Anthracycline Cardiomyopathy Is Mediated by Depletion of
the Cardiac Stem Cell Pool and Is Rescued by Restoration
of Progenitor Cell Function
by Antonella De Angelis, Elena Piegari, Donato Cappetta, Laura Marino, Amelia
Filippelli, Liberato Berrino, João Ferreira-Martins, Hanqiao Zheng, Toru Hosoda,
Marcello Rota, Konrad Urbanek, Jan Kajstura, Annarosa Leri, Francesco Rossi, and
Piero Anversa
Circulation
Volume 121(2):276-292
January 19, 2010
Copyright © American Heart Association, Inc. All rights reserved.
Figure 1. CPC death and growth.
Antonella De Angelis et al. Circulation. 2010;121:276-292
Copyright © American Heart Association, Inc. All rights reserved.
Figure 1 (Continued).
Antonella De Angelis et al. Circulation. 2010;121:276-292
Copyright © American Heart Association, Inc. All rights reserved.
Figure 2. Cell-cycle regulators and oxidative stress.
Antonella De Angelis et al. Circulation. 2010;121:276-292
Copyright © American Heart Association, Inc. All rights reserved.
Figure 2 (Continued).
Antonella De Angelis et al. Circulation. 2010;121:276-292
Copyright © American Heart Association, Inc. All rights reserved.
Figure 3. Telomere-telomerase and p53 function.
Antonella De Angelis et al. Circulation. 2010;121:276-292
Copyright © American Heart Association, Inc. All rights reserved.
Figure 3 (Continued).
Antonella De Angelis et al. Circulation. 2010;121:276-292
Copyright © American Heart Association, Inc. All rights reserved.
Figure 4. Doxorubicin-induced cardiomyopathy.
Antonella De Angelis et al. Circulation. 2010;121:276-292
Copyright © American Heart Association, Inc. All rights reserved.
Figure 4 (Continued).
Antonella De Angelis et al. Circulation. 2010;121:276-292
Copyright © American Heart Association, Inc. All rights reserved.
Figure 4 (Continued).
Antonella De Angelis et al. Circulation. 2010;121:276-292
Copyright © American Heart Association, Inc. All rights reserved.
Figure 5. Doxorubicin (DOXO) and gene expression in CPCs. Transcriptional profiling of CPCs in
the absence and presence of doxorubicin by quantitative reverse transcription–polymerase
chain reaction array.
Antonella De Angelis et al. Circulation. 2010;121:276-292
Copyright © American Heart Association, Inc. All rights reserved.
Figure 6. CPC death and growth.
Antonella De Angelis et al. Circulation. 2010;121:276-292
Copyright © American Heart Association, Inc. All rights reserved.
Figure 7. CPC treatment, ventricular function, and animal survival.
Antonella De Angelis et al. Circulation. 2010;121:276-292
Copyright © American Heart Association, Inc. All rights reserved.
Figure 8. Myocardial regeneration and doxorubicin-induced cardiomyopathy.
Antonella De Angelis et al. Circulation. 2010;121:276-292
Copyright © American Heart Association, Inc. All rights reserved.
Figure 8 (Continued).
Antonella De Angelis et al. Circulation. 2010;121:276-292
Copyright © American Heart Association, Inc. All rights reserved.