Teacher’s Profile
1. PERSONAL DETAILS:
Name
: Dr.(Mrs.) Akalpita Umesh Arvindekar
Date of Birth
: 11/04/1959
Sex
: Female
Marital Status
: Married
Languages known
: Engligh, Marathi, Hindi, Kannada
Postal Address
: 1151, Aruna Residency, Sykes Extension, 416 001
E. mail
: [email protected]
Website
: -
Web
: -
Phone
: 0231-2609153(office)
Mobile
: 09762746409
Fax
: 0231-2692333 (Univ)
2. EDUCATIONAL QUALIFICATION:
1
Degree
Subjects
Examination
Passed
Name of
Institution
Board/
University
S.S.C.
General
B.Sc.
M.Sc.
Chemistry Bot.
Zoology
Biochemistry
Ph.D.
Biochemistry
CSIR / NET
Life Sciences
Mysore Board
Karnatka University,
Dharwar
Karnataka University
Dharwar
Shivaji University,
Kolhapur
Life Science
Year
Class
Year of
passing
Grade/
Class
1974
1st class
1979
1st class
1981
1st class
1st rank
1996
1989
TITLE OF Ph. D. THESIS:
“Biochemistry of cell wall α glucans in Saccharomyces ceriviseae”
3. SCHOLARSHIPS AND ACHIEVEMENTS
National Merit Scholarship holder for post graduate studies.
Worked as JRF from 1983-84 at Biochemistry Department of Manasgangotri Mysore
Awarded NET CSIR JRF in 1989
4. RESEARCH AREA OF INTERESTS
Earlier worked on yeast cell wall glucans and fermentation technology
Working on evaluation of Ayurvedic plant components in treatment of Diabetes. Studies
include isolation and identification of bioactives, mechanism of drug action through in
vivo and in vitro studies.
Working on alpha glucosidase inhibitors, insulin secretagogues, insulin mimetics, protein
glycation inhibitors, glycogen phosphorylase inhibitors, GLUT 2 and SGLT2 inhibition in
treatment of diabetes mellitus
2
5. TEACHING EXPERIENCE:
25 years of teaching experience

N
o
.
Name
Degree Awarded Ph.D. Students
Research Topic
Year
Current
position
1. Mr. Santosh Sankh (2006)
Study of fermentation parameters: A project towards optimization of ethanol production in
Saccharomyces cerevisiae
Currently working as Senior Scientist – Reliance Life Sciences, Navi Mumbai
2. Mr Ashok Dattatray Chougale (2008)
Study of hypoglycemic activity and insulin like action of plant components in treatment of diabetes
mellitus
Currently working as Assistant Professor in Biochemistry at New College, Kolhapur
3. Ms. Varsha Adhikrao Ghadyale (2009)
Study of effect of medicinal plants on gastric uptake of glucose and non-specific glycosylation of
proteins
Currently working as Assistant Professor at Gogate Joglekar College, Ratnagiri
4. Ms. Preeti Prakash Aklujkar (2010)
Role of cell wall bound glycogen in Saccharomyces cerevisiae and optimization of ethanol
production
Planning to start her own private enterprise
5. Mr. Swapnil Balasaheb Patil (2013)
Study of insulin secretagogue action and antidiabetic activity of plant components in treatment of
diabetes mellitus
Working as Post Doc in Stem Cells in diabetic foot therapy at Galaway University, Ireland
6. Mr. Chaitanya Ramesh Kulkarni (2012)
Study of plant components having insulin sensitizer action and antihyperglycemic activity in
treatment of diabetes mellitus
Working as Senior Scientific Officer at Pranav Agro Products, Sangli
7. Ms. Vandana Ramchandra Dongare (2012)
3
Isolation and identification of active component from Foeniculum vulgare having antidiabetic
Activity
Working as Lecturer at Birnale College of Pharmacy, Sangli
8. Mr. Shreehari Subhash Taklikar (2013)
Study of some medicinal plants in treatment of diabetes mellitus
Working as Research Officer at Phytopharma, Kolhapur
9. Mr. Shrimant Nivasrao Panaskar (2013)
Study of antidiabetic activity of some medicinal plants
Working as Production Manager at Preventine Life, Mumbai
10. Madhav M. Joglekar (2014)
Role of plant components in nonspecific glycation inhibition and in prevention of secondary
complications in diabetes mellitus
Working as R & D Manager at Wockhardt Pharma, Aurangabad

N
o
Name
Research students working
Research topic
Working since
1.Tanaji A. More (2012)
Study of plant components having insulin mimetic and non specific protein glycation inhibitory
activity optimising antidiabetic treatment using combinatorial drug therapy
2.Ashwini D. Jagdale (2012)
Antidiabetic effect of some plant component and study of their role in inhibition of non specific
glycation and aldose reductase enzyme
3.Snehalata P.Kamble (2013)
Effect of plant components on intestinal alpha glucosidase, GLUT, SGLT transporters in treatment of
diabetes mellitus
4. Megha L.nalawade (2013)
Study of metabolic changes during prediabetes and prevention of progression to diabetes using plant
components
5.Laxman N. Bavkar (2013)
Evaluation of plant components as inhibitors of non specific protein glycation in prevention of
