University of Groningen
Towards optimal decision making in personalized medicine
Cao, Qi
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2016
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Citation for published version (APA):
Cao, Q. (2016). Towards optimal decision making in personalized medicine: Potential value assessment of
biomarkers in heart failure exemplars [Groningen]: University of Groningen
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Download date: 12-07-2017
Towards optimal decision making in
personalized medicine
Potential value assessment of biomarkers in heart failure exemplars
Qi Cao
The research presented in this thesis was performed within the framework of the Center for
Translational Molecular Medicine; project TRIUMPH and ENGINE, and supported by the
Dutch Heart Foundation.
The printing of this thesis was financially supported by:
University Medical Center Groningen
University of Groningen
Copyright © Qi Cao, Groningen 2015
All rights reserved. No part of this thesis may be reproduced or transmitted in any form by
any means, without permission of the copyright owner
ISBN: 978-94-6299-228-3
Cover design: Qi Cao
Cover lay-out: Ridderprint BV, Ridderkerk
Lay out: Qi Cao
Printed by: Ridderprint BV, Ridderkerk
Towards optimal decision making in
personalized medicine
Potential value assessment of biomarkers in heart failure exemplars
PhD thesis
to obtain the degree of PhD at the
University of Groningen
on the authority of the
Rector Magnificus Prof. E. Sterken
and in accordance with
the decision by the College of Deans.
This thesis will be defended in public on
Monday 11 January 2016 at 14.30 hours
by
Qi Cao
born on 11 December 1983
in Beijing, China
Supervisors
Prof. E. Buskens
Prof. J.L. Hillege
Co-supervisor
Dr. D. Postmus
Assessment Committee
Prof. M.J. Postma
Prof. M.G.M. Hunink
Prof. A.W. Hoes
Paranymphs
Pepijn Vemer
Zhuozhao Zhan
Contents
Chapter 1
General introduction. ...............................................................................................................................9
Part I. DEVELOPMENT OF RISK-STRATIFIED TREATMENT RECOMMENDATIONS
Chapter 2
The PREVEND risk model for new onset heart failure with preserved and reduced ejection fraction. 23
Chapter 3
Using Subpopulation Treatment Effect Pattern Plot to identify more efficient resource allocation
policies: A case study in disease management of heart failure. .......................................................... 43
Part II. QUANTIFICATION OF THE ADDED VALUE OF INCLUDING BIOMARKERS
Chapter 4
The WAP four-disulfide core domain protein HE4: a novel biomarker for heart failure. .................... 61
Chapter 5
Continuous-time semi-Markov models in health economic decision making: an illustrative example in
heart failure disease management. ...................................................................................................... 85
Chapter 6
Probability elicitation to inform early health economic evaluations of new medical technologies: a
case study in heart failure disease management. .............................................................................. 109
Chapter 7
Potential economic value of biomarkers in optimized patient care: an exemplary assessment study in
heart failure disease management. .................................................................................................... 133
Chapter 8
General discussion. ............................................................................................................................. 151
Summary. ........................................................................................................................................... 165
Nederlandse samenvatting. .............................................................................................................. 169
Acknowledgements. .......................................................................................................................... 173
About the author. .............................................................................................................................. 177