Table S1. Human RA and RB domains listed in SMART database as of March 2007
Code
Domain
boundary
Uniprot accession no.
Protein
Synonyms
SwissProt Primary Acc
no./Comment
RA domain (61)
RA1_P1
39–133
UPI00006C0AEE
Afadin
AF-6, MLLT4
P55196
RA2_P1
246–319
UPI00006C0AEE
Afadin
AF-6, MLLT4
P55196
RA3_P2
181–271
UPI0000456382
RASSF4
AD037
Isoform A of Q9H2L5
RA4_P3
798–885
Q12967
RalGDS
RalGEF
RA5_P4
23–119
O75901
PAMCI
PCIP1
RA6_P5
6–89
UPI00005FB10F
RASSF8
C12orf2, HOJ-1
PAM COOH-terminal interactor
protein 1
Q8NHQ8
RA7_P6
100–186
UPI000013EE4C
GRB7
B47
Q14451
RA8_P7
15–114
Q13459
Myosin-IXb
MYR5, MYO9B
RA9_P8
8–94
UPI0000481B4A
GRB7
B47
RA10_P9
683–770
Q5VU94
RGL1
RA11_P10
269–355
UPI0000D61296
RAPH1
RA12_P11
50–181
UPI00006C1104
PREDICTED (NCBI A/N:
XP_945864)
RA13_P12
610–700
UPI0000198509
RGL3
Q14451
Lamellipodin, proline-rich EVH1
Q70E73
ligand 2, PREL-2, RMO1, ALS2CR9
Similar to peptidylglycine alpha
amidating monooxygenase
COOH-terminal interactor
Q3MIN7
Code
Domain
boundary
Uniprot accession no.
Protein
Synonyms
SwissProt Primary Acc
no./Comment
RA14_P13
749–835
UPI000013EC9D
RAPGEF6
PDZ-GEF2, RA-GEF-2,
Q8TEU7
RA15_P14
172–262
Q86WG9
RASSF6
RA16_P15
100–186
Q53YD3
GRB7- variant
RA17_P16
176–263
UPI0000D60F24
AB1IP
RIAM, PREL-1, proline-rich protein
73, RARP-1
Q7Z5R6
RA18_P17
754–840
UPI00006C07F2
RAPGEF2
nRap GEP, PDZ-GEF1, RA-GEF
Q9Y4G8
RA19_P18
144–259
Q5U651
Rain
RASIP1
RA20_P19
124–218
Q5TZT2
RASSF1
RA21_P20
39–133
P55196-3
Afadin
MLLT4
Isoform 3 of P55196
RA22_P20
245–347
P55196-3
Afadin
MLLT4
Isoform 3 of P55196
RA23_P21
321–407
UPI0000D61297
RAPH1
Lamellipodin, Proline-rich EVH1
Q70E73
ligand 2, PREL-2, RMO1, ALS2CR9
RA24_P22
61–126
Q1WD23
MLL/AF6 fusion protein
RA25_P23
106–192
Q14449
GRB14
RA26_P24
624–705
UPI000013F14D
RIN1
Ras inhibitor JC99
RA27_P25
2135–2238
UPI0000D60F9E
PLCE1
RA28_P26
166–250
Q13322
GRB10
EC 3.1.4.11, PLC-epsilon-1,
Q9P212
pancreas-enriched phospholipase C
GRBIR, KIAA0207
RA29_P27
799–885
UPI0000457339
RAPGEF6
PDZ-GEF2, RA-GEF-2, RAPGEF6
Isoform B of Q6ZTQ3,
Isoform C of RASSf1
Q13671
Q8TEU7
Code
Uniprot accession no.
Protein
Synonyms
RA30_P28
Domain
boundary
836–927
SwissProt Primary Acc
no./Comment
Isoform 2 of Q8WYP3
Q8WYP3-2
RIN2
RASSF4, Ras inhibitor JC265
RA31_P29
296–382
UPI0000D61298
RAPH1
Lamellipodin, proline-rich EVH1
Q70E73
ligand 2, PREL-2, RMO1, ALS2CR9
RA32_P30
797–884
Q6ZSD5
RA33_P31
492–573
Q59FL5
CDNA FLJ45617 fis,
clone BRTHA3026916
Ras inhibitor RIN1 variant
RA34_P32
6–89
Q02833
RASSF7
RA35_P33
648–735
O15211
RGL2
HRAS1-related cluster protein 1,
C11orf13
RAB2L
RA36_P34
174–265
UPI0000D61025
RASSF2
KIAA0168
RA37_P35
6–89
Q02833-2
RASSF7
RA38_P36
166–250
Q13322-2
GRB10
HRAS1-related cluster protein 1,
C11orf13
GRBIR, KIAA0207
RA39_P37
272–364
Q8WWW0
RASSF5
RapL, NORE1
RA40_P38
79–187
Q86WH2
RASSF3
RA41_P39
41–131
UPI00006C1988
RGL3
Q8WWW0 (isoform C of RASSF5 is
actually renamed as RapL
Q86WH2 (correct entry for
RASSF3)
Q3MIN7
RA42_P40
800–887
Q6NSK7
RIN3
Q8TB24
RA43_P41
78–170
Q8TEK8
FLJ00186
RA44_P42
119–211
Q8WXF4
RASSF5
RapL, NORE1
Q8TEK8 is a fragment of RASSF5
(Q8WWW0)
Q8WWW0 (isoform C of Q8WWW0
is actually renamed as RapL
RA45_P43
395–494
UPI00001AE9B4
Diacylglycerol kinase
theta
EC 2.7.1.107, DGK-theta, DAG
kinase theta
Q6ZSD5
97% similar to RASSF2 (P50749),
isoform 1 of RASSF2
Isoform 2 of Q02833,
Isoform 1 of Q13322
P52824
Code
Domain
boundary
Uniprot accession no.