secondary complications in diabetes mellitus
4
6. FIELD OF EXERTISE
Diabetes – Animal studies, in vivo and in vitro studies
Bioprospecting – Isolation and identification of bioactives
Evaluation of mechanism of drug action
Clinical studies in Diabetes
7. REVIEWER OF THE INTERNATIONAL JOURNALS
J. of Inst Brew.
Analytical Biochemistry
J. of enz. Inhibition and medicinal chemistry
Food Res. International
ECAM
Food Biochemistry
Plant Foods for Human Nutrition
Food Chemistry
Natural Products Research
Pharmaceutical Biology
BMC Complementary and Alternative medicine
Food and Chemical Toxicology
Food Biophysics
European Food Research and Technology
Applied Microbiology and Biotechnology
Food Science and Technology
8. TECHNICAL AND ANALYTICAL SKILLS:
TLC, Column chromatography, HPLC, HPTLC, Animal studies (diabetes
induction and evaluation of diabetic status), Enzyme assays, islet studies
Spectrofluorimetry studies, Western blot, etc
9. FUNDED PROJECTS
.
Research Projects in Progress/ Completed
Title of Project/Scheme
Funding agency
Funds
received
Year
Worked as
5
1. Study of non specific protein
glycation inhibitors from plant
sources in treatment of diabetes
mellitus”
UGC
14.87 lakhs 2013-16 Principal
Investigator
2. Establishing a Resource Centre
RGSTC
100.90 lakhs 2014-17 Principal
for Studies on Ayurvedic medicines (Govt. of Maharashtra)
Investigator
in treatment of diabetes mellitus
10. WORKSHOPS AND SEMINARS ATTENDEDAND ORGANIZED
1. Poster presented on Antihyperglycemic and antioxidant effect of transanethole in the
treatment of Diabetes mellitus. Ashwini D. Jagdale, Tanaji A. More, Madhav M.
Joglekar, Vandana R. Dongre, and Akalpita U. Arvindekar* Challenges and
Opportunities in Life Sciences Feb 08 – 09 , 2013Department of Biochemistry,
Shivaji University, Kolhapur, Maharashtra
2. Poster presented on “Antidiabetic activity of linalool in treatment of diabetes mellitus
Tanaji More, Ashwini Jagdale, Madhav M. Joglekar, and Akalpita U. Arvindekar*
Challenges and Opportunities in Life Sciences Feb 08 – 09 , 2013 Department of
Biochemistry, Shivaji University, Kolhapur, Maharashtra
3. International symposium on Proteomics Beyond IDs ……and 4 th Annual Meeting of
Proteomics Society (INDIA) held from 22-24 November , 2012 at CSIR – National
Chemical Laboratory, Pune
4. Paper presented entitled, nonenzymatic protein glycation inhibition by Piper nigrum
pet ether extract” M. M. Joglekar, C. R. Kulkarni, S. N. Panaskar, Dr. A. U. Arvindekar,
Inernational conference on natural products and biomedical technology (ICNPBT2011) held during 10-12 January, in the department of
Biochemistry and
Biotechnology, Annamalai University (TN-India).
5. Paper presented entitled, “Insulin secretagogue, alpha-glucosidase inhibitory and
antioxidant activity of Myristica malabarica in treatment of diabetes mellitus.” S. B.
Patil, S. S. Taklikar, S. N. Panaskar, Dr. A. U. Arvindekar at Inernational conference
on natural products and biomedical technology (ICNPBT-2011) held during 10-12
January, in the department of Biochemistry and Biotechnology, Annamalai University
(TN-India).
