; (e) dichlorobenzene;
(f) C8H17OH; (g) xylene; (h) methylcyclohexane; (i) tolunene; (j) nonanal; and (k) unknown compound.