Protein
Synonyms
SwissProt Primary Acc
no./Comment
RA46_P44
61–164
UPI00005EDD9A
Uncharacterized protein
KIAA1849
RA47_P45
172–262
Q8N5A9
RASSF4
AD037
Isoform A of Q9H2L5
RA48_P46
198–292
UPI000045710E
RASSF1
RDA32
Isoform E of Q9NS23
RA49_P47
1827–1930
Q5VWL4
PLCE1
Phospholipase C epsilon 1
RA50_P48
263–353
UPI0000D60F4D
RASSF4
AD037
RA51_P49
606–692
Q9Y4G8
RAPGEF2
nRap GEP, PDZ-GEF1, RA-GEF
RA52_P50
876–963
Q76LB3
RIN3
RA53_P51
562–643
Q13671-2
RIN1
Ras inhibitor JC99
Isoform RIN1-delta of Q13671
RA54_P52
176–263
Q7Z5R6
AB1IP
Q7Z5R6
RA55_P53
14–112
UPI000013D213
(Similar to) MYO9A
RIAM, PREL-1, proline-rich protein
73, RARP-1
Myosin IXA
RA56_P54
216–306
Q6ZTQ3
RASSF6
RA57_P55
39–133
UPI0000711FDA
Afadin
AF-6, MLLT4
P55196
RA58_P55
245–347
UPI0000711FDA
Afadin
AF-6, MLLT4
P55196
RA59_P56
371–458
Q92942
RGL2
RA60_P57
39–133
UPI00004574E7
Afadin
AF-6, MLLT4
P55196
RA61_P57
245–347
UPI00004574E7
Afadin
AF-6, MLLT4
P55196
Q96JH8
Isoform A of Q9H2L5
Q8TB24
98% similar to Q6P986
Code
Uniprot accession no.
Protein
Synonyms
RA62_P58
Domain
boundary
27–114
SwissProt Primary Acc
no./Comment
Q12967
UPI0000112BF0
RalGDS
RalGEF
RA63_P59
749–835
UPI000020C537
RAPGEF6
PDZ-GEF2,
RA-GEF-2
RA64_P60
274–351
Q59GG4
RA65_P61
1–82
Q8NHQ8
RASSF5 isoform B
variant
RASSF8
RBD1_P1
594–661
Q59GK8
TIAM-1 variant
Fragment of Q13009
RBD2_P2
765–832
UPI000013DE6F
TIAM-1
Q13009
RBD3_P3
82–153
UPI0000D616C2
RGS14
Q506M1/ O43566
RBD4_P3
155–225
UPI0000D616C2
RGS14
O43566/ Q506M1
RBD5_P4
8–80
UPI0000574D65
Araf
RBD6_P5
149–220
Q506M1
RGS14
RBD7_P5
222–292
Q506M1
RGS14
RBD8_P6
962–1032
O14924
RGS12
RBD9_P6
1034–1104
O14924
RGS12
RBD10_P7
348–419
Q6ZUP9
TIAM2
RBD11_P8
1056–1127
Q59EY7
TIAM2-varient
Q8TEU7
C12orf2, HOJ-1
RB domain (19)
EC 2.7.11.1,
CDNA FLJ43470 fis, clone
OCBBF2037547
P14056
Code
Uniprot accession no.
Protein
RBD12_P9
Domain
boundary
19–91
Synonyms
SwissProt Primary Acc
no./Comment
Q96II5
ARAF
RBD13_P10
155–227
P15056
BRAF
RBD14_P11
834–905
Q5VYA5
TIAM2
RBD15_P12
302–373
UPI000013E850
RGS14
Q5VYA4 (Q5VYA5 is wrong entry in
database)
Q506M1
RBD16_P12
375–445
UPI000013E850
RGS14
Q506M1
RBD17_P13
56–131
P04049
RAF1
RBD18_P14
360–430
Q8WX95
RGS12TS-S isoform
RBD19_P14
432–502
Q8WX95
RGS12TS-S isoform
EC 2.7.11.1, p94, v-Raf murine
sarcoma viral oncogene homolog B1
C 2.7.11.1,
Raf-1, C-RAF, cRaf