DECLARATIONS OF INTEREST
Please refer to the attached guidance notes before completing this register entry. In addition to
guidance on each section, examples of information required are also provided. Where you have
no relevant interests in the relevant category, please enter ‘none’ in the register entry.
Please return this form by e-mail and also a printed signed copy in addition to the e-mailed
version; updates after this need only be provided electronically.
Name:
Professor Pamela Shaw
Please list all MRC bodies you are a member of: E.g. Council, Strategy Board, Research Board, Expert
Panel etc and your position (e.g. chair, member).
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Neurosciences and Mental Health Board, Board member
Main form of employment: Name of University and Department or other employing body (include
location), and your position.
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University of Sheffield
Research group/department web page: Provide a link to any relevant web pages for your research
group or individual page on your organisation’s web site.
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www.sitran.dept.sheffield.ac.uk
Please give details of any potential conflicts of interests arising out of the following:
1. Personal Remuneration: Including employment, pensions, consultancies, directorships, honoraria.
See section 1 for further guidance.
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Consultancy for Biogen Idec, Sanofi-Aventis, Ono Pharma
2. Shareholdings and Financial Interests in companies: Include the names of companies involved in
medical/biomedical research, pharmaceuticals, biotechnology, healthcare provision and related fields
where shareholdings or other financial interests. See section 2 for thresholds and further guidance.
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None
3. Research Income during current session (1 April 2012-31 March 2013): Declare all research
income from bodies supported by the MRC and research income from other sources above the limit of
£50k per grant for the year. See section 3 for further guidance.
You do not need to provide the total value of the award or your total anticipated grant income within
the year though you may wish to do so.
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MOTOR NEURONE DISEASE ASSOCIATION 2008·2012 PhD Studentship (£78,618).
Mitochondrial redox dysfunction in MND: a therapeutic role for the peroxiredoxins. Jointly
with Dr C Wood-Allum.
MOTOR NEURONE DISEASE ASSOCIATION 2008 - 2012 (£159,817) Sheffield Care and
Research Centre for Motor Neuron Disorders Programme grant.
EUROPEAN UNION FRAMEWORK 7: 2008 ·2012 Sheffield component (£797,000).
Mitochondrial dysfunction in neurodegenerative diseases: towards new therapeutics.
Mitotarget Consortium. Joint PI PJ Shaw and AJ Grierson.
MOTOR NEURONE DISEASE ASSOCIATION 2008 ·2012 £168,068. Evaluation of the impact
of a cough-assist mechanical in-exsufflator (MI·E) device on morbidity, quality of life and
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survival in patients with motor neurone disease (MND) using non-invasive ventilation (NIV).
PI.
MEDICAL RESEARCH COUNCIL Centre for Developmental and Biomedical Genetics Fellowship
Award 2008-2012 (- £200K). Investigation of the role of TDP43 mutations in motor neuron
injury. Clinical Training Fellowship for Dr Channa Hewamadduma. PI jointly with Dr Andrew
Grierson and Professor Philip Ingham.
DEPARTMENT OF HEALTH NIHR CLINICAL RESEARCH NETWORK FOR DEMENTIAS AND
NEURODEGENERATIVE DISEASES (DeNDroN) 2006 -2011 (£1,041,280). Supplementary
resources for Motor Neuron Disease and Huntington's disease. 2006 -2011
MEDICAL RESEARCH COUNCIL CENTRE FOR DEVELOPMENTAL AND BIOMEDICAL GENETICS
2007-2012 £2,383,148 PI Prof. Philip Ingham. PJ Shaw is one of 12 named co-applicants.
MEDICAL RESEARCH COUNCIL MOTOR NEURONE DISEASE ASSOCIATION 2008 -2012
(£531,772) TDP-43 and alternative splicing in motor neurone disease. Clinical Training
Fellowship for Dr Robin Highley. Jointly with Prof Paul Ince and Dr Janine Kirby.
MOTOR NEURONE DISEASE ASSOCIATION 2008-2012 £378,278 LlCALS A Randomised
controlled trial of lithium carbonate in ALS. PI Professor Nigel Leigh King's College Hospital,
London.
MOTOR NEURONE DISEASE ASSOCIATION 2009 - 2013 (£148,058). Creation of a national
DNA and cell line repository for genetic research into motor neurone disease Extension
Grant. Joint 3 centre programme between Universities of Sheffield, Birmingham and
Institute of Psychiatry, King's College, London.
EPSRC 2009 - 2012 (£2.4million) Engineering virus like nanoparticles for targeting the
CNS.Jointly with Dr Guiseppe Battaglia and multiple members of Tissue Engineering,
Chemistry and Physics departments.
MEDICAL RESEARCH COUNCIL MND ASSOCIATION 2009-2012 (£ 232,710) Analysis of
physical activity as a risk factor for MND in genetically susceptible individuals. Research
training fellowship for Dr Ceryl Moore. PI Jointly with Dr Chris McDermott.
