DEPARTMENT OF STATIS TICS
COLLEGE OF ARTS & SCIENCES
330.972.6886 (TELEPHONE)
Course Description
3470:670
Advanced Biostatistics
3 credits
Prerequisite: 3470:470/570 Biostatistics and Epidemiology.
Course Description: Statistical issues and methods for biological, medical and
health sciences including: clinical trials, equivalence studies, genomics, comparative
effectiveness studies, survival analysis, and bioassay. Computer applications.
Course Topics:
Clinical Trials
Designs and inference methods for different types of trials (superiority/noninferiority testing, equivalence testing, etc.)
More on sample size and power
Randomization and treatment masking
Various patient randomization schemes
Issues related to patient adherence and data quality control
Intention-to-treat analysis
Group sequential methods (O’Brien-Flemming, Pocock, Haybittle-Peto, alpha
spending function)
Bayesian adaptive clinical trials
Meta-analysis
Bioassays
Direct assays
Indirect assays: Quantitative assay/Quantal assays
Parallel line assay
Slope ratio assay
Survival Analysis
Frailty models
Competing and semi-competing risk models
Bioinformatics
Introduction to genomics
Microarray data: The statistical challenges
Topics in Public Health
Comparative effectiveness studies
Quality-of-life studies
Introduction to statistical process control for healthcare
Fall 2014