THE PHYSICIAN’S CHOICE FOR
ADVANCED SCAR TREATMENT
MAKE EVERY
OUTCOME
BEAUTIFUL
Complete the scar healing process by offering the
only Advanced Scar Treatment with FDA-Cleared
Silishield™ Technology plus the protection of SPF 30.
SILISHIELD™ PATENTED CROSSLINKING SILICONE + SPF 30
by
CORNEUM
EPIDERMIS
DERMIS
HOW
BIOCORNEUM
WORKS
Scar Treatment Mechanism of Action 2
1. Healthy skin
has a mature
stratum corneum
that protects the
layers below and
helps to prevent
transepidermal
water loss (TEWL).
The Science of Scar Reduction
BIOCORNEUM’s key ingredient, FDA-Cleared Silishield™
patented crosslinking silicone, advances the benefits
of traditional silicone sheeting through the comfort
and ease of a gel. Silishield forms a protective shield
over the scar area that is optimal for physiological
healing and cosmetic improvement. Silishield’s patented
technology, made with medical grade silicone, helps to
keep skin hydrated and after 2-3 months of use, can
normalize excessive collagen formation, that
contributes to abnormal scarring1,2.
1
2. A surgical
H20
incision or injury
creates a gap in the
skin’s layers.
EPIDERMIS
Keratinocytes
DERMIS
Collagen
Fibroblast
H20
DERMIS
Collagen
the
reepithelialized area
with silicone gel
restores the barrier
function of the
UV
stratum corneum,
reducing water
loss and turning
off the stimulation
of keratinocytes.
BIOCORNEUM’s
sunscreen agents
protect the scar
from the darkening
effects of sun
exposure.
Keratinocytes
Collagen
Easy, Effective Care for Skin Recovery
• FDA-Cleared Silishield™ Technology plus the
protection of SPF 30
2
Fibroblast
• Silky-smooth clear gel His0simple to apply and is
quick-drying
2
H0
H220
• Forms a breathable, flexible protective shield that
like a second skin
STRATUM moves
CORNEUM
• Self-adhering – won’t peel, no tape required
• Ideal for skin that must flex a lot (such as around
joints), irregular
surfaces, as well as large scar areas
Keratinocytes
EPIDERMIS
• Ideal for face, neck, chest, hands, and other areas
Collagen
exposed
to the sun
DERMIS
• Once dry, continues to work when makeup, lotion, or
additional SPF protection is applied over it
3. Within one
to two weeks,
reepithelialization
is complete, but the
stratum corneum is
immature. This
allows abnormally
high levels of TEWL.
Dehydration is
signaled (blue
arrows) to
keratinocytes,
setting the scarring
process in motion.
• Suitable for children over the age of 6 months
RESULTS
H 0 H20
H20 Silicone gel reduces TEWL2 and normalizes
signaling H20
UV
UV
UV
H20 Silicone gel reduces TEWL and normalizes signaling H20
UV
2. Silicone
polymers
crosslink.
H0
H20 Silicone gel reduces TEWL2 and normalizes signaling H20
H20
H20
UV
H20
H20
UV
2
3. Volatile
silicones
evaporate.
5
H20
H20
BIOCORNEUM
should be used
UV
twice a day for two
to three months.
3
4. Polysiloxanes
and Silicon
Dioxide remain
adhered to skin,
creating the
silicone sheet
barrier.
6
H20
4
5. SPF 30
ingredients
help provide
protection from
discoloration
caused by
the sun.
H20
UV
After - 3 months
UV
1
The International Clinical Recommendations on Scar
Management named silicone as the single most
recommended topical (non-invasive) treatment for scars3.
Before
BIOCORNEUM
applied to the
skin.