6. Poster presented on “ Rat hepatic glycogen phosphorylase inhibitory activity and
antioxidant property of Caryophyllus aromaticusin treatment of Diabetes mellitus” C.R.
Kulkarni, S. B. Patil, S. S. Taklikar, V. A. Ghadyale and A. U. Arvindekar at National
Symposium on “Recent Trends in Life Sciences” (RTLS- 2011) on the 4th and 5th of March,
2011, organized by Department of Biochemistry, Shivaji University, Kolhapur
6
7. Poster presented on “ Inhibition of alpha glucosidase and antioxidant activity by Swertia
chirata methanolic extract S. N. Panaskar, S.S. Taklikar, C. R. Kulkarni and A.U. Arvindekar
National Symposium on “Recent Trends in Life Sciences” (RTLS- 2011) on the 4th and 5th of
March, 2011, organized by Department of Biochemistry, Shivaji University, Kolhapur
8. Paper presented entitled, “Inhibition of rat hepatic glycogen phosphorylase activity by
Cinnamomum zeylanicum,- a novel therapy in the treatment of Diabetes mellitus, C.R.
Kulkarni, S. B. Patil, M. M. Joglekar, Dr. A. U. Arvindekar at oral competition at
XXXIII Conference of Indian Botanical Society and International Symposium on the
New Horizons of Botany dated on 10th to 12th November, 2010 organized by
Department of Botany, Shivaji University, Kolhapur (MS-India).
9.
Poster presented entitled, “Anti-Hyperglycemic Activity of Myristica malabarica in
Treatment of Diabetes Mellitus.” S. B. Patil, S. S. Taklikar, C. R. Kulkarni, Dr. A. U.
Arvindekar at Poster competition at XXXIII Conference of Indian Botanical Society
and International Symposium on the New Horizons of Botany dated on 10th to 12th
November, 2010 organized by Department of Botany, Shivaji University, Kolhapur
(MS-India).
10 . Poster presented entitled, “Anti-Hyperglycemic Activity of Aegle marmelos
corrrea fruit extract in streptozotocin induced diabetic rats: Histopathological
perspective” S. S. Taklikar, S. N. Panaskar, S. B. Patil, Dr. A. U. Arvindekar at
Poster competition at XXXIII Conference of Indian Botanical Society and
International Symposium on the New Horizons of Botany dated on 10th to 12th
November, 2010 organized by Department of Botany, Shivaji University, Kolhapur
11. RESEARCH PUBLICATIONS (PUBLISHED)
International
1. Gycogen – a covalently linked component of the cell wall in Saccharomyces cerevisiae (2002)
Arvindekar A. U. and Patil N. B. Yeast, 19, 131-139. Imapct factor 2.3
2. Availability of substratum enhances ethanol production in Saccharomyces cerevisiae (2004) Sankh
S. N. & Arvindekar A. U. Biotechnology Letters, 26, 1821 – 1824. Impact factor 1.6
3. A Simplified Method for the Isolation and Estimation of Cell Wall Bound Glycogen in
Saccharomyces cerevisiae (2008) Sankh S. N., Aklujkar P.P., & Arvindekar A. U Journal of
Institute of Brewing Volume 114 (3) 205 - 208, 2008. Impact factor 1.3
4. Optimization of Alloxan is essential to induce stable diabetes for prolonged period, (2007)
Chougale A. D., Panaskar, S. N., Gurao P. M., & Arvindekar A. U., Asian Journal of
Biochemistry, 2, (6) 402 - 408.