MOTOR NEURONE DISEASE ASSOCIATION 2009 - 2012 £170,750 Comparison of gene
expression profile in two S001 G93A mouse models showing strain specific difference in
motor neuron disease phenotype. Jointly with Dr Catenna Bendotti, Mario Negri Institute
Milan.
EU FRAMEWORK 7 HEALTH 2010 TWO STAGE GRANT. 2010 -2015 E8,998,359 (Sheffield
component E700,506) or total E927,675 Euromotor: Systems Biology In ALS. PJ Shaw one
of 16 PI's.
SHEFFIELD HOSPITALS CHARITABLE TRUST 2010 -2013 £63,370. A zebrafish model 01
motor neurone disease as a tool for drug screening. Jointly with Dr Tennare Ramesh.
NIHR HEALTH TECHNOLOGY ASSESSMENT PROGRAMME: Clinical Evaluation and trials. 2010
-2013 £1.472,060 A controlled adjunct trial in patients with respiratory muscle weakness
due to motor neurone disease of the NeuRxl4 diaphragm pacing system (DiPALS). Jointly
with Dr Chris McDermott.
MOTOR NEURONE DISEASE ASSOCIATION 2010 -2013 £300,000 A controlled adjunct trial in
patients with respiratory muscle weakness due to motor neurone disease of the NeuRx/4
diaphragm pacing system (DiPALS). Jointly with Dr Chris McDermott.
MOTOR NEURONE DISEASE ASSOCIATION 2010-2012 £162,761 Screening microRNAs as
blood based biomarkers for motor neurone disease (MND). PI Jointly with Dr Janine Kirby
and Dr Emily Goodall.
FOUNDATION THEIRRY LATRAN 2010 -2011 €30,000 Utilization 01 features of the eany
disease phenotypes in a zebrafish model of ALS for pharmacological screening to detect
small molecule neuroprotective compounds. Coapplicant with Tennore Ramesh.
MOTOR NEURONE DISEASE ASSOCIATION 2011 -2014 £195,000 Identification of
progressive neuronal stress from early development to adulthood and utilisation of this
readout in a pharmacological screen in the sod1 transgenic zebrafish model of ALSIMND.
Jointly with Dr Tennore Ramesh.
MEDICAL RESEARCH COUNCIL DEVELOPMENTAL PATHWAY FUNDING SCHEME 2010 - 2012
£656,000 SMN replacement therapy for spinal muscular atrophy. Co - applicant with
Professor Mimoun Azzouz, Professor Paul Ince and Dr Ke Ning.
EU FRAMEWORK 7 MARIE CURIE 2012 - 2015 E 271,943 Title: screening of candidate
targets for astrocyte toxicity in motor neurone disease. PI Fellowship for Laura Ferraiuolo
MEDICAL RESEARCH COUNCIL 2012 -2014 £396,130 Oxidative DNA Damage And
Transcriptional Impairment In Brain Ageing As An Easy Contributor To Cognitive
Impairment. Co-applicant with Dr Stephen Wharton.
THIERRY LATRAN FONDATION 2012-2014 E 122,000 Role of C90RF72 in proteostasis. K de
Vos, AJ Grierson, PJ Shaw.
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MEDICAL RESEARCH COUNCIL 2012-2014 £190,197 Characterisation of biological pathways
dysregulated in ALS cases with hexanucleotide expansions of C90RF72. Clinical training
Fellowship for Dr Johnathan Cooper-Knock.
EU JOINT PROGRAMME FOR NEURODEGENERATION I MEDICAL RESEARCH COUNCIL 20122015 Sampling and biomarker Optimisation and Harmonisation In ALS and other motor
neuron diseases (SOPHIA). PI for UK component.
4. Major academic collaborators [national and international]: Declare all significant collaborations
outside your primary institution or organisation. See section 4 for further guidance.
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Professor Ammar al Chalabi King's College London
Professor Karen Morrison University of Birmingham
Collaboration with multiple UK and European ALS/MND investigators in relation to the
Euromotor and SOPHIA multicentre collaborative grants.
Collaboration with multiple DeNDRoN investigators and MND Centre Directors in relation to
the DIPALS and PROGAS clinical studies.
Collaboration with Professors Jun Xu, Zhengliang Gao and Zhuyel Nie Tongji University
Shanghai, China in relation to iPS derived motor neurons as a model to study the
pathophysiology of motor neuron degeneration.
Collaboration with Professor Brian Kasper Ohio State University, USA in relation to glial
pathophysiology in ALS/MND.
5. Un-remunerated involvement with and membership of medical, bio-medical,
pharmaceutical, healthcare provision or science organisations or health
policy/communication and similar activities/organisations: This may include non-executive and
advisory positions, directorships and other positions of authority. See section 5 for further guidance.
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None
6. Political/pressure group associations: Members are expected not to occupy paid posts, or hold
high-profile unpaid roles within a political party, pressure group or similar organisation. Any
political/pressure group association should be declared. See section 6 for further guidance.
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None
7. Family: Provide details of any potential conflicts that may arise out of any known interests of
immediate family. See section 7 for further guidance.
Please indicate which section (1-6) above applies. Family members do not need to be identified, either
by name or their relationship to you.
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None