UV
6. For maximum
H20 Silicone gel reduces TEWL and normalizes
signaling H20
H20
H20
effectiveness,
3
Fibroblast
H20
Fibroblast
H20 of
1.reduces
Thin TEWL
layer
H20 Silicone gel
and normalizes signaling H20
4
H0
5. Treatment of
H 0 H220
H20 Silicone gel reduces TEWL2 and normalizes
signaling H20
UV
EPIDERMIS
Silishield™ Mechanism of Action
H0
H20 H220
Fibroblast
STRATUM
CORNEUM
STRATUM
DERMIS
STRATUM
CORNEUM
H0
H220
CORNEUM
Sunscreen agents protect the area from
sun exposure’s
darkening effects while BIOCORNEUM maintains its
silky-smooth feel and clear appearance. It is peace of
mind protection that goes everywhere EPIDERMIS
the day demands.Keratinocytes
0
4. ExcessHcollagen
2
production leads to
abnormal scarring.
This results from
keratinocytes
producing cytokines
(red arrows), which
in turn activate
Keratinocytes
dermal fibroblasts
that then synthesize
Collagen
and release
collagen.
H20
STRATUM
CORNEUM
DERMIS
Collagen
Fibroblast
H20
EPIDERMIS
Keratinocytes
Before
After - 3 months
Before
After - 3 months
5
H20
AVAILABLE EXCLUSIVELY FROM PHYSICIANS
BIOCORNEUM.
Every Scar. Every Day.
39% to 68% of patients develop
hypertrophic scars after surgery 4.
BIOCORNEUM gives patients
control toward a beautiful recovery.
BIOCORNEUM by Sientra is the only advanced scar
treatment with FDA-Cleared Silishield™ patented
crosslinking medical grade silicone plus the protection
of SPF 30 — to support healing skin inside and out.
BIOCORNEUM forms an invisible shield to create an
optimal healing environment that can:
• prevent and minimize the formation of hypertrophic
and keloid scars,
• decrease the appearance of old scars, and
• help to restore the function of affected skin.
For maximum effectiveness, BIOCORNEUM should
have 24-hour contact with the scar area for the
duration of the treatment. This can be achieved by
applying BIOCORNEUM twice a day.
Recommended minimum treatment time:
Recommended sizing:
Length of scar based on a linear scar
with a coverage width of 0.5 inch, at
two applications per day.
2-3 INCHES
10g
new scars: 60 DAYS
4-6 INCHES
20g
older scars: 90 DAYS
7-9 INCHES
50g
How to apply BIOCORNEUM
• Ensure that the affected area is clean and dry.
• Apply a thin, even layer two times a day (morning and
evening) over the scar area.
• Allow to dry completely.
• After application wait 15 minutes before sun exposure.
1. Suetake T, Sasai S, Zhen YX, Tagami H. Effects of silicone gel
sheet on the stratum corneum hydration. Br J Plast Surg.
2000;53:503–507.
2. Mustoe TA. Evolution of silicone therapy and mechanism of action
in scar management. Aesth Plast Surg. 2008;32:82-92.
3. Gold MH, McGuire M, Mustoe TA et al. Updated international clinical
recommendations on scar management: Part 2 - algorithms for scar
prevention and treatment. Dermatol Surg. 2014;40:825-831.
4. Chernoff WG, Cramer H, Su-Huang S. The efficacy of topical
silicone gel elastomers in the treatment of hypertrophic scars,
keloid scars, and post-laser exfoliation erythema. Aesth Plast Surg.
2007;31(15):495-500.
MDC-0200 R1
• Once dry, BIOCORNEUM can be covered with pressure
garments, clothing, cosmetics or additional sunscreen
as needed.
• If the affected area is subject to abrasion, it may be
beneficial to repeat the application.
Important: BIOCORNEUM is for external use only. Avoid direct
contact with eyes, mucous membranes, third degree burns, and open
wounds. BIOCORNEUM should not be used on damaged or broken
skin. This product has not been shown to help prevent skin cancer
or early skin aging.
Manufactured in the USA for
Sientra, Inc., Santa Barbara CA 93117
Silishield™ is a trademark of Sientra, Inc.
US Patents: #5,741,509, #8,021,683, #8,263,114
© 2017 Sientra, Inc. All rights reserved.
sientra.com • 888.708.0808