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5. Alpha glucosidase inhibition by stem extract of Tinospora cordifolia (2009) Ashok D. Chougale,
Varsha A. Ghadyale, Shrimant N. Panaskar and Akalpita U. Arvindekar, Journal of Enzyme
Inhibition and Medicinal Chemistry 24(4) 998–1001. Impact factor 1.5
6. Insulin Secretagogue, Alpha-glucosidase and Antioxidant Activity of Some Selected Spices in
Streptozotocin-induced Diabetic Rats, (2011) Swapnil Balasaheb Patil, Varsha Adhikrao
Ghadyale, Shreehari Subhash Taklikar, Chaitanya Ramesh, Kulkarni, & Akalpita Umesh
Arvindekar Plant Foods for Human Nutrition, 66:85–90. Impact factor 2.5
7. Study of Two Pools of Glycogen in Saccharomyces cerevisiae and their Role in Fermentation
Performance, (2011) Preetee S. Deshpande, Santosh N. Sankh and Akalpita U. Arvindekar*
Journal of Institute of Brewing 117(1), 113–119. Impact factor 1.2
8. Effective Control of Postprandial Glucose Level through Inhibition of Intestinal Alpha Glucosidase
by cymbopogon martinii (Roxb.) (2011) Varsha Ghadyale, Shrihari Takalikar, Vivek Haldavnekar,
and Akalpita Arvindekar Evidence-Based Complementary and Alternative Medicine Volume
2012, Article ID 372909, 6 pages doi:10.1155/2012/372909 Impact factor 4.7
9. Improvement of Ethanol Production Using Saccharomyces cerevisiae by Enhancement of Biomass
and Nutrient Supplementation (2011) Santosh N. Sankh & Preetee S. Deshpande & Akalpita U.
Arvindekar Applied Biochemistry and Biotechnology 164:1237–1245, Impact factor 1.9
10. Antihyperglycemic and antihyperlipidemic effect of Santalum album in streptozotocin induced
diabetic rats (2011) Chaitanya R. Kulkarni, Madhav M. Joglekar, Swapnil B. Patil, Dr. Akalpita
U. Arvindekar* Pharmaceutical Biology. DOI: 10.3109/13880209.2011.604677
Impact factor 0.98.
11. Inhibition of aldose reductase and anti-cataract action of trans-anethole isolated from Foeniculum
vulgare Mill. Fruits (2012)Vandana Dongare , Chaitanya Kulkarni , Manish Kondawar ,
Chandrakant Magdum,Vivek Haldavnekar, Akalpita Arvindekar,⇑ Food Chemistry 132(2012)
385–390 Impact factor 3.5
12. Insulinotropic and b-cell protective action of cuminaldehyde,cuminol and an inhibitor isolated from
Cuminum cyminum instreptozotocin-induced diabetic rats. (2013) Swapnil B. Patil, Shreehari S.
Takalikar, Madhav M. Joglekar, Vivek S. Haldavnekarand Akalpita U. Arvindekar, British
Journal of Nutrition, doi:10.1017/S0007114513000627 Impact Factor 3.1
13. Aegle marmelos Correa leaf extract prevents secondary complications in streptozotocininduced diabetic rats anddemonstration of limonene as a potent antiglycating agent, (2013),
Shrimant N. Panaskar, Madhav M. Joglekar, Shreehari S. Taklikar, Vivek S. Haldavnekar and
Akalpita U.Arvindekar, Journal of Pharmacy and Pharmacology, doi: 10.1111/jphp.12044
Imapct Factor 2.1
14 Antidiabetic activity of Kalanchoe pinnata in streptozotocin induced diabetic rats by glucose
independent insulin secretagogue action (2013) Swapnil B. Patil, Vandana R. Dongare,
8
Chaitanya R. Kulkarni, Madhav M. Joglekar, and Akalpita U. Arvindekar, Pharmaceutical
Biology, DOI: 10.3109/13880209.2013.794364
15. A novel mechanism for antiglycative action of limonene through stabilization of protein
Conformation (2013) Madhav M. Joglekar,a Shrimant N. Panaskar,a Ashok D. Chougale,b
Mahesh J. Kulkarnib and Akalpita U. Arvindekar*, Molecular Biosystems 9; 2463 -72
Impact Factor 3.3
16. Inhibition of advanced glycation end product formation by cymene – A common food constituent
(2013) Madhav M. Joglekar, Shrimant N. Panaskar, Akalpita U. Arvindekar*Journal of Functional
Foods (2013), http://dx.doi.org/10.1016/j.jff.2013.09.024 Impact factor 2.5
National
1.Treatment of Diabetes mellitus using Ayurvedic preparation X-14, Chougale A. D., Haldavnekar
V.S. & Arvindekar –A. U,(2006) Ayucon 1, 84 – 89.
2. Hypoglycemic effect of Foeniculum vulgare Mill. Fruit on dexamethasone induced insulin
resistant rats (2010) Dongare V. R., Arvindekar A. U., Magdum C. S. Research Journal of
Pharmacognosy and Phytochemistry, 2 (02) 163-165